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The map label for this gene is yisK [H]

Identifier: 225686902

GI number: 225686902

Start: 1136867

End: 1137733

Strand: Reverse

Name: yisK [H]

Synonym: BMEA_B1154

Alternate gene names: 225686902

Gene position: 1137733-1136867 (Counterclockwise)

Preceding gene: 225686903

Following gene: 225686901

Centisome position: 95.97

GC content: 58.94

Gene sequence:

>867_bases
ATGGTGAAGTTTCTGAGTTTTTCGACCTGCGGGGGCAGGCACTATGGCGTGCTGAAAGAGGACGGTATTGTCGATCTTTC
GGCGCGCCATGGGTCTCGCTGGCCGACCTTGCGTGAGGTGATCGAGGCCGGTGTGCTGGCGCAGCTTGCGCAGGAGGCGG
CAGGGCTTGCCGCCGATGTTCCGCTTTCTTCCATCACCTATGAGATTCCAATTCCTTCGCCGGGAAAGATCATCTGTGTC
GGTGTCAATTTTCCAGATCGAAACGAGGAATACAAGGATGGGCAGGCTGCGCCGGCCAATCCCTCGCTCTTCGTCCGGTT
TCCCCGCTCCTTCACCGGGCATGAGCGCCCGCTGATGCGTCCGCCGGAAAGCCCGCAGCTCGATTATGAAGGCGAGATAG
CCATCGTCATCGGCAAGGGCGGGCGGCGTATTGCGGAAAAGGATGCGCTCGATCACATAGCGGCACTTACGCTGTGCAAT
GAAGGCACGATCCGCGACTGGGTGCGCCATGCGAAATTCAACGTGACGCAAGGCAAGAATTTTGATGCCACCGGCTCCAT
CGGGCCATGGCTGGTGCCTTATACGGATGAAAGCCAGATAGCCGATATTCAGTTGACGACGCGGGTAAATGGCGAGGTGC
GCCAGCAGGATCGCACCAGCCGCATGATCTTCTCTTTCCGCAAGATCATCAATTATGTCTCCACTTTCACGACGCTGGTG
CCGGGTGACGTGATCGTCTGCGGCACGCCGACGGGTGCGGGCGCGCGTTTCGACCCGCCAATCTGGCTGAAACCCGGCGA
TGTGGTGGAAGTGGAGGCGGAGGGCATCGGCCTCTTGCGCAACACCATTGCCGATGAAAAGGTTTAA

Upstream 100 bases:

>100_bases
TGTTGAAGGCACAGCCGATCGTCGCGCCGTAATGGGCGACCTTGATGCCACCCGCCTATGCAGGCGGGTGGTGCGGGACG
GAAGGAAATCTGAGGAGATC

Downstream 100 bases:

>100_bases
TCCATGCTGACGAAGGACGAAATTGAAGCTGCCGCCGCTGCATTGGATGGAGCGGAGAAGACCCGCAGGCAGGTCGGTCT
GCTCTCGCTCAAGCATCCGG

Product: Fumarylacetoacetate hydrolase domain-containing protein 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MVKFLSFSTCGGRHYGVLKEDGIVDLSARHGSRWPTLREVIEAGVLAQLAQEAAGLAADVPLSSITYEIPIPSPGKIICV
GVNFPDRNEEYKDGQAAPANPSLFVRFPRSFTGHERPLMRPPESPQLDYEGEIAIVIGKGGRRIAEKDALDHIAALTLCN
EGTIRDWVRHAKFNVTQGKNFDATGSIGPWLVPYTDESQIADIQLTTRVNGEVRQQDRTSRMIFSFRKIINYVSTFTTLV
PGDVIVCGTPTGAGARFDPPIWLKPGDVVEVEAEGIGLLRNTIADEKV

Sequences:

>Translated_288_residues
MVKFLSFSTCGGRHYGVLKEDGIVDLSARHGSRWPTLREVIEAGVLAQLAQEAAGLAADVPLSSITYEIPIPSPGKIICV
GVNFPDRNEEYKDGQAAPANPSLFVRFPRSFTGHERPLMRPPESPQLDYEGEIAIVIGKGGRRIAEKDALDHIAALTLCN
EGTIRDWVRHAKFNVTQGKNFDATGSIGPWLVPYTDESQIADIQLTTRVNGEVRQQDRTSRMIFSFRKIINYVSTFTTLV
PGDVIVCGTPTGAGARFDPPIWLKPGDVVEVEAEGIGLLRNTIADEKV
>Mature_288_residues
MVKFLSFSTCGGRHYGVLKEDGIVDLSARHGSRWPTLREVIEAGVLAQLAQEAAGLAADVPLSSITYEIPIPSPGKIICV
GVNFPDRNEEYKDGQAAPANPSLFVRFPRSFTGHERPLMRPPESPQLDYEGEIAIVIGKGGRRIAEKDALDHIAALTLCN
EGTIRDWVRHAKFNVTQGKNFDATGSIGPWLVPYTDESQIADIQLTTRVNGEVRQQDRTSRMIFSFRKIINYVSTFTTLV
PGDVIVCGTPTGAGARFDPPIWLKPGDVVEVEAEGIGLLRNTIADEKV

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI40786394, Length=278, Percent_Identity=35.2517985611511, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI156231349, Length=278, Percent_Identity=35.2517985611511, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI13654274, Length=214, Percent_Identity=34.1121495327103, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI66348062, Length=181, Percent_Identity=34.8066298342541, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI215422413, Length=181, Percent_Identity=34.8066298342541, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1787428, Length=208, Percent_Identity=30.7692307692308, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17557057, Length=198, Percent_Identity=35.8585858585859, Blast_Score=113, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6324161, Length=231, Percent_Identity=26.4069264069264, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28572127, Length=287, Percent_Identity=30.3135888501742, Blast_Score=140, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24663695, Length=217, Percent_Identity=34.1013824884793, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28571789, Length=206, Percent_Identity=30.0970873786408, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 31513; Mature: 31513

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKFLSFSTCGGRHYGVLKEDGIVDLSARHGSRWPTLREVIEAGVLAQLAQEAAGLAADV
CEEEEEEECCCCCEECEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECC
PLSSITYEIPIPSPGKIICVGVNFPDRNEEYKDGQAAPANPSLFVRFPRSFTGHERPLMR
CCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
PPESPQLDYEGEIAIVIGKGGRRIAEKDALDHIAALTLCNEGTIRDWVRHAKFNVTQGKN
CCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHEECCCCCHHHHHHHHEEEECCCCC
FDATGSIGPWLVPYTDESQIADIQLTTRVNGEVRQQDRTSRMIFSFRKIINYVSTFTTLV
CCCCCCCCCEEEEECCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PGDVIVCGTPTGAGARFDPPIWLKPGDVVEVEAEGIGLLRNTIADEKV
CCCEEEEECCCCCCCCCCCCEEECCCCEEEEECCCCHHHHHHHHCCCC
>Mature Secondary Structure
MVKFLSFSTCGGRHYGVLKEDGIVDLSARHGSRWPTLREVIEAGVLAQLAQEAAGLAADV
CEEEEEEECCCCCEECEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECC
PLSSITYEIPIPSPGKIICVGVNFPDRNEEYKDGQAAPANPSLFVRFPRSFTGHERPLMR
CCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
PPESPQLDYEGEIAIVIGKGGRRIAEKDALDHIAALTLCNEGTIRDWVRHAKFNVTQGKN
CCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHEECCCCCHHHHHHHHEEEECCCCC
FDATGSIGPWLVPYTDESQIADIQLTTRVNGEVRQQDRTSRMIFSFRKIINYVSTFTTLV
CCCCCCCCCEEEEECCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PGDVIVCGTPTGAGARFDPPIWLKPGDVVEVEAEGIGLLRNTIADEKV
CCCEEEEECCCCCCCCCCCCEEECCCCEEEEECCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]