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The map label for this gene is phoQ [H]

Identifier: 225852130

GI number: 225852130

Start: 613972

End: 615207

Strand: Direct

Name: phoQ [H]

Synonym: BMEA_A0643

Alternate gene names: 225852130

Gene position: 613972-615207 (Clockwise)

Preceding gene: 225852129

Following gene: 225852131

Centisome position: 28.88

GC content: 58.66

Gene sequence:

>1236_bases
TTGACCGCACATCTCTTCAGCCTCGTCGGGGCGGTCAGCGTCTCGGGCGAGGGCACGCTACAGGGGCGCCCCGAACTGGG
GGACCTGCGCTATTCGAGCCCGCTTTCGGGCTGGTACTGGTCCGTCGATCCGGTAACGCCCAATCTGACCGGCAAGCTTG
AATCGCCTTCGCTGGTGGGGCGCATCGTGCCGGAAATGCCCGTGTCACAAGCCCCCTTCGACAGCTCCTTCATGCGCAGC
TACACCTTGCCGGGCCTCGACAATGAAGAGCTTTCCATCGTCGAAACCGAAGTGGTGCTGGATAATTCCAACCGTGTCGC
GCGCTTTCGCGTCATGGGCAATCTTAGCGAAGTACTCAACGAAATAGCAAATTTCCGGGCGCGGCTGCTTGTCTATCTTG
GCGTGTTCGGCATTGGCAGCATTCTCATCAATGCCGCTGTCATTCTTTTCGGCCTGCGCCCGCTGGATAAGGTTCGTCAG
GCGCTTGCCGATATCCGCGAAGGGCGCTCGTCCAGGCTGGATGCAACCTTGCCGCTGGAAATCGCGCCGCTGGCACGGGA
AATGAATGCGCTCATAGAAAACAATCGCCGCATCATGGAGCGGTCGCGAACCCAGGTCGGTAATCTCGCCCATTCGCTGA
AAACGCCGCTCTCCGTTCTGGTGAACGAAGCCCGTGCCATGGGCGGTGCGCCCGGACGCATCGTGCAGGAACAAAGCGAG
GCCATGCAGGTGCAAATCCAGCATTATCTGCAACGCGCGCGCATCGCAGCACAGCGCGATAGTGTGGTTTTCCGAACGCC
TGTCACACCCGTTCTGGAGCGGTTGCATCGGGTGACGGCAAAATTGCATCCAACTTTCAATATTTCCTTCAGGAACGATC
TTCCCGGTGCCGTCTTTGCAGGCGAACGGGAAGATCTGGAGGAAATCATCGGCAATCTTCTCGAAAATGCCGGTAAATGG
GGGCGCAAATGCATCACTATCCGCCTTGCGGCAGTCGCCGGCGAGCAAAGGCAATTTGAAATCGTCATTGAGGACGATGG
GCCGGGGCTTGAGGCAGACAAGATTGAAGCAGCCCTTAAACGCGGCAGCCGCGTCGATGAAACAAAGCCCGGAACGGGTC
TGGGGCTCGCCATTGTTCAGGATACGGTGCGCGAATATGGCGGCAGTCTGCATCTTGGCAAGGATGCGCTTGGCGGATTG
GCTGTCCGGGTCGTGTTGCCGTTGACGCAAGATTGA

Upstream 100 bases:

>100_bases
CACACTTTCGACATTATGGGTCATTGTGGCGCTGGTCGTGGTCGCCACTTTCATCAGCTCACTCTATGGCGAGGCCGCGC
GAAACAATTTCGAACGGCTT

Downstream 100 bases:

>100_bases
CGGTTGTCTTTGGCCGAAAGCGGATTAGAAGGTAAAACAAATGTCGCATGATGCGACTGTATGCGTGCTGATTGTTATGA
AGGCCGGTTTGTTATGATGA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MTAHLFSLVGAVSVSGEGTLQGRPELGDLRYSSPLSGWYWSVDPVTPNLTGKLESPSLVGRIVPEMPVSQAPFDSSFMRS
YTLPGLDNEELSIVETEVVLDNSNRVARFRVMGNLSEVLNEIANFRARLLVYLGVFGIGSILINAAVILFGLRPLDKVRQ
ALADIREGRSSRLDATLPLEIAPLAREMNALIENNRRIMERSRTQVGNLAHSLKTPLSVLVNEARAMGGAPGRIVQEQSE
AMQVQIQHYLQRARIAAQRDSVVFRTPVTPVLERLHRVTAKLHPTFNISFRNDLPGAVFAGEREDLEEIIGNLLENAGKW
GRKCITIRLAAVAGEQRQFEIVIEDDGPGLEADKIEAALKRGSRVDETKPGTGLGLAIVQDTVREYGGSLHLGKDALGGL
AVRVVLPLTQD

Sequences:

>Translated_411_residues
MTAHLFSLVGAVSVSGEGTLQGRPELGDLRYSSPLSGWYWSVDPVTPNLTGKLESPSLVGRIVPEMPVSQAPFDSSFMRS
YTLPGLDNEELSIVETEVVLDNSNRVARFRVMGNLSEVLNEIANFRARLLVYLGVFGIGSILINAAVILFGLRPLDKVRQ
ALADIREGRSSRLDATLPLEIAPLAREMNALIENNRRIMERSRTQVGNLAHSLKTPLSVLVNEARAMGGAPGRIVQEQSE
AMQVQIQHYLQRARIAAQRDSVVFRTPVTPVLERLHRVTAKLHPTFNISFRNDLPGAVFAGEREDLEEIIGNLLENAGKW
GRKCITIRLAAVAGEQRQFEIVIEDDGPGLEADKIEAALKRGSRVDETKPGTGLGLAIVQDTVREYGGSLHLGKDALGGL
AVRVVLPLTQD
>Mature_410_residues
TAHLFSLVGAVSVSGEGTLQGRPELGDLRYSSPLSGWYWSVDPVTPNLTGKLESPSLVGRIVPEMPVSQAPFDSSFMRSY
TLPGLDNEELSIVETEVVLDNSNRVARFRVMGNLSEVLNEIANFRARLLVYLGVFGIGSILINAAVILFGLRPLDKVRQA
LADIREGRSSRLDATLPLEIAPLAREMNALIENNRRIMERSRTQVGNLAHSLKTPLSVLVNEARAMGGAPGRIVQEQSEA
MQVQIQHYLQRARIAAQRDSVVFRTPVTPVLERLHRVTAKLHPTFNISFRNDLPGAVFAGEREDLEEIIGNLLENAGKWG
RKCITIRLAAVAGEQRQFEIVIEDDGPGLEADKIEAALKRGSRVDETKPGTGLGLAIVQDTVREYGGSLHLGKDALGGLA
VRVVLPLTQD

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=264, Percent_Identity=30.3030303030303, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1788393, Length=255, Percent_Identity=22.7450980392157, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787894, Length=236, Percent_Identity=23.3050847457627, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=26.7857142857143, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 44932; Mature: 44801

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAHLFSLVGAVSVSGEGTLQGRPELGDLRYSSPLSGWYWSVDPVTPNLTGKLESPSLVG
CCHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHH
RIVPEMPVSQAPFDSSFMRSYTLPGLDNEELSIVETEVVLDNSNRVARFRVMGNLSEVLN
HHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCEEEEEECCCHHHHHH
EIANFRARLLVYLGVFGIGSILINAAVILFGLRPLDKVRQALADIREGRSSRLDATLPLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCEE
IAPLAREMNALIENNRRIMERSRTQVGNLAHSLKTPLSVLVNEARAMGGAPGRIVQEQSE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AMQVQIQHYLQRARIAAQRDSVVFRTPVTPVLERLHRVTAKLHPTFNISFRNDLPGAVFA
HHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEC
GEREDLEEIIGNLLENAGKWGRKCITIRLAAVAGEQRQFEIVIEDDGPGLEADKIEAALK
CCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHH
RGSRVDETKPGTGLGLAIVQDTVREYGGSLHLGKDALGGLAVRVVLPLTQD
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECHHHHCCEEEEEEEECCCC
>Mature Secondary Structure 
TAHLFSLVGAVSVSGEGTLQGRPELGDLRYSSPLSGWYWSVDPVTPNLTGKLESPSLVG
CHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHH
RIVPEMPVSQAPFDSSFMRSYTLPGLDNEELSIVETEVVLDNSNRVARFRVMGNLSEVLN
HHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCEEEEEECCCHHHHHH
EIANFRARLLVYLGVFGIGSILINAAVILFGLRPLDKVRQALADIREGRSSRLDATLPLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCEE
IAPLAREMNALIENNRRIMERSRTQVGNLAHSLKTPLSVLVNEARAMGGAPGRIVQEQSE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AMQVQIQHYLQRARIAAQRDSVVFRTPVTPVLERLHRVTAKLHPTFNISFRNDLPGAVFA
HHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEC
GEREDLEEIIGNLLENAGKWGRKCITIRLAAVAGEQRQFEIVIEDDGPGLEADKIEAALK
CCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHH
RGSRVDETKPGTGLGLAIVQDTVREYGGSLHLGKDALGGLAVRVVLPLTQD
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECHHHHCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]