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The map label for this gene is nanM [H]

Identifier: 225686222

GI number: 225686222

Start: 376859

End: 378043

Strand: Direct

Name: nanM [H]

Synonym: BMEA_B0390

Alternate gene names: 225686222

Gene position: 376859-378043 (Clockwise)

Preceding gene: 225686221

Following gene: 225686223

Centisome position: 31.79

GC content: 56.62

Gene sequence:

>1185_bases
ATGGAGTGGAGGAAATGCATGTTCAGTCTTATTCGCGCAAAACGACTGGCGATCGGTATCGCGGCTCTTGCATGGTCTAC
AGGTGCCGTGATGGCATCTGAACATTGGCCGGATCTGCCCGTGGGGATCAAGAATGGTGCAGCCGCCCGGATCGGCAATA
TGGCCTATGTCGGCCTCGGCTCCGCCGGAACTGATTTTTATGCGCTTGACCTGAACAATCCCTCCAAGGGCTGGGTAAAG
CGGGCAAACTTCATCGGCCCCGCAACAAACGGAGCAGCAATGGCTGCGGCAGGCGGAAAAATCTTCGCTTTCAGCGGTAA
TGGCAAGGCAACGCCGGATGCGAAATCCCCCATCATTTTCGATACGGCCTATGTTTATGATCCGGGTTCGGATGGCTGGT
CCAAGCTCGACACGCAAACGCCGGTTGGGCTTTCCGGCGCAAAAGCCGTTGGGCTTGCTGACGGCCGGATTGCCATCTTT
GGCGGATATAATAAGGAACTCTTCGACAAATATCTGGCTGATGTGGGCGCGATCGATAAAGACAAGGAGCCGGAAGCTTA
CAGGAAGCTGGTCGATTCCTATATGGGCATGAAGCCGGAGGCCTATCGATGGAACGACGAGGTTCTGGTTTACGATCCTG
CTGGCAATAATTGGGGTTCGCTTGGCGCCAATCCGTTTCTGCCCAATTGCGATCCGGCAATGGCAACAATGGGTGAGGGT
GATTTTCTGCTTGTGAGCGGTGAGATCAAACCGGGCCTGCGAACACCTGAAGCCAAATTGGTGAAAATCCGGGATGGTGC
GGCGCACTGGCAGAAAGTGAGTGATCTTCCGCCGCTCTCCGGTTCCGAACCACAGGAGGGAGTGGCTGGCGCCTATGCCG
GAAAGGCTGGCGATGATGTGCTTGTCGCTGGTGGAGCGAATTTCAAGGGTGCACAGGCCAATGCTGCGGCTGGAAAATGG
TTTGCGCATGACGGCCTTGCGAAAAGCTGGCGTGATGATGTCTATGCTTTTGATGGCAAGGACTGGAAGGTGGCCGGCAA
GCTGCCGCGCGGTCTGGCCTATGGCGCAGCCTTCGATGCGCCGGGCGGTCTTCTGGTCGTGGGCGGTGAAGATAGAGACG
GCAAGGCCCGCAAGGAGGTTTTCCTCCTCAAATGGGATGGCAAGGCCCTCTCGGTCGAAAACTGA

Upstream 100 bases:

>100_bases
CCGCAGTCATGCGTCCTGATATTGTTGCCGCTGAACTGGGGGCGGATGCCGGAATTATCGGTGTGGCCGATCTGGCCGCG
ACATATTTTTCCTAAAACCA

Downstream 100 bases:

>100_bases
CTTCGCAGTGGAAAGAGCGCTTCCATCGATACCATTTAAACCGGAAGCGTTCTTTTTTTGAAAGCTTGGCGACGATGCTT
CTTTGCGTTATTGTTCCAAA

Product: N-acetylneuraminic acid mutarotase

Products: NA

Alternate protein names: N-acetylneuraminate mutarotase; Neu5Ac mutarotase; Sialic acid epimerase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MEWRKCMFSLIRAKRLAIGIAALAWSTGAVMASEHWPDLPVGIKNGAAARIGNMAYVGLGSAGTDFYALDLNNPSKGWVK
RANFIGPATNGAAMAAAGGKIFAFSGNGKATPDAKSPIIFDTAYVYDPGSDGWSKLDTQTPVGLSGAKAVGLADGRIAIF
GGYNKELFDKYLADVGAIDKDKEPEAYRKLVDSYMGMKPEAYRWNDEVLVYDPAGNNWGSLGANPFLPNCDPAMATMGEG
DFLLVSGEIKPGLRTPEAKLVKIRDGAAHWQKVSDLPPLSGSEPQEGVAGAYAGKAGDDVLVAGGANFKGAQANAAAGKW
FAHDGLAKSWRDDVYAFDGKDWKVAGKLPRGLAYGAAFDAPGGLLVVGGEDRDGKARKEVFLLKWDGKALSVEN

Sequences:

>Translated_394_residues
MEWRKCMFSLIRAKRLAIGIAALAWSTGAVMASEHWPDLPVGIKNGAAARIGNMAYVGLGSAGTDFYALDLNNPSKGWVK
RANFIGPATNGAAMAAAGGKIFAFSGNGKATPDAKSPIIFDTAYVYDPGSDGWSKLDTQTPVGLSGAKAVGLADGRIAIF
GGYNKELFDKYLADVGAIDKDKEPEAYRKLVDSYMGMKPEAYRWNDEVLVYDPAGNNWGSLGANPFLPNCDPAMATMGEG
DFLLVSGEIKPGLRTPEAKLVKIRDGAAHWQKVSDLPPLSGSEPQEGVAGAYAGKAGDDVLVAGGANFKGAQANAAAGKW
FAHDGLAKSWRDDVYAFDGKDWKVAGKLPRGLAYGAAFDAPGGLLVVGGEDRDGKARKEVFLLKWDGKALSVEN
>Mature_394_residues
MEWRKCMFSLIRAKRLAIGIAALAWSTGAVMASEHWPDLPVGIKNGAAARIGNMAYVGLGSAGTDFYALDLNNPSKGWVK
RANFIGPATNGAAMAAAGGKIFAFSGNGKATPDAKSPIIFDTAYVYDPGSDGWSKLDTQTPVGLSGAKAVGLADGRIAIF
GGYNKELFDKYLADVGAIDKDKEPEAYRKLVDSYMGMKPEAYRWNDEVLVYDPAGNNWGSLGANPFLPNCDPAMATMGEG
DFLLVSGEIKPGLRTPEAKLVKIRDGAAHWQKVSDLPPLSGSEPQEGVAGAYAGKAGDDVLVAGGANFKGAQANAAAGKW
FAHDGLAKSWRDDVYAFDGKDWKVAGKLPRGLAYGAAFDAPGGLLVVGGEDRDGKARKEVFLLKWDGKALSVEN

Specific function: Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, whic

COG id: COG3055

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 7 Kelch repeats [H]

Homologues:

Organism=Escherichia coli, GI87082419, Length=379, Percent_Identity=32.7176781002639, Blast_Score=186, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015915
- InterPro:   IPR019936 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 41560; Mature: 41560

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWRKCMFSLIRAKRLAIGIAALAWSTGAVMASEHWPDLPVGIKNGAAARIGNMAYVGLG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCEEECCEEEEEEC
SAGTDFYALDLNNPSKGWVKRANFIGPATNGAAMAAAGGKIFAFSGNGKATPDAKSPIIF
CCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCEEE
DTAYVYDPGSDGWSKLDTQTPVGLSGAKAVGLADGRIAIFGGYNKELFDKYLADVGAIDK
EEEEEECCCCCCHHHCCCCCCCCCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHCCCCC
DKEPEAYRKLVDSYMGMKPEAYRWNDEVLVYDPAGNNWGSLGANPFLPNCDPAMATMGEG
CCCHHHHHHHHHHHHCCCCCCEECCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCC
DFLLVSGEIKPGLRTPEAKLVKIRDGAAHWQKVSDLPPLSGSEPQEGVAGAYAGKAGDDV
CEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCE
LVAGGANFKGAQANAAAGKWFAHDGLAKSWRDDVYAFDGKDWKVAGKLPRGLAYGAAFDA
EEECCCCCCCCCCCCCCCCEEECCCHHHHHCCCEEEECCCCEEEECCCCCCEECCCCCCC
PGGLLVVGGEDRDGKARKEVFLLKWDGKALSVEN
CCCEEEECCCCCCCCCCEEEEEEEECCCEEECCC
>Mature Secondary Structure
MEWRKCMFSLIRAKRLAIGIAALAWSTGAVMASEHWPDLPVGIKNGAAARIGNMAYVGLG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCEEECCEEEEEEC
SAGTDFYALDLNNPSKGWVKRANFIGPATNGAAMAAAGGKIFAFSGNGKATPDAKSPIIF
CCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCEEE
DTAYVYDPGSDGWSKLDTQTPVGLSGAKAVGLADGRIAIFGGYNKELFDKYLADVGAIDK
EEEEEECCCCCCHHHCCCCCCCCCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHCCCCC
DKEPEAYRKLVDSYMGMKPEAYRWNDEVLVYDPAGNNWGSLGANPFLPNCDPAMATMGEG
CCCHHHHHHHHHHHHCCCCCCEECCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCC
DFLLVSGEIKPGLRTPEAKLVKIRDGAAHWQKVSDLPPLSGSEPQEGVAGAYAGKAGDDV
CEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCE
LVAGGANFKGAQANAAAGKWFAHDGLAKSWRDDVYAFDGKDWKVAGKLPRGLAYGAAFDA
EEECCCCCCCCCCCCCCCCEEECCCHHHHHCCCEEEECCCCEEEECCCCCCEECCCCCCC
PGGLLVVGGEDRDGKARKEVFLLKWDGKALSVEN
CCCEEEECCCCCCCCCCEEEEEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA