Click here to switch to the map view.

The map label for this gene is degS [H]

Identifier: 225851884

GI number: 225851884

Start: 370589

End: 371962

Strand: Direct

Name: degS [H]

Synonym: BMEA_A0377

Alternate gene names: 225851884

Gene position: 370589-371962 (Clockwise)

Preceding gene: 225851882

Following gene: 225851885

Centisome position: 17.43

GC content: 58.44

Gene sequence:

>1374_bases
TTGAAGGTGACGCTGCGCTATCAGATCGTTGCACTGGCGATTATCCCCCTGATCGTGGCCATTCTCACGATCACGGCCTT
CATCACCTGGCAGTCGGCCAATCTTGTCCAGAGCAGTATTGCGACCTTTGAGAAGAATATGCTCAAGGCGAAGGAGACGG
AGCTTTTGAACCTCACCAATCTGGCGCTTTCGGCGATCCAGAAGGTTTATGAGGAGGCCGGGCCGAACGATGAGGACGCG
ATGGAGAAGGTGCGGGCTATTCTCACCTCGCTCGATTATGGCCGTGACGGCTATTTCTTCGTTTATGATTACAACGGCAA
CAATGTCGTGCATCCGCGCCAGTTGTTCCGCCCCGGCCATAACTGGCTCAATCTCACCGATCCCGATGGCGACCGCGTGA
TCGCCAATCTGATTGCCAAGGCGAAGGAGGGCGGAGGGCTGCACCGATATAAATGGGAAAAGCCGTCCAGCCACGAAATG
GCGGACAAGCTTTCCTTTGCGGTCGGCCTCGACAAATGGAAGTGGATGCTGGGGACGGGCGTTTATCTCGATGACGTCTA
TGCCCAGACAGCCGCAGCGAATGCGGATTTCCGCGCCAATATCCGCACCACTTTCCTGATTGTCAGCCTCATCGCCGTAC
CCGCGGTCATGCTGGTTTTCGCGACCTGCATGCTGCTCAACCTGCGTGAGCGGCGCATGGCCGATACCAAGCTGAAGGAG
CTTGCGCAGCGCATCATCGATACGCAGGAGGAGGAGCGTGCGCGGCTTGCGCGCGAACTCCATGACGGTATTTCGCAGAA
TCTGGTCGGTGTGCGTTATGCCATTGATCTGGCAAGCCGGCAGGTGCGCACCGGCAGTGGTGGTGCGCCGCAGGCCATCG
AAAAGGCCTCCGATGCGCTGAACGGGGCCATCAAGGAAGTGCGGCGTCTGTCGCATGATCTGCGCCCGCGCATTCTGGAC
GATCTTGGCCTCACCGTCGCGCTCAAGGCGCTTTGCGAGCGCACCGGTATTGAAACCCGCTTCAAGGCGGATAGTTTGCA
GGAAACCATCAAGCCGGAGCCGAGCACCGCACTTTATCGCGTGGTGCAGGAGGCGCTCACCAATGTCGAGCGCCATTCCG
GCGCGACACGGGTGGATATCCGGCTGAAAGGTGCGCATGGCAAGGTGACGATGACCATTGCCGATAATGGCAATGGTTTT
GCTGTCCGGGGCCTGAAAGATCCGCTTTCCGGCCTTGGCCTGCGCAACATGCAGGAACGGATGGCGCATTTTGGCGGTGT
GCTCTTGGTTGAAACGAGTGCAGATGGTACGCAACTGACCGCACGTCTGCCGAAATCGGCAACGGAAAGAAGGCTGGAAC
CGGAAGTCGCATGA

Upstream 100 bases:

>100_bases
AAATCGGCAACTGTGTTCTGCTCGCGCCCTCTTCTTTTGCACTTTTCGCGAAGGGATTTAATCCCTAAGGTCGCCCGGCA
AAAGCCGAAAAAGCCGGAGG

Downstream 100 bases:

>100_bases
CGAATGAATGCAAGATTCGCGTATTGTTGGTGGACAATCATCCGCTGGTGCTGGACGGCCTGCGCGCCGTGCTTGAAACC
TATGACGATATTGATATTGC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MKVTLRYQIVALAIIPLIVAILTITAFITWQSANLVQSSIATFEKNMLKAKETELLNLTNLALSAIQKVYEEAGPNDEDA
MEKVRAILTSLDYGRDGYFFVYDYNGNNVVHPRQLFRPGHNWLNLTDPDGDRVIANLIAKAKEGGGLHRYKWEKPSSHEM
ADKLSFAVGLDKWKWMLGTGVYLDDVYAQTAAANADFRANIRTTFLIVSLIAVPAVMLVFATCMLLNLRERRMADTKLKE
LAQRIIDTQEEERARLARELHDGISQNLVGVRYAIDLASRQVRTGSGGAPQAIEKASDALNGAIKEVRRLSHDLRPRILD
DLGLTVALKALCERTGIETRFKADSLQETIKPEPSTALYRVVQEALTNVERHSGATRVDIRLKGAHGKVTMTIADNGNGF
AVRGLKDPLSGLGLRNMQERMAHFGGVLLVETSADGTQLTARLPKSATERRLEPEVA

Sequences:

>Translated_457_residues
MKVTLRYQIVALAIIPLIVAILTITAFITWQSANLVQSSIATFEKNMLKAKETELLNLTNLALSAIQKVYEEAGPNDEDA
MEKVRAILTSLDYGRDGYFFVYDYNGNNVVHPRQLFRPGHNWLNLTDPDGDRVIANLIAKAKEGGGLHRYKWEKPSSHEM
ADKLSFAVGLDKWKWMLGTGVYLDDVYAQTAAANADFRANIRTTFLIVSLIAVPAVMLVFATCMLLNLRERRMADTKLKE
LAQRIIDTQEEERARLARELHDGISQNLVGVRYAIDLASRQVRTGSGGAPQAIEKASDALNGAIKEVRRLSHDLRPRILD
DLGLTVALKALCERTGIETRFKADSLQETIKPEPSTALYRVVQEALTNVERHSGATRVDIRLKGAHGKVTMTIADNGNGF
AVRGLKDPLSGLGLRNMQERMAHFGGVLLVETSADGTQLTARLPKSATERRLEPEVA
>Mature_457_residues
MKVTLRYQIVALAIIPLIVAILTITAFITWQSANLVQSSIATFEKNMLKAKETELLNLTNLALSAIQKVYEEAGPNDEDA
MEKVRAILTSLDYGRDGYFFVYDYNGNNVVHPRQLFRPGHNWLNLTDPDGDRVIANLIAKAKEGGGLHRYKWEKPSSHEM
ADKLSFAVGLDKWKWMLGTGVYLDDVYAQTAAANADFRANIRTTFLIVSLIAVPAVMLVFATCMLLNLRERRMADTKLKE
LAQRIIDTQEEERARLARELHDGISQNLVGVRYAIDLASRQVRTGSGGAPQAIEKASDALNGAIKEVRRLSHDLRPRILD
DLGLTVALKALCERTGIETRFKADSLQETIKPEPSTALYRVVQEALTNVERHSGATRVDIRLKGAHGKVTMTIADNGNGF
AVRGLKDPLSGLGLRNMQERMAHFGGVLLVETSADGTQLTARLPKSATERRLEPEVA

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4564

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=214, Percent_Identity=31.3084112149533, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788812, Length=202, Percent_Identity=29.2079207920792, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787474, Length=166, Percent_Identity=26.5060240963855, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50645; Mature: 50645

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVTLRYQIVALAIIPLIVAILTITAFITWQSANLVQSSIATFEKNMLKAKETELLNLTN
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALSAIQKVYEEAGPNDEDAMEKVRAILTSLDYGRDGYFFVYDYNGNNVVHPRQLFRPGH
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEECHHHHHCCCC
NWLNLTDPDGDRVIANLIAKAKEGGGLHRYKWEKPSSHEMADKLSFAVGLDKWKWMLGTG
CEEECCCCCHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHCCHHHHHHHCCC
VYLDDVYAQTAAANADFRANIRTTFLIVSLIAVPAVMLVFATCMLLNLRERRMADTKLKE
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAQRIIDTQEEERARLARELHDGISQNLVGVRYAIDLASRQVRTGSGGAPQAIEKASDAL
HHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHH
NGAIKEVRRLSHDLRPRILDDLGLTVALKALCERTGIETRFKADSLQETIKPEPSTALYR
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHH
VVQEALTNVERHSGATRVDIRLKGAHGKVTMTIADNGNGFAVRGLKDPLSGLGLRNMQER
HHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEEEECCCEEEECCCCCCHHCCCHHHHHHH
MAHFGGVLLVETSADGTQLTARLPKSATERRLEPEVA
HHHHCCEEEEEECCCCCEEEHHCCCHHHHHCCCCCCC
>Mature Secondary Structure
MKVTLRYQIVALAIIPLIVAILTITAFITWQSANLVQSSIATFEKNMLKAKETELLNLTN
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALSAIQKVYEEAGPNDEDAMEKVRAILTSLDYGRDGYFFVYDYNGNNVVHPRQLFRPGH
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEECHHHHHCCCC
NWLNLTDPDGDRVIANLIAKAKEGGGLHRYKWEKPSSHEMADKLSFAVGLDKWKWMLGTG
CEEECCCCCHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHCCHHHHHHHCCC
VYLDDVYAQTAAANADFRANIRTTFLIVSLIAVPAVMLVFATCMLLNLRERRMADTKLKE
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAQRIIDTQEEERARLARELHDGISQNLVGVRYAIDLASRQVRTGSGGAPQAIEKASDAL
HHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHH
NGAIKEVRRLSHDLRPRILDDLGLTVALKALCERTGIETRFKADSLQETIKPEPSTALYR
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHH
VVQEALTNVERHSGATRVDIRLKGAHGKVTMTIADNGNGFAVRGLKDPLSGLGLRNMQER
HHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEEEECCCEEEECCCCCCHHCCCHHHHHHH
MAHFGGVLLVETSADGTQLTARLPKSATERRLEPEVA
HHHHCCEEEEEECCCCCEEEHHCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]