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The map label for this gene is hflC [H]

Identifier: 225630544

GI number: 225630544

Start: 858946

End: 859818

Strand: Direct

Name: hflC [H]

Synonym: WRi_007990

Alternate gene names: 225630544

Gene position: 858946-859818 (Clockwise)

Preceding gene: 225630543

Following gene: 225630545

Centisome position: 59.41

GC content: 32.07

Gene sequence:

>873_bases
ATGAGTAGTAATATTAAAATTGTTTTTGTTTCTGTATTTGTTGTTTTATTGATTGTTTTATCTAATTCAATATTTGTTGT
GCAAGAAACAAAGCAAGCAATAGTTATACAACTGGGTAAAGTTGTAAGGGATGTTAGGGAAAGTGGCTTATATTTTAAGT
TGCCATTCATAAATAGTGTAGAGTTTCTTGATAAAAGAGTTTTAGATTTAAGTCCTGATAAGATCCCAAGGGAAGTGATA
ACAGCGGATCAAAAACGTATTATAGTAGATGCGTATGCAAAATATAAAATAACAAATCCTGTTACTTTTTACCAGGCTGT
GAGGAATGAATCAGGTCTGGTTAGAAGATTATATCCGGTTATAGAAGCACACATAAGAGAAAATATAGGCAGATTTTCGT
TGATTAGCTTGTTGAATGAAAAAAGATCAGAGGTTATGCAATTGATTCAGCGTGGAGTTTATTCTGAAGCTGAAAAATTT
GGCATAGAAATAATAGATGTAAGAATTAAGAGAGCAGATTTACCAGAAGAAAATAGTTCTGCAATATTTCGCCGTATGCA
AACTGAAAGGGAAAAAGAAGCAAAAGAAATTAGAGCAGAAGGAGAGCAAGCTGGGCAGGAAGTTAGATCAAAAGCTGATA
AATTAAAAAGGGAAATTATCTCCAGTGCAGTAAAAGAATCGTACGAAATAAGGGGCCGTGGTTATGCTGAAGCAACTAGA
ATTTATAATGAGGCATTTAAAGTTGATGAAGAGTTCTTTAACTTTTATCGCTCTATGAGCGCTTACAGTAAATCATTTGC
CGAAAATAATACTAAATTTGTACTTTCACCAAACAATAACTTTTTAGATATTTTAAATAAAGGATGGAAATAA

Upstream 100 bases:

>100_bases
CTATGGAAAATATTTTCAGTAAGGTAGACAAAGTTGTTGTAACTGATGATCTGAAAGGTATGTTTTCTTATTTACCTCTT
ACAAATTTAGGAAAATAACC

Downstream 100 bases:

>100_bases
TTTATGAAAAGTAAGGCATTTATTTTATCTATATTTGCATATTTTCTAATTGCGTTTTCTTCGTATGCTAATATGTTTGA
TTGGAATGCAAAAAAGGTCG

Product: hflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSSNIKIVFVSVFVVLLIVLSNSIFVVQETKQAIVIQLGKVVRDVRESGLYFKLPFINSVEFLDKRVLDLSPDKIPREVI
TADQKRIIVDAYAKYKITNPVTFYQAVRNESGLVRRLYPVIEAHIRENIGRFSLISLLNEKRSEVMQLIQRGVYSEAEKF
GIEIIDVRIKRADLPEENSSAIFRRMQTEREKEAKEIRAEGEQAGQEVRSKADKLKREIISSAVKESYEIRGRGYAEATR
IYNEAFKVDEEFFNFYRSMSAYSKSFAENNTKFVLSPNNNFLDILNKGWK

Sequences:

>Translated_290_residues
MSSNIKIVFVSVFVVLLIVLSNSIFVVQETKQAIVIQLGKVVRDVRESGLYFKLPFINSVEFLDKRVLDLSPDKIPREVI
TADQKRIIVDAYAKYKITNPVTFYQAVRNESGLVRRLYPVIEAHIRENIGRFSLISLLNEKRSEVMQLIQRGVYSEAEKF
GIEIIDVRIKRADLPEENSSAIFRRMQTEREKEAKEIRAEGEQAGQEVRSKADKLKREIISSAVKESYEIRGRGYAEATR
IYNEAFKVDEEFFNFYRSMSAYSKSFAENNTKFVLSPNNNFLDILNKGWK
>Mature_289_residues
SSNIKIVFVSVFVVLLIVLSNSIFVVQETKQAIVIQLGKVVRDVRESGLYFKLPFINSVEFLDKRVLDLSPDKIPREVIT
ADQKRIIVDAYAKYKITNPVTFYQAVRNESGLVRRLYPVIEAHIRENIGRFSLISLLNEKRSEVMQLIQRGVYSEAEKFG
IEIIDVRIKRADLPEENSSAIFRRMQTEREKEAKEIRAEGEQAGQEVRSKADKLKREIISSAVKESYEIRGRGYAEATRI
YNEAFKVDEEFFNFYRSMSAYSKSFAENNTKFVLSPNNNFLDILNKGWK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=312, Percent_Identity=30.7692307692308, Blast_Score=144, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17569497, Length=216, Percent_Identity=28.7037037037037, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193209764, Length=199, Percent_Identity=26.6331658291457, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17569493, Length=199, Percent_Identity=26.6331658291457, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281365664, Length=202, Percent_Identity=30.6930693069307, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24657857, Length=202, Percent_Identity=30.6930693069307, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI62484448, Length=202, Percent_Identity=30.6930693069307, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI62484274, Length=202, Percent_Identity=30.6930693069307, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 33541; Mature: 33410

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNIKIVFVSVFVVLLIVLSNSIFVVQETKQAIVIQLGKVVRDVRESGLYFKLPFINSV
CCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHCCCEEEECCCCHH
EFLDKRVLDLSPDKIPREVITADQKRIIVDAYAKYKITNPVTFYQAVRNESGLVRRLYPV
HHHHHHHHCCCCCCCCHHHHCCCCCEEEEEHHHHEEECCCHHHHHHHHCCCCHHHHHHHH
IEAHIRENIGRFSLISLLNEKRSEVMQLIQRGVYSEAEKFGIEIIDVRIKRADLPEENSS
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCHH
AIFRRMQTEREKEAKEIRAEGEQAGQEVRSKADKLKREIISSAVKESYEIRGRGYAEATR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IYNEAFKVDEEFFNFYRSMSAYSKSFAENNTKFVLSPNNNFLDILNKGWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHCCCCC
>Mature Secondary Structure 
SSNIKIVFVSVFVVLLIVLSNSIFVVQETKQAIVIQLGKVVRDVRESGLYFKLPFINSV
CCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHCCCEEEECCCCHH
EFLDKRVLDLSPDKIPREVITADQKRIIVDAYAKYKITNPVTFYQAVRNESGLVRRLYPV
HHHHHHHHCCCCCCCCHHHHCCCCCEEEEEHHHHEEECCCHHHHHHHHCCCCHHHHHHHH
IEAHIRENIGRFSLISLLNEKRSEVMQLIQRGVYSEAEKFGIEIIDVRIKRADLPEENSS
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCHH
AIFRRMQTEREKEAKEIRAEGEQAGQEVRSKADKLKREIISSAVKESYEIRGRGYAEATR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IYNEAFKVDEEFFNFYRSMSAYSKSFAENNTKFVLSPNNNFLDILNKGWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]