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The map label for this gene is sufS [H]

Identifier: 225852445

GI number: 225852445

Start: 929061

End: 930305

Strand: Direct

Name: sufS [H]

Synonym: BMEA_A0972

Alternate gene names: 225852445

Gene position: 929061-930305 (Clockwise)

Preceding gene: 225852444

Following gene: 225852446

Centisome position: 43.71

GC content: 55.58

Gene sequence:

>1245_bases
ATGGATCAGAAGAATCCGCTCACCATGGCCTATGATGTCGAGGCCATACGCAGGGATTTCCCGATTTTGTCGCGGCAGGT
GCACGGCAAAACGCTCGTTTATCTGGATAACGGCGCTTCCGCACAGAAGCCGCAAAGCGTTATCGACGCGGTAACTCATG
CTTACGCGAATGAATATGCCAATGTTCATCGCGGTTTGCATTTTCTCTCGAACGCTGCCACCGACGCTTATGAGAAGTCG
CGTGAAACCGTGCGACGTTTTCTCAATGCCGGTTCTGTGGACGAGATCGTCTTCACCAAGAATGCGACAGAGGCGATCAA
TACCGTCGCTTATGGCTATGGAATGCCGTTCATCGGCGAGGGCGATGAAATCCTGCTCTCGATCATGGAGCATCATTCCA
ACATCGTGCCGTGGCATTTCATACGCGAACGCCAGGGCGCGAAACTGGTTTTCACACCAGTCGACGATAACGGTGTTTTC
CACATCGAAGAGTTCGAGAAGCGCCTGAGCGAACGTACCAAACTCGTTGCCATCACGCATATGTCGAATACACTCGGCAC
GGTGGTCCCGATCAAGAAGATCGTGGAGCTTGCCCATGCACGCGGCGTTCCGGTTCTGGTCGATGGCAGTCAGGGTGCAG
TGCACCTGCCGGTCGATGTGCAGGATCTGGGCTGTGACTGGTATGTCTTTACCGGCCACAAAGTCTATGGCCCTTCGGGC
ATCGGCGTGCTTTATGGACGCGCGCAAATGCTGGAAAAGATGCGCCCGTTCCAGGGCGGGGGCGAAATGATCGAGGAAGT
GACGGAGGAAAACGTCACCTACAATCATCCGCCACACCGCTTTGAAGCAGGCACGCCGCCTATCGTTCAGGCGATTGGTC
TGGGTGCGGCGCTTGAATATATGGAAAAGATCGGGCGTCATGCGATCCTGGCTCACGAGGCAGACTTGCGTGATTATGCG
CATGAACGGCTCGGCCGGATCAACAGCTTGCGCATTTTCGGCAATGCGCCGGACAAGGGCGCAATCATCTCCTTCGCGCT
TGAAGGCATTCATGCCCATGACGTGTCGATGGTGATCGATCGGGCGGGGGTCGCGGTGCGCGCGGGAACGCATTGTGCGC
AACCGCTCTTGAAACGCTTTGGCGTCACCTCTACATGCCGTGCATCCTTTGCCCTTTATAATACCCGCGCCGAAGTAGAC
GCATTGGCTGAAGCCTTGGAAAAGGCAAGGAAGTTTTTCGGATGA

Upstream 100 bases:

>100_bases
GCTCGCCGTTCATGCTTGAGTGAATTGGGCCTGATTGAACAGGACGGGGCGGGAGTTTCCCGCTTCCTCCTTTCCTGCCG
GGAAGGCAGAAGGAACGATC

Downstream 100 bases:

>100_bases
CCGATATGGAACAGAAAGTTCAGGACAAGGCTGAAACCGGGCCTGCCAGTGAAACGGCAACGGCTGAAGGTAGTGCCGTG
TTTTCCGCTTCAGCAATTCC

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MDQKNPLTMAYDVEAIRRDFPILSRQVHGKTLVYLDNGASAQKPQSVIDAVTHAYANEYANVHRGLHFLSNAATDAYEKS
RETVRRFLNAGSVDEIVFTKNATEAINTVAYGYGMPFIGEGDEILLSIMEHHSNIVPWHFIRERQGAKLVFTPVDDNGVF
HIEEFEKRLSERTKLVAITHMSNTLGTVVPIKKIVELAHARGVPVLVDGSQGAVHLPVDVQDLGCDWYVFTGHKVYGPSG
IGVLYGRAQMLEKMRPFQGGGEMIEEVTEENVTYNHPPHRFEAGTPPIVQAIGLGAALEYMEKIGRHAILAHEADLRDYA
HERLGRINSLRIFGNAPDKGAIISFALEGIHAHDVSMVIDRAGVAVRAGTHCAQPLLKRFGVTSTCRASFALYNTRAEVD
ALAEALEKARKFFG

Sequences:

>Translated_414_residues
MDQKNPLTMAYDVEAIRRDFPILSRQVHGKTLVYLDNGASAQKPQSVIDAVTHAYANEYANVHRGLHFLSNAATDAYEKS
RETVRRFLNAGSVDEIVFTKNATEAINTVAYGYGMPFIGEGDEILLSIMEHHSNIVPWHFIRERQGAKLVFTPVDDNGVF
HIEEFEKRLSERTKLVAITHMSNTLGTVVPIKKIVELAHARGVPVLVDGSQGAVHLPVDVQDLGCDWYVFTGHKVYGPSG
IGVLYGRAQMLEKMRPFQGGGEMIEEVTEENVTYNHPPHRFEAGTPPIVQAIGLGAALEYMEKIGRHAILAHEADLRDYA
HERLGRINSLRIFGNAPDKGAIISFALEGIHAHDVSMVIDRAGVAVRAGTHCAQPLLKRFGVTSTCRASFALYNTRAEVD
ALAEALEKARKFFG
>Mature_414_residues
MDQKNPLTMAYDVEAIRRDFPILSRQVHGKTLVYLDNGASAQKPQSVIDAVTHAYANEYANVHRGLHFLSNAATDAYEKS
RETVRRFLNAGSVDEIVFTKNATEAINTVAYGYGMPFIGEGDEILLSIMEHHSNIVPWHFIRERQGAKLVFTPVDDNGVF
HIEEFEKRLSERTKLVAITHMSNTLGTVVPIKKIVELAHARGVPVLVDGSQGAVHLPVDVQDLGCDWYVFTGHKVYGPSG
IGVLYGRAQMLEKMRPFQGGGEMIEEVTEENVTYNHPPHRFEAGTPPIVQAIGLGAALEYMEKIGRHAILAHEADLRDYA
HERLGRINSLRIFGNAPDKGAIISFALEGIHAHDVSMVIDRAGVAVRAGTHCAQPLLKRFGVTSTCRASFALYNTRAEVD
ALAEALEKARKFFG

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=398, Percent_Identity=24.8743718592965, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI156713448, Length=427, Percent_Identity=28.1030444964871, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1787970, Length=407, Percent_Identity=46.4373464373464, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1789175, Length=403, Percent_Identity=39.7022332506204, Blast_Score=315, Evalue=5e-87,
Organism=Escherichia coli, GI48994898, Length=396, Percent_Identity=25.5050505050505, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI25143064, Length=229, Percent_Identity=30.1310043668122, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193211090, Length=374, Percent_Identity=24.0641711229947, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=403, Percent_Identity=25.3101736972705, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20129463, Length=280, Percent_Identity=30.7142857142857, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45737; Mature: 45737

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQKNPLTMAYDVEAIRRDFPILSRQVHGKTLVYLDNGASAQKPQSVIDAVTHAYANEYA
CCCCCCEEEEEEHHHHHHCCCHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
NVHRGLHFLSNAATDAYEKSRETVRRFLNAGSVDEIVFTKNATEAINTVAYGYGMPFIGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCC
GDEILLSIMEHHSNIVPWHFIRERQGAKLVFTPVDDNGVFHIEEFEKRLSERTKLVAITH
CHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHCCCEEEEEEE
MSNTLGTVVPIKKIVELAHARGVPVLVDGSQGAVHLPVDVQDLGCDWYVFTGHKVYGPSG
CCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECCCCHHHCCCCEEEEECCEEECCCC
IGVLYGRAQMLEKMRPFQGGGEMIEEVTEENVTYNHPPHRFEAGTPPIVQAIGLGAALEY
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
MEKIGRHAILAHEADLRDYAHERLGRINSLRIFGNAPDKGAIISFALEGIHAHDVSMVID
HHHHCCCEEEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHH
RAGVAVRAGTHCAQPLLKRFGVTSTCRASFALYNTRAEVDALAEALEKARKFFG
HCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDQKNPLTMAYDVEAIRRDFPILSRQVHGKTLVYLDNGASAQKPQSVIDAVTHAYANEYA
CCCCCCEEEEEEHHHHHHCCCHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
NVHRGLHFLSNAATDAYEKSRETVRRFLNAGSVDEIVFTKNATEAINTVAYGYGMPFIGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCC
GDEILLSIMEHHSNIVPWHFIRERQGAKLVFTPVDDNGVFHIEEFEKRLSERTKLVAITH
CHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHCCCEEEEEEE
MSNTLGTVVPIKKIVELAHARGVPVLVDGSQGAVHLPVDVQDLGCDWYVFTGHKVYGPSG
CCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECCCCHHHCCCCEEEEECCEEECCCC
IGVLYGRAQMLEKMRPFQGGGEMIEEVTEENVTYNHPPHRFEAGTPPIVQAIGLGAALEY
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
MEKIGRHAILAHEADLRDYAHERLGRINSLRIFGNAPDKGAIISFALEGIHAHDVSMVID
HHHHCCCEEEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHH
RAGVAVRAGTHCAQPLLKRFGVTSTCRASFALYNTRAEVDALAEALEKARKFFG
HCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]