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The map label for this gene is hutI [H]

Identifier: 225686690

GI number: 225686690

Start: 893760

End: 895931

Strand: Direct

Name: hutI [H]

Synonym: BMEA_B0913

Alternate gene names: 225686690

Gene position: 893760-895931 (Clockwise)

Preceding gene: 225686686

Following gene: 225686691

Centisome position: 75.39

GC content: 60.45

Gene sequence:

>2172_bases
ATGACCAAGAATTCAAGCACCGTTTTCACCCATGCGCGCATTGCGACGCTGGAAGAAAAGGCCGCAAATCTCGGCTTGAT
CGAAGAAGCTGCACTGGTCGTCAAGGACGCCAGGATCGTCTATGCCGGTCCTGAAAACAAGCTTCCGGACGAATATGCTT
CCTTTGAGAAGATAGATTGCGGCAACCGGCTCATCACGCCGGGATTGATTGATTGCCACACCCATCTTGTCCATGCGGGC
AATCGCGCGCATGAGTTCGAGTTGCGCTTGCAGGGCGCAACCTATGAGGAAGTCGCACGCGCTGGCGGCGGCATTGTTTC
ATCGGTCCGGAACCTGCGCGCGGCAAGCGAAGACGATCTGGTGCGCGAAACCCTGCCGCGTCTTGATGCGCTGATTGCCG
AAGGCGTCACCACCGTCGAGGTAAAATCCGGCTATGGTCTCGACCGCGACAGCGAAATCAAATCGCTGAAGGCAGCCCGC
CGTCTCGGCGAAGAGCGTGACGTGGCGATCCGCACCACGTTCCTCGGCGCGCACGCGCTTCCCCCCGAAATGAACGGCGA
TAAGGCAGCCTATATCGACCGCGTTATCAACGACATGCTGCCCGCCATTGCCGAACAGGGGCTGGCCGATGCCGTTGACG
GTTTTTGCGAAGGCATTGCCTTCCTGCCGGATGAAATCGCCCGCGTTTTCGATGCGGCCAAGGCACATGATATTCCGGTC
AAGCTTCACGCCGACCAATTGTCCAACCTGCATGGCGCAGCCCTTGCCGCATCCTACGGCGCGCTTTCAGCCGACCATCT
GGAATATACGGATGCGGACGGTGCTGCCGCCATGGCGAGCGCCGGAACGGTGGCCGTGCTGCTGCCCGGCGCCTATTATT
TTATCCGCGAAACACAAAAACCACCGGTCGAAGCCTTCCGCGCCGCAGGCACGAAGATGGCGCTTGCCACCGACAACAAT
CCAGGCACCTCGCCGCTGACTTCGCTGCTGCTCACCATGAATATGGGGGCAACGCTCTTCCGCATGACGGTCGAGGAATG
CATCGCAGGCGTCACCCGCGAAGCAGCGCGGGCGCTGGGCATTCTCGATCAAACCGGCACGCTCGAAATCGGCAAGGATG
CCGATCTCGCCATTTGGGACATCGAGCGCCCGGCTGAACTCGTCTACCGCATCGGCTTCAACCCGCTCTGGAAGCGGGTT
TTCAAAGGCCAGATCAAACCGCACGTCCGAATGGAGCCTTTCATGACAATCATCCTCAAGCCCGGTTCCGTCCCGCTGGA
GACCCTCGAAAAAATCTATCGTGAAGGGCTTCCCGTCCGCATCGACCCTGCATTCCATGCCGGTATCGAAAAAGCTGCCG
CGCGCATTGCGGAAATCGCGGCAGGAGACGCGCCGGTTTACGGCATCAATACCGGTTTCGGAAAACTCGCCTCGATCCGT
ATTGCAGCGGGCGATGTCGCCACGCTTCAACGCAATCTGATCCTGTCGCATTGCTGCGGCGTCGGCGAACCGCTTTCGGA
AAATATCGTCCGCCTCATCATGGCGCTGAAGCTGGTTTCGCTCGGGCGCGGCGCGTCCGGCGTGCAGCTTGAAGTCATTA
CGCTTATCGAGGCCATGCTGGAAAAAGGTGTGATCCCGATGATCCCGGAAAAGGGCTCTGTCGGCGCTTCCGGCGACCTT
GCGCCACTTGCCCATATGACCGCCGCCATGATTGGCGAAGGCGAAGCCTTTTATCGGGGCGAGCGCCTCTCCGGCGCAAA
GGCGCTGGGAAAGGCGGGCCTGAAGCCGGTCGTGCTTGCAGCCAAGGAAGGGCTGGCGCTTATCAACGGCACCCAGACCT
CGACCGCGCTTGCACTTGCAGGTCTTTTCCGCGCCCACCGCGCGGCACGAACCGCGCTCATCACCGGCGCATTATCCACC
GATGCCGCCATGGGATCGGATGCGCCTTTCCATGAGGAAATTCACCAGCTTCGCGGCCATAAGGGACAGATCGATGCAGG
CCGGGCATTGCGCACCCTGCTTGAAGGGTCTGCTATCCGCCGAAGCCACCTTGAAGGCGACCAGCGCGTGCAGGATCCCT
ATTGCACCGCTGCCAGCCGCAGGTTGACGGTGCCTGTCTCGATATTCTGCGCCAGGCCGCACGCACATTGGAAATCGAAG
CCAATGCCGTGA

Upstream 100 bases:

>100_bases
GCGCTCTTTCAACAGCTTACCGCCATGCGCATTTTTTTCTTTGCTGTTTCCATAATATGTATATACATTATTGTGAAACA
GCGGAAGCGAGAAAACGCTC

Downstream 100 bases:

>100_bases
CCGACAATCCGCTCGTGCTTTCGGATGGGCGCGCCGTATCGGGCGGCAATTTCCATGCTGAGCCTGTTGCCTTTGCCGCC
GACCAGATTGCGCTTGCGGT

Product: imidazolonepropionase

Products: NA

Alternate protein names: Imidazolonepropionase; Imidazolone-5-propionate hydrolase; Histidine ammonia-lyase; Histidase [H]

Number of amino acids: Translated: 723; Mature: 722

Protein sequence:

>723_residues
MTKNSSTVFTHARIATLEEKAANLGLIEEAALVVKDARIVYAGPENKLPDEYASFEKIDCGNRLITPGLIDCHTHLVHAG
NRAHEFELRLQGATYEEVARAGGGIVSSVRNLRAASEDDLVRETLPRLDALIAEGVTTVEVKSGYGLDRDSEIKSLKAAR
RLGEERDVAIRTTFLGAHALPPEMNGDKAAYIDRVINDMLPAIAEQGLADAVDGFCEGIAFLPDEIARVFDAAKAHDIPV
KLHADQLSNLHGAALAASYGALSADHLEYTDADGAAAMASAGTVAVLLPGAYYFIRETQKPPVEAFRAAGTKMALATDNN
PGTSPLTSLLLTMNMGATLFRMTVEECIAGVTREAARALGILDQTGTLEIGKDADLAIWDIERPAELVYRIGFNPLWKRV
FKGQIKPHVRMEPFMTIILKPGSVPLETLEKIYREGLPVRIDPAFHAGIEKAAARIAEIAAGDAPVYGINTGFGKLASIR
IAAGDVATLQRNLILSHCCGVGEPLSENIVRLIMALKLVSLGRGASGVQLEVITLIEAMLEKGVIPMIPEKGSVGASGDL
APLAHMTAAMIGEGEAFYRGERLSGAKALGKAGLKPVVLAAKEGLALINGTQTSTALALAGLFRAHRAARTALITGALST
DAAMGSDAPFHEEIHQLRGHKGQIDAGRALRTLLEGSAIRRSHLEGDQRVQDPYCTAASRRLTVPVSIFCARPHAHWKSK
PMP

Sequences:

>Translated_723_residues
MTKNSSTVFTHARIATLEEKAANLGLIEEAALVVKDARIVYAGPENKLPDEYASFEKIDCGNRLITPGLIDCHTHLVHAG
NRAHEFELRLQGATYEEVARAGGGIVSSVRNLRAASEDDLVRETLPRLDALIAEGVTTVEVKSGYGLDRDSEIKSLKAAR
RLGEERDVAIRTTFLGAHALPPEMNGDKAAYIDRVINDMLPAIAEQGLADAVDGFCEGIAFLPDEIARVFDAAKAHDIPV
KLHADQLSNLHGAALAASYGALSADHLEYTDADGAAAMASAGTVAVLLPGAYYFIRETQKPPVEAFRAAGTKMALATDNN
PGTSPLTSLLLTMNMGATLFRMTVEECIAGVTREAARALGILDQTGTLEIGKDADLAIWDIERPAELVYRIGFNPLWKRV
FKGQIKPHVRMEPFMTIILKPGSVPLETLEKIYREGLPVRIDPAFHAGIEKAAARIAEIAAGDAPVYGINTGFGKLASIR
IAAGDVATLQRNLILSHCCGVGEPLSENIVRLIMALKLVSLGRGASGVQLEVITLIEAMLEKGVIPMIPEKGSVGASGDL
APLAHMTAAMIGEGEAFYRGERLSGAKALGKAGLKPVVLAAKEGLALINGTQTSTALALAGLFRAHRAARTALITGALST
DAAMGSDAPFHEEIHQLRGHKGQIDAGRALRTLLEGSAIRRSHLEGDQRVQDPYCTAASRRLTVPVSIFCARPHAHWKSK
PMP
>Mature_722_residues
TKNSSTVFTHARIATLEEKAANLGLIEEAALVVKDARIVYAGPENKLPDEYASFEKIDCGNRLITPGLIDCHTHLVHAGN
RAHEFELRLQGATYEEVARAGGGIVSSVRNLRAASEDDLVRETLPRLDALIAEGVTTVEVKSGYGLDRDSEIKSLKAARR
LGEERDVAIRTTFLGAHALPPEMNGDKAAYIDRVINDMLPAIAEQGLADAVDGFCEGIAFLPDEIARVFDAAKAHDIPVK
LHADQLSNLHGAALAASYGALSADHLEYTDADGAAAMASAGTVAVLLPGAYYFIRETQKPPVEAFRAAGTKMALATDNNP
GTSPLTSLLLTMNMGATLFRMTVEECIAGVTREAARALGILDQTGTLEIGKDADLAIWDIERPAELVYRIGFNPLWKRVF
KGQIKPHVRMEPFMTIILKPGSVPLETLEKIYREGLPVRIDPAFHAGIEKAAARIAEIAAGDAPVYGINTGFGKLASIRI
AAGDVATLQRNLILSHCCGVGEPLSENIVRLIMALKLVSLGRGASGVQLEVITLIEAMLEKGVIPMIPEKGSVGASGDLA
PLAHMTAAMIGEGEAFYRGERLSGAKALGKAGLKPVVLAAKEGLALINGTQTSTALALAGLFRAHRAARTALITGALSTD
AAMGSDAPFHEEIHQLRGHKGQIDAGRALRTLLEGSAIRRSHLEGDQRVQDPYCTAASRRLTVPVSIFCARPHAHWKSKP
MP

Specific function: Unknown

COG id: COG1228

COG function: function code Q; Imidazolonepropionase and related amidohydrolases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI223972677, Length=379, Percent_Identity=38.2585751978892, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI4504333, Length=288, Percent_Identity=39.9305555555556, Blast_Score=190, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17555004, Length=372, Percent_Identity=31.7204301075269, Blast_Score=175, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17567831, Length=267, Percent_Identity=37.0786516853933, Blast_Score=153, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013108
- InterPro:   IPR005921
- InterPro:   IPR005920
- InterPro:   IPR008948
- InterPro:   IPR011059
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF07969 Amidohydro_3; PF00221 PAL [H]

EC number: =3.5.2.7; =4.3.1.3 [H]

Molecular weight: Translated: 77082; Mature: 76950

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNSSTVFTHARIATLEEKAANLGLIEEAALVVKDARIVYAGPENKLPDEYASFEKIDC
CCCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHEEECCEEEEECCCCCCCHHHHCCCCCCC
GNRLITPGLIDCHTHLVHAGNRAHEFELRLQGATYEEVARAGGGIVSSVRNLRAASEDDL
CCEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHCCCHHHHHHHHHHCCCHHHH
VRETLPRLDALIAEGVTTVEVKSGYGLDRDSEIKSLKAARRLGEERDVAIRTTFLGAHAL
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCC
PPEMNGDKAAYIDRVINDMLPAIAEQGLADAVDGFCEGIAFLPDEIARVFDAAKAHDIPV
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCE
KLHADQLSNLHGAALAASYGALSADHLEYTDADGAAAMASAGTVAVLLPGAYYFIRETQK
EEEHHHHCCCHHHHHHHHHCCCCCCCCEECCCCCCHHHHCCCEEEEEECCCEEEEECCCC
PPVEAFRAAGTKMALATDNNPGTSPLTSLLLTMNMGATLFRMTVEECIAGVTREAARALG
CHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ILDQTGTLEIGKDADLAIWDIERPAELVYRIGFNPLWKRVFKGQIKPHVRMEPFMTIILK
CCCCCCCEEECCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHCCCCCCEEECCEEEEEEC
PGSVPLETLEKIYREGLPVRIDPAFHAGIEKAAARIAEIAAGDAPVYGINTGFGKLASIR
CCCCCHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEE
IAAGDVATLQRNLILSHCCGVGEPLSENIVRLIMALKLVSLGRGASGVQLEVITLIEAML
EECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHH
EKGVIPMIPEKGSVGASGDLAPLAHMTAAMIGEGEAFYRGERLSGAKALGKAGLKPVVLA
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHCCCCEEEEE
AKEGLALINGTQTSTALALAGLFRAHRAARTALITGALSTDAAMGSDAPFHEEIHQLRGH
ECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHCCC
KGQIDAGRALRTLLEGSAIRRSHLEGDQRVQDPYCTAASRRLTVPVSIFCARPHAHWKSK
CCCCCHHHHHHHHHCCHHHHHHHCCCCHHCCCCHHHHCCCEEEEEEEEEEECCCCCCCCC
PMP
CCC
>Mature Secondary Structure 
TKNSSTVFTHARIATLEEKAANLGLIEEAALVVKDARIVYAGPENKLPDEYASFEKIDC
CCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHEEECCEEEEECCCCCCCHHHHCCCCCCC
GNRLITPGLIDCHTHLVHAGNRAHEFELRLQGATYEEVARAGGGIVSSVRNLRAASEDDL
CCEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHCCCHHHHHHHHHHCCCHHHH
VRETLPRLDALIAEGVTTVEVKSGYGLDRDSEIKSLKAARRLGEERDVAIRTTFLGAHAL
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCC
PPEMNGDKAAYIDRVINDMLPAIAEQGLADAVDGFCEGIAFLPDEIARVFDAAKAHDIPV
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCE
KLHADQLSNLHGAALAASYGALSADHLEYTDADGAAAMASAGTVAVLLPGAYYFIRETQK
EEEHHHHCCCHHHHHHHHHCCCCCCCCEECCCCCCHHHHCCCEEEEEECCCEEEEECCCC
PPVEAFRAAGTKMALATDNNPGTSPLTSLLLTMNMGATLFRMTVEECIAGVTREAARALG
CHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ILDQTGTLEIGKDADLAIWDIERPAELVYRIGFNPLWKRVFKGQIKPHVRMEPFMTIILK
CCCCCCCEEECCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHCCCCCCEEECCEEEEEEC
PGSVPLETLEKIYREGLPVRIDPAFHAGIEKAAARIAEIAAGDAPVYGINTGFGKLASIR
CCCCCHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEE
IAAGDVATLQRNLILSHCCGVGEPLSENIVRLIMALKLVSLGRGASGVQLEVITLIEAML
EECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHH
EKGVIPMIPEKGSVGASGDLAPLAHMTAAMIGEGEAFYRGERLSGAKALGKAGLKPVVLA
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHCCCCEEEEE
AKEGLALINGTQTSTALALAGLFRAHRAARTALITGALSTDAAMGSDAPFHEEIHQLRGH
ECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHCCC
KGQIDAGRALRTLLEGSAIRRSHLEGDQRVQDPYCTAASRRLTVPVSIFCARPHAHWKSK
CCCCCHHHHHHHHHCCHHHHHHHCCCCHHCCCCHHHHCCCEEEEEEEEEEECCCCCCCCC
PMP
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]