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The map label for this gene is rkpK [H]

Identifier: 225686335

GI number: 225686335

Start: 506275

End: 507699

Strand: Direct

Name: rkpK [H]

Synonym: BMEA_B0518

Alternate gene names: 225686335

Gene position: 506275-507699 (Clockwise)

Preceding gene: 225686334

Following gene: 225686336

Centisome position: 42.7

GC content: 62.6

Gene sequence:

>1425_bases
ATGAAAATTGCAGTTATCGGAACGGGCTATGTCGGTCTTGTCAGCGGCACCTGCTTTGCCGCCTGGGGGCACGAGGTGGT
CTGTGTGGACAAGAACGCCCGCAAGATCGCAGTGCTCGAACGCGGCATCCTGCCGATCTACGAACCGGGCCTTGACGAAC
TGGTGGAACGCAATTGCGCCGAGGGCCGACTGCGTTTCACCTGCAATCTGGCGGAAGCCGTGCGTGGCGCTGAGATGGTA
TTCATCGCCGTTGGCACGCCGCCGCGCGCTGGCCACGGCGACGCGGACCTGTCCTTTGTCTATATGGCGGCACGTGAACT
GGCTCCGCTGATTGATGAAAACGCCGTGGTGGTGGTCAAATCCACCGTGCCGGTGGGAACCGGCGATATCGTGCAGAAGC
TAATCGGCTCGGTGCGACGGGCAGGCACTTTCTCCGTCGCTTCCAACCCGGAATTCCTGCGTGAAGGCGTCGCCATCCGC
GATTTCCTCTATCCGGACCGCGTCGTGATCGGCGTGGAAGACGAGCGCGCCCGCAAGGCCCTGCTGGACCTCTACGGCAC
GCCGCTAAAGGAGCAGAAGACGCCGATTGTGGTAACGCAGCGCCGCACATCAGAGCTGATCAAATATGCCGCCAATGCGT
TTCTGGCCACCAAGATCACCTTCATCAACGAGCTGGCCGATCTGTGTGAGCATGTGGGCAGCGATGTCAGCCAGCTTGCG
CTCGGCATCGGCCTCGACAAGCGCATCGGTGAGAGCTTCCTCAATGCCGGCCCTGGTTATGGCGGCTCCTGCTTCCCAAA
GGACACGCTGGCGCTGCTGCGTACCGCGCAGGACCATGGCGTTGCGCTGCGCATCGTGGAGGAAACCGTCACTGCCAATG
AGGCGCGCAAGCGCCGCATGGCCTTGAAGGTGCTTGACGCACTGGGCGGCGACGTGGAGGGGCTCACCATCGCCGTCATG
GGCCTGACGTTCAAGCCCGACACGGACGATATGCGCGATGCGCCTTCTGTGCCGCTGATCGAAACCTTGCAGCGCTTTGG
CGCCCGTATCCGCGCCTACGATCCGATCGGCGCGGAAAATGCCCGCAACATCCTGTCCGATGTCGAACTATGCGACGACC
CCTATGAATGCGTGCGCGCCGCCGACGCCATGGTCGTCATCACCGAATGGGACAGTATCCGGCGACTGGACCTGTCGCGC
GTGCGTCAGGCCATGCGTCAGCCCGTACTGATCGATCTCAGGAACGCTTATGAGCCGAACGTGGCCGAAAATCTGGGCTT
CCGCGTCTCGGCGGTGGGCCGCGCCGCTACCGCACGCCACGAAACCAGCATCAAGGATGTGCTTTCACTGCTGGCGAGCC
GTTCCCGCCGCGCTGACAGCGCGGAGGAATTGGTCCCGGAAGGGGGAGGCTCCAATGACCTTTAA

Upstream 100 bases:

>100_bases
CCGGTATCGGCGGGCGCGACATCCACAAAGTCATCTTCAATCCGCACTGGCGCGTCGGCGCGACCGGCAATCCTGATCAG
AAATAGGGGGTCATAAAGCC

Downstream 100 bases:

>100_bases
ACTGGAAAAGGCATTTCATGCGTTTGTCGCCCTGCCGACAGTGACCATCCTCCTGATGGCGACAACGGCGTTTGCCGGGC
CGGTGGCGTCGGCGCCACAG

Product: nucleotide sugar dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MKIAVIGTGYVGLVSGTCFAAWGHEVVCVDKNARKIAVLERGILPIYEPGLDELVERNCAEGRLRFTCNLAEAVRGAEMV
FIAVGTPPRAGHGDADLSFVYMAARELAPLIDENAVVVVKSTVPVGTGDIVQKLIGSVRRAGTFSVASNPEFLREGVAIR
DFLYPDRVVIGVEDERARKALLDLYGTPLKEQKTPIVVTQRRTSELIKYAANAFLATKITFINELADLCEHVGSDVSQLA
LGIGLDKRIGESFLNAGPGYGGSCFPKDTLALLRTAQDHGVALRIVEETVTANEARKRRMALKVLDALGGDVEGLTIAVM
GLTFKPDTDDMRDAPSVPLIETLQRFGARIRAYDPIGAENARNILSDVELCDDPYECVRAADAMVVITEWDSIRRLDLSR
VRQAMRQPVLIDLRNAYEPNVAENLGFRVSAVGRAATARHETSIKDVLSLLASRSRRADSAEELVPEGGGSNDL

Sequences:

>Translated_474_residues
MKIAVIGTGYVGLVSGTCFAAWGHEVVCVDKNARKIAVLERGILPIYEPGLDELVERNCAEGRLRFTCNLAEAVRGAEMV
FIAVGTPPRAGHGDADLSFVYMAARELAPLIDENAVVVVKSTVPVGTGDIVQKLIGSVRRAGTFSVASNPEFLREGVAIR
DFLYPDRVVIGVEDERARKALLDLYGTPLKEQKTPIVVTQRRTSELIKYAANAFLATKITFINELADLCEHVGSDVSQLA
LGIGLDKRIGESFLNAGPGYGGSCFPKDTLALLRTAQDHGVALRIVEETVTANEARKRRMALKVLDALGGDVEGLTIAVM
GLTFKPDTDDMRDAPSVPLIETLQRFGARIRAYDPIGAENARNILSDVELCDDPYECVRAADAMVVITEWDSIRRLDLSR
VRQAMRQPVLIDLRNAYEPNVAENLGFRVSAVGRAATARHETSIKDVLSLLASRSRRADSAEELVPEGGGSNDL
>Mature_474_residues
MKIAVIGTGYVGLVSGTCFAAWGHEVVCVDKNARKIAVLERGILPIYEPGLDELVERNCAEGRLRFTCNLAEAVRGAEMV
FIAVGTPPRAGHGDADLSFVYMAARELAPLIDENAVVVVKSTVPVGTGDIVQKLIGSVRRAGTFSVASNPEFLREGVAIR
DFLYPDRVVIGVEDERARKALLDLYGTPLKEQKTPIVVTQRRTSELIKYAANAFLATKITFINELADLCEHVGSDVSQLA
LGIGLDKRIGESFLNAGPGYGGSCFPKDTLALLRTAQDHGVALRIVEETVTANEARKRRMALKVLDALGGDVEGLTIAVM
GLTFKPDTDDMRDAPSVPLIETLQRFGARIRAYDPIGAENARNILSDVELCDDPYECVRAADAMVVITEWDSIRRLDLSR
VRQAMRQPVLIDLRNAYEPNVAENLGFRVSAVGRAATARHETSIKDVLSLLASRSRRADSAEELVPEGGGSNDL

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=467, Percent_Identity=35.9743040685225, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI296040443, Length=462, Percent_Identity=32.9004329004329, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI296040438, Length=368, Percent_Identity=34.7826086956522, Blast_Score=215, Evalue=9e-56,
Organism=Escherichia coli, GI1788340, Length=366, Percent_Identity=32.7868852459016, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI48994968, Length=361, Percent_Identity=30.1939058171745, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17560350, Length=465, Percent_Identity=34.6236559139785, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI17136908, Length=462, Percent_Identity=37.012987012987, Blast_Score=285, Evalue=6e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 51402; Mature: 51402

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAVIGTGYVGLVSGTCFAAWGHEVVCVDKNARKIAVLERGILPIYEPGLDELVERNCA
CEEEEEECCHHHHHCCCEEEECCCEEEEECCCCCEEEEHHCCCCCCCCCCHHHHHHCCCC
EGRLRFTCNLAEAVRGAEMVFIAVGTPPRAGHGDADLSFVYMAARELAPLIDENAVVVVK
CCEEEEEEEHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
STVPVGTGDIVQKLIGSVRRAGTFSVASNPEFLREGVAIRDFLYPDRVVIGVEDERARKA
CCCCCCCHHHHHHHHHHHHHCCCEEECCCHHHHHCCCHHHHHCCCCEEEEECCHHHHHHH
LLDLYGTPLKEQKTPIVVTQRRTSELIKYAANAFLATKITFINELADLCEHVGSDVSQLA
HHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LGIGLDKRIGESFLNAGPGYGGSCFPKDTLALLRTAQDHGVALRIVEETVTANEARKRRM
HHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHH
ALKVLDALGGDVEGLTIAVMGLTFKPDTDDMRDAPSVPLIETLQRFGARIRAYDPIGAEN
HHHHHHHHCCCCCCEEEEEEEEEECCCCCHHCCCCCCCHHHHHHHHCCEEEECCCCCCHH
ARNILSDVELCDDPYECVRAADAMVVITEWDSIRRLDLSRVRQAMRQPVLIDLRNAYEPN
HHHHHHHHHHCCCHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCC
VAENLGFRVSAVGRAATARHETSIKDVLSLLASRSRRADSAEELVPEGGGSNDL
HHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCC
>Mature Secondary Structure
MKIAVIGTGYVGLVSGTCFAAWGHEVVCVDKNARKIAVLERGILPIYEPGLDELVERNCA
CEEEEEECCHHHHHCCCEEEECCCEEEEECCCCCEEEEHHCCCCCCCCCCHHHHHHCCCC
EGRLRFTCNLAEAVRGAEMVFIAVGTPPRAGHGDADLSFVYMAARELAPLIDENAVVVVK
CCEEEEEEEHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
STVPVGTGDIVQKLIGSVRRAGTFSVASNPEFLREGVAIRDFLYPDRVVIGVEDERARKA
CCCCCCCHHHHHHHHHHHHHCCCEEECCCHHHHHCCCHHHHHCCCCEEEEECCHHHHHHH
LLDLYGTPLKEQKTPIVVTQRRTSELIKYAANAFLATKITFINELADLCEHVGSDVSQLA
HHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LGIGLDKRIGESFLNAGPGYGGSCFPKDTLALLRTAQDHGVALRIVEETVTANEARKRRM
HHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHH
ALKVLDALGGDVEGLTIAVMGLTFKPDTDDMRDAPSVPLIETLQRFGARIRAYDPIGAEN
HHHHHHHHCCCCCCEEEEEEEEEECCCCCHHCCCCCCCHHHHHHHHCCEEEECCCCCCHH
ARNILSDVELCDDPYECVRAADAMVVITEWDSIRRLDLSRVRQAMRQPVLIDLRNAYEPN
HHHHHHHHHHCCCHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCC
VAENLGFRVSAVGRAATARHETSIKDVLSLLASRSRRADSAEELVPEGGGSNDL
HHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]