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The map label for this gene is phoP [H]

Identifier: 225852129

GI number: 225852129

Start: 613133

End: 613822

Strand: Direct

Name: phoP [H]

Synonym: BMEA_A0642

Alternate gene names: 225852129

Gene position: 613133-613822 (Clockwise)

Preceding gene: 225852128

Following gene: 225852130

Centisome position: 28.84

GC content: 57.97

Gene sequence:

>690_bases
TTGCGTATCCTGATTGTTGAAGACGACAAGGACCTGAACCGCCAGCTTTCCGAAGCGATGATTGCCGCAGGTTATGTCGT
TGACAGCGCCTATGACGGCGAAGAAGGCCACTATCTGGGCGATACAGAACCTTATGATGCGGTGGTGCTGGATATCGGCC
TGCCGCAGATGGACGGTATCAGCGTTGTGGAGCGCTGGCGGCGCAGCGGGCGCACCATACCTGTTCTCATGCTGACCGCG
CGCGATCGCTGGAGCGACAAGGTGGCTGGCATCGATGCGGGTGCGGATGACTATGTGGCAAAGCCTTTCCATATTGAAGA
GGTTCTGGCCCGGCTGCGCGCCCTGATCCGCCGTGCTGCCGGTCATGCATCGTCAGAATTCGTCTGCGGGCCGCTGCATC
TCGATACGAAGACGTCGAAGGCGAGTATCGATGGCGTGGCGCTCAAGCTGACCTCGCATGAATATCGCCTCCTGTCCTAT
ATGATGCACCATATGGACGAAGTGGTTTCGCGCACCGAGCTTGTGGAACATCTTTACGATCAGGATTTCGACCGCGATTC
CAATACGATTGAAGTTTTCGTCGGGCGCCTGCGCAAGAAAATGGGCGTTGATCTCATCGAGACCGTTCGCGGCATGGGCT
ATCGTATGCGCTCGGGCGGCGAGGGCGAAGCAAAAGGGAGCGGCAGCTGA

Upstream 100 bases:

>100_bases
AGTGGCGGTTCCAGCCCAATAAAGCGTTCTCTTTATTGATGGATCGGCTGTAGCCGCTCTATTGGGCTATCGTTGTAGCT
TTTGACGGGAGACTGTCCGC

Downstream 100 bases:

>100_bases
AGCTTCCTCGCGTCTTTCCCGCCTGGCGCTCGCTCGCCGTCCGCGTCGTCACACTTTCGACATTATGGGTCATTGTGGCG
CTGGTCGTGGTCGCCACTTT

Product: winged helix family two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MRILIVEDDKDLNRQLSEAMIAAGYVVDSAYDGEEGHYLGDTEPYDAVVLDIGLPQMDGISVVERWRRSGRTIPVLMLTA
RDRWSDKVAGIDAGADDYVAKPFHIEEVLARLRALIRRAAGHASSEFVCGPLHLDTKTSKASIDGVALKLTSHEYRLLSY
MMHHMDEVVSRTELVEHLYDQDFDRDSNTIEVFVGRLRKKMGVDLIETVRGMGYRMRSGGEGEAKGSGS

Sequences:

>Translated_229_residues
MRILIVEDDKDLNRQLSEAMIAAGYVVDSAYDGEEGHYLGDTEPYDAVVLDIGLPQMDGISVVERWRRSGRTIPVLMLTA
RDRWSDKVAGIDAGADDYVAKPFHIEEVLARLRALIRRAAGHASSEFVCGPLHLDTKTSKASIDGVALKLTSHEYRLLSY
MMHHMDEVVSRTELVEHLYDQDFDRDSNTIEVFVGRLRKKMGVDLIETVRGMGYRMRSGGEGEAKGSGS
>Mature_229_residues
MRILIVEDDKDLNRQLSEAMIAAGYVVDSAYDGEEGHYLGDTEPYDAVVLDIGLPQMDGISVVERWRRSGRTIPVLMLTA
RDRWSDKVAGIDAGADDYVAKPFHIEEVLARLRALIRRAAGHASSEFVCGPLHLDTKTSKASIDGVALKLTSHEYRLLSY
MMHHMDEVVSRTELVEHLYDQDFDRDSNTIEVFVGRLRKKMGVDLIETVRGMGYRMRSGGEGEAKGSGS

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=43.1192660550459, Blast_Score=180, Evalue=7e-47,
Organism=Escherichia coli, GI1789402, Length=216, Percent_Identity=42.5925925925926, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=40.7239819004525, Blast_Score=168, Evalue=3e-43,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=42.3423423423423, Blast_Score=161, Evalue=3e-41,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=38.0733944954128, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=32.8888888888889, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=33.7777777777778, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=34.841628959276, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=34.6320346320346, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=31.5315315315315, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.140350877193, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787229, Length=220, Percent_Identity=29.5454545454545, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1788550, Length=139, Percent_Identity=34.5323741007194, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1790299, Length=137, Percent_Identity=27.007299270073, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25560; Mature: 25560

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILIVEDDKDLNRQLSEAMIAAGYVVDSAYDGEEGHYLGDTEPYDAVVLDIGLPQMDGI
CEEEEEECCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
SVVERWRRSGRTIPVLMLTARDRWSDKVAGIDAGADDYVAKPFHIEEVLARLRALIRRAA
HHHHHHHHCCCCEEEEEEECCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GHASSEFVCGPLHLDTKTSKASIDGVALKLTSHEYRLLSYMMHHMDEVVSRTELVEHLYD
CCCCCCEEEECEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRLRKKMGVDLIETVRGMGYRMRSGGEGEAKGSGS
CCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure
MRILIVEDDKDLNRQLSEAMIAAGYVVDSAYDGEEGHYLGDTEPYDAVVLDIGLPQMDGI
CEEEEEECCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
SVVERWRRSGRTIPVLMLTARDRWSDKVAGIDAGADDYVAKPFHIEEVLARLRALIRRAA
HHHHHHHHCCCCEEEEEEECCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GHASSEFVCGPLHLDTKTSKASIDGVALKLTSHEYRLLSYMMHHMDEVVSRTELVEHLYD
CCCCCCEEEECEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRLRKKMGVDLIETVRGMGYRMRSGGEGEAKGSGS
CCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA