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The map label for this gene is alkJ [H]

Identifier: 225686210

GI number: 225686210

Start: 360174

End: 361808

Strand: Direct

Name: alkJ [H]

Synonym: BMEA_B0377

Alternate gene names: 225686210

Gene position: 360174-361808 (Clockwise)

Preceding gene: 225686209

Following gene: 225686211

Centisome position: 30.38

GC content: 58.96

Gene sequence:

>1635_bases
ATGGCATACGCTCTTCCGCAGGATGCCTGTTTTGACTTCATTATTGTGGGTGGCGGTACGGCGGGGTGTATCCTCGCTGA
AGCCCTGACCCGTTCCGGGCGCAACAGGGTTCTGCTTTGTGAAGCCGGCGGCGAAGCGCGATCACCGTGGATCCGCATTC
CGGCGGGTTTCTACAAACTTCTGGTTAACAGGCGCTACAATTGGGGGTTCTGGAGCGAGGAAGAGGCTGCGACGAATTTC
CGTCGTATTGCCATCCCGCGTGGCAAGGGCCTTGGCGGTTCGACGCTCATCAACGGCATGATCTATGTCCGTGGGCAACC
ACAGGATTATGAAGGCTGGCGGGAACGAGGTGCAACGGGCTGGGGCTGGGATGACGTCCTGCCCTATTTCAAGGCCATAG
AACGCTGGACCTTGCCTGATCCTGACGGGCTGCGCGGGCGCTCCGGCCCGCTTCCCGTTAACGAGGTGGTGGAGAAAACT
CCGATAGGCGATGCATTTATAGCCGCTGCTGTGGCGCAGGGGCAGTGCTTCAATCCTGATTATAACGGTCGGCGGCAAGA
CGGAGTGGGCTGGTATCAGGTAAACCAGGCAGGCGGCGAGCGCTATTCGGCAGATCGCGCATGGCTGGAGCAGGCCCGCA
AACGACCTAACCTCACGGTTCTTACCGGCGCGCGCGTCATGCGTATCCTGCTGGAAGGCAGGAAAGCTGCCGGTGTTGCG
CTTCGCCATAAGGGAAGCGAGCAGACCGTATATGGGGCGGAAGTTATCCTTGCGGCGGGGGCGGTGCAGACACCGCAGCT
TCTGGAGCTTTCGGGTATCGGCGATCCGGTGCGCCTGCAAGGAATTGGTATCGAACCGATTCACGCCTTGCCGGGTGTGG
GCGAAAATTATCTTGACCATTTCTGCACACGCATGAACTGGCGTGTATCACAGCCGATTACACTAAACGAATTGACACGC
GGGCCCCGTCTCGTCGGAGAAGTTCTGAAATATGTGCTTAAGAGGCGTGGAGTACTGACCTATGGCACCGGCCTGAACCA
TGCGTTTCTGCGCTCCCGGCCGGAGCTTGACCGGCCCGATGTGCAGTTTTTCTTCATGCACGCGAGCTATGCCAATGCGG
CCGAGCGTAAATTGCATCGCTTCCCCGGCATGACGCTGGGCGTGACGCAATTACGTCCGCGGTCGTGCGGTTCCATCCAT
GCCATCTCGCCGGATTTGAGCGTACAGCCAGCAATCGCTCCGAATTTTCTCGATCACGAGGAAGACCGTCGCGTGATGGT
CGATGGGATGAAGCTTGCGCGGGATATTATCGAGCAAAAGCCGATGGATGCCTTCCGTGTTGCGGAACTCAGTCCGGGCT
CGAATTGCAACAGCGACGAGGACTGGCTGTCCTTCGCGCGAGCCAATGGCCAGACGATTTATCACGCCGCCGGAACCTGC
CGCATGGGCGTCGATCCATTGGCAGTGGTTGATCCTTCATTGTGCGTCCACGGTATTGCCGGACTGCGCGTGATCGATGC
ATCCGTCATGCCTGAAATGGTTTCCGGCAACACGCAGGCTGCAGTCATGATGCTGGCCGCCAAAGCTGCGGATATTGTTC
TGGAAGATAAGGGACAGGCGCCCGCAGGGCGCTGA

Upstream 100 bases:

>100_bases
CATTTCGGCCGCCCGATGCTGCGCCAGCAAATTCGTCTCATGGCTGAACATATGGGTGCAAAGGCGAACGCCGACGTGCA
GAAGCCGACGGAGTAAAAGC

Downstream 100 bases:

>100_bases
ACAATGGATATGCAGGAGGAATTAATGTATCCCAATCTTACCCTCATTGTAGGTGGCGAGGAACGGAACAAAGGTTCGGC
GGGAACATTGTGTCTTACCG

Product: oxidoreductase, GMC family protein

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAYALPQDACFDFIIVGGGTAGCILAEALTRSGRNRVLLCEAGGEARSPWIRIPAGFYKLLVNRRYNWGFWSEEEAATNF
RRIAIPRGKGLGGSTLINGMIYVRGQPQDYEGWRERGATGWGWDDVLPYFKAIERWTLPDPDGLRGRSGPLPVNEVVEKT
PIGDAFIAAAVAQGQCFNPDYNGRRQDGVGWYQVNQAGGERYSADRAWLEQARKRPNLTVLTGARVMRILLEGRKAAGVA
LRHKGSEQTVYGAEVILAAGAVQTPQLLELSGIGDPVRLQGIGIEPIHALPGVGENYLDHFCTRMNWRVSQPITLNELTR
GPRLVGEVLKYVLKRRGVLTYGTGLNHAFLRSRPELDRPDVQFFFMHASYANAAERKLHRFPGMTLGVTQLRPRSCGSIH
AISPDLSVQPAIAPNFLDHEEDRRVMVDGMKLARDIIEQKPMDAFRVAELSPGSNCNSDEDWLSFARANGQTIYHAAGTC
RMGVDPLAVVDPSLCVHGIAGLRVIDASVMPEMVSGNTQAAVMMLAAKAADIVLEDKGQAPAGR

Sequences:

>Translated_544_residues
MAYALPQDACFDFIIVGGGTAGCILAEALTRSGRNRVLLCEAGGEARSPWIRIPAGFYKLLVNRRYNWGFWSEEEAATNF
RRIAIPRGKGLGGSTLINGMIYVRGQPQDYEGWRERGATGWGWDDVLPYFKAIERWTLPDPDGLRGRSGPLPVNEVVEKT
PIGDAFIAAAVAQGQCFNPDYNGRRQDGVGWYQVNQAGGERYSADRAWLEQARKRPNLTVLTGARVMRILLEGRKAAGVA
LRHKGSEQTVYGAEVILAAGAVQTPQLLELSGIGDPVRLQGIGIEPIHALPGVGENYLDHFCTRMNWRVSQPITLNELTR
GPRLVGEVLKYVLKRRGVLTYGTGLNHAFLRSRPELDRPDVQFFFMHASYANAAERKLHRFPGMTLGVTQLRPRSCGSIH
AISPDLSVQPAIAPNFLDHEEDRRVMVDGMKLARDIIEQKPMDAFRVAELSPGSNCNSDEDWLSFARANGQTIYHAAGTC
RMGVDPLAVVDPSLCVHGIAGLRVIDASVMPEMVSGNTQAAVMMLAAKAADIVLEDKGQAPAGR
>Mature_543_residues
AYALPQDACFDFIIVGGGTAGCILAEALTRSGRNRVLLCEAGGEARSPWIRIPAGFYKLLVNRRYNWGFWSEEEAATNFR
RIAIPRGKGLGGSTLINGMIYVRGQPQDYEGWRERGATGWGWDDVLPYFKAIERWTLPDPDGLRGRSGPLPVNEVVEKTP
IGDAFIAAAVAQGQCFNPDYNGRRQDGVGWYQVNQAGGERYSADRAWLEQARKRPNLTVLTGARVMRILLEGRKAAGVAL
RHKGSEQTVYGAEVILAAGAVQTPQLLELSGIGDPVRLQGIGIEPIHALPGVGENYLDHFCTRMNWRVSQPITLNELTRG
PRLVGEVLKYVLKRRGVLTYGTGLNHAFLRSRPELDRPDVQFFFMHASYANAAERKLHRFPGMTLGVTQLRPRSCGSIHA
ISPDLSVQPAIAPNFLDHEEDRRVMVDGMKLARDIIEQKPMDAFRVAELSPGSNCNSDEDWLSFARANGQTIYHAAGTCR
MGVDPLAVVDPSLCVHGIAGLRVIDASVMPEMVSGNTQAAVMMLAAKAADIVLEDKGQAPAGR

Specific function: Converts aliphatic medium-chain-length alcohols into aldehydes. May be linked to the electron transfer chain [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=539, Percent_Identity=38.2189239332096, Blast_Score=335, Evalue=7e-92,
Organism=Escherichia coli, GI1786503, Length=536, Percent_Identity=36.3805970149254, Blast_Score=322, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI17532301, Length=551, Percent_Identity=34.8457350272232, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24642048, Length=567, Percent_Identity=34.7442680776014, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24642055, Length=572, Percent_Identity=34.0909090909091, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI45551458, Length=571, Percent_Identity=34.8511383537653, Blast_Score=271, Evalue=9e-73,
Organism=Drosophila melanogaster, GI45549471, Length=571, Percent_Identity=34.8511383537653, Blast_Score=271, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24642039, Length=580, Percent_Identity=35, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI17137792, Length=560, Percent_Identity=34.1071428571429, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI18859995, Length=566, Percent_Identity=35.6890459363958, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI24642042, Length=567, Percent_Identity=34.7442680776014, Blast_Score=258, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24642059, Length=571, Percent_Identity=34.1506129597198, Blast_Score=256, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24642035, Length=582, Percent_Identity=34.192439862543, Blast_Score=255, Evalue=7e-68,
Organism=Drosophila melanogaster, GI24642037, Length=570, Percent_Identity=34.0350877192982, Blast_Score=245, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24650267, Length=566, Percent_Identity=31.9787985865724, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI18859993, Length=571, Percent_Identity=32.9246935201401, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24642051, Length=570, Percent_Identity=30.1754385964912, Blast_Score=208, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24645930, Length=587, Percent_Identity=29.3015332197615, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24642057, Length=587, Percent_Identity=26.2350936967632, Blast_Score=139, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 59615; Mature: 59484

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYALPQDACFDFIIVGGGTAGCILAEALTRSGRNRVLLCEAGGEARSPWIRIPAGFYKL
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCHHHHHH
LVNRRYNWGFWSEEEAATNFRRIAIPRGKGLGGSTLINGMIYVRGQPQDYEGWRERGATG
HHHCCCCCCCCCCHHHHCCEEEEEECCCCCCCCHHEECCEEEEECCCCCCHHHHHCCCCC
WGWDDVLPYFKAIERWTLPDPDGLRGRSGPLPVNEVVEKTPIGDAFIAAAVAQGQCFNPD
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCC
YNGRRQDGVGWYQVNQAGGERYSADRAWLEQARKRPNLTVLTGARVMRILLEGRKAAGVA
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCEE
LRHKGSEQTVYGAEVILAAGAVQTPQLLELSGIGDPVRLQGIGIEPIHALPGVGENYLDH
EECCCCCCEEEHHHEEEECCCCCCCCEEEECCCCCCEEEEECCCCHHHHCCCCCHHHHHH
FCTRMNWRVSQPITLNELTRGPRLVGEVLKYVLKRRGVLTYGTGLNHAFLRSRPELDRPD
HHHHCCCCCCCCEEHHHHCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCCCCCC
VQFFFMHASYANAAERKLHRFPGMTLGVTQLRPRSCGSIHAISPDLSVQPAIAPNFLDHE
EEEEEEECHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
EDRRVMVDGMKLARDIIEQKPMDAFRVAELSPGSNCNSDEDWLSFARANGQTIYHAAGTC
CCCEEEHHHHHHHHHHHHHCCCCHHEEEECCCCCCCCCHHHHHHHHHCCCCEEEEECCEE
RMGVDPLAVVDPSLCVHGIAGLRVIDASVMPEMVSGNTQAAVMMLAAKAADIVLEDKGQA
ECCCCCHHHCCHHHHHHHHCCCEEECHHHHHHHHCCCCHHHHHHHHHHHHCEEEECCCCC
PAGR
CCCC
>Mature Secondary Structure 
AYALPQDACFDFIIVGGGTAGCILAEALTRSGRNRVLLCEAGGEARSPWIRIPAGFYKL
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCHHHHHH
LVNRRYNWGFWSEEEAATNFRRIAIPRGKGLGGSTLINGMIYVRGQPQDYEGWRERGATG
HHHCCCCCCCCCCHHHHCCEEEEEECCCCCCCCHHEECCEEEEECCCCCCHHHHHCCCCC
WGWDDVLPYFKAIERWTLPDPDGLRGRSGPLPVNEVVEKTPIGDAFIAAAVAQGQCFNPD
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCC
YNGRRQDGVGWYQVNQAGGERYSADRAWLEQARKRPNLTVLTGARVMRILLEGRKAAGVA
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCEE
LRHKGSEQTVYGAEVILAAGAVQTPQLLELSGIGDPVRLQGIGIEPIHALPGVGENYLDH
EECCCCCCEEEHHHEEEECCCCCCCCEEEECCCCCCEEEEECCCCHHHHCCCCCHHHHHH
FCTRMNWRVSQPITLNELTRGPRLVGEVLKYVLKRRGVLTYGTGLNHAFLRSRPELDRPD
HHHHCCCCCCCCEEHHHHCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCCCCCC
VQFFFMHASYANAAERKLHRFPGMTLGVTQLRPRSCGSIHAISPDLSVQPAIAPNFLDHE
EEEEEEECHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
EDRRVMVDGMKLARDIIEQKPMDAFRVAELSPGSNCNSDEDWLSFARANGQTIYHAAGTC
CCCEEEHHHHHHHHHHHHHCCCCHHEEEECCCCCCCCCHHHHHHHHHCCCCEEEEECCEE
RMGVDPLAVVDPSLCVHGIAGLRVIDASVMPEMVSGNTQAAVMMLAAKAADIVLEDKGQA
ECCCCCHHHCCHHHHHHHHCCCEEECHHHHHHHHCCCCHHHHHHHHHHHHCEEEECCCCC
PAGR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11390693 [H]