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The map label for this gene is fabI1 [H]

Identifier: 225851955

GI number: 225851955

Start: 444505

End: 445323

Strand: Direct

Name: fabI1 [H]

Synonym: BMEA_A0451

Alternate gene names: 225851955

Gene position: 444505-445323 (Clockwise)

Preceding gene: 225851953

Following gene: 225851956

Centisome position: 20.91

GC content: 56.78

Gene sequence:

>819_bases
ATGACCGCACAGTCTGGTTTGTTGCAGGGCAAGCGTGGATTGATTCTAGGCGTGGCCAATAATCGCTCTATCGCTTGGGG
CATTGCAAAAGCCGCCCGTGAAGCTGGCGCAGAGCTTGCATTCACCTATCAGGGTGACGCATTGAAGAAGCGTGTGGAGC
CGCTGGCCGAGGAGCTTGGCGCCTTCGTCGCCGGACATTGCGACGTCGCCGATGCGGCGAGCATCGATGCGGTTTTTGAA
ACGCTTGAGAAGAAGTGGGGCAAGCTCGACTTCCTGGTGCACGCAATCGGTTTCTCCGACAAGGACGAGCTGACCGGCCG
CTATATCGATACGTCGGAAGCCAATTTCACCAATACGATGCTGATTTCGGTCTATTCGCTGACGGCGGTTTCGCGCCGCG
CGGAAAAGCTGATGGCCGATGGCGGATCGATTCTGACGCTGACCTATTACGGCGCTGAAAAGGTCATGCCGAATTACAAT
GTCATGGGCGTGGCCAAGGCAGCCCTTGAGGCGAGCGTGAAATATCTGGCCGTCGATCTTGGCCCCCAGAACATTCGCGT
CAATGCAATCTCGGCTGGCCCCATCAAGACGCTTGCCGCTTCCGGCATTGGTGACTTCCGCTATATCCTGAAGTGGAACG
AATATAATGCGCCGCTGCGCCGCACCGTCACGATCGACGAGGTGGGTGATGTCGGCCTTTATTTCCTTTCGGACCTGTCG
CGTTCGGTTACAGGCGAAGTGCACCATGCCGACAGCGGCTATCATGTCATTGGCATGAAAGCGGTTGACGCACCGGATAT
CTCGGTCGTGAAAGACTGA

Upstream 100 bases:

>100_bases
AACGTGACAATACCAGCCTTTTTATCCGCAATTGCTTGAAGGATAGCGAAGCCTGTGCGATAGGGCAAAGAAGTTCATTA
TTTTTCAATGAGGACCCTTA

Downstream 100 bases:

>100_bases
AGCAGCTAATACGCAATCCCGAAAAGTTGACCGGCTTTTCGGGATTTTTCTTTGTCTTTTCCGATGCGGGAAAGTTATCC
AGTTTATTCATTGGCGGCAG

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 1 [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MTAQSGLLQGKRGLILGVANNRSIAWGIAKAAREAGAELAFTYQGDALKKRVEPLAEELGAFVAGHCDVADAASIDAVFE
TLEKKWGKLDFLVHAIGFSDKDELTGRYIDTSEANFTNTMLISVYSLTAVSRRAEKLMADGGSILTLTYYGAEKVMPNYN
VMGVAKAALEASVKYLAVDLGPQNIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIDEVGDVGLYFLSDLS
RSVTGEVHHADSGYHVIGMKAVDAPDISVVKD

Sequences:

>Translated_272_residues
MTAQSGLLQGKRGLILGVANNRSIAWGIAKAAREAGAELAFTYQGDALKKRVEPLAEELGAFVAGHCDVADAASIDAVFE
TLEKKWGKLDFLVHAIGFSDKDELTGRYIDTSEANFTNTMLISVYSLTAVSRRAEKLMADGGSILTLTYYGAEKVMPNYN
VMGVAKAALEASVKYLAVDLGPQNIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIDEVGDVGLYFLSDLS
RSVTGEVHHADSGYHVIGMKAVDAPDISVVKD
>Mature_271_residues
TAQSGLLQGKRGLILGVANNRSIAWGIAKAAREAGAELAFTYQGDALKKRVEPLAEELGAFVAGHCDVADAASIDAVFET
LEKKWGKLDFLVHAIGFSDKDELTGRYIDTSEANFTNTMLISVYSLTAVSRRAEKLMADGGSILTLTYYGAEKVMPNYNV
MGVAKAALEASVKYLAVDLGPQNIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIDEVGDVGLYFLSDLSR
SVTGEVHHADSGYHVIGMKAVDAPDISVVKD

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=193, Percent_Identity=31.0880829015544, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787545, Length=259, Percent_Identity=50.5791505791506, Blast_Score=261, Evalue=3e-71,
Organism=Escherichia coli, GI2367365, Length=253, Percent_Identity=29.2490118577075, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082100, Length=263, Percent_Identity=28.8973384030418, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789378, Length=260, Percent_Identity=28.8461538461538, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787905, Length=243, Percent_Identity=27.9835390946502, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24644337, Length=196, Percent_Identity=30.1020408163265, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 29209; Mature: 29077

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQSGLLQGKRGLILGVANNRSIAWGIAKAAREAGAELAFTYQGDALKKRVEPLAEELG
CCCCCCCCCCCCEEEEEEECCCEEEHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHH
AFVAGHCDVADAASIDAVFETLEKKWGKLDFLVHAIGFSDKDELTGRYIDTSEANFTNTM
HHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHCCCEEEECCCCCCCCEE
LISVYSLTAVSRRAEKLMADGGSILTLTYYGAEKVMPNYNVMGVAKAALEASVKYLAVDL
EEHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHCCCCCCCHHHHHHHHHHCEEEEEEEE
GPQNIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIDEVGDVGLYFLSDLS
CCCEEEEEEEECCCHHHHHHCCCCCEEEEEEECCCCCCEEEEEEHHCCCCHHHHHHHHHH
RSVTGEVHHADSGYHVIGMKAVDAPDISVVKD
HHHCCCEEECCCCEEEEEEEEECCCCCEEECC
>Mature Secondary Structure 
TAQSGLLQGKRGLILGVANNRSIAWGIAKAAREAGAELAFTYQGDALKKRVEPLAEELG
CCCCCCCCCCCEEEEEEECCCEEEHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHH
AFVAGHCDVADAASIDAVFETLEKKWGKLDFLVHAIGFSDKDELTGRYIDTSEANFTNTM
HHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHCCCEEEECCCCCCCCEE
LISVYSLTAVSRRAEKLMADGGSILTLTYYGAEKVMPNYNVMGVAKAALEASVKYLAVDL
EEHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHCCCCCCCHHHHHHHHHHCEEEEEEEE
GPQNIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIDEVGDVGLYFLSDLS
CCCEEEEEEEECCCHHHHHHCCCCCEEEEEEECCCCCCEEEEEEHHCCCCHHHHHHHHHH
RSVTGEVHHADSGYHVIGMKAVDAPDISVVKD
HHHCCCEEECCCCEEEEEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]