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The map label for this gene is thyX [H]

Identifier: 225630864

GI number: 225630864

Start: 1263805

End: 1264659

Strand: Direct

Name: thyX [H]

Synonym: WRi_011720

Alternate gene names: 225630864

Gene position: 1263805-1264659 (Clockwise)

Preceding gene: 225630863

Following gene: 225630865

Centisome position: 87.41

GC content: 33.68

Gene sequence:

>855_bases
ATGAATGAAGCAACCAAACGAACTATAGTAAAAGAAATAGATGCAATCTTATATGAAGAACATAAGGTATTAGACCATGG
ATTTATTCGAGTAGTGGATTATATGGGCTCTGATAGCGCTATAGTTCAAGCTGCTCGTGTTTCTTATGGCAAGGGAACAA
AACAGATAAGTCAGGATGAAGCACTTATAAAGTATTTAATGAGACATCATCATACAACTCCATTTGAAATGTGTGAAATT
AAGTTTCACGTGAAACTTCCAATTTTTGTTGCAAGGCAATGGATAAGGCATAGAACTGCAAATGTGAATGAATATTCAGC
AAGGTATTCAATACTTGATGATGAATTTTATACACCTAAACCAGAACAAGTTGCAAAACAATCTGACAATAATAAACAAG
GTAGCGGGGAAGCTTTTGATCCAGATACCTCAAAGGAAATAATAGATTCTCTAACAAATGACTCTAATTTAGTATATTCT
CATTATGAAAAATTTATTGAGCAGGGGCTTGCAAGAGAAATTGCCAGAACTAACCTAATGCTTAATTACTACACGCAATT
TTATTGGAAAATAGATCTGCATAATCTCCTTCATTTTTTGAAGCTTAGAGCTGATAAGCATGCCCAATATGAAATCAGAG
TTTATGCAGAAGTTATGCTGGATATAATAAAAAAATGGGTTCCACTGGCCTACAATGCCTTTGTTGAATATTGCCTAGAA
TCAGCCTGTATTTCAAGAACTGGTCTAGAAATAATTCGCAAATTAATTAAAGGGGAAAACGTTACTAGAAAAGAAAGTAA
TATTGGTAAAAGAGAATGGGGCGAGCTGATGTCTATACTTGATAAACAATCTTAA

Upstream 100 bases:

>100_bases
AATAAACAATTCACATCATTTATGGAGAGGATATGAAGCAATGCATGAAAAACTCAATTCATGTGGAGCTGATATCTCCA
TTTCGTCTTGAGGATATTTT

Downstream 100 bases:

>100_bases
AGATAAAGGCATACGTGTCAATCTCCTCTGTCAGTTATAGCTCTTTCCATAAAAGTCCGGATGTGATAGGATAAGGGTAG
ATGATGATAAGGAGGTTGAA

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNEATKRTIVKEIDAILYEEHKVLDHGFIRVVDYMGSDSAIVQAARVSYGKGTKQISQDEALIKYLMRHHHTTPFEMCEI
KFHVKLPIFVARQWIRHRTANVNEYSARYSILDDEFYTPKPEQVAKQSDNNKQGSGEAFDPDTSKEIIDSLTNDSNLVYS
HYEKFIEQGLAREIARTNLMLNYYTQFYWKIDLHNLLHFLKLRADKHAQYEIRVYAEVMLDIIKKWVPLAYNAFVEYCLE
SACISRTGLEIIRKLIKGENVTRKESNIGKREWGELMSILDKQS

Sequences:

>Translated_284_residues
MNEATKRTIVKEIDAILYEEHKVLDHGFIRVVDYMGSDSAIVQAARVSYGKGTKQISQDEALIKYLMRHHHTTPFEMCEI
KFHVKLPIFVARQWIRHRTANVNEYSARYSILDDEFYTPKPEQVAKQSDNNKQGSGEAFDPDTSKEIIDSLTNDSNLVYS
HYEKFIEQGLAREIARTNLMLNYYTQFYWKIDLHNLLHFLKLRADKHAQYEIRVYAEVMLDIIKKWVPLAYNAFVEYCLE
SACISRTGLEIIRKLIKGENVTRKESNIGKREWGELMSILDKQS
>Mature_284_residues
MNEATKRTIVKEIDAILYEEHKVLDHGFIRVVDYMGSDSAIVQAARVSYGKGTKQISQDEALIKYLMRHHHTTPFEMCEI
KFHVKLPIFVARQWIRHRTANVNEYSARYSILDDEFYTPKPEQVAKQSDNNKQGSGEAFDPDTSKEIIDSLTNDSNLVYS
HYEKFIEQGLAREIARTNLMLNYYTQFYWKIDLHNLLHFLKLRADKHAQYEIRVYAEVMLDIIKKWVPLAYNAFVEYCLE
SACISRTGLEIIRKLIKGENVTRKESNIGKREWGELMSILDKQS

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 33235; Mature: 33235

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEATKRTIVKEIDAILYEEHKVLDHGFIRVVDYMGSDSAIVQAARVSYGKGTKQISQDE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHH
ALIKYLMRHHHTTPFEMCEIKFHVKLPIFVARQWIRHRTANVNEYSARYSILDDEFYTPK
HHHHHHHHHCCCCCHHEEEEEEEEECHHHHHHHHHHHHCCCCHHHHHHHEEECCCCCCCC
PEQVAKQSDNNKQGSGEAFDPDTSKEIIDSLTNDSNLVYSHYEKFIEQGLAREIARTNLM
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LNYYTQFYWKIDLHNLLHFLKLRADKHAQYEIRVYAEVMLDIIKKWVPLAYNAFVEYCLE
HHHHHHHHHEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SACISRTGLEIIRKLIKGENVTRKESNIGKREWGELMSILDKQS
HHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNEATKRTIVKEIDAILYEEHKVLDHGFIRVVDYMGSDSAIVQAARVSYGKGTKQISQDE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHH
ALIKYLMRHHHTTPFEMCEIKFHVKLPIFVARQWIRHRTANVNEYSARYSILDDEFYTPK
HHHHHHHHHCCCCCHHEEEEEEEEECHHHHHHHHHHHHCCCCHHHHHHHEEECCCCCCCC
PEQVAKQSDNNKQGSGEAFDPDTSKEIIDSLTNDSNLVYSHYEKFIEQGLAREIARTNLM
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LNYYTQFYWKIDLHNLLHFLKLRADKHAQYEIRVYAEVMLDIIKKWVPLAYNAFVEYCLE
HHHHHHHHHEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SACISRTGLEIIRKLIKGENVTRKESNIGKREWGELMSILDKQS
HHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA