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The map label for this gene is parC [H]

Identifier: 225852271

GI number: 225852271

Start: 761863

End: 764175

Strand: Direct

Name: parC [H]

Synonym: BMEA_A0794

Alternate gene names: 225852271

Gene position: 761863-764175 (Clockwise)

Preceding gene: 225852270

Following gene: 225852275

Centisome position: 35.84

GC content: 58.11

Gene sequence:

>2313_bases
ATGGGAAAAAGTCTGATTCCGCCCGGCGACGGCGAAGAACACATTGAACGGGTCGATCTGAAATCGGCTCTTGAGGAACG
TTACCTCGCTTATGCGTTGTCAACGATCATGCATCGTGCGCTGCCGGACGTGCGCGACGGCTTAAAGCCGGTGCACCGCC
GCATCATGCACGCCATGCGCCTCCTGCGGCTTAATCCCGATCAGGCTTATGCGAAATGCGCCCGTATCGTTGGCGATGTC
ATGGGCAAGTTCCATCCCCATGGCGATGCCTCGATCTATGATGCGCTGGTGCGGCTCGCGCAGGATTTCGCCGTGCGCTA
TCCGCTCGTGGACGGGCAGGGCAATTTCGGCAATATCGACGGCGATAACGCCGCCGCCATGCGCTACACCGAAGCGCGCA
TGACGGAAGTGGCGACGCTGCTTCTGGAAGGCATCAACGAAAACGCCATTGATTTCCGTCCGACCTATAATGAGGAAGAC
GAAGAACCCATCGTTCTTCCCGGCGCTTTTCCCAACCTGCTTGCAAACGGTTCGGCGGGCATCGCGGTCGGTATGGCCAC
CAATATTCCGCCGCATAATGTGGCGGAGCTTTGCTCGTCGGCGCTTTATCTCATCAATCATCCCGATGCGCCGGTGGAGG
AACTCGTAACCTCGCCCGAACAATGGGCGGAGATTGAACAAGAGTCCAAGACCGATCCGGCAGCACTTCTGAAATGCAAG
GTGCGTGGCCCGGATTTCCCGACCGGGGGCATCCTCGTCGAAGAGCATGGCAATATTCTTGAGGCCTATCGCACGGGGCG
CGGCGCATTTCGCGTTCGTGCCCGCTGGCACAAGGAAGAGGGCAATCGCGGCACCTGGGTGATTGTCGTCACCGAAATTC
CCTATCAGGTGCAGAAGTCGCGCCTCATCGAAAAGATCGCGGAACTGCTTCTGGCAAAGAAGCTGCCGCTGCTTGACGAT
ATTCGTGATGAATCGGCGGAAGATATCCGCATTGTTCTGGAGCCGAAGAACCGCACGGTCGATCCCGAGCTGCTGATGGA
ATCGCTGTTCAAGCTGACCGAGCTTGAAAGCCGCGTTTCATTGAACATGAACGTGCTGTCGCACGGCAAGGTGCCGAATG
TCCTGTCGCTGGGTGCTGTCCTGCGCGAATGGCTGGAGCATCGCAAGGAGGTGCTGGTTCGCCGGTCGCAATTCCGGCTG
GCGGAGATCGAAAAGCGTCTCGAAATCCTTGGCGGCTTCCTGATCGCCTATCTCAATCTGGATGAGGTGATCCGCATCAT
CCGTGAGGAAGACGAGCCGAAGCAGGAATTGATGCGTGCTTTTGAACTGACTGACGTTCAGGCCGAATCCATCCTCAATA
TGCGCCTGCGTTCATTGCGCAAGCTTGAGGAATTCGAGATCCGCAAGGAGTTCGATGACCTCACTGCCGAAAAGACGGAC
CTGGAAGGTCTGCTCGCTTCCGGCACGCGCCAGTGGAAGAAGATCAGCACCGAAATCAAGGCGGTGCGCGAAAAGTTTGG
CCCGACGACCAGGCTTGGCAAGCGCCGTACGACTTTCGCCCATGCTCCGACGCACGATCTTGAAGATATCCATCAGGCTA
TGATCGAGCGTGAGCCGGTAACGATCGTGGTTTCCGAAAAGGGCTGGCTGCGCGCCATGAAGGGGCATCTGGCCGACTTC
TCGACGCTTTCTTTCAAGGAGGGCGACAAGCTCAAGCTTGCCTTCCATGCCGAGACGACCGACAAGCTTTTGTTCTTCAC
CACGGGCGGCAAGTTCTTCACCATCGGTGCCAACACGCTGCCGGGCGGCCGCGGCCACGGCGAGCCGATCCGCATTCTGG
TCGATATGGAAAACGATCAGGATATACTGACGGCCTTCGTGCACGATCCATCCGCAAAGCTGCTGCTTGTCAGCCATGAG
GGCAATGGTTTCATTGTTCCGGAAAGCGAGGCGGTCGCCAATACCCGCAAGGGCAAGCAGGTCATGAACGTCAAGGCCCC
GGATGAGGCGAAGCTTTGCCAGCGCGTTTCGGGCGATCACATTGCTGTCGTCGGCGAAAACCGCAAGATGCTGGTCTTCC
CGCTTTCCGATATCCCGGAAATGACACGCGGCAAGGGCGTGCGCCTGCAAAAATACAAGGATGGCGGGGTTTGCGACGTT
CGCACCTTCGCAATTGCCGATGGCCTGTCATGGCAGGATTCGGCGGATCGCACCTTCAATCGCAGCAAGGAAGAACTGGT
CGAGTGGATCGGCGCACGCGCCTCTGCGGGCCGTCTGGTGCCGAAGGGTTTTCCGCGTTCGGGCAAATTCTGA

Upstream 100 bases:

>100_bases
GCTTGACCGCCGATCTGGTCCAGTCAGATCGGGGCTCTAATGTAGAGGATTGGTTTTCTTCAACTCTTGCTGACGAATCG
CACAGTTGGTACTGAGAGAT

Downstream 100 bases:

>100_bases
TGGATAGAGCATTTTCGAGCCAAAAATGTGAAACGCCTATGCGGGGAAATCAGTCCACTGGACTGATTTTTGATCCCGCT
CCGATGCGTTGGAAAATGCG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 770; Mature: 769

Protein sequence:

>770_residues
MGKSLIPPGDGEEHIERVDLKSALEERYLAYALSTIMHRALPDVRDGLKPVHRRIMHAMRLLRLNPDQAYAKCARIVGDV
MGKFHPHGDASIYDALVRLAQDFAVRYPLVDGQGNFGNIDGDNAAAMRYTEARMTEVATLLLEGINENAIDFRPTYNEED
EEPIVLPGAFPNLLANGSAGIAVGMATNIPPHNVAELCSSALYLINHPDAPVEELVTSPEQWAEIEQESKTDPAALLKCK
VRGPDFPTGGILVEEHGNILEAYRTGRGAFRVRARWHKEEGNRGTWVIVVTEIPYQVQKSRLIEKIAELLLAKKLPLLDD
IRDESAEDIRIVLEPKNRTVDPELLMESLFKLTELESRVSLNMNVLSHGKVPNVLSLGAVLREWLEHRKEVLVRRSQFRL
AEIEKRLEILGGFLIAYLNLDEVIRIIREEDEPKQELMRAFELTDVQAESILNMRLRSLRKLEEFEIRKEFDDLTAEKTD
LEGLLASGTRQWKKISTEIKAVREKFGPTTRLGKRRTTFAHAPTHDLEDIHQAMIEREPVTIVVSEKGWLRAMKGHLADF
STLSFKEGDKLKLAFHAETTDKLLFFTTGGKFFTIGANTLPGGRGHGEPIRILVDMENDQDILTAFVHDPSAKLLLVSHE
GNGFIVPESEAVANTRKGKQVMNVKAPDEAKLCQRVSGDHIAVVGENRKMLVFPLSDIPEMTRGKGVRLQKYKDGGVCDV
RTFAIADGLSWQDSADRTFNRSKEELVEWIGARASAGRLVPKGFPRSGKF

Sequences:

>Translated_770_residues
MGKSLIPPGDGEEHIERVDLKSALEERYLAYALSTIMHRALPDVRDGLKPVHRRIMHAMRLLRLNPDQAYAKCARIVGDV
MGKFHPHGDASIYDALVRLAQDFAVRYPLVDGQGNFGNIDGDNAAAMRYTEARMTEVATLLLEGINENAIDFRPTYNEED
EEPIVLPGAFPNLLANGSAGIAVGMATNIPPHNVAELCSSALYLINHPDAPVEELVTSPEQWAEIEQESKTDPAALLKCK
VRGPDFPTGGILVEEHGNILEAYRTGRGAFRVRARWHKEEGNRGTWVIVVTEIPYQVQKSRLIEKIAELLLAKKLPLLDD
IRDESAEDIRIVLEPKNRTVDPELLMESLFKLTELESRVSLNMNVLSHGKVPNVLSLGAVLREWLEHRKEVLVRRSQFRL
AEIEKRLEILGGFLIAYLNLDEVIRIIREEDEPKQELMRAFELTDVQAESILNMRLRSLRKLEEFEIRKEFDDLTAEKTD
LEGLLASGTRQWKKISTEIKAVREKFGPTTRLGKRRTTFAHAPTHDLEDIHQAMIEREPVTIVVSEKGWLRAMKGHLADF
STLSFKEGDKLKLAFHAETTDKLLFFTTGGKFFTIGANTLPGGRGHGEPIRILVDMENDQDILTAFVHDPSAKLLLVSHE
GNGFIVPESEAVANTRKGKQVMNVKAPDEAKLCQRVSGDHIAVVGENRKMLVFPLSDIPEMTRGKGVRLQKYKDGGVCDV
RTFAIADGLSWQDSADRTFNRSKEELVEWIGARASAGRLVPKGFPRSGKF
>Mature_769_residues
GKSLIPPGDGEEHIERVDLKSALEERYLAYALSTIMHRALPDVRDGLKPVHRRIMHAMRLLRLNPDQAYAKCARIVGDVM
GKFHPHGDASIYDALVRLAQDFAVRYPLVDGQGNFGNIDGDNAAAMRYTEARMTEVATLLLEGINENAIDFRPTYNEEDE
EPIVLPGAFPNLLANGSAGIAVGMATNIPPHNVAELCSSALYLINHPDAPVEELVTSPEQWAEIEQESKTDPAALLKCKV
RGPDFPTGGILVEEHGNILEAYRTGRGAFRVRARWHKEEGNRGTWVIVVTEIPYQVQKSRLIEKIAELLLAKKLPLLDDI
RDESAEDIRIVLEPKNRTVDPELLMESLFKLTELESRVSLNMNVLSHGKVPNVLSLGAVLREWLEHRKEVLVRRSQFRLA
EIEKRLEILGGFLIAYLNLDEVIRIIREEDEPKQELMRAFELTDVQAESILNMRLRSLRKLEEFEIRKEFDDLTAEKTDL
EGLLASGTRQWKKISTEIKAVREKFGPTTRLGKRRTTFAHAPTHDLEDIHQAMIEREPVTIVVSEKGWLRAMKGHLADFS
TLSFKEGDKLKLAFHAETTDKLLFFTTGGKFFTIGANTLPGGRGHGEPIRILVDMENDQDILTAFVHDPSAKLLLVSHEG
NGFIVPESEAVANTRKGKQVMNVKAPDEAKLCQRVSGDHIAVVGENRKMLVFPLSDIPEMTRGKGVRLQKYKDGGVCDVR
TFAIADGLSWQDSADRTFNRSKEELVEWIGARASAGRLVPKGFPRSGKF

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=703, Percent_Identity=39.402560455192, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI1788562, Length=660, Percent_Identity=38.3333333333333, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17535065, Length=174, Percent_Identity=30.4597701149425, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=377, Percent_Identity=26.2599469496021, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136538, Length=180, Percent_Identity=30, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 86371; Mature: 86240

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKSLIPPGDGEEHIERVDLKSALEERYLAYALSTIMHRALPDVRDGLKPVHRRIMHAMR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
LLRLNPDQAYAKCARIVGDVMGKFHPHGDASIYDALVRLAQDFAVRYPLVDGQGNFGNID
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCC
GDNAAAMRYTEARMTEVATLLLEGINENAIDFRPTYNEEDEEPIVLPGAFPNLLANGSAG
CCCCHHEEHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCEEECCCCHHHHCCCCCC
IAVGMATNIPPHNVAELCSSALYLINHPDAPVEELVTSPEQWAEIEQESKTDPAALLKCK
EEEEEECCCCCHHHHHHHHCCEEEEECCCCCHHHHHCCCHHHHHHHHHCCCCCCCEEEEE
VRGPDFPTGGILVEEHGNILEAYRTGRGAFRVRARWHKEEGNRGTWVIVVTEIPYQVQKS
ECCCCCCCCCEEEECCCCCHHHHHCCCCEEEEEEEEECCCCCCCEEEEEEECCCHHHHHH
RLIEKIAELLLAKKLPLLDDIRDESAEDIRIVLEPKNRTVDPELLMESLFKLTELESRVS
HHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHE
LNMNVLSHGKVPNVLSLGAVLREWLEHRKEVLVRRSQFRLAEIEKRLEILGGFLIAYLNL
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
DEVIRIIREEDEPKQELMRAFELTDVQAESILNMRLRSLRKLEEFEIRKEFDDLTAEKTD
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LEGLLASGTRQWKKISTEIKAVREKFGPTTRLGKRRTTFAHAPTHDLEDIHQAMIEREPV
HHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCHHHHHHHHHCCCCE
TIVVSEKGWLRAMKGHLADFSTLSFKEGDKLKLAFHAETTDKLLFFTTGGKFFTIGANTL
EEEECCCCHHHHHHHHHCCCCEEECCCCCEEEEEEECCCCCCEEEEEECCEEEEECCCCC
PGGRGHGEPIRILVDMENDQDILTAFVHDPSAKLLLVSHEGNGFIVPESEAVANTRKGKQ
CCCCCCCCCEEEEEECCCCCCEEEEEEECCCCEEEEEEECCCEEEECCCHHHHHHHCCCE
VMNVKAPDEAKLCQRVSGDHIAVVGENRKMLVFPLSDIPEMTRGKGVRLQKYKDGGVCDV
EEECCCCCHHHHHHHCCCCEEEEEECCCEEEEEECCCCCHHHCCCCCEEEEECCCCCEEE
RTFAIADGLSWQDSADRTFNRSKEELVEWIGARASAGRLVPKGFPRSGKF
EEEEEECCCCCCCCCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GKSLIPPGDGEEHIERVDLKSALEERYLAYALSTIMHRALPDVRDGLKPVHRRIMHAMR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
LLRLNPDQAYAKCARIVGDVMGKFHPHGDASIYDALVRLAQDFAVRYPLVDGQGNFGNID
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCC
GDNAAAMRYTEARMTEVATLLLEGINENAIDFRPTYNEEDEEPIVLPGAFPNLLANGSAG
CCCCHHEEHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCEEECCCCHHHHCCCCCC
IAVGMATNIPPHNVAELCSSALYLINHPDAPVEELVTSPEQWAEIEQESKTDPAALLKCK
EEEEEECCCCCHHHHHHHHCCEEEEECCCCCHHHHHCCCHHHHHHHHHCCCCCCCEEEEE
VRGPDFPTGGILVEEHGNILEAYRTGRGAFRVRARWHKEEGNRGTWVIVVTEIPYQVQKS
ECCCCCCCCCEEEECCCCCHHHHHCCCCEEEEEEEEECCCCCCCEEEEEEECCCHHHHHH
RLIEKIAELLLAKKLPLLDDIRDESAEDIRIVLEPKNRTVDPELLMESLFKLTELESRVS
HHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHE
LNMNVLSHGKVPNVLSLGAVLREWLEHRKEVLVRRSQFRLAEIEKRLEILGGFLIAYLNL
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
DEVIRIIREEDEPKQELMRAFELTDVQAESILNMRLRSLRKLEEFEIRKEFDDLTAEKTD
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LEGLLASGTRQWKKISTEIKAVREKFGPTTRLGKRRTTFAHAPTHDLEDIHQAMIEREPV
HHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCHHHHHHHHHCCCCE
TIVVSEKGWLRAMKGHLADFSTLSFKEGDKLKLAFHAETTDKLLFFTTGGKFFTIGANTL
EEEECCCCHHHHHHHHHCCCCEEECCCCCEEEEEEECCCCCCEEEEEECCEEEEECCCCC
PGGRGHGEPIRILVDMENDQDILTAFVHDPSAKLLLVSHEGNGFIVPESEAVANTRKGKQ
CCCCCCCCCEEEEEECCCCCCEEEEEEECCCCEEEEEEECCCEEEECCCHHHHHHHCCCE
VMNVKAPDEAKLCQRVSGDHIAVVGENRKMLVFPLSDIPEMTRGKGVRLQKYKDGGVCDV
EEECCCCCHHHHHHHCCCCEEEEEECCCEEEEEECCCCCHHHCCCCCEEEEECCCCCEEE
RTFAIADGLSWQDSADRTFNRSKEELVEWIGARASAGRLVPKGFPRSGKF
EEEEEECCCCCCCCCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]