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The map label for this gene is dxs [H]

Identifier: 225851972

GI number: 225851972

Start: 455335

End: 457266

Strand: Direct

Name: dxs [H]

Synonym: BMEA_A0469

Alternate gene names: 225851972

Gene position: 455335-457266 (Clockwise)

Preceding gene: 225851971

Following gene: 225851973

Centisome position: 21.42

GC content: 62.01

Gene sequence:

>1932_bases
ATGTCCCGACCCTCAACACCGCTCCTCGATAAGGCGCCGACGCCAGACCGTCTTCGCGCCCTGCCGGAGCAGGACCTGCC
GCAACTGGCGGAAGAATTGCGCACCGAGCTGATCGACGCGGTTTCCACCACGGGCGGGCATCTGGGCGCGGGCTTGGGCG
TTGTGGAATTGACGGTTGCGTTGCATCATGTTTTCAACACACCCTATGATCGCATCATCTGGGATGTCGGCCATCAGGCC
TATCCGCACAAGATCCTGACCGGGCGGCGCGACCGCATCCGCACATTGCGCCAGGCGGGCGGGCTTTCGGGCTTCACCAA
GCGTGCGGAGAGCGAATACGATCCCTTTGGCGCGGCCCATTCCTCGACCTCCATTTCCGCAGGCCTCGGCATGGCGGTGG
CGAGCGAGCTTTCGGGCGAAAAGCGCAATGTGATCGCCGTCATCGGCGATGGTTCCATGTCAGCGGGCATGGCCTATGAA
GCGATGAACAATGCCGGTGCTCTGGATGCGCGCCTGATCGTTATTCTCAACGACAATGATATGTCGATTGCGCCGCCGAC
GGGCGCAATGAGTGCCTATCTGGCGCGCCTCGTTTCCGGGCGCACCTATCGCAGTGTGCGCGAGGCGGCGAAGCAGGTGG
CGCAAAAGCTGCCCAAATTCCTTCAGGACAAGGCGCGCAAATCGGAAGAATATGCCCGCGCCTTTTTCACCGGCGGCACG
CTGTTCGAGGAGCTTGGCTTCTATTATGTCGGCCCGATCGACGGGCATAATCTCGACCACCTGCTGCCGGTTCTGAAAAA
TGTCCGCGATACGCAGAAAGGCCCGGTGCTGATCCATGTCGTGACACAGAAGGGTAAGGGCTATGCGCCGGCCGAAGCTG
CCGCCGACAAATATCACGGCGTCAACAAGTTCGACGTCATCACCGGCAAGCAGGCGAAGCCCCCGGCAAATGCGCCGAGC
TACACCAAGATTTTCGGCACAAGCCTGATTGAGGAAGCGCGCCACGACGACAAGATCGTCGCCGTCACCGCCGCCATGCC
GACAGGCACGGGGCTGGACCTTTTTGGCGAGGCTTTCCCGAAGCGCGTCTTCGATGTCGGCATTGCCGAGCAGCATGCCG
TCACATTCGCTGCCGGTCTTGCAAGCGAGGGGTACAAGCCCTTCTGCGCCATTTATTCCACCTTTCTCCAGCGCGGCTAC
GATCAGGTCGTGCACGATGTTTCGATCCAGAACCTGCCCGTGCGCTTCCCCATCGACCGCGCCGGGCTGGTGGGCGCGGA
TGGCCCCACCCATGCAGGCTCGTTCGATACGGGCTTTCTTGCAGCCCTTCCGGGCTTCGTGGTGATGGCCGCATCTGACG
AAGCCGAGCTTCGCCATATGGTGCGCACGGCTGCCGAATATGACGAAGGCCCGATCTCCTTCCGCTATCCGCGCGGTGAT
GGTGTGGGCGTCGATCTGCCGGAGCGCGGCTCGGTGCTGGAAATCGGCAAGGGCCGCATCGTGCGCGAAGGCACCAAGGT
GGCGCTTCTTTCCTTCGGTACACGCTTGCAGGAATGTCTTGCAGCCGCTGAAGAACTGGGCGCTGCCGGCCTGTCGACGA
CAGTGGCCGATGCACGTTTCGCCAAGCCGCTCGACCATGACCTGATCCGCCGTCTGGCGCGTGAACATGAAGTGCTGGTG
ATGGTGGAAGAAGGTGCGGTCGGCGGGTTTGGCAGCCATGTGCTGCAATTCCTCGCCACGGACGGGCTTCTGGATCGCGG
CTTCAAGGTGCGGGCGCTGACGCTCCCCGATATCTATCAGGACCATGGCAAGCCGGATGCCATGTATGCCGAAGCGGGCC
TTGACCGTACGGGCATTGTGCGCACGGTTTTTGCCGCACTTCATCGCGATGAACTGGGCCATGAAGCACTGCCGACACCG
TTTCGTGCCTGA

Upstream 100 bases:

>100_bases
TCAGAATGCTTGATCTCGGCCCGATGCCTGTTATACCGGCAAAGGTTTAGAGAAATTCCAGCAAGACTTGCCTGCCCCAA
CCAACTGATAGGGTATAAGA

Downstream 100 bases:

>100_bases
AACAGATGAACGGCCAGTCCACCGATAACCGTCCGCGCCTTGACCAGCTTTTGGTTGAGCGCGGATTTTTCGCGACACGC
TCGCGCGCCCGTGACGCTAT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 643; Mature: 642

Protein sequence:

>643_residues
MSRPSTPLLDKAPTPDRLRALPEQDLPQLAEELRTELIDAVSTTGGHLGAGLGVVELTVALHHVFNTPYDRIIWDVGHQA
YPHKILTGRRDRIRTLRQAGGLSGFTKRAESEYDPFGAAHSSTSISAGLGMAVASELSGEKRNVIAVIGDGSMSAGMAYE
AMNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLVSGRTYRSVREAAKQVAQKLPKFLQDKARKSEEYARAFFTGGT
LFEELGFYYVGPIDGHNLDHLLPVLKNVRDTQKGPVLIHVVTQKGKGYAPAEAAADKYHGVNKFDVITGKQAKPPANAPS
YTKIFGTSLIEEARHDDKIVAVTAAMPTGTGLDLFGEAFPKRVFDVGIAEQHAVTFAAGLASEGYKPFCAIYSTFLQRGY
DQVVHDVSIQNLPVRFPIDRAGLVGADGPTHAGSFDTGFLAALPGFVVMAASDEAELRHMVRTAAEYDEGPISFRYPRGD
GVGVDLPERGSVLEIGKGRIVREGTKVALLSFGTRLQECLAAAEELGAAGLSTTVADARFAKPLDHDLIRRLAREHEVLV
MVEEGAVGGFGSHVLQFLATDGLLDRGFKVRALTLPDIYQDHGKPDAMYAEAGLDRTGIVRTVFAALHRDELGHEALPTP
FRA

Sequences:

>Translated_643_residues
MSRPSTPLLDKAPTPDRLRALPEQDLPQLAEELRTELIDAVSTTGGHLGAGLGVVELTVALHHVFNTPYDRIIWDVGHQA
YPHKILTGRRDRIRTLRQAGGLSGFTKRAESEYDPFGAAHSSTSISAGLGMAVASELSGEKRNVIAVIGDGSMSAGMAYE
AMNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLVSGRTYRSVREAAKQVAQKLPKFLQDKARKSEEYARAFFTGGT
LFEELGFYYVGPIDGHNLDHLLPVLKNVRDTQKGPVLIHVVTQKGKGYAPAEAAADKYHGVNKFDVITGKQAKPPANAPS
YTKIFGTSLIEEARHDDKIVAVTAAMPTGTGLDLFGEAFPKRVFDVGIAEQHAVTFAAGLASEGYKPFCAIYSTFLQRGY
DQVVHDVSIQNLPVRFPIDRAGLVGADGPTHAGSFDTGFLAALPGFVVMAASDEAELRHMVRTAAEYDEGPISFRYPRGD
GVGVDLPERGSVLEIGKGRIVREGTKVALLSFGTRLQECLAAAEELGAAGLSTTVADARFAKPLDHDLIRRLAREHEVLV
MVEEGAVGGFGSHVLQFLATDGLLDRGFKVRALTLPDIYQDHGKPDAMYAEAGLDRTGIVRTVFAALHRDELGHEALPTP
FRA
>Mature_642_residues
SRPSTPLLDKAPTPDRLRALPEQDLPQLAEELRTELIDAVSTTGGHLGAGLGVVELTVALHHVFNTPYDRIIWDVGHQAY
PHKILTGRRDRIRTLRQAGGLSGFTKRAESEYDPFGAAHSSTSISAGLGMAVASELSGEKRNVIAVIGDGSMSAGMAYEA
MNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLVSGRTYRSVREAAKQVAQKLPKFLQDKARKSEEYARAFFTGGTL
FEELGFYYVGPIDGHNLDHLLPVLKNVRDTQKGPVLIHVVTQKGKGYAPAEAAADKYHGVNKFDVITGKQAKPPANAPSY
TKIFGTSLIEEARHDDKIVAVTAAMPTGTGLDLFGEAFPKRVFDVGIAEQHAVTFAAGLASEGYKPFCAIYSTFLQRGYD
QVVHDVSIQNLPVRFPIDRAGLVGADGPTHAGSFDTGFLAALPGFVVMAASDEAELRHMVRTAAEYDEGPISFRYPRGDG
VGVDLPERGSVLEIGKGRIVREGTKVALLSFGTRLQECLAAAEELGAAGLSTTVADARFAKPLDHDLIRRLAREHEVLVM
VEEGAVGGFGSHVLQFLATDGLLDRGFKVRALTLPDIYQDHGKPDAMYAEAGLDRTGIVRTVFAALHRDELGHEALPTPF
RA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=524, Percent_Identity=24.0458015267176, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4507521, Length=524, Percent_Identity=24.0458015267176, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI225637461, Length=516, Percent_Identity=23.4496124031008, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI225637459, Length=516, Percent_Identity=23.4496124031008, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI225637463, Length=516, Percent_Identity=23.4496124031008, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI133778974, Length=441, Percent_Identity=21.9954648526077, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786622, Length=625, Percent_Identity=51.84, Blast_Score=620, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI17539652, Length=425, Percent_Identity=27.2941176470588, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17538422, Length=281, Percent_Identity=27.0462633451957, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551847, Length=664, Percent_Identity=24.3975903614458, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI45550715, Length=664, Percent_Identity=24.3975903614458, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24645119, Length=427, Percent_Identity=26.463700234192, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24666278, Length=647, Percent_Identity=24.7295208655332, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21358145, Length=225, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24650940, Length=225, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69186; Mature: 69055

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPSTPLLDKAPTPDRLRALPEQDLPQLAEELRTELIDAVSTTGGHLGAGLGVVELTVA
CCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
LHHVFNTPYDRIIWDVGHQAYPHKILTGRRDRIRTLRQAGGLSGFTKRAESEYDPFGAAH
HHHHHCCCHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCC
SSTSISAGLGMAVASELSGEKRNVIAVIGDGSMSAGMAYEAMNNAGALDARLIVILNDND
CCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCEEEEEEECCCC
MSIAPPTGAMSAYLARLVSGRTYRSVREAAKQVAQKLPKFLQDKARKSEEYARAFFTGGT
CEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LFEELGFYYVGPIDGHNLDHLLPVLKNVRDTQKGPVLIHVVTQKGKGYAPAEAAADKYHG
HHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHCC
VNKFDVITGKQAKPPANAPSYTKIFGTSLIEEARHDDKIVAVTAAMPTGTGLDLFGEAFP
CCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHH
KRVFDVGIAEQHAVTFAAGLASEGYKPFCAIYSTFLQRGYDQVVHDVSIQNLPVRFPIDR
HHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCC
AGLVGADGPTHAGSFDTGFLAALPGFVVMAASDEAELRHMVRTAAEYDEGPISFRYPRGD
CCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCC
GVGVDLPERGSVLEIGKGRIVREGTKVALLSFGTRLQECLAAAEELGAAGLSTTVADARF
CCCCCCCCCCCEEEECCCEEEECCCEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AKPLDHDLIRRLAREHEVLVMVEEGAVGGFGSHVLQFLATDGLLDRGFKVRALTLPDIYQ
CCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHCCCEEEEEECCHHHH
DHGKPDAMYAEAGLDRTGIVRTVFAALHRDELGHEALPTPFRA
HCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SRPSTPLLDKAPTPDRLRALPEQDLPQLAEELRTELIDAVSTTGGHLGAGLGVVELTVA
CCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
LHHVFNTPYDRIIWDVGHQAYPHKILTGRRDRIRTLRQAGGLSGFTKRAESEYDPFGAAH
HHHHHCCCHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCC
SSTSISAGLGMAVASELSGEKRNVIAVIGDGSMSAGMAYEAMNNAGALDARLIVILNDND
CCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCEEEEEEECCCC
MSIAPPTGAMSAYLARLVSGRTYRSVREAAKQVAQKLPKFLQDKARKSEEYARAFFTGGT
CEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LFEELGFYYVGPIDGHNLDHLLPVLKNVRDTQKGPVLIHVVTQKGKGYAPAEAAADKYHG
HHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHCC
VNKFDVITGKQAKPPANAPSYTKIFGTSLIEEARHDDKIVAVTAAMPTGTGLDLFGEAFP
CCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHH
KRVFDVGIAEQHAVTFAAGLASEGYKPFCAIYSTFLQRGYDQVVHDVSIQNLPVRFPIDR
HHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCC
AGLVGADGPTHAGSFDTGFLAALPGFVVMAASDEAELRHMVRTAAEYDEGPISFRYPRGD
CCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCC
GVGVDLPERGSVLEIGKGRIVREGTKVALLSFGTRLQECLAAAEELGAAGLSTTVADARF
CCCCCCCCCCCEEEECCCEEEECCCEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AKPLDHDLIRRLAREHEVLVMVEEGAVGGFGSHVLQFLATDGLLDRGFKVRALTLPDIYQ
CCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHCCCEEEEEECCHHHH
DHGKPDAMYAEAGLDRTGIVRTVFAALHRDELGHEALPTPFRA
HCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA