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The map label for this gene is mdtA [H]

Identifier: 225851824

GI number: 225851824

Start: 302613

End: 303764

Strand: Direct

Name: mdtA [H]

Synonym: BMEA_A0310

Alternate gene names: 225851824

Gene position: 302613-303764 (Clockwise)

Preceding gene: 225851822

Following gene: 225851825

Centisome position: 14.24

GC content: 60.33

Gene sequence:

>1152_bases
ATGAAATCCTGGAAGCAGATTGCTCTGTGCCTGCTCATCATTCTCGCCGCCACAGGTGGCTGGTATGTTTATAAGAACAA
CAATGGCGCGGCGCAATTGGCCCTATCTTCTGGAGATGCGCCCGGCAATGTGTCTCAGGCTCAGCCCAAAAAACAGCCGA
AGAACCATGCAGCCCCCCTTGTCGTGGTGGCGGCGGCCGGCGAAGAAACCATCAATAATCGCCTGACCGCCATCGGTTCG
GCGCGGGCCCTGAGCACGGTTTCCGTGACGCCCTATTCCAGCGGCTACATGACCAAGCTCCATGTCAGGGCGGGCGATAC
GGTGAAGGAAGGCGATCTGATTGCCGAACTGGACGCCGAAACCGAGCAGATTGCCGTTGCCAAGGCCGAAACGGCGCTGA
AGGATGCACAAACCACCCGCCAGCGCATTGCACGGCTGCGTGCAACCAACACGGCGACCGAAGTGCAGGCCGTGGGGGCC
GAACTTGCTGTCGCCAATGCGCAGCTTGCGCTTCAGGATGCCCAACTTGCGCTGAGCCGCCGCATGGTGCGCGCGCCGAT
CACCGGCATTGTCGGTATTCTTCCGGTCAATGCCGGCAATTACGTCACGGCACAGACTTCCATCGCACGCATCGATGACC
GCTCGACCGTTCTGATCGATATCTGGGTGCCGGAACGTTTCGCACCGCAGATCAAGGTCGGACAGCCGCTCACCGCAGAA
TCCACCGCTTTCCCCGGCGAGATTTATAAGGGCCGGATCAATGCCGTGGACAATATGCTGGATGAGGCAAGCCGCACCCT
GCATGTTCGTGCCGAAGTGCCAAATGCCGAGGACCGCCTGCGTGCGGGCATGTCCTTTTCAGTGACCATTCTCTTCCCCG
GCGATAACTATCCCTCGGTCGATCCGCTGGCGATCCAGTGGGGGGCTGACGGCTCCTATGTCTGGCGCATCGAAAACGGA
ATTGCGAAGAAAATACCCGTCCGTATCGTGCAGCGCAGTTCCGACAATATTTTGATAGACGGCCCGGTGAAGCGGGGCGA
CATGATTGTCACGCAGGGCGTACAGACCGTGCGCGACGATGCGCCGGTGCGCGTGAAGGGCGAGCAGGGCGTCAGCGCTC
TTGCCCCCGCCGCAATGCATGACGAAGGGTGA

Upstream 100 bases:

>100_bases
TTTGCCGCGTGGAGACGAAAATTGTCGCCTTCGCTGCAATGAAACTGGTTTTGGACGCGGGCTGTCGGGGATGACAAGGC
GGCCCTGGCCGGAGGGCTGA

Downstream 100 bases:

>100_bases
GGGGCTGACGGAGCGTGAGTAACAAGAACCCTTCTTCCGGCGGTTCGACGGCGCTTTTCATCCGCCGCCCCGTCTTTGCC
TTCGTCATCAATATCCTGAT

Product: RND family efflux transporter

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MKSWKQIALCLLIILAATGGWYVYKNNNGAAQLALSSGDAPGNVSQAQPKKQPKNHAAPLVVVAAAGEETINNRLTAIGS
ARALSTVSVTPYSSGYMTKLHVRAGDTVKEGDLIAELDAETEQIAVAKAETALKDAQTTRQRIARLRATNTATEVQAVGA
ELAVANAQLALQDAQLALSRRMVRAPITGIVGILPVNAGNYVTAQTSIARIDDRSTVLIDIWVPERFAPQIKVGQPLTAE
STAFPGEIYKGRINAVDNMLDEASRTLHVRAEVPNAEDRLRAGMSFSVTILFPGDNYPSVDPLAIQWGADGSYVWRIENG
IAKKIPVRIVQRSSDNILIDGPVKRGDMIVTQGVQTVRDDAPVRVKGEQGVSALAPAAMHDEG

Sequences:

>Translated_383_residues
MKSWKQIALCLLIILAATGGWYVYKNNNGAAQLALSSGDAPGNVSQAQPKKQPKNHAAPLVVVAAAGEETINNRLTAIGS
ARALSTVSVTPYSSGYMTKLHVRAGDTVKEGDLIAELDAETEQIAVAKAETALKDAQTTRQRIARLRATNTATEVQAVGA
ELAVANAQLALQDAQLALSRRMVRAPITGIVGILPVNAGNYVTAQTSIARIDDRSTVLIDIWVPERFAPQIKVGQPLTAE
STAFPGEIYKGRINAVDNMLDEASRTLHVRAEVPNAEDRLRAGMSFSVTILFPGDNYPSVDPLAIQWGADGSYVWRIENG
IAKKIPVRIVQRSSDNILIDGPVKRGDMIVTQGVQTVRDDAPVRVKGEQGVSALAPAAMHDEG
>Mature_383_residues
MKSWKQIALCLLIILAATGGWYVYKNNNGAAQLALSSGDAPGNVSQAQPKKQPKNHAAPLVVVAAAGEETINNRLTAIGS
ARALSTVSVTPYSSGYMTKLHVRAGDTVKEGDLIAELDAETEQIAVAKAETALKDAQTTRQRIARLRATNTATEVQAVGA
ELAVANAQLALQDAQLALSRRMVRAPITGIVGILPVNAGNYVTAQTSIARIDDRSTVLIDIWVPERFAPQIKVGQPLTAE
STAFPGEIYKGRINAVDNMLDEASRTLHVRAEVPNAEDRLRAGMSFSVTILFPGDNYPSVDPLAIQWGADGSYVWRIENG
IAKKIPVRIVQRSSDNILIDGPVKRGDMIVTQGVQTVRDDAPVRVKGEQGVSALAPAAMHDEG

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=365, Percent_Identity=28.7671232876712, Blast_Score=102, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40870; Mature: 40870

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSWKQIALCLLIILAATGGWYVYKNNNGAAQLALSSGDAPGNVSQAQPKKQPKNHAAPL
CCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCE
VVVAAAGEETINNRLTAIGSARALSTVSVTPYSSGYMTKLHVRAGDTVKEGDLIAELDAE
EEEEECCCHHHHCHHEEEECCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCEEEECCCC
TEQIAVAKAETALKDAQTTRQRIARLRATNTATEVQAVGAELAVANAQLALQDAQLALSR
CHHEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEECHHEEHHHHHHHHHH
RMVRAPITGIVGILPVNAGNYVTAQTSIARIDDRSTVLIDIWVPERFAPQIKVGQPLTAE
HHHHCCCCCEEEEEEECCCCEEEECCEEEEECCCCEEEEEEECCCCCCCCEECCCCCCCC
STAFPGEIYKGRINAVDNMLDEASRTLHVRAEVPNAEDRLRAGMSFSVTILFPGDNYPSV
CCCCCCHHHCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCCCEEEEEEEECCCCCCCC
DPLAIQWGADGSYVWRIENGIAKKIPVRIVQRSSDNILIDGPVKRGDMIVTQGVQTVRDD
CCEEEEECCCCCEEEEECCCCCCCCCEEEEEECCCCEEEECCCCCCCEEEECCCHHHHCC
APVRVKGEQGVSALAPAAMHDEG
CCEEEECCCCCHHHCCCCCCCCC
>Mature Secondary Structure
MKSWKQIALCLLIILAATGGWYVYKNNNGAAQLALSSGDAPGNVSQAQPKKQPKNHAAPL
CCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCE
VVVAAAGEETINNRLTAIGSARALSTVSVTPYSSGYMTKLHVRAGDTVKEGDLIAELDAE
EEEEECCCHHHHCHHEEEECCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCEEEECCCC
TEQIAVAKAETALKDAQTTRQRIARLRATNTATEVQAVGAELAVANAQLALQDAQLALSR
CHHEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEECHHEEHHHHHHHHHH
RMVRAPITGIVGILPVNAGNYVTAQTSIARIDDRSTVLIDIWVPERFAPQIKVGQPLTAE
HHHHCCCCCEEEEEEECCCCEEEECCEEEEECCCCEEEEEEECCCCCCCCEECCCCCCCC
STAFPGEIYKGRINAVDNMLDEASRTLHVRAEVPNAEDRLRAGMSFSVTILFPGDNYPSV
CCCCCCHHHCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCCCEEEEEEEECCCCCCCC
DPLAIQWGADGSYVWRIENGIAKKIPVRIVQRSSDNILIDGPVKRGDMIVTQGVQTVRDD
CCEEEEECCCCCEEEEECCCCCCCCCEEEEEECCCCEEEECCCCCCCEEEECCCHHHHCC
APVRVKGEQGVSALAPAAMHDEG
CCEEEECCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA