Click here to switch to the map view.

The map label for this gene is pcaR [H]

Identifier: 225686419

GI number: 225686419

Start: 599594

End: 600364

Strand: Direct

Name: pcaR [H]

Synonym: BMEA_B0612

Alternate gene names: 225686419

Gene position: 599594-600364 (Clockwise)

Preceding gene: 225686415

Following gene: 225686421

Centisome position: 50.58

GC content: 59.01

Gene sequence:

>771_bases
ATGCGAGAAACAGATTTTGTCGGAGGCTTTGCCAAGGGATTGCGGGTCATAGAGGCTTTCGGAGAAGACAGGCCGCGCCT
GTCGATTGCCGATGTCTCAAAAATCACAGGGCTTGACCGTGCTACCGCGCGGCGCTGCCTTCTGACCCTCGCAGAGCTTG
GCTATGCCGAATATGATGGCAAATTCTTCATGCTGCTGCCGCGCATTCTGCGGCTCGGCCATGCTTATCTTTCCGGCACG
CCGCTGCCGACAATCATCCAGCCGCACCTCGACCGCCTTTCGCAAAGCGTGGGAGAAAGCGCCTCCGCTTCCGTGCTCGA
CGGGGCGGAGATTGTTTATATCGCGCGTGCTTCGCAAATGCGCGTCATCTCGATCAATCTCATGGCAGGAAGCCGTCTGC
CCGCCTATTGCGCATCGATGGGCCGCGTTCTGCTGGCTTGGCTGGACGAAAGCGAAGCACGCACCATCCTGGAACAAACC
GAACTGCGGGCCCGCACGCCTTTCACCCAGAAAGACCCGGAAAAACTGATGGAGGAACTGCGCCGCATTCGCGCGCAGGG
CTTCGCGGTCAATGATCAGGAGCTTGAACTGGGCCTGCGCTCGATTGCGGTTCCCGTTTTCAATCACCGCGGCGCGGTCG
TTGCGGCGCTCAATATTGGCGCGCCCGTCGCCCATGTCGAAGTCAGCGATCTGGTCGGGCGCATATTGCCGGAAATGCTG
AAAATTCAATCGGAATTGCGCAGCATGTTGCGGCAGCGCCTGTTTGAATAG

Upstream 100 bases:

>100_bases
CCCGATTTATCCATCGCGACTTAACCGGGTCAATCAGTTTGTGCGCTATTTGACATTTGTTCAATTATCGCACAAACTGA
CCGAAATATGAGGAGGATGA

Downstream 100 bases:

>100_bases
TCCAAGTCATTGGGCAGTAACCGGCATGGAAGCGGAGAGCCGTTCTCTTTCTCGCAGGCGGAATGCGCGCGGCGTCTCAC
CTGTCATTTTCTGGAAAAAG

Product: beta-ketoadipate pathway transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MRETDFVGGFAKGLRVIEAFGEDRPRLSIADVSKITGLDRATARRCLLTLAELGYAEYDGKFFMLLPRILRLGHAYLSGT
PLPTIIQPHLDRLSQSVGESASASVLDGAEIVYIARASQMRVISINLMAGSRLPAYCASMGRVLLAWLDESEARTILEQT
ELRARTPFTQKDPEKLMEELRRIRAQGFAVNDQELELGLRSIAVPVFNHRGAVVAALNIGAPVAHVEVSDLVGRILPEML
KIQSELRSMLRQRLFE

Sequences:

>Translated_256_residues
MRETDFVGGFAKGLRVIEAFGEDRPRLSIADVSKITGLDRATARRCLLTLAELGYAEYDGKFFMLLPRILRLGHAYLSGT
PLPTIIQPHLDRLSQSVGESASASVLDGAEIVYIARASQMRVISINLMAGSRLPAYCASMGRVLLAWLDESEARTILEQT
ELRARTPFTQKDPEKLMEELRRIRAQGFAVNDQELELGLRSIAVPVFNHRGAVVAALNIGAPVAHVEVSDLVGRILPEML
KIQSELRSMLRQRLFE
>Mature_256_residues
MRETDFVGGFAKGLRVIEAFGEDRPRLSIADVSKITGLDRATARRCLLTLAELGYAEYDGKFFMLLPRILRLGHAYLSGT
PLPTIIQPHLDRLSQSVGESASASVLDGAEIVYIARASQMRVISINLMAGSRLPAYCASMGRVLLAWLDESEARTILEQT
ELRARTPFTQKDPEKLMEELRRIRAQGFAVNDQELELGLRSIAVPVFNHRGAVVAALNIGAPVAHVEVSDLVGRILPEML
KIQSELRSMLRQRLFE

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786468, Length=224, Percent_Identity=33.0357142857143, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788131, Length=224, Percent_Identity=32.5892857142857, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI87082359, Length=227, Percent_Identity=25.9911894273128, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786715, Length=213, Percent_Identity=27.6995305164319, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788581, Length=221, Percent_Identity=28.5067873303167, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1789999, Length=214, Percent_Identity=28.5046728971963, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28399; Mature: 28399

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRETDFVGGFAKGLRVIEAFGEDRPRLSIADVSKITGLDRATARRCLLTLAELGYAEYDG
CCCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHCCCHHCCC
KFFMLLPRILRLGHAYLSGTPLPTIIQPHLDRLSQSVGESASASVLDGAEIVYIARASQM
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEEEECCCE
RVISINLMAGSRLPAYCASMGRVLLAWLDESEARTILEQTELRARTPFTQKDPEKLMEEL
EEEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
RRIRAQGFAVNDQELELGLRSIAVPVFNHRGAVVAALNIGAPVAHVEVSDLVGRILPEML
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHEEHHHHHHHHHHHHH
KIQSELRSMLRQRLFE
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRETDFVGGFAKGLRVIEAFGEDRPRLSIADVSKITGLDRATARRCLLTLAELGYAEYDG
CCCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHCCCHHCCC
KFFMLLPRILRLGHAYLSGTPLPTIIQPHLDRLSQSVGESASASVLDGAEIVYIARASQM
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEEEECCCE
RVISINLMAGSRLPAYCASMGRVLLAWLDESEARTILEQTELRARTPFTQKDPEKLMEEL
EEEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
RRIRAQGFAVNDQELELGLRSIAVPVFNHRGAVVAALNIGAPVAHVEVSDLVGRILPEML
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHEEHHHHHHHHHHHHH
KIQSELRSMLRQRLFE
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]