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The map label for this gene is ilvA [H]

Identifier: 225852554

GI number: 225852554

Start: 1038314

End: 1039573

Strand: Direct

Name: ilvA [H]

Synonym: BMEA_A1092

Alternate gene names: 225852554

Gene position: 1038314-1039573 (Clockwise)

Preceding gene: 225852552

Following gene: 225852555

Centisome position: 48.85

GC content: 54.13

Gene sequence:

>1260_bases
ATGATGACCCCCTTCGTCAAATCCGTGGCCCAGGCAGAAAAGGCAATGCGCGCGCTCTTTTGCGAAACGCCATTGCAACG
CAACGATTATCTGTCGCGGAAATATGGTGCGCAGATTTGGCTGAAACGCGAAGACCTGACGCCGGTGCGCTCCTACAAGC
TGCGCGGTGCCTTCAATTTTATTTCCAAAGCCGTTGAAACAACAGATAAAAATGCCGTTTTCGTCTGTGCTTCCGCCGGC
AATCATGCGCAGGGCTTTGCATTCGTCTGCCGGCATTTCGGGCGCAAGGGCGTGGTTTTCATGCCAGTCACCACGCCGCA
GCAGAAAATCGACAAGACGCGCACCTTTGGCGGAGAATTCATCGAAATCAAACTTGTCGGCGATATTTTCGATGTCTGTT
ATGCCGCCTCGCGGGAATTCGCAGCCGCCAACAAGGGCGTGATGGTGCCACCCTTCGACCATCCCGGCATTGTTGAAGGG
CAGGCGACAGTCGCGCTGGAAATCGAGCGGCAATTGCCGGACGACAGCAAGCCGGACCTCGTGCTCCTGCCGGTTGGCGG
TGGCGGGCTTTCAAGCGGCGTAACGCAATATATCGCCGATCTTGGCTGGAAAACCGCTTTCCGCTTTGTGGAGCCGCAGG
GCGCGGCAAGCCTCAAGGCCAGCCTGGAGGCGGGCAAGCGGGTCAAGCTTTCGCATATCGATAATTTTGTCGATGGTGCT
GCCGTTGCAGAAATCGGCAAAGAAAATTTCAAACTTCTCAAAGGCTTCGATCCGAAAACTGTCATAACGGTTCCGGAAAA
CAAGCTCTGCGCGACCATTGTTGAAATGCTGAATATTGAAGGTGTTGTGCTGGAACCGGCCGGTGCGCTCGGCATCGATG
CGCTCAAGGATTTCAAGAAAAGCGACATCAAGGGCAAACGCATCGTTATCGTCGTTTCTGGCGGCAATTTCGATTTCGAG
CGGCTGCCGGATGTGCGGGAAAGGGCGCTTCGTTTTGAAGGGCTGAAGAAATATTTCATTTTCCGCTTTCCTCAGTGCCC
CGGCGCATTGCGCTCCTTCCTTGACCTTCTGGGGCCGGATGACGATATTGCGCGCTTTGAATATCTCAAGAAATCGGCGC
GAAATTTCGGCTCGGTGCTAATCGGTATCGAAACCAGGGACGCGGCAAATTTCAAGCTTCTGGAGAAGAAGTTTGCCGAA
TCCGGCTGGGCCTATCAGGATATCAGCGATAATCAGGTTCTGGCCGATTTCATCATCTGA

Upstream 100 bases:

>100_bases
GACTTGCGGGTTCAAGTCCCGCCGACCGCACCACCTTTCCCTATTGTCCGAAATCCATATATCCTTGGGGCAATTTTTGC
AGGAAAATCCAGAAAGCTGA

Downstream 100 bases:

>100_bases
CACAAAGTTTTCGCGCAAAACCATTTGCTTTTTGGGCGAAAACGCTCCATATGCCAATTCAGGCGCATGGGCCGACTGAT
TTTCATCGGCTTTCCCGGAC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MMTPFVKSVAQAEKAMRALFCETPLQRNDYLSRKYGAQIWLKREDLTPVRSYKLRGAFNFISKAVETTDKNAVFVCASAG
NHAQGFAFVCRHFGRKGVVFMPVTTPQQKIDKTRTFGGEFIEIKLVGDIFDVCYAASREFAAANKGVMVPPFDHPGIVEG
QATVALEIERQLPDDSKPDLVLLPVGGGGLSSGVTQYIADLGWKTAFRFVEPQGAASLKASLEAGKRVKLSHIDNFVDGA
AVAEIGKENFKLLKGFDPKTVITVPENKLCATIVEMLNIEGVVLEPAGALGIDALKDFKKSDIKGKRIVIVVSGGNFDFE
RLPDVRERALRFEGLKKYFIFRFPQCPGALRSFLDLLGPDDDIARFEYLKKSARNFGSVLIGIETRDAANFKLLEKKFAE
SGWAYQDISDNQVLADFII

Sequences:

>Translated_419_residues
MMTPFVKSVAQAEKAMRALFCETPLQRNDYLSRKYGAQIWLKREDLTPVRSYKLRGAFNFISKAVETTDKNAVFVCASAG
NHAQGFAFVCRHFGRKGVVFMPVTTPQQKIDKTRTFGGEFIEIKLVGDIFDVCYAASREFAAANKGVMVPPFDHPGIVEG
QATVALEIERQLPDDSKPDLVLLPVGGGGLSSGVTQYIADLGWKTAFRFVEPQGAASLKASLEAGKRVKLSHIDNFVDGA
AVAEIGKENFKLLKGFDPKTVITVPENKLCATIVEMLNIEGVVLEPAGALGIDALKDFKKSDIKGKRIVIVVSGGNFDFE
RLPDVRERALRFEGLKKYFIFRFPQCPGALRSFLDLLGPDDDIARFEYLKKSARNFGSVLIGIETRDAANFKLLEKKFAE
SGWAYQDISDNQVLADFII
>Mature_419_residues
MMTPFVKSVAQAEKAMRALFCETPLQRNDYLSRKYGAQIWLKREDLTPVRSYKLRGAFNFISKAVETTDKNAVFVCASAG
NHAQGFAFVCRHFGRKGVVFMPVTTPQQKIDKTRTFGGEFIEIKLVGDIFDVCYAASREFAAANKGVMVPPFDHPGIVEG
QATVALEIERQLPDDSKPDLVLLPVGGGGLSSGVTQYIADLGWKTAFRFVEPQGAASLKASLEAGKRVKLSHIDNFVDGA
AVAEIGKENFKLLKGFDPKTVITVPENKLCATIVEMLNIEGVVLEPAGALGIDALKDFKKSDIKGKRIVIVVSGGNFDFE
RLPDVRERALRFEGLKKYFIFRFPQCPGALRSFLDLLGPDDDIARFEYLKKSARNFGSVLIGIETRDAANFKLLEKKFAE
SGWAYQDISDNQVLADFII

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI33469958, Length=321, Percent_Identity=29.9065420560748, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI11345492, Length=328, Percent_Identity=26.219512195122, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI19923959, Length=303, Percent_Identity=26.7326732673267, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1790207, Length=393, Percent_Identity=35.3689567430025, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1789505, Length=321, Percent_Identity=28.9719626168224, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71991565, Length=312, Percent_Identity=33.974358974359, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17537387, Length=400, Percent_Identity=31.25, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17508781, Length=289, Percent_Identity=28.0276816608997, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320930, Length=405, Percent_Identity=32.3456790123457, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322631, Length=321, Percent_Identity=28.6604361370716, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6319788, Length=320, Percent_Identity=27.5, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355833, Length=325, Percent_Identity=30.1538461538462, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24645328, Length=259, Percent_Identity=30.1158301158301, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 46283; Mature: 46283

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTPFVKSVAQAEKAMRALFCETPLQRNDYLSRKYGAQIWLKREDLTPVRSYKLRGAFNF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEECCCCCHHHHHHHHHHHHH
ISKAVETTDKNAVFVCASAGNHAQGFAFVCRHFGRKGVVFMPVTTPQQKIDKTRTFGGEF
HHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCE
IEIKLVGDIFDVCYAASREFAAANKGVMVPPFDHPGIVEGQATVALEIERQLPDDSKPDL
EEEEEHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCEECCCEEEEEEEECCCCCCCCCCE
VLLPVGGGGLSSGVTQYIADLGWKTAFRFVEPQGAASLKASLEAGKRVKLSHIDNFVDGA
EEEECCCCCHHHHHHHHHHHCCHHHHHEEECCCCCHHHHHHHHCCCEEEHHHHHHHHCHH
AVAEIGKENFKLLKGFDPKTVITVPENKLCATIVEMLNIEGVVLEPAGALGIDALKDFKK
HHHHHCHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHH
SDIKGKRIVIVVSGGNFDFERLPDVRERALRFEGLKKYFIFRFPQCPGALRSFLDLLGPD
CCCCCCEEEEEEECCCCCHHHCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCC
DDIARFEYLKKSARNFGSVLIGIETRDAANFKLLEKKFAESGWAYQDISDNQVLADFII
CHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCEECCCCCCCCHHHHCC
>Mature Secondary Structure
MMTPFVKSVAQAEKAMRALFCETPLQRNDYLSRKYGAQIWLKREDLTPVRSYKLRGAFNF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEECCCCCHHHHHHHHHHHHH
ISKAVETTDKNAVFVCASAGNHAQGFAFVCRHFGRKGVVFMPVTTPQQKIDKTRTFGGEF
HHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCE
IEIKLVGDIFDVCYAASREFAAANKGVMVPPFDHPGIVEGQATVALEIERQLPDDSKPDL
EEEEEHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCEECCCEEEEEEEECCCCCCCCCCE
VLLPVGGGGLSSGVTQYIADLGWKTAFRFVEPQGAASLKASLEAGKRVKLSHIDNFVDGA
EEEECCCCCHHHHHHHHHHHCCHHHHHEEECCCCCHHHHHHHHCCCEEEHHHHHHHHCHH
AVAEIGKENFKLLKGFDPKTVITVPENKLCATIVEMLNIEGVVLEPAGALGIDALKDFKK
HHHHHCHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHH
SDIKGKRIVIVVSGGNFDFERLPDVRERALRFEGLKKYFIFRFPQCPGALRSFLDLLGPD
CCCCCCEEEEEEECCCCCHHHCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCC
DDIARFEYLKKSARNFGSVLIGIETRDAANFKLLEKKFAESGWAYQDISDNQVLADFII
CHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCEECCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]