Click here to switch to the map view.

The map label for this gene is glmS [H]

Identifier: 225686671

GI number: 225686671

Start: 873479

End: 874510

Strand: Reverse

Name: glmS [H]

Synonym: BMEA_B0894

Alternate gene names: 225686671

Gene position: 874510-873479 (Counterclockwise)

Preceding gene: 225686672

Following gene: 225686670

Centisome position: 73.77

GC content: 58.62

Gene sequence:

>1032_bases
ATGAACAGCCCTTCCTCCCTGATGTTGCAGGAAACAGAACAATCGCCTGCCGTCGTTGCGAAGCTGCTTGAAAAAGAGGC
GGGGACGTTTGCGGAAATCGCCCGTATCTTCCGGAAAAATGACCCTGCCGTCATTACCACGGCTGCGCGCGGCTCGTCGG
ATCATGCTGCGACCTTCTTCAAATATCTGATAGAAATTGCAACAGGCGTCCCCGTTGCTTCCATCGGTCCGTCCATTGCT
TCGGTTTACGGCAGCAGGCTCAAGCTGAAAAACGGGTTGCATTTCACGGTGTCGCAATCGGGCGCAAGCCCCGATATCAT
AGCGGCGCAGGAGGCGGCCAAAAAGGGTGGGGCGACGACGATTGCCGTTGTCAATGTCGTGGGAAGCCCGCTTGCCAGGG
ATGCCGATATTGTTCTGGCGCTCCATGCGGGCGAGGAAAAAAGCGTCGCCGCTACCAAATCCTTCATCGCATCGGTTGCC
GCACTTTCCGGTGTTGTGGCAGCAAGCAGCGGCGATGCGGGTTTGCGCGGCGGGCTTGAGCGCCTGCCGGAAGCATTGGC
CGCAACCCGGCCCGAGGGCCGCGAGGTGGTTGAAAATCTTCTCTTCAACGCTCGCTCGCTTTACACAGGCGGGCGCGGCA
CGGCCTTTGCCATTTCGCTGGAAGCGGCGCTGAAGGCCAAGGAAACCGCCAATATCCATGCGGAAGCCTTTTCATTGGCC
GAACTGATGCATGGCCCCATGCGTCTTATTGAAGAGGGTTTTCCCATTGTTTCCTTCCTGCCGCGGGATGAGGCTTTCGA
CACCAATATTGCGGCGCTGAAGCGGCCGCATTCTTTCGGGGCAAGCATCGTGACGCTTTCCGATGCGCAAACGCCGGGCT
TCCGCCTGCCATCGGCAAGCACGGGTAGCCCGCATCTCGATCCGCTCGTCTCGCTCATCAATTATTACCGCGTCATAGAA
GCGGTCACGCGCCGCAAGGGTTTCGATCCCGACAAGCCGCGCAATCTCAACAAGGTTACGGTGACGGTATGA

Upstream 100 bases:

>100_bases
TCTCGCATCTCGAAGACGATCGGATCGTTGAATATACCCGCTCGCATTATCGTGCTGACGCTTATGACTTTGTTGCGGAA
TTGAAAATTGGAGAATGACT

Downstream 100 bases:

>100_bases
TGAAGAAATCAGCAATTGCAGGCGCGCGCATCTTCGACGGTGAGCGCTTTCATGACCAGAGCGCGCTGGTATTCAGCGAT
GGCCAGATCGAGGCCATCGT

Product: Sugar isomerase SIS

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MNSPSSLMLQETEQSPAVVAKLLEKEAGTFAEIARIFRKNDPAVITTAARGSSDHAATFFKYLIEIATGVPVASIGPSIA
SVYGSRLKLKNGLHFTVSQSGASPDIIAAQEAAKKGGATTIAVVNVVGSPLARDADIVLALHAGEEKSVAATKSFIASVA
ALSGVVAASSGDAGLRGGLERLPEALAATRPEGREVVENLLFNARSLYTGGRGTAFAISLEAALKAKETANIHAEAFSLA
ELMHGPMRLIEEGFPIVSFLPRDEAFDTNIAALKRPHSFGASIVTLSDAQTPGFRLPSASTGSPHLDPLVSLINYYRVIE
AVTRRKGFDPDKPRNLNKVTVTV

Sequences:

>Translated_343_residues
MNSPSSLMLQETEQSPAVVAKLLEKEAGTFAEIARIFRKNDPAVITTAARGSSDHAATFFKYLIEIATGVPVASIGPSIA
SVYGSRLKLKNGLHFTVSQSGASPDIIAAQEAAKKGGATTIAVVNVVGSPLARDADIVLALHAGEEKSVAATKSFIASVA
ALSGVVAASSGDAGLRGGLERLPEALAATRPEGREVVENLLFNARSLYTGGRGTAFAISLEAALKAKETANIHAEAFSLA
ELMHGPMRLIEEGFPIVSFLPRDEAFDTNIAALKRPHSFGASIVTLSDAQTPGFRLPSASTGSPHLDPLVSLINYYRVIE
AVTRRKGFDPDKPRNLNKVTVTV
>Mature_343_residues
MNSPSSLMLQETEQSPAVVAKLLEKEAGTFAEIARIFRKNDPAVITTAARGSSDHAATFFKYLIEIATGVPVASIGPSIA
SVYGSRLKLKNGLHFTVSQSGASPDIIAAQEAAKKGGATTIAVVNVVGSPLARDADIVLALHAGEEKSVAATKSFIASVA
ALSGVVAASSGDAGLRGGLERLPEALAATRPEGREVVENLLFNARSLYTGGRGTAFAISLEAALKAKETANIHAEAFSLA
ELMHGPMRLIEEGFPIVSFLPRDEAFDTNIAALKRPHSFGASIVTLSDAQTPGFRLPSASTGSPHLDPLVSLINYYRVIE
AVTRRKGFDPDKPRNLNKVTVTV

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG2222

COG function: function code M; Predicted phosphosugar isomerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=315, Percent_Identity=30.7936507936508, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI205277386, Length=312, Percent_Identity=28.2051282051282, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1790167, Length=320, Percent_Identity=31.25, Blast_Score=121, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17532899, Length=322, Percent_Identity=26.3975155279503, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17532897, Length=322, Percent_Identity=26.3975155279503, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17539970, Length=322, Percent_Identity=26.7080745341615, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322745, Length=322, Percent_Identity=28.2608695652174, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323731, Length=228, Percent_Identity=29.3859649122807, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21357745, Length=334, Percent_Identity=28.7425149700599, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 35971; Mature: 35971

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSPSSLMLQETEQSPAVVAKLLEKEAGTFAEIARIFRKNDPAVITTAARGSSDHAATFF
CCCCCCCEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
KYLIEIATGVPVASIGPSIASVYGSRLKLKNGLHFTVSQSGASPDIIAAQEAAKKGGATT
HHHHHHHCCCCHHHCCHHHHHHHHHHHEECCCCEEEEECCCCCCCEEHHHHHHHCCCCEE
IAVVNVVGSPLARDADIVLALHAGEEKSVAATKSFIASVAALSGVVAASSGDAGLRGGLE
EEEEEHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHH
RLPEALAATRPEGREVVENLLFNARSLYTGGRGTAFAISLEAALKAKETANIHAEAFSLA
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHCCHHHHHHHHH
ELMHGPMRLIEEGFPIVSFLPRDEAFDTNIAALKRPHSFGASIVTLSDAQTPGFRLPSAS
HHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHCCCHHCCCEEEEEECCCCCCCCCCCCC
TGSPHLDPLVSLINYYRVIEAVTRRKGFDPDKPRNLNKVTVTV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MNSPSSLMLQETEQSPAVVAKLLEKEAGTFAEIARIFRKNDPAVITTAARGSSDHAATFF
CCCCCCCEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
KYLIEIATGVPVASIGPSIASVYGSRLKLKNGLHFTVSQSGASPDIIAAQEAAKKGGATT
HHHHHHHCCCCHHHCCHHHHHHHHHHHEECCCCEEEEECCCCCCCEEHHHHHHHCCCCEE
IAVVNVVGSPLARDADIVLALHAGEEKSVAATKSFIASVAALSGVVAASSGDAGLRGGLE
EEEEEHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHH
RLPEALAATRPEGREVVENLLFNARSLYTGGRGTAFAISLEAALKAKETANIHAEAFSLA
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHCCHHHHHHHHH
ELMHGPMRLIEEGFPIVSFLPRDEAFDTNIAALKRPHSFGASIVTLSDAQTPGFRLPSAS
HHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHCCCHHCCCEEEEEECCCCCCCCCCCCC
TGSPHLDPLVSLINYYRVIEAVTRRKGFDPDKPRNLNKVTVTV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA