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The map label for this gene is aroE [H]

Identifier: 225686209

GI number: 225686209

Start: 359351

End: 360169

Strand: Direct

Name: aroE [H]

Synonym: BMEA_B0376

Alternate gene names: 225686209

Gene position: 359351-360169 (Clockwise)

Preceding gene: 225686208

Following gene: 225686210

Centisome position: 30.31

GC content: 59.71

Gene sequence:

>819_bases
ATGATTACCGGACATACCAAGCTTTACGGCATTGTCGCCAATCCGATTGCCCATGTAAAAACGCCTGAGGAGGTGAACAA
GCATTTTGCGGCCTTGGGCCATGACGGCGTGCTGGTTCCTTTTCATGTTCTGCCGGAAAATCTGGCACAGTTCGTCAACA
GCCTTCGCAAGCTCGAAAATCTGGGCGGGCTGGTTGTCACCGTGCCACACAAGACGGCAATTCTCTCCCTTTGTGACAGG
CTGGAAGGCGATGCCGCCGCTATTGGGGCTGCCAACGTCATCCGGCGCGAGAGTGATGGCACGCTTGTCGGTGTCATGTT
GGACGGCAAGGGGTTTGTGAGTGGGCTTGTGGCCAGCGATATTGACGTCACCGGCATGAACGCCTGTCTCCTTGGCGCGG
GCGGGGCGGCTTCGGCCATCGCCTTTGCCTTGGCGGAGGCCGGCGTCGCGCGGCTCACCATTGTAAACCGTTCCGAGGAC
AAAGCTCGCGATCTTGCTGCGCGAGTGAGTGAGCGTTATCCCGCTGTCCAGATCGATGCCGGAGCACCGCAAACGGCAAG
CCGCGATCTCATCATCAATGCGACATCGCTGGGTCTTCGGGCTGGTGATCCGCTGCCGCTTGACGATCTTGCCTTCCATG
CCGGCCAGATCGTCGCGGAAGTGATCATGGAGCCGGAAGTGACGCCGCTTCTGGCTGCTGCCCGCGACAAGGGTGCGCGC
ATTCATTTCGGCCGCCCGATGCTGCGCCAGCAAATTCGTCTCATGGCTGAACATATGGGTGCAAAGGCGAACGCCGACGT
GCAGAAGCCGACGGAGTAA

Upstream 100 bases:

>100_bases
GAAGTGGCTGATGTCGCGCTTTGGCTCACCTCCACTGAATCCAGTTTTGTGACCGGCCAGACCGTCGATGTGGCTGGCGG
TCTTTATATGGCCTGACATT

Downstream 100 bases:

>100_bases
AAGCATGGCATACGCTCTTCCGCAGGATGCCTGTTTTGACTTCATTATTGTGGGTGGCGGTACGGCGGGGTGTATCCTCG
CTGAAGCCCTGACCCGTTCC

Product: Shikimate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MITGHTKLYGIVANPIAHVKTPEEVNKHFAALGHDGVLVPFHVLPENLAQFVNSLRKLENLGGLVVTVPHKTAILSLCDR
LEGDAAAIGAANVIRRESDGTLVGVMLDGKGFVSGLVASDIDVTGMNACLLGAGGAASAIAFALAEAGVARLTIVNRSED
KARDLAARVSERYPAVQIDAGAPQTASRDLIINATSLGLRAGDPLPLDDLAFHAGQIVAEVIMEPEVTPLLAAARDKGAR
IHFGRPMLRQQIRLMAEHMGAKANADVQKPTE

Sequences:

>Translated_272_residues
MITGHTKLYGIVANPIAHVKTPEEVNKHFAALGHDGVLVPFHVLPENLAQFVNSLRKLENLGGLVVTVPHKTAILSLCDR
LEGDAAAIGAANVIRRESDGTLVGVMLDGKGFVSGLVASDIDVTGMNACLLGAGGAASAIAFALAEAGVARLTIVNRSED
KARDLAARVSERYPAVQIDAGAPQTASRDLIINATSLGLRAGDPLPLDDLAFHAGQIVAEVIMEPEVTPLLAAARDKGAR
IHFGRPMLRQQIRLMAEHMGAKANADVQKPTE
>Mature_272_residues
MITGHTKLYGIVANPIAHVKTPEEVNKHFAALGHDGVLVPFHVLPENLAQFVNSLRKLENLGGLVVTVPHKTAILSLCDR
LEGDAAAIGAANVIRRESDGTLVGVMLDGKGFVSGLVASDIDVTGMNACLLGAGGAASAIAFALAEAGVARLTIVNRSED
KARDLAARVSERYPAVQIDAGAPQTASRDLIINATSLGLRAGDPLPLDDLAFHAGQIVAEVIMEPEVTPLLAAARDKGAR
IHFGRPMLRQQIRLMAEHMGAKANADVQKPTE

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=262, Percent_Identity=31.2977099236641, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789675, Length=234, Percent_Identity=30.7692307692308, Blast_Score=90, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320332, Length=244, Percent_Identity=26.6393442622951, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 28544; Mature: 28544

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITGHTKLYGIVANPIAHVKTPEEVNKHFAALGHDGVLVPFHVLPENLAQFVNSLRKLEN
CCCCCEEEEEEECCCHHHCCCHHHHHHHHHHHCCCCEEEEHHHCHHHHHHHHHHHHHHHH
LGGLVVTVPHKTAILSLCDRLEGDAAAIGAANVIRRESDGTLVGVMLDGKGFVSGLVASD
CCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCEEEEEECCCHHHHHHHHCC
IDVTGMNACLLGAGGAASAIAFALAEAGVARLTIVNRSEDKARDLAARVSERYPAVQIDA
CCCCCCCEEEEECCCHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHHHHHHCCCEEEEEC
GAPQTASRDLIINATSLGLRAGDPLPLDDLAFHAGQIVAEVIMEPEVTPLLAAARDKGAR
CCCCCCCCCEEEEEHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCE
IHFGRPMLRQQIRLMAEHMGAKANADVQKPTE
EECCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MITGHTKLYGIVANPIAHVKTPEEVNKHFAALGHDGVLVPFHVLPENLAQFVNSLRKLEN
CCCCCEEEEEEECCCHHHCCCHHHHHHHHHHHCCCCEEEEHHHCHHHHHHHHHHHHHHHH
LGGLVVTVPHKTAILSLCDRLEGDAAAIGAANVIRRESDGTLVGVMLDGKGFVSGLVASD
CCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCEEEEEECCCHHHHHHHHCC
IDVTGMNACLLGAGGAASAIAFALAEAGVARLTIVNRSEDKARDLAARVSERYPAVQIDA
CCCCCCCEEEEECCCHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHHHHHHCCCEEEEEC
GAPQTASRDLIINATSLGLRAGDPLPLDDLAFHAGQIVAEVIMEPEVTPLLAAARDKGAR
CCCCCCCCCEEEEEHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCE
IHFGRPMLRQQIRLMAEHMGAKANADVQKPTE
EECCCHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]