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The map label for this gene is folK [H]

Identifier: 225852535

GI number: 225852535

Start: 1015719

End: 1016252

Strand: Direct

Name: folK [H]

Synonym: BMEA_A1072

Alternate gene names: 225852535

Gene position: 1015719-1016252 (Clockwise)

Preceding gene: 225852534

Following gene: 225852540

Centisome position: 47.78

GC content: 59.36

Gene sequence:

>534_bases
GTGAGCACTCCGCCGAAACCATTGCGCGCCTGGCTTGGCCTCGGCGGCAATATCGATGATCCGATCATCTCCATGGCGAG
CGCGCTTCGTATGCTGGATGGACGGAGCGACACGAGGGTTGTTTCCGTATCCCCGGTCTACCGGACCCCGCCATGGGGCA
AGACGGATCAGGCCTGGTTCCACAATGCCTGCGCGCAAATCGAAACGGCCTTGCAGCCACTGGAACTGATTGCGGTCTGT
CTGGACGTGGAGCGATCCTTGAAACGTGTGCGGCTGGAACGGTGGGGACCACGCATCATCGATATCGATATTCTTGTTAT
GCAGGATGAGACGGGCAGGGCAATCACGATGCAGGAACCGGCATTGGAGCTTCCGCATCCACGTATGCACGAGCGAGCCT
TCGTTCTGGCGCCGCTCAATGATATCGCACCTTCGCTGCCTGTCGGTGCGAGAACTGTTGCTGAATGGGCTGCCGATTGC
GACCGTGCGGAAATGGAAAAAGCCCGCACGGATGCGGGCTGGTGGTTGGAATAG

Upstream 100 bases:

>100_bases
GGTTTCCTCAGATAAAGCGGGCTGAGATCACGATCCGCAAGCCGAATGCCCCGGTTTCGGGCGTCCTCGATTATGTGGAA
GTAACCGTGGTTTACCCCCA

Downstream 100 bases:

>100_bases
AGCGTTTTTTGAGCCAAAAGTGTAAAACGGTCTGGCGTCGGATAACGCGACAAAACAAATAGTTGGAGCGGTTCCAACGA
TTGCGTTTTAACTACAGCCT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MSTPPKPLRAWLGLGGNIDDPIISMASALRMLDGRSDTRVVSVSPVYRTPPWGKTDQAWFHNACAQIETALQPLELIAVC
LDVERSLKRVRLERWGPRIIDIDILVMQDETGRAITMQEPALELPHPRMHERAFVLAPLNDIAPSLPVGARTVAEWAADC
DRAEMEKARTDAGWWLE

Sequences:

>Translated_177_residues
MSTPPKPLRAWLGLGGNIDDPIISMASALRMLDGRSDTRVVSVSPVYRTPPWGKTDQAWFHNACAQIETALQPLELIAVC
LDVERSLKRVRLERWGPRIIDIDILVMQDETGRAITMQEPALELPHPRMHERAFVLAPLNDIAPSLPVGARTVAEWAADC
DRAEMEKARTDAGWWLE
>Mature_176_residues
STPPKPLRAWLGLGGNIDDPIISMASALRMLDGRSDTRVVSVSPVYRTPPWGKTDQAWFHNACAQIETALQPLELIAVCL
DVERSLKRVRLERWGPRIIDIDILVMQDETGRAITMQEPALELPHPRMHERAFVLAPLNDIAPSLPVGARTVAEWAADCD
RAEMEKARTDAGWWLE

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=138, Percent_Identity=37.6811594202899, Blast_Score=94, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324073, Length=151, Percent_Identity=36.4238410596026, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19829; Mature: 19698

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPPKPLRAWLGLGGNIDDPIISMASALRMLDGRSDTRVVSVSPVYRTPPWGKTDQAWF
CCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCEECCCCCCCCHHHH
HNACAQIETALQPLELIAVCLDVERSLKRVRLERWGPRIIDIDILVMQDETGRAITMQEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCEEEECCC
ALELPHPRMHERAFVLAPLNDIAPSLPVGARTVAEWAADCDRAEMEKARTDAGWWLE
CCCCCCCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STPPKPLRAWLGLGGNIDDPIISMASALRMLDGRSDTRVVSVSPVYRTPPWGKTDQAWF
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCEECCCCCCCCHHHH
HNACAQIETALQPLELIAVCLDVERSLKRVRLERWGPRIIDIDILVMQDETGRAITMQEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCEEEECCC
ALELPHPRMHERAFVLAPLNDIAPSLPVGARTVAEWAADCDRAEMEKARTDAGWWLE
CCCCCCCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]