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The map label for this gene is xdhA [H]

Identifier: 225851893

GI number: 225851893

Start: 379076

End: 380551

Strand: Direct

Name: xdhA [H]

Synonym: BMEA_A0386

Alternate gene names: 225851893

Gene position: 379076-380551 (Clockwise)

Preceding gene: 225851892

Following gene: 225851894

Centisome position: 17.83

GC content: 60.84

Gene sequence:

>1476_bases
ATGGGCCAATCTGCAAGACATGAAATCCGCTTCCTTCTGAACGGTGAAACAATCGTTCTCGACCGTGTTTCGCCGACCGA
AACGCTGCTTGATTATCTGCGCCTGTCTGCCAGGCTGCGCGGCACCAAGGAAGGCTGTGGTGAAGGCGATTGCGGGGCCT
ACACGGTGCTGGTCGGCCGGGTTGTCGATGGCGGCCTCGTTTATGAAAGCGTCAATGCCTGCATCCGCTTTGTCGGCTCG
CTGGATGGCTGTCATGTCGTGACCATCGAATATCTGCGCGGGGCGGATGGCGATCTTCATCCGGTGCAAAAGGCGATGGT
TGAATTTCATGGTTCGCAATGCGGCTTTTGTACCCCGGGCTTCGTCATGTCGCTTTATGCGCTGTGGATGCGTGATCCGA
GGCCTGCCGATGCGGCAATCGAAAAGGCATTGCAGGACAATCTCTGCCGTTGCACCGGCTATGAGGCGATCATGCGCGCC
GCGCGCGCCATTTCCGATTATGGCAATGTGGCGCAGGATCCGCTTGCTGCCGAGCGTGCCCATGTTCTGCAACGCCTTAC
GGCCCTGCGCGACGGTGCGCGGGTGGAGGTGGGGGCGGGCAAGGATCGCCTGATCGTGCCAGCCGATCTCGATGATTTTG
CCACCATTCTGGCGGCAGAGCCGAAAGCCACCATCGTTGCCGGTTCAACCGATGTGGGCCTGTGGGTCACAAAGATGATG
CGCGACATTTCCCCGGTGGTCTTCATCGGCCATCTGGAAGAACTGCACTCCATCCGTGAGGAAAATGGTGTTGTCACCAT
TGGCGCAGGCGTGACCTATACGCAAGCTTTCGGTTTTCTGGCTGGCCGCATTCCGGCTTTGGGCCAGCTCATCAACCGCA
TCGGCGGCGAGCAGGTGCGCAATATGGGCACCATCGGCGGCAATATCGCCAACGGTTCGCCCATTGGCGACACGCCGCCG
CTGATTGCGCTTGGCGCAACGCTGACCTTGCGCAAGGGGGCGGAGCGGCGCACCATTGCGCTGGAGGATTTTTTCATAGC
CTATGGCAAGCAGGATCGTGGCGCGGGCGAGTTCGTGGAGGCTGTGCATGTGCCGCTTCCCGGTGAGGGAAGCCGGTTTG
CAGCCTACAAGGTTTCCAAGCGGCGCGAGGAAGACATTACCGCTTCGCTCGGCGCTTTCCATCTGATGCTCGACGCTGCG
GGAAATGTCGCCCATATCCGCATCGCCTATGGCGGCATGGCGGCGACGCCGAAGCGCGCACATGCGGTGGAAACTGCCCT
CATGGGCAAGCCATGGACGGAAGCGACGGTCGAGGCCGCACTTGAAGCCTATGCACAGGATTATACCCCGCTGACCGATA
TGCGCGCCACGGCGGAATATCGCCTGCTTGTTGCGCGCAACATGCTGCGCCGTTTCTATCTTGAAACGACCGGCAGCGGC
GAAACGCTCGGCGCCCTTCGCGGCGAGGCGGCGTGA

Upstream 100 bases:

>100_bases
TGCATTTGCGCTTTGGCATTTGCGGTGGAAAAGCGCATTATCGTTTACCGCGCCTGGTTTCGCCCTTTTCCTGTTCGACA
TGCTGGGGGAGCTGAGCAAT

Downstream 100 bases:

>100_bases
ACGGAGGCAGACATGAACAGGCATTCCGCAACCGATATCAAGACCGCCCGCATCCGGGGCGGTGTCGCCACCGAACAGAA
ACACGATTCCGCACATAAGC

Product: xanthine dehydrogenase small subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MGQSARHEIRFLLNGETIVLDRVSPTETLLDYLRLSARLRGTKEGCGEGDCGAYTVLVGRVVDGGLVYESVNACIRFVGS
LDGCHVVTIEYLRGADGDLHPVQKAMVEFHGSQCGFCTPGFVMSLYALWMRDPRPADAAIEKALQDNLCRCTGYEAIMRA
ARAISDYGNVAQDPLAAERAHVLQRLTALRDGARVEVGAGKDRLIVPADLDDFATILAAEPKATIVAGSTDVGLWVTKMM
RDISPVVFIGHLEELHSIREENGVVTIGAGVTYTQAFGFLAGRIPALGQLINRIGGEQVRNMGTIGGNIANGSPIGDTPP
LIALGATLTLRKGAERRTIALEDFFIAYGKQDRGAGEFVEAVHVPLPGEGSRFAAYKVSKRREEDITASLGAFHLMLDAA
GNVAHIRIAYGGMAATPKRAHAVETALMGKPWTEATVEAALEAYAQDYTPLTDMRATAEYRLLVARNMLRRFYLETTGSG
ETLGALRGEAA

Sequences:

>Translated_491_residues
MGQSARHEIRFLLNGETIVLDRVSPTETLLDYLRLSARLRGTKEGCGEGDCGAYTVLVGRVVDGGLVYESVNACIRFVGS
LDGCHVVTIEYLRGADGDLHPVQKAMVEFHGSQCGFCTPGFVMSLYALWMRDPRPADAAIEKALQDNLCRCTGYEAIMRA
ARAISDYGNVAQDPLAAERAHVLQRLTALRDGARVEVGAGKDRLIVPADLDDFATILAAEPKATIVAGSTDVGLWVTKMM
RDISPVVFIGHLEELHSIREENGVVTIGAGVTYTQAFGFLAGRIPALGQLINRIGGEQVRNMGTIGGNIANGSPIGDTPP
LIALGATLTLRKGAERRTIALEDFFIAYGKQDRGAGEFVEAVHVPLPGEGSRFAAYKVSKRREEDITASLGAFHLMLDAA
GNVAHIRIAYGGMAATPKRAHAVETALMGKPWTEATVEAALEAYAQDYTPLTDMRATAEYRLLVARNMLRRFYLETTGSG
ETLGALRGEAA
>Mature_490_residues
GQSARHEIRFLLNGETIVLDRVSPTETLLDYLRLSARLRGTKEGCGEGDCGAYTVLVGRVVDGGLVYESVNACIRFVGSL
DGCHVVTIEYLRGADGDLHPVQKAMVEFHGSQCGFCTPGFVMSLYALWMRDPRPADAAIEKALQDNLCRCTGYEAIMRAA
RAISDYGNVAQDPLAAERAHVLQRLTALRDGARVEVGAGKDRLIVPADLDDFATILAAEPKATIVAGSTDVGLWVTKMMR
DISPVVFIGHLEELHSIREENGVVTIGAGVTYTQAFGFLAGRIPALGQLINRIGGEQVRNMGTIGGNIANGSPIGDTPPL
IALGATLTLRKGAERRTIALEDFFIAYGKQDRGAGEFVEAVHVPLPGEGSRFAAYKVSKRREEDITASLGAFHLMLDAAG
NVAHIRIAYGGMAATPKRAHAVETALMGKPWTEATVEAALEAYAQDYTPLTDMRATAEYRLLVARNMLRRFYLETTGSGE
TLGALRGEAA

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=517, Percent_Identity=29.7872340425532, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI71773480, Length=527, Percent_Identity=27.7039848197343, Blast_Score=167, Evalue=3e-41,
Organism=Escherichia coli, GI1789231, Length=279, Percent_Identity=32.6164874551971, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786480, Length=168, Percent_Identity=35.1190476190476, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789232, Length=162, Percent_Identity=34.5679012345679, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540638, Length=532, Percent_Identity=31.015037593985, Blast_Score=234, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI32566215, Length=474, Percent_Identity=27.0042194092827, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17539860, Length=464, Percent_Identity=27.3706896551724, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17737937, Length=485, Percent_Identity=30.3092783505155, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24647201, Length=513, Percent_Identity=26.3157894736842, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24647199, Length=506, Percent_Identity=26.2845849802372, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24647197, Length=510, Percent_Identity=27.0588235294118, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24647195, Length=502, Percent_Identity=26.6932270916335, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24647193, Length=513, Percent_Identity=25.5360623781676, Blast_Score=116, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 52768; Mature: 52637

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQSARHEIRFLLNGETIVLDRVSPTETLLDYLRLSARLRGTKEGCGEGDCGAYTVLVGR
CCCCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
VVDGGLVYESVNACIRFVGSLDGCHVVTIEYLRGADGDLHPVQKAMVEFHGSQCGFCTPG
HHCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCHH
FVMSLYALWMRDPRPADAAIEKALQDNLCRCTGYEAIMRAARAISDYGNVAQDPLAAERA
HHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHCCHHCCCHHHHHH
HVLQRLTALRDGARVEVGAGKDRLIVPADLDDFATILAAEPKATIVAGSTDVGLWVTKMM
HHHHHHHHHCCCCEEEECCCCCCEEEECCCHHHHHHHCCCCCCEEEECCCCHHHHHHHHH
RDISPVVFIGHLEELHSIREENGVVTIGAGVTYTQAFGFLAGRIPALGQLINRIGGEQVR
HHCCCEEEEHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHCHHHHH
NMGTIGGNIANGSPIGDTPPLIALGATLTLRKGAERRTIALEDFFIAYGKQDRGAGEFVE
HCCCCCCCCCCCCCCCCCCCEEEECCEEEECCCCCCCEEEEEHHHHEECCCCCCHHHHHH
AVHVPLPGEGSRFAAYKVSKRREEDITASLGAFHLMLDAAGNVAHIRIAYGGMAATPKRA
EEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCCCCCHHH
HAVETALMGKPWTEATVEAALEAYAQDYTPLTDMRATAEYRLLVARNMLRRFYLETTGSG
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ETLGALRGEAA
CCHHCCCCCCC
>Mature Secondary Structure 
GQSARHEIRFLLNGETIVLDRVSPTETLLDYLRLSARLRGTKEGCGEGDCGAYTVLVGR
CCCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
VVDGGLVYESVNACIRFVGSLDGCHVVTIEYLRGADGDLHPVQKAMVEFHGSQCGFCTPG
HHCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCHH
FVMSLYALWMRDPRPADAAIEKALQDNLCRCTGYEAIMRAARAISDYGNVAQDPLAAERA
HHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHCCHHCCCHHHHHH
HVLQRLTALRDGARVEVGAGKDRLIVPADLDDFATILAAEPKATIVAGSTDVGLWVTKMM
HHHHHHHHHCCCCEEEECCCCCCEEEECCCHHHHHHHCCCCCCEEEECCCCHHHHHHHHH
RDISPVVFIGHLEELHSIREENGVVTIGAGVTYTQAFGFLAGRIPALGQLINRIGGEQVR
HHCCCEEEEHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHCHHHHH
NMGTIGGNIANGSPIGDTPPLIALGATLTLRKGAERRTIALEDFFIAYGKQDRGAGEFVE
HCCCCCCCCCCCCCCCCCCCEEEECCEEEECCCCCCCEEEEEHHHHEECCCCCCHHHHHH
AVHVPLPGEGSRFAAYKVSKRREEDITASLGAFHLMLDAAGNVAHIRIAYGGMAATPKRA
EEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCCCCCHHH
HAVETALMGKPWTEATVEAALEAYAQDYTPLTDMRATAEYRLLVARNMLRRFYLETTGSG
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ETLGALRGEAA
CCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]