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The map label for this gene is penA [H]

Identifier: 225630926

GI number: 225630926

Start: 1334777

End: 1336324

Strand: Reverse

Name: penA [H]

Synonym: WRi_012430

Alternate gene names: 225630926

Gene position: 1336324-1334777 (Counterclockwise)

Preceding gene: 225630928

Following gene: 225630923

Centisome position: 92.42

GC content: 35.47

Gene sequence:

>1548_bases
ATGCAAGCATTACTTAAAAATAAGCTCCGCTCACTGTGTTTTATAGTACCATTATTTATATTTTATATAATAATTATTTT
TCGCATATTCTCTTTAACATTTGATCAACTTACTACTTCAGAAAATTTTAGAAAAGATAATATAGTACATAAACAACCCG
ATATTTTAGATAGAAATGGAGTGGTAATAGCAACAAATGTGCCCACAACATCACTATATATAGATGCAACCAAAGTAAAG
AATCCGGAAAGTATAGCAGCACAACTGTGTTCTACTTTGCATGACCTCGAATACAAGAACTTATATAGAGTACTTACTTC
AGAAAAGAAATTTGCTTGGATAAAGCGGCACTTGACTCCAAAAGAATTACTAGCGATCAAAAACGCTGGTGTACCAGGAG
TAAATTTTTATGACGACATAAAGCGTATATATCCTCACAGTAATTTATTTTCACACGTGCTTGGTTACACTGACATAGAT
GGCAACGGTATTGCAGGAGTTGAGGCATATATAAGTAAAAATAATGAGCAAGAAAAGCCCATAATACTATCCTTAGATAC
ACGAGTGCAAAGCATAGTGCATGAAGAGCTAACTAAAGCTGTAAGCAGATATCAGGCACTTGGCGGAGTAGGAATTGTTT
TAAATGTGAGAAATAGTGAAGTTATCTCGATGGTCAGCCTACCTGATTTTAATCCCAACTTACAGAATAAGGCAGAAGAC
GTACAAAAGTTTAATCGCGCCAGTCTTGGGGTATATGAGATGGGGTCGGTATTAAAATACTTTACAATAGCCGCAGCGCT
TGATGCGAACGCTACAAAAACTAGCGATTTATATGACGTATCAACACCAATCACCATTGGAAAGTATAAAATTCAGGATT
TTCATAAATCTAAAATTCCAAAAATTACTGTGCAAGATATATTTGTAAAATCATCCAACATTGGTGCAGCAAAAATTGCA
GTCAAACTAGGTATTGAAAAACAGGTAGAATACTTTAAAGCTATGAAGCTATTTTCTCCTTTGAAAATAGAAATACCAGA
AAAATCCACACCGATAATCCCGGATAAATGGAGTGAAAACACTTTAATAACAGCATCTTATGGTTATGGCATAGCTGTAA
CTCCTATACATCTTGCACAAACTGCAGCAGCATTAATCAACAATGGGATATTTCATAACGCAACCTTGATGTTGAATAAA
AGAAGTATAGGAGAGCAAATTATCTCAAGAAGAACTTCCAGGGAAATGAGAAAATTATTACGTGCAGCAGTAACAGATGG
CACTGGCAGAAAAGCAAAAATAAAGGCATATTCAATAGGAGGAAAAACTGGATCGGCGGAAAAAGTTGTAGATGGTAAAT
ATAGCAAAGATGCAAACATAGCATCATTTATAGGAGTGCTAACTATGCTTGACCCAAGGTACATAGTGCTAATTGCTATT
GATGAGCCTCAAGGGATGCACCATACCGGGGGAGTAATTGCTGCGCCTATAGTAAGAAACATTATAAATAGAGTAGCACC
TATACTAAATGTTACACCTGAGATGTAA

Upstream 100 bases:

>100_bases
TCTAAAGTAATAGCTAATATGTCCACAGCTCTTTTTACCCCGGCACAAAAACCTCGTGGTTCAGCTAAGATGATTTCCAT
TTTTGTCAAATCAAGTAAAT

Downstream 100 bases:

>100_bases
AATTATGATTGCTTTACTATAATTTCAAATTTATCATTACCAAAATCCTTATTAATATACCAAGAACCATCATCTTTAGT
TACAAATTCAAGACCTTTAA

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MQALLKNKLRSLCFIVPLFIFYIIIIFRIFSLTFDQLTTSENFRKDNIVHKQPDILDRNGVVIATNVPTTSLYIDATKVK
NPESIAAQLCSTLHDLEYKNLYRVLTSEKKFAWIKRHLTPKELLAIKNAGVPGVNFYDDIKRIYPHSNLFSHVLGYTDID
GNGIAGVEAYISKNNEQEKPIILSLDTRVQSIVHEELTKAVSRYQALGGVGIVLNVRNSEVISMVSLPDFNPNLQNKAED
VQKFNRASLGVYEMGSVLKYFTIAAALDANATKTSDLYDVSTPITIGKYKIQDFHKSKIPKITVQDIFVKSSNIGAAKIA
VKLGIEKQVEYFKAMKLFSPLKIEIPEKSTPIIPDKWSENTLITASYGYGIAVTPIHLAQTAAALINNGIFHNATLMLNK
RSIGEQIISRRTSREMRKLLRAAVTDGTGRKAKIKAYSIGGKTGSAEKVVDGKYSKDANIASFIGVLTMLDPRYIVLIAI
DEPQGMHHTGGVIAAPIVRNIINRVAPILNVTPEM

Sequences:

>Translated_515_residues
MQALLKNKLRSLCFIVPLFIFYIIIIFRIFSLTFDQLTTSENFRKDNIVHKQPDILDRNGVVIATNVPTTSLYIDATKVK
NPESIAAQLCSTLHDLEYKNLYRVLTSEKKFAWIKRHLTPKELLAIKNAGVPGVNFYDDIKRIYPHSNLFSHVLGYTDID
GNGIAGVEAYISKNNEQEKPIILSLDTRVQSIVHEELTKAVSRYQALGGVGIVLNVRNSEVISMVSLPDFNPNLQNKAED
VQKFNRASLGVYEMGSVLKYFTIAAALDANATKTSDLYDVSTPITIGKYKIQDFHKSKIPKITVQDIFVKSSNIGAAKIA
VKLGIEKQVEYFKAMKLFSPLKIEIPEKSTPIIPDKWSENTLITASYGYGIAVTPIHLAQTAAALINNGIFHNATLMLNK
RSIGEQIISRRTSREMRKLLRAAVTDGTGRKAKIKAYSIGGKTGSAEKVVDGKYSKDANIASFIGVLTMLDPRYIVLIAI
DEPQGMHHTGGVIAAPIVRNIINRVAPILNVTPEM
>Mature_515_residues
MQALLKNKLRSLCFIVPLFIFYIIIIFRIFSLTFDQLTTSENFRKDNIVHKQPDILDRNGVVIATNVPTTSLYIDATKVK
NPESIAAQLCSTLHDLEYKNLYRVLTSEKKFAWIKRHLTPKELLAIKNAGVPGVNFYDDIKRIYPHSNLFSHVLGYTDID
GNGIAGVEAYISKNNEQEKPIILSLDTRVQSIVHEELTKAVSRYQALGGVGIVLNVRNSEVISMVSLPDFNPNLQNKAED
VQKFNRASLGVYEMGSVLKYFTIAAALDANATKTSDLYDVSTPITIGKYKIQDFHKSKIPKITVQDIFVKSSNIGAAKIA
VKLGIEKQVEYFKAMKLFSPLKIEIPEKSTPIIPDKWSENTLITASYGYGIAVTPIHLAQTAAALINNGIFHNATLMLNK
RSIGEQIISRRTSREMRKLLRAAVTDGTGRKAKIKAYSIGGKTGSAEKVVDGKYSKDANIASFIGVLTMLDPRYIVLIAI
DEPQGMHHTGGVIAAPIVRNIINRVAPILNVTPEM

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=521, Percent_Identity=26.295585412668, Blast_Score=186, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 57163; Mature: 57163

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQALLKNKLRSLCFIVPLFIFYIIIIFRIFSLTFDQLTTSENFRKDNIVHKQPDILDRNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
VVIATNVPTTSLYIDATKVKNPESIAAQLCSTLHDLEYKNLYRVLTSEKKFAWIKRHLTP
EEEEECCCCCEEEEEEHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHCCCH
KELLAIKNAGVPGVNFYDDIKRIYPHSNLFSHVLGYTDIDGNGIAGVEAYISKNNEQEKP
HHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCC
IILSLDTRVQSIVHEELTKAVSRYQALGGVGIVLNVRNSEVISMVSLPDFNPNLQNKAED
EEEEECHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEEECCCCCCCCCHHHHH
VQKFNRASLGVYEMGSVLKYFTIAAALDANATKTSDLYDVSTPITIGKYKIQDFHKSKIP
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEECEEEHHHHHHCCCC
KITVQDIFVKSSNIGAAKIAVKLGIEKQVEYFKAMKLFSPLKIEIPEKSTPIIPDKWSEN
EEEEHHEEEECCCCCCEEEEEEECCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCC
TLITASYGYGIAVTPIHLAQTAAALINNGIFHNATLMLNKRSIGEQIISRRTSREMRKLL
EEEEEECCCCEEECHHHHHHHHHHHHHCCCEECEEEEEECHHHHHHHHHHHHHHHHHHHH
RAAVTDGTGRKAKIKAYSIGGKTGSAEKVVDGKYSKDANIASFIGVLTMLDPRYIVLIAI
HHHHCCCCCCEEEEEEEEECCCCCCCCHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEE
DEPQGMHHTGGVIAAPIVRNIINRVAPILNVTPEM
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQALLKNKLRSLCFIVPLFIFYIIIIFRIFSLTFDQLTTSENFRKDNIVHKQPDILDRNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
VVIATNVPTTSLYIDATKVKNPESIAAQLCSTLHDLEYKNLYRVLTSEKKFAWIKRHLTP
EEEEECCCCCEEEEEEHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHCCCH
KELLAIKNAGVPGVNFYDDIKRIYPHSNLFSHVLGYTDIDGNGIAGVEAYISKNNEQEKP
HHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCC
IILSLDTRVQSIVHEELTKAVSRYQALGGVGIVLNVRNSEVISMVSLPDFNPNLQNKAED
EEEEECHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEEECCCCCCCCCHHHHH
VQKFNRASLGVYEMGSVLKYFTIAAALDANATKTSDLYDVSTPITIGKYKIQDFHKSKIP
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEECEEEHHHHHHCCCC
KITVQDIFVKSSNIGAAKIAVKLGIEKQVEYFKAMKLFSPLKIEIPEKSTPIIPDKWSEN
EEEEHHEEEECCCCCCEEEEEEECCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCC
TLITASYGYGIAVTPIHLAQTAAALINNGIFHNATLMLNKRSIGEQIISRRTSREMRKLL
EEEEEECCCCEEECHHHHHHHHHHHHHCCCEECEEEEEECHHHHHHHHHHHHHHHHHHHH
RAAVTDGTGRKAKIKAYSIGGKTGSAEKVVDGKYSKDANIASFIGVLTMLDPRYIVLIAI
HHHHCCCCCCEEEEEEEEECCCCCCCCHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEE
DEPQGMHHTGGVIAAPIVRNIINRVAPILNVTPEM
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]