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The map label for this gene is paaF [C]

Identifier: 225852275

GI number: 225852275

Start: 767046

End: 768095

Strand: Direct

Name: paaF [C]

Synonym: BMEA_A0798

Alternate gene names: 225852275

Gene position: 767046-768095 (Clockwise)

Preceding gene: 225852271

Following gene: 225852276

Centisome position: 36.08

GC content: 58.29

Gene sequence:

>1050_bases
ATGCAGATTGACTTCGGTGGTGGTAGCGAGATTGGCTTTGAACGCAAGGGTAAAGCGGGACTTGTGAAGCTTACACGGAC
CGCAGCACTCAATGCGCTGACGCATAATATGATTCTGGCGCTCGATCGCGCCTTGCAGGCCTGGGAAGATGACCCGGAAG
TGGCTTGTGTGATTCTCGAAGGTGAGGGGCGGGCTTTCTGCGCCGGCGGCGATGTGGTCGCAGCCTTCAAGGCCGGACAG
GCCGGCACGCCCGCCTATGAATTCTTTCATGACGAATATCGGCTCAATGCACGGATCGGTCGTTTTCCAAAACCCTATGT
CTCGCTCATCAATGGCATCGTGATGGGCGGCGGCGCAGGCATTTCCGTGCATGGATCGCATCGCATCGTGACCGAGAACA
CCATGTTCGCCATGCCGGAAACAGGTATCGGTTTTTTCCCGGATGTGGGCGGCAGCGCTTTCCTGCCGCATCTGCATGAT
AATTTCGGCTATTATCTCGCCTTGACAGGCAACCGCATCCGCTGGGGCGATTGCCTGCAAAGCGGCATCGCAACCCATGC
CGTTGCGGCAAGCGATCTGGAGGATGTGCGCGACGATATCATCGCCACTGGCGATATCGACGCCGCGCTTACCCGCAGCC
AGTACCCGGATTTTGAAACCTCTGTCGAAATACGCCAGCTTGTGGCCGAATGTTTTTCCGGCGCCACGCTGGCCGATTGT
ATCGAGGCGCTGGAACGGGCCGCCGAGGCGGGCAACAAATCCGCCAGGGACATATTGACGGTTATGGCTACGCGCTCGCC
GACCAGCCTCGCGGTTACGTTCCGCCAGCTTGCCGATGGCCGCCCGCTTGGCCTCGATGACTGTATGCGCATGGAATATC
GCATCACAAGCCGGATGCTGGAAGCACAGGATTTCTATGAAGGCGTTCGTGCGCTTCTGATCGACAAGGACGGCGCCCCC
GCCTGGAAACCGGCGACGCTGGAAGAGGTCAAGCCTGAACAGGTTAATGCCTATTTCGCCAATCTGGGTGACAGGGAACT
GACATTGTGA

Upstream 100 bases:

>100_bases
TTTATCATGGGAAAAGCGATGAAACCAAGAACATTGACCTGTGCAGGATTGACGCGGGGCGTCTCACTTTCTACCCATTT
GTAGGAACGGGAGAAAAGAT

Downstream 100 bases:

>100_bases
TGAGGAGCGGCTGATGCATATGAACGAGCTGTGCCAGCACATTCAACCCAGCGGAACCGAATGGGCCTTCACATGGTTCA
TGCGGCTCCTCGCACTGGCG

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MQIDFGGGSEIGFERKGKAGLVKLTRTAALNALTHNMILALDRALQAWEDDPEVACVILEGEGRAFCAGGDVVAAFKAGQ
AGTPAYEFFHDEYRLNARIGRFPKPYVSLINGIVMGGGAGISVHGSHRIVTENTMFAMPETGIGFFPDVGGSAFLPHLHD
NFGYYLALTGNRIRWGDCLQSGIATHAVAASDLEDVRDDIIATGDIDAALTRSQYPDFETSVEIRQLVAECFSGATLADC
IEALERAAEAGNKSARDILTVMATRSPTSLAVTFRQLADGRPLGLDDCMRMEYRITSRMLEAQDFYEGVRALLIDKDGAP
AWKPATLEEVKPEQVNAYFANLGDRELTL

Sequences:

>Translated_349_residues
MQIDFGGGSEIGFERKGKAGLVKLTRTAALNALTHNMILALDRALQAWEDDPEVACVILEGEGRAFCAGGDVVAAFKAGQ
AGTPAYEFFHDEYRLNARIGRFPKPYVSLINGIVMGGGAGISVHGSHRIVTENTMFAMPETGIGFFPDVGGSAFLPHLHD
NFGYYLALTGNRIRWGDCLQSGIATHAVAASDLEDVRDDIIATGDIDAALTRSQYPDFETSVEIRQLVAECFSGATLADC
IEALERAAEAGNKSARDILTVMATRSPTSLAVTFRQLADGRPLGLDDCMRMEYRITSRMLEAQDFYEGVRALLIDKDGAP
AWKPATLEEVKPEQVNAYFANLGDRELTL
>Mature_349_residues
MQIDFGGGSEIGFERKGKAGLVKLTRTAALNALTHNMILALDRALQAWEDDPEVACVILEGEGRAFCAGGDVVAAFKAGQ
AGTPAYEFFHDEYRLNARIGRFPKPYVSLINGIVMGGGAGISVHGSHRIVTENTMFAMPETGIGFFPDVGGSAFLPHLHD
NFGYYLALTGNRIRWGDCLQSGIATHAVAASDLEDVRDDIIATGDIDAALTRSQYPDFETSVEIRQLVAECFSGATLADC
IEALERAAEAGNKSARDILTVMATRSPTSLAVTFRQLADGRPLGLDDCMRMEYRITSRMLEAQDFYEGVRALLIDKDGAP
AWKPATLEEVKPEQVNAYFANLGDRELTL

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=355, Percent_Identity=43.6619718309859, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI37594469, Length=303, Percent_Identity=42.5742574257426, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI194097323, Length=177, Percent_Identity=31.0734463276836, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1787659, Length=186, Percent_Identity=27.4193548387097, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI221142681, Length=182, Percent_Identity=27.4725274725275, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25144160, Length=349, Percent_Identity=42.1203438395415, Blast_Score=264, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI25144157, Length=349, Percent_Identity=42.1203438395415, Blast_Score=264, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI25145438, Length=188, Percent_Identity=27.6595744680851, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17536985, Length=141, Percent_Identity=27.6595744680851, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=172, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=360, Percent_Identity=30, Blast_Score=160, Evalue=4e-40,
Organism=Drosophila melanogaster, GI28571730, Length=331, Percent_Identity=43.8066465256798, Blast_Score=260, Evalue=9e-70,
Organism=Drosophila melanogaster, GI28571729, Length=331, Percent_Identity=43.8066465256798, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI20129971, Length=186, Percent_Identity=27.4193548387097, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24653477, Length=186, Percent_Identity=27.4193548387097, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19922422, Length=179, Percent_Identity=25.1396648044693, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 37790; Mature: 37790

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIDFGGGSEIGFERKGKAGLVKLTRTAALNALTHNMILALDRALQAWEDDPEVACVILE
CEECCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
GEGRAFCAGGDVVAAFKAGQAGTPAYEFFHDEYRLNARIGRFPKPYVSLINGIVMGGGAG
CCCCEEEECCCEEEEEECCCCCCCHHHHHHHHHEEECCCCCCCCHHHHHHHHEEECCCCC
ISVHGSHRIVTENTMFAMPETGIGFFPDVGGSAFLPHLHDNFGYYLALTGNRIRWGDCLQ
EEEECCEEEEECCEEEECCCCCCCCCCCCCCCEECCCCCCCCCEEEEEECCEEEHHHHHH
SGIATHAVAASDLEDVRDDIIATGDIDAALTRSQYPDFETSVEIRQLVAECFSGATLADC
HCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHH
IEALERAAEAGNKSARDILTVMATRSPTSLAVTFRQLADGRPLGLDDCMRMEYRITSRML
HHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
EAQDFYEGVRALLIDKDGAPAWKPATLEEVKPEQVNAYFANLGDRELTL
HHHHHHHHHHEEEEECCCCCCCCCCCHHHCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQIDFGGGSEIGFERKGKAGLVKLTRTAALNALTHNMILALDRALQAWEDDPEVACVILE
CEECCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
GEGRAFCAGGDVVAAFKAGQAGTPAYEFFHDEYRLNARIGRFPKPYVSLINGIVMGGGAG
CCCCEEEECCCEEEEEECCCCCCCHHHHHHHHHEEECCCCCCCCHHHHHHHHEEECCCCC
ISVHGSHRIVTENTMFAMPETGIGFFPDVGGSAFLPHLHDNFGYYLALTGNRIRWGDCLQ
EEEECCEEEEECCEEEECCCCCCCCCCCCCCCEECCCCCCCCCEEEEEECCEEEHHHHHH
SGIATHAVAASDLEDVRDDIIATGDIDAALTRSQYPDFETSVEIRQLVAECFSGATLADC
HCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHH
IEALERAAEAGNKSARDILTVMATRSPTSLAVTFRQLADGRPLGLDDCMRMEYRITSRML
HHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
EAQDFYEGVRALLIDKDGAPAWKPATLEEVKPEQVNAYFANLGDRELTL
HHHHHHHHHHEEEEECCCCCCCCCCCHHHCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA