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The map label for this gene is fabH

Identifier: 225630649

GI number: 225630649

Start: 1004824

End: 1005732

Strand: Reverse

Name: fabH

Synonym: WRi_009330

Alternate gene names: 225630649

Gene position: 1005732-1004824 (Counterclockwise)

Preceding gene: 225630650

Following gene: 225630646

Centisome position: 69.56

GC content: 37.51

Gene sequence:

>909_bases
ATGTTGAGTAACAACGAAATTGCATCGATAGTTGAGACGAGCGATGAATGGATAAGGCAGAGAACAGGAATAGTTCAAAG
GCATATAGCAGATGAAGGAGAACTAACGTCAGATCTAGCTGTAAATGCAGCAAAAAGTGCTATAGAAAAAGCTAAAATTT
CAGTAGATGAAATTGACTTGATTATAGTTGCTACAACAACTCCTGATAAAACTTTTCCTAGCTGTGCAACGATTGTACAA
AGTAAGTTAAAATGTAAAAACGCATTTGCTTTTGATGTACAAGCAGCATGCTCTGGTTTTATATATGCAGTTACAGTTGC
TGATTCGCTCATAAAATCTAACAATAGAATTAAATATGCATTGGTTATAGGTGCTGAAATAATGTCTAGGATTGTTGATT
GGGAAGATAGGTCAACTTGTGTACTCTTTGGTGATGGTGCTGGTGCAGTGGTGATGAAATCAGAAATGGGTAGAAGCGGC
ATCATATCAACAAACTTATACTCTGACGGCAATGTGGACATACTATGTACGAACGGAGGGATATCCTCAACTGGTGATTC
TGGAAAAATATGCATGAATGGAAGAGAAGTGTTTAAACATGCAGTGGATAAGTTAACAGCCTCAGTAGAGGAAACTCTGA
AATGCAATAATTTGAAAATCACTGATATTGACTGGTTAATTCCCCATCAAGCAAACATTCGTATTATTGAAGCAGTAGTA
AAGAAATTAGATTTTCCTATAGAGAAAGTGATTAATACCGTTGATAAGCATGCAAACACCTCAGCGGCATCAATTCCACT
GGCCTTAGACTATGCAATACAAGAATCAAAAATAAAATCAGGAAATCTGGTACTGCTGATTTCAATAGGTGCAGGCCTGA
CCTGGGGTTCCGTGTTGCTGCACTATTAG

Upstream 100 bases:

>100_bases
AATGCAATTAGTGAAAATTTAAATCAAAAGATAATTAACGGGGTAAGTCATATTGAATAAAAGTTTCATATTAAGCACTG
GATCTTACCTACCAAGAAAA

Downstream 100 bases:

>100_bases
ACTTCCTGCATTACCTCCTGTCATCCAAGTACCCTCTTTGTCATTCCAGTGCCTCTTTCTCCTGTCATCCCAGTGCCCCC
TTTTGTCATCCCAGTAGCCC

Product: 3-oxoacyl-(acyl-carrier-protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MLSNNEIASIVETSDEWIRQRTGIVQRHIADEGELTSDLAVNAAKSAIEKAKISVDEIDLIIVATTTPDKTFPSCATIVQ
SKLKCKNAFAFDVQAACSGFIYAVTVADSLIKSNNRIKYALVIGAEIMSRIVDWEDRSTCVLFGDGAGAVVMKSEMGRSG
IISTNLYSDGNVDILCTNGGISSTGDSGKICMNGREVFKHAVDKLTASVEETLKCNNLKITDIDWLIPHQANIRIIEAVV
KKLDFPIEKVINTVDKHANTSAASIPLALDYAIQESKIKSGNLVLLISIGAGLTWGSVLLHY

Sequences:

>Translated_302_residues
MLSNNEIASIVETSDEWIRQRTGIVQRHIADEGELTSDLAVNAAKSAIEKAKISVDEIDLIIVATTTPDKTFPSCATIVQ
SKLKCKNAFAFDVQAACSGFIYAVTVADSLIKSNNRIKYALVIGAEIMSRIVDWEDRSTCVLFGDGAGAVVMKSEMGRSG
IISTNLYSDGNVDILCTNGGISSTGDSGKICMNGREVFKHAVDKLTASVEETLKCNNLKITDIDWLIPHQANIRIIEAVV
KKLDFPIEKVINTVDKHANTSAASIPLALDYAIQESKIKSGNLVLLISIGAGLTWGSVLLHY
>Mature_302_residues
MLSNNEIASIVETSDEWIRQRTGIVQRHIADEGELTSDLAVNAAKSAIEKAKISVDEIDLIIVATTTPDKTFPSCATIVQ
SKLKCKNAFAFDVQAACSGFIYAVTVADSLIKSNNRIKYALVIGAEIMSRIVDWEDRSTCVLFGDGAGAVVMKSEMGRSG
IISTNLYSDGNVDILCTNGGISSTGDSGKICMNGREVFKHAVDKLTASVEETLKCNNLKITDIDWLIPHQANIRIIEAVV
KKLDFPIEKVINTVDKHANTSAASIPLALDYAIQESKIKSGNLVLLISIGAGLTWGSVLLHY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=302, Percent_Identity=49.0066225165563, Blast_Score=283, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_WOLPM (Q73GG9)

Other databases:

- EMBL:   AE017196
- RefSeq:   NP_966713.1
- ProteinModelPortal:   Q73GG9
- SMR:   Q73GG9
- EnsemblBacteria:   EBWOLT00000003875
- GeneID:   2738468
- GenomeReviews:   AE017196_GR
- KEGG:   wol:WD0985
- TIGR:   WD_0985
- GeneTree:   EBGT00050000031462
- HOGENOM:   HBG649927
- OMA:   ICATSTP
- PhylomeDB:   Q73GG9
- ProtClustDB:   CLSK739999
- BioCyc:   WPIP955:WD_0985-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 32578; Mature: 32578

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 245-245 ACT_SITE 275-275

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSNNEIASIVETSDEWIRQRTGIVQRHIADEGELTSDLAVNAAKSAIEKAKISVDEIDL
CCCCCHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEECEEEE
IIVATTTPDKTFPSCATIVQSKLKCKNAFAFDVQAACSGFIYAVTVADSLIKSNNRIKYA
EEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHCCEEEEEEHHHHHHHCCCCEEEE
LVIGAEIMSRIVDWEDRSTCVLFGDGAGAVVMKSEMGRSGIISTNLYSDGNVDILCTNGG
EEECHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCEEEEEECCCCEEEEEECCC
ISSTGDSGKICMNGREVFKHAVDKLTASVEETLKCNNLKITDIDWLIPHQANIRIIEAVV
CCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHH
KKLDFPIEKVINTVDKHANTSAASIPLALDYAIQESKIKSGNLVLLISIGAGLTWGSVLL
HHCCCCHHHHHHHHHHCCCCCCCCCCEEEEEHHHHCCCCCCCEEEEEEECCCCCHHHHHC
HY
CC
>Mature Secondary Structure
MLSNNEIASIVETSDEWIRQRTGIVQRHIADEGELTSDLAVNAAKSAIEKAKISVDEIDL
CCCCCHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEECEEEE
IIVATTTPDKTFPSCATIVQSKLKCKNAFAFDVQAACSGFIYAVTVADSLIKSNNRIKYA
EEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHCCEEEEEEHHHHHHHCCCCEEEE
LVIGAEIMSRIVDWEDRSTCVLFGDGAGAVVMKSEMGRSGIISTNLYSDGNVDILCTNGG
EEECHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCEEEEEECCCCEEEEEECCC
ISSTGDSGKICMNGREVFKHAVDKLTASVEETLKCNNLKITDIDWLIPHQANIRIIEAVV
CCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHH
KKLDFPIEKVINTVDKHANTSAASIPLALDYAIQESKIKSGNLVLLISIGAGLTWGSVLL
HHCCCCHHHHHHHHHHCCCCCCCCCCEEEEEHHHHCCCCCCCEEEEEEECCCCCHHHHHC
HY
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA