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The map label for this gene is guaD [H]

Identifier: 225851898

GI number: 225851898

Start: 386200

End: 387504

Strand: Direct

Name: guaD [H]

Synonym: BMEA_A0391

Alternate gene names: 225851898

Gene position: 386200-387504 (Clockwise)

Preceding gene: 225851897

Following gene: 225851899

Centisome position: 18.17

GC content: 58.85

Gene sequence:

>1305_bases
ATGACAAAGCTTCTCATCCGCGGCCGTGTGCTGACTTTTCGTGACGAGCCGCAAAGCCTCGATGACAGCCATGCCTATCG
CTATATCGAAGACGGTGCGGTTCTGGTCGAAAACGGCCGTATCCTGCGCCTTGGCGACTATGCCGAGGTCAGCGGTGAAG
CGGGCGCGGATGTGAAACTCGCCGATCACCGCCCGCACCTCGTTGTGCCGGGCTTCATCGACACGCATATCCATTATCCG
CAGACGCAGGTCGTGGCTTCCTATGCTGCCAATCTTCTGGAATGGCTCAACACCTATACATTTGTGGCCGAGCAGAAATT
TGCCGACGAACAGCACGCCGAATTCATCGCGGAACACTTTCTTGACGAGTTGATCCGCCACGGCACCACCACGGCGGTCG
CTTATTGTTCCGTGCATCCCCAGAGCGTGGATGCCTATTTCCGCGCTTCGCAGCATCGCAACATGCGTATGCTGGGCGGC
AAGGTGATGATGGATCGCAATGCTCCTCCCGCACTTTGCGACACGGCGCAATCGGGCTACGACGATACGAAGGCGCTGAT
TGCGCGCTGGCAGGGCCAGGGCCGCCTTGATTACGTGATTACGCCGCGCTTTGCGATCACGTCCACCCCGGAGCAGCTTG
AAGCAAGCCAGACGCTGGTGCGCGAACATCCTGAATGTTTCGTGCAGACCCATCTGTCGGAAAATCACGACGAGATCGCT
TTCACACGGTCGCTCTACCCGGATGCGCCCGATTATCTGGGCATTTATGAACATTACAGCCTTCTGGGCAACAAGACCCT
GCTTGGCCATTCCATCCATCTGGAAGAGCGCGAAGTGCGCCTGATGGCGGAAACCGGCTCGATTGCCGTTTTCTGTCCGA
CTTCCAACCTGTTTCTCGGTTCCGGCCTTTTCGACCGCGACCGGCTGAAGGCGGCGGGCGTGCGCATGGCCGTTGCCACC
GATATCGGTGGCGGCACAAGCTTTTCCACGCTGCGCACCATGGACGAGGGTTACAAGGTTCTGCAACTGCGCGGGCAGCG
CCTGAACCCGTTCCAGTCGTTCTATATGATGACGCTCGGCAATGCCCGTGCGCTCTCCATGGAAGACAGGATCGGCACGC
TGGAAGAGGGCACGGAAGCCGATATCGTGGTGCTCGATTCCTCCGCCACATCGCCCATGCGCCTGCGCATGGCGGCAGGA
GCGACGCTGGAGCAGGAACTGTTCCTGTTGCAGACGCTGGGTGACGACCGCGCCATTGTTGAAACCTATGTGGCGGGTAA
ACCCATGAAAGCCGATCTTTTGTAA

Upstream 100 bases:

>100_bases
CGCCCGCCAACGTTACCGGCGTGACGGACGAGGAACGCCAGCTTCTGGCCTCCTGGTATCAATCCGTGACGACAGGCCCA
AAAGAGGGGACCAAGACCGA

Downstream 100 bases:

>100_bases
GAGAAGAAAGCGGGCTTCGTTGATTTTATTCGGGCAGCGCGGAATAGTCCTGCCAGCTACACATCATATCGGGAATCTCA
TGTCCGCCATCGCCGATCCG

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTKLLIRGRVLTFRDEPQSLDDSHAYRYIEDGAVLVENGRILRLGDYAEVSGEAGADVKLADHRPHLVVPGFIDTHIHYP
QTQVVASYAANLLEWLNTYTFVAEQKFADEQHAEFIAEHFLDELIRHGTTTAVAYCSVHPQSVDAYFRASQHRNMRMLGG
KVMMDRNAPPALCDTAQSGYDDTKALIARWQGQGRLDYVITPRFAITSTPEQLEASQTLVREHPECFVQTHLSENHDEIA
FTRSLYPDAPDYLGIYEHYSLLGNKTLLGHSIHLEEREVRLMAETGSIAVFCPTSNLFLGSGLFDRDRLKAAGVRMAVAT
DIGGGTSFSTLRTMDEGYKVLQLRGQRLNPFQSFYMMTLGNARALSMEDRIGTLEEGTEADIVVLDSSATSPMRLRMAAG
ATLEQELFLLQTLGDDRAIVETYVAGKPMKADLL

Sequences:

>Translated_434_residues
MTKLLIRGRVLTFRDEPQSLDDSHAYRYIEDGAVLVENGRILRLGDYAEVSGEAGADVKLADHRPHLVVPGFIDTHIHYP
QTQVVASYAANLLEWLNTYTFVAEQKFADEQHAEFIAEHFLDELIRHGTTTAVAYCSVHPQSVDAYFRASQHRNMRMLGG
KVMMDRNAPPALCDTAQSGYDDTKALIARWQGQGRLDYVITPRFAITSTPEQLEASQTLVREHPECFVQTHLSENHDEIA
FTRSLYPDAPDYLGIYEHYSLLGNKTLLGHSIHLEEREVRLMAETGSIAVFCPTSNLFLGSGLFDRDRLKAAGVRMAVAT
DIGGGTSFSTLRTMDEGYKVLQLRGQRLNPFQSFYMMTLGNARALSMEDRIGTLEEGTEADIVVLDSSATSPMRLRMAAG
ATLEQELFLLQTLGDDRAIVETYVAGKPMKADLL
>Mature_433_residues
TKLLIRGRVLTFRDEPQSLDDSHAYRYIEDGAVLVENGRILRLGDYAEVSGEAGADVKLADHRPHLVVPGFIDTHIHYPQ
TQVVASYAANLLEWLNTYTFVAEQKFADEQHAEFIAEHFLDELIRHGTTTAVAYCSVHPQSVDAYFRASQHRNMRMLGGK
VMMDRNAPPALCDTAQSGYDDTKALIARWQGQGRLDYVITPRFAITSTPEQLEASQTLVREHPECFVQTHLSENHDEIAF
TRSLYPDAPDYLGIYEHYSLLGNKTLLGHSIHLEEREVRLMAETGSIAVFCPTSNLFLGSGLFDRDRLKAAGVRMAVATD
IGGGTSFSTLRTMDEGYKVLQLRGQRLNPFQSFYMMTLGNARALSMEDRIGTLEEGTEADIVVLDSSATSPMRLRMAAGA
TLEQELFLLQTLGDDRAIVETYVAGKPMKADLL

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=378, Percent_Identity=30.6878306878307, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1789249, Length=426, Percent_Identity=47.4178403755869, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319963, Length=330, Percent_Identity=31.2121212121212, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24643849, Length=437, Percent_Identity=33.1807780320366, Blast_Score=210, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 48427; Mature: 48296

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLLIRGRVLTFRDEPQSLDDSHAYRYIEDGAVLVENGRILRLGDYAEVSGEAGADVKL
CCEEEEECEEEEECCCCCCCCCCCCEEEEECCEEEEECCCEEEECCHHHCCCCCCCCEEE
ADHRPHLVVPGFIDTHIHYPQTQVVASYAANLLEWLNTYTFVAEQKFADEQHAEFIAEHF
ECCCCCEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LDELIRHGTTTAVAYCSVHPQSVDAYFRASQHRNMRMLGGKVMMDRNAPPALCDTAQSGY
HHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEECCEEEECCCCCCHHHHCCCCCC
DDTKALIARWQGQGRLDYVITPRFAITSTPEQLEASQTLVREHPECFVQTHLSENHDEIA
CHHHHHHHHHCCCCCEEEEECCCEEECCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEE
FTRSLYPDAPDYLGIYEHYSLLGNKTLLGHSIHLEEREVRLMAETGSIAVFCPTSNLFLG
EEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCEEEEEEECCCEEEEECCCCEEEE
SGLFDRDRLKAAGVRMAVATDIGGGTSFSTLRTMDEGYKVLQLRGQRLNPFQSFYMMTLG
CCCCCHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCC
NARALSMEDRIGTLEEGTEADIVVLDSSATSPMRLRMAAGATLEQELFLLQTLGDDRAIV
CCEEEEHHHCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHH
ETYVAGKPMKADLL
HHHHCCCCCCCCCC
>Mature Secondary Structure 
TKLLIRGRVLTFRDEPQSLDDSHAYRYIEDGAVLVENGRILRLGDYAEVSGEAGADVKL
CEEEEECEEEEECCCCCCCCCCCCEEEEECCEEEEECCCEEEECCHHHCCCCCCCCEEE
ADHRPHLVVPGFIDTHIHYPQTQVVASYAANLLEWLNTYTFVAEQKFADEQHAEFIAEHF
ECCCCCEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LDELIRHGTTTAVAYCSVHPQSVDAYFRASQHRNMRMLGGKVMMDRNAPPALCDTAQSGY
HHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEECCEEEECCCCCCHHHHCCCCCC
DDTKALIARWQGQGRLDYVITPRFAITSTPEQLEASQTLVREHPECFVQTHLSENHDEIA
CHHHHHHHHHCCCCCEEEEECCCEEECCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEE
FTRSLYPDAPDYLGIYEHYSLLGNKTLLGHSIHLEEREVRLMAETGSIAVFCPTSNLFLG
EEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCEEEEEEECCCEEEEECCCCEEEE
SGLFDRDRLKAAGVRMAVATDIGGGTSFSTLRTMDEGYKVLQLRGQRLNPFQSFYMMTLG
CCCCCHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCC
NARALSMEDRIGTLEEGTEADIVVLDSSATSPMRLRMAAGATLEQELFLLQTLGDDRAIV
CCEEEEHHHCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHH
ETYVAGKPMKADLL
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]