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The map label for this gene is xasA [C]

Identifier: 225686177

GI number: 225686177

Start: 318874

End: 320439

Strand: Direct

Name: xasA [C]

Synonym: BMEA_B0339

Alternate gene names: 225686177

Gene position: 318874-320439 (Clockwise)

Preceding gene: 225686171

Following gene: 225686178

Centisome position: 26.9

GC content: 55.11

Gene sequence:

>1566_bases
TTGATTTCAGTTGTATTTTTTCAGGTGAATATAATGACAACACCAACCGCATCACCAGCAGCAGGCAAGCCTGCCGCTGT
AACACCCGCCAGAATGGCGAAGCTTAGTGTGCTTACGCTTGCCATCATGAATGTGACGGCTGTGGTCAGCTTGCGCGGGC
TACCGTCGGAAGCAACTTACGGCCTGACTTCGGTTTTTTATTATATCTTTGCAGCCGTTTTCTTTCTTATTCCCGTATCG
ATTGTCGCGGCCGAGCTTGCGACCGGCTGGCCGCAAAAAGGCGGCGTGTTCCGCTGGGTGGGTGAAGCCTTCGGCCCAAG
ATGGGGCTTTCTCGCGATCTTCCTTGTCTGGGTGGAATCCACCATCTGGTTCCCGACGGTTCTGACCTTCGGTGCGGTCG
CAATTGCCTTCGCCGGGCCGGGGCAAAGATGGGATGAGGCGCTTGCCGCAAACAAGCTCTATACGATTGGCATCGTGCTC
GTGGTCTATTGGGCCGCGACATGGGTGAGCCTGCACAGATTGAAATCCGCTGCGCGTATTGCAAAGTGGGGCGGCATGAT
CGGAACCATCATTCCGGCGGCAATCCTCATCGTTCTGGGCTTTACCTATTATTTTTCGGGCAACTATATCGAAGTGCAGC
TTGCATGGCGCGATCTGATCCCGGATTTCACCAATTTCAACAATCTGGTTCTGGCGGCCGGTATTTTCCTGTTCTATGCG
GGCATGGAAATGAACGCTATCCATGTGCGTGAAATCGATAATCCGGCCAGAAATTATCCGCTGGCCATCCTGATCTCTTC
GCTTGTCACCGTTGCAATCTTCGTGTTGGGAACGCTGGCCATCGCCTTCATCATTCCCGCATCGCAGATCAATCTGGTCC
AGAGCCTGCTGATCACCTACGACTCCTTTTTCAAGCTTTTCGGTATTGACTGGCTTTCTCCCGTCATGGCGATCGCTCTG
GCTTTCGGTGTGCTGGGCGGTGTGACCGTCTGGGTTGCCGGTCCGTCGTCTGCTTTGTCGGTGGTTGGCCGGGCGGGCTA
TCTGCCGCCTTTCTTCCAGAAGGTGAATGCAAAGGGCGCGCCGAGCCATATTCTCATCGTGCAGGGCCTGATCGTCACAT
TTCTGGCCATCATGTTTGCGGTGCTGCCATCCGTTCAGGCGGCCTATCAGATACTGAGCCAGCTTACTGTGACGCTTTAT
CTGATCATGTATCTGCTGATGTTCGCGGCTGCCATTCATCTGCGCTACAGCGAGCCGAACACGCCGCGTCCATACCGGGT
TCCATTCGGTGCCTTCGGTATGTGGCTCTTTGCCGGTGTGGGACTTGTCGGTTCGCTCATAGCCTTTGTTCTCAGCTTCG
TGCCGCCGTCACAAATCGCTGTCGGCAGCCCCAGCGCCTATATCTGGATGCTGATTGCAGGCAATGTGATTTTCGTCGCT
ATCCCATTGATTACCTACGCAATTCGCAAGCCGCACTGGAAAACGCCGGAAGGGTCGGCCGATTTTGAGCCGTTCAACTG
GGAAAAGGAAGGCCGGATGCCGGGTTCCCAGCAAGCCGCAGGCTGA

Upstream 100 bases:

>100_bases
CAAATCGCATCCTTCACCGAAGATTACCCCGTCGATGGGAACCGGCTTTCACCACACATAATGATCGGCGTCTGGTCGCG
GGAGCGACCATGCCGCCTGC

Downstream 100 bases:

>100_bases
AAAGCCCGTCCTGCAAAAGCTATGGAGACATCTTAATGTCAAGCTCATCAGATGCGATCAAAGCCGCTCTTGAGAAGGGA
CGCGCAGCAGGCCTTTCTGC

Product: glutamate/gamma-aminobutyrate antiporter

Products: L-glutamate [Cytoplasm]; 4-aminobutyrate [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MISVVFFQVNIMTTPTASPAAGKPAAVTPARMAKLSVLTLAIMNVTAVVSLRGLPSEATYGLTSVFYYIFAAVFFLIPVS
IVAAELATGWPQKGGVFRWVGEAFGPRWGFLAIFLVWVESTIWFPTVLTFGAVAIAFAGPGQRWDEALAANKLYTIGIVL
VVYWAATWVSLHRLKSAARIAKWGGMIGTIIPAAILIVLGFTYYFSGNYIEVQLAWRDLIPDFTNFNNLVLAAGIFLFYA
GMEMNAIHVREIDNPARNYPLAILISSLVTVAIFVLGTLAIAFIIPASQINLVQSLLITYDSFFKLFGIDWLSPVMAIAL
AFGVLGGVTVWVAGPSSALSVVGRAGYLPPFFQKVNAKGAPSHILIVQGLIVTFLAIMFAVLPSVQAAYQILSQLTVTLY
LIMYLLMFAAAIHLRYSEPNTPRPYRVPFGAFGMWLFAGVGLVGSLIAFVLSFVPPSQIAVGSPSAYIWMLIAGNVIFVA
IPLITYAIRKPHWKTPEGSADFEPFNWEKEGRMPGSQQAAG

Sequences:

>Translated_521_residues
MISVVFFQVNIMTTPTASPAAGKPAAVTPARMAKLSVLTLAIMNVTAVVSLRGLPSEATYGLTSVFYYIFAAVFFLIPVS
IVAAELATGWPQKGGVFRWVGEAFGPRWGFLAIFLVWVESTIWFPTVLTFGAVAIAFAGPGQRWDEALAANKLYTIGIVL
VVYWAATWVSLHRLKSAARIAKWGGMIGTIIPAAILIVLGFTYYFSGNYIEVQLAWRDLIPDFTNFNNLVLAAGIFLFYA
GMEMNAIHVREIDNPARNYPLAILISSLVTVAIFVLGTLAIAFIIPASQINLVQSLLITYDSFFKLFGIDWLSPVMAIAL
AFGVLGGVTVWVAGPSSALSVVGRAGYLPPFFQKVNAKGAPSHILIVQGLIVTFLAIMFAVLPSVQAAYQILSQLTVTLY
LIMYLLMFAAAIHLRYSEPNTPRPYRVPFGAFGMWLFAGVGLVGSLIAFVLSFVPPSQIAVGSPSAYIWMLIAGNVIFVA
IPLITYAIRKPHWKTPEGSADFEPFNWEKEGRMPGSQQAAG
>Mature_521_residues
MISVVFFQVNIMTTPTASPAAGKPAAVTPARMAKLSVLTLAIMNVTAVVSLRGLPSEATYGLTSVFYYIFAAVFFLIPVS
IVAAELATGWPQKGGVFRWVGEAFGPRWGFLAIFLVWVESTIWFPTVLTFGAVAIAFAGPGQRWDEALAANKLYTIGIVL
VVYWAATWVSLHRLKSAARIAKWGGMIGTIIPAAILIVLGFTYYFSGNYIEVQLAWRDLIPDFTNFNNLVLAAGIFLFYA
GMEMNAIHVREIDNPARNYPLAILISSLVTVAIFVLGTLAIAFIIPASQINLVQSLLITYDSFFKLFGIDWLSPVMAIAL
AFGVLGGVTVWVAGPSSALSVVGRAGYLPPFFQKVNAKGAPSHILIVQGLIVTFLAIMFAVLPSVQAAYQILSQLTVTLY
LIMYLLMFAAAIHLRYSEPNTPRPYRVPFGAFGMWLFAGVGLVGSLIAFVLSFVPPSQIAVGSPSAYIWMLIAGNVIFVA
IPLITYAIRKPHWKTPEGSADFEPFNWEKEGRMPGSQQAAG

Specific function: Probable Amino Acid Transporter. Involved In Extreme Acid Resistance. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=437, Percent_Identity=24.0274599542334, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI115648022, Length=437, Percent_Identity=24.0274599542334, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI186910308, Length=435, Percent_Identity=24.367816091954, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI186910306, Length=435, Percent_Identity=24.367816091954, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI186910304, Length=435, Percent_Identity=24.367816091954, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1787768, Length=492, Percent_Identity=31.9105691056911, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI2367353, Length=348, Percent_Identity=22.4137931034483, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081798, Length=394, Percent_Identity=24.1116751269036, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=352, Percent_Identity=24.7159090909091, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357367, Length=388, Percent_Identity=24.2268041237113, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221331183, Length=357, Percent_Identity=25.7703081232493, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17647653, Length=357, Percent_Identity=25.7703081232493, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24664379, Length=357, Percent_Identity=25.7703081232493, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 56532; Mature: 56532

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVVFFQVNIMTTPTASPAAGKPAAVTPARMAKLSVLTLAIMNVTAVVSLRGLPSEATY
CEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
GLTSVFYYIFAAVFFLIPVSIVAAELATGWPQKGGVFRWVGEAFGPRWGFLAIFLVWVES
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHCCCHHHHHHHHHHHHH
TIWFPTVLTFGAVAIAFAGPGQRWDEALAANKLYTIGIVLVVYWAATWVSLHRLKSAARI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKWGGMIGTIIPAAILIVLGFTYYFSGNYIEVQLAWRDLIPDFTNFNNLVLAAGIFLFYA
HHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHC
GMEMNAIHVREIDNPARNYPLAILISSLVTVAIFVLGTLAIAFIIPASQINLVQSLLITY
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
DSFFKLFGIDWLSPVMAIALAFGVLGGVTVWVAGPSSALSVVGRAGYLPPFFQKVNAKGA
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCHHHHHCCCCCC
PSHILIVQGLIVTFLAIMFAVLPSVQAAYQILSQLTVTLYLIMYLLMFAAAIHLRYSEPN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
TPRPYRVPFGAFGMWLFAGVGLVGSLIAFVLSFVPPSQIAVGSPSAYIWMLIAGNVIFVA
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEEHHHHCCHHHHH
IPLITYAIRKPHWKTPEGSADFEPFNWEKEGRMPGSQQAAG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MISVVFFQVNIMTTPTASPAAGKPAAVTPARMAKLSVLTLAIMNVTAVVSLRGLPSEATY
CEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
GLTSVFYYIFAAVFFLIPVSIVAAELATGWPQKGGVFRWVGEAFGPRWGFLAIFLVWVES
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHCCCHHHHHHHHHHHHH
TIWFPTVLTFGAVAIAFAGPGQRWDEALAANKLYTIGIVLVVYWAATWVSLHRLKSAARI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKWGGMIGTIIPAAILIVLGFTYYFSGNYIEVQLAWRDLIPDFTNFNNLVLAAGIFLFYA
HHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHC
GMEMNAIHVREIDNPARNYPLAILISSLVTVAIFVLGTLAIAFIIPASQINLVQSLLITY
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
DSFFKLFGIDWLSPVMAIALAFGVLGGVTVWVAGPSSALSVVGRAGYLPPFFQKVNAKGA
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCHHHHHCCCCCC
PSHILIVQGLIVTFLAIMFAVLPSVQAAYQILSQLTVTLYLIMYLLMFAAAIHLRYSEPN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
TPRPYRVPFGAFGMWLFAGVGLVGSLIAFVLSFVPPSQIAVGSPSAYIWMLIAGNVIFVA
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEEHHHHCCHHHHH
IPLITYAIRKPHWKTPEGSADFEPFNWEKEGRMPGSQQAAG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-aminobutyrate [Cytoplasm]; L-glutamate [Periplasm] [C]

Specific reaction: 4-aminobutyrate [Cytoplasm] + L-glutamate [Periplasm] = L-glutamate [Cytoplasm] + 4-aminobutyrate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8366052 [H]