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The map label for this gene is ureC [H]

Identifier: 225851819

GI number: 225851819

Start: 296849

End: 298561

Strand: Direct

Name: ureC [H]

Synonym: BMEA_A0303

Alternate gene names: 225851819

Gene position: 296849-298561 (Clockwise)

Preceding gene: 225851818

Following gene: 225851820

Centisome position: 13.96

GC content: 60.3

Gene sequence:

>1713_bases
ATGCCAGCAAGAATTAGCCGCGCCACCTATGCGCAAATGTTCGGCCCCACCGTTGGCGACAAGGTGCGCCTTGCCGATAC
GGATCTCATCATCGAAGTCGAGCGCGACCTCACCACCTATGGCGAGGAAGTGAAGTTCGGCGGCGGCAAGGTTATCCGCG
ACGGTATGGGCCAGAGCCAGCTTTCCCGCGCCGAAGGCGCGATGGACACCGTCATCACCAATGCGCTGATCCTCGACCAT
AGCGGCATCTACAAGGCGGATATCGGGCTTCTCGACGGGCGCATCGCCCTCATCGGCAAGGCAGGCAATCCCGATACGCA
GCCCGGCATCTCGATCATCATCGGCCCCGGCACGGAGATCATCGCTGGCGAAGGCAAGATCGTCACCGCGGGCGGCATCG
ATACCCATGTCCATTTCATCTCGCCGCAACAGGTGGATGAGGCGCTGAATGCGGGCATCACCTGCATGGTTGGCGGCGGC
ACCGGCCCCGCGCATGGCACGCTTGCCACCACCTGCACGCCTGGCCCCTGGCACATCGCCCGGCTGATCCAGTCCTTCGA
TGGCCTGCCGATGAATATCGGTGTGTTCGGCAAGGGCAATGCCTCGCTGCCCGGCGCATTGGAAGAAATGGTTCGCGCCG
GCGCCTGCGGCCTGAAACTGCATGAGGACTGGGGTTGCACACCGGCGGCTATCGACAATTGCCTTTCGGTTGCCGATCAT
TTCGACGTTCAGGTGGCGATCCACACCGATACGCTCAATGAAGGTGGCTTCGTTGAAGATACGCTCAATGCCTTCAAGGG
ACGCACGATCCACTCTTTCCATACGGAAGGTGCGGGCGGTGGGCACGCGCCCGATATCATCCGCGTTTGCCAATATCCGA
ACGTGCTGCCTGCTTCGACCAACCCGACCCGGCCCTACACGGTCAACACGATTGCGGAACATCTCGACATGCTGATGGTC
TGCCATCACCTGTCGCCTGCAATCCCTGAGGATATCGCCTTTGCCGAAAGCCGCATCCGCAAGGAAACGATTGCGGCGGA
AGATATTCTGCACGACATGGGCGCCTTCTCGATCATTTCCTCCGACAGCCAGGCGATGGGCCGTGTGGGTGAAATGATCA
TCCGCTGCTGGCAGACGGCAGACAAGATGAAGAAACAGCGCGGCAGCCTGCCTGACGATAGGCCGGGCAACGACAATTAC
CGCGCCCGCCGTTATATTGCCAAATATACGATCAATCCTGCTATCGCGCATGGCATGGCGCATGAGATCGGCTCCGTGGA
AGTGGGCAAGCGTGCGGATCTGGTGCTGTGGAACTCGGCCTTCTTCGGTGTCAAACCGGATATGGTGCTGCTTGGCGGCT
GGATCGCCACCGCCCCCATGGGCGATGCAAACGGTTCCATCCCCACTCCGCAGCCTATGCATACCCGCCCCATGTTCGGC
TCGTTCGGCAAGGCGCTCACCAACACGTCCATCACGTTTGTTTCGCAAGCAGCGATGGATGAGGGCCTGCGTGAGAAGAT
CGGCGTGGACAAGCAGCTGGTGGCGGTCGTCAATACGCGCGGCGGCATCGGCAAGCATTCCATGATCCTCAACAATGCCA
TGCCGCAGATGGAAGTGGACCCGGAAACCTATGAAGTGCGTGCGGACGGCGAACTTCTCACCTGTGAGCCGGTAGACGTG
GTACCAATGGCGCAACGCTACTTCCTGTTTTGA

Upstream 100 bases:

>100_bases
GGAACGCGATGTGACGCTCGTTCCCATCAGGGGCCATCGCGAGATTTATGGCTTCCGCCAGATGATCATGGGCAAACTTT
AAGGGCGACGGAGATGTTTC

Downstream 100 bases:

>100_bases
GCCGGAGTATGAGATATGTTTCGAGCAATTGCCATCATTCGTGCCCATGAAGTGATCGATGCCGTTCCGGCCAGCCATAT
CGTCCTGGAGCGCGATGAGC

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha 1 [H]

Number of amino acids: Translated: 570; Mature: 569

Protein sequence:

>570_residues
MPARISRATYAQMFGPTVGDKVRLADTDLIIEVERDLTTYGEEVKFGGGKVIRDGMGQSQLSRAEGAMDTVITNALILDH
SGIYKADIGLLDGRIALIGKAGNPDTQPGISIIIGPGTEIIAGEGKIVTAGGIDTHVHFISPQQVDEALNAGITCMVGGG
TGPAHGTLATTCTPGPWHIARLIQSFDGLPMNIGVFGKGNASLPGALEEMVRAGACGLKLHEDWGCTPAAIDNCLSVADH
FDVQVAIHTDTLNEGGFVEDTLNAFKGRTIHSFHTEGAGGGHAPDIIRVCQYPNVLPASTNPTRPYTVNTIAEHLDMLMV
CHHLSPAIPEDIAFAESRIRKETIAAEDILHDMGAFSIISSDSQAMGRVGEMIIRCWQTADKMKKQRGSLPDDRPGNDNY
RARRYIAKYTINPAIAHGMAHEIGSVEVGKRADLVLWNSAFFGVKPDMVLLGGWIATAPMGDANGSIPTPQPMHTRPMFG
SFGKALTNTSITFVSQAAMDEGLREKIGVDKQLVAVVNTRGGIGKHSMILNNAMPQMEVDPETYEVRADGELLTCEPVDV
VPMAQRYFLF

Sequences:

>Translated_570_residues
MPARISRATYAQMFGPTVGDKVRLADTDLIIEVERDLTTYGEEVKFGGGKVIRDGMGQSQLSRAEGAMDTVITNALILDH
SGIYKADIGLLDGRIALIGKAGNPDTQPGISIIIGPGTEIIAGEGKIVTAGGIDTHVHFISPQQVDEALNAGITCMVGGG
TGPAHGTLATTCTPGPWHIARLIQSFDGLPMNIGVFGKGNASLPGALEEMVRAGACGLKLHEDWGCTPAAIDNCLSVADH
FDVQVAIHTDTLNEGGFVEDTLNAFKGRTIHSFHTEGAGGGHAPDIIRVCQYPNVLPASTNPTRPYTVNTIAEHLDMLMV
CHHLSPAIPEDIAFAESRIRKETIAAEDILHDMGAFSIISSDSQAMGRVGEMIIRCWQTADKMKKQRGSLPDDRPGNDNY
RARRYIAKYTINPAIAHGMAHEIGSVEVGKRADLVLWNSAFFGVKPDMVLLGGWIATAPMGDANGSIPTPQPMHTRPMFG
SFGKALTNTSITFVSQAAMDEGLREKIGVDKQLVAVVNTRGGIGKHSMILNNAMPQMEVDPETYEVRADGELLTCEPVDV
VPMAQRYFLF
>Mature_569_residues
PARISRATYAQMFGPTVGDKVRLADTDLIIEVERDLTTYGEEVKFGGGKVIRDGMGQSQLSRAEGAMDTVITNALILDHS
GIYKADIGLLDGRIALIGKAGNPDTQPGISIIIGPGTEIIAGEGKIVTAGGIDTHVHFISPQQVDEALNAGITCMVGGGT
GPAHGTLATTCTPGPWHIARLIQSFDGLPMNIGVFGKGNASLPGALEEMVRAGACGLKLHEDWGCTPAAIDNCLSVADHF
DVQVAIHTDTLNEGGFVEDTLNAFKGRTIHSFHTEGAGGGHAPDIIRVCQYPNVLPASTNPTRPYTVNTIAEHLDMLMVC
HHLSPAIPEDIAFAESRIRKETIAAEDILHDMGAFSIISSDSQAMGRVGEMIIRCWQTADKMKKQRGSLPDDRPGNDNYR
ARRYIAKYTINPAIAHGMAHEIGSVEVGKRADLVLWNSAFFGVKPDMVLLGGWIATAPMGDANGSIPTPQPMHTRPMFGS
FGKALTNTSITFVSQAAMDEGLREKIGVDKQLVAVVNTRGGIGKHSMILNNAMPQMEVDPETYEVRADGELLTCEPVDVV
PMAQRYFLF

Specific function: May protect brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral [H]

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950 [H]

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha [H]

EC number: =3.5.1.5 [H]

Molecular weight: Translated: 61001; Mature: 60870

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS01120 UREASE_1 ; PS00145 UREASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPARISRATYAQMFGPTVGDKVRLADTDLIIEVERDLTTYGEEVKFGGGKVIRDGMGQSQ
CCCCCCHHHHHHHHCCCCCCEEEEECCEEEEEECCCHHHCCCEEECCCCEEEECCCCHHH
LSRAEGAMDTVITNALILDHSGIYKADIGLLDGRIALIGKAGNPDTQPGISIIIGPGTEI
HHHHHHHHHHHHHHEEEEECCCCEEECCEEECCEEEEEECCCCCCCCCCEEEEECCCCEE
IAGEGKIVTAGGIDTHVHFISPQQVDEALNAGITCMVGGGTGPAHGTLATTCTPGPWHIA
EECCCEEEEECCCCEEEEEECHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCHHHHH
RLIQSFDGLPMNIGVFGKGNASLPGALEEMVRAGACGLKLHEDWGCTPAAIDNCLSVADH
HHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHC
FDVQVAIHTDTLNEGGFVEDTLNAFKGRTIHSFHTEGAGGGHAPDIIRVCQYPNVLPAST
CEEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCC
NPTRPYTVNTIAEHLDMLMVCHHLSPAIPEDIAFAESRIRKETIAAEDILHDMGAFSIIS
CCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
SDSQAMGRVGEMIIRCWQTADKMKKQRGSLPDDRPGNDNYRARRYIAKYTINPAIAHGMA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEEEECCHHHHHHHH
HEIGSVEVGKRADLVLWNSAFFGVKPDMVLLGGWIATAPMGDANGSIPTPQPMHTRPMFG
HHCCCEECCCCCCEEEEECEECCCCCCEEEEECEEEECCCCCCCCCCCCCCCCCCCCCHH
SFGKALTNTSITFVSQAAMDEGLREKIGVDKQLVAVVNTRGGIGKHSMILNNAMPQMEVD
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHCCCCCCCCC
PETYEVRADGELLTCEPVDVVPMAQRYFLF
CCEEEEEECCCEEEECCCCCCCCCHHHHCC
>Mature Secondary Structure 
PARISRATYAQMFGPTVGDKVRLADTDLIIEVERDLTTYGEEVKFGGGKVIRDGMGQSQ
CCCCCHHHHHHHHCCCCCCEEEEECCEEEEEECCCHHHCCCEEECCCCEEEECCCCHHH
LSRAEGAMDTVITNALILDHSGIYKADIGLLDGRIALIGKAGNPDTQPGISIIIGPGTEI
HHHHHHHHHHHHHHEEEEECCCCEEECCEEECCEEEEEECCCCCCCCCCEEEEECCCCEE
IAGEGKIVTAGGIDTHVHFISPQQVDEALNAGITCMVGGGTGPAHGTLATTCTPGPWHIA
EECCCEEEEECCCCEEEEEECHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCHHHHH
RLIQSFDGLPMNIGVFGKGNASLPGALEEMVRAGACGLKLHEDWGCTPAAIDNCLSVADH
HHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHC
FDVQVAIHTDTLNEGGFVEDTLNAFKGRTIHSFHTEGAGGGHAPDIIRVCQYPNVLPAST
CEEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCC
NPTRPYTVNTIAEHLDMLMVCHHLSPAIPEDIAFAESRIRKETIAAEDILHDMGAFSIIS
CCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
SDSQAMGRVGEMIIRCWQTADKMKKQRGSLPDDRPGNDNYRARRYIAKYTINPAIAHGMA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEEEECCHHHHHHHH
HEIGSVEVGKRADLVLWNSAFFGVKPDMVLLGGWIATAPMGDANGSIPTPQPMHTRPMFG
HHCCCEECCCCCCEEEEECEECCCCCCEEEEECEEEECCCCCCCCCCCCCCCCCCCCCHH
SFGKALTNTSITFVSQAAMDEGLREKIGVDKQLVAVVNTRGGIGKHSMILNNAMPQMEVD
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHCCCCCCCCC
PETYEVRADGELLTCEPVDVVPMAQRYFLF
CCEEEEEECCCEEEECCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA