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The map label for this gene is adk [H]

Identifier: 225630281

GI number: 225630281

Start: 542137

End: 542778

Strand: Reverse

Name: adk [H]

Synonym: WRi_004990

Alternate gene names: 225630281

Gene position: 542778-542137 (Counterclockwise)

Preceding gene: 225630282

Following gene: 225630280

Centisome position: 37.54

GC content: 31.78

Gene sequence:

>642_bases
ATGATCATTACGATTTTTGGTCCTCCAGGTTCTGGTAAAGGTACTCAGTCAAGCTTGTTAATAGCAAAATATAATTTAAA
ATTAATTTCAGTAGGGGATTTATTAAGGAATATTATATCTAGCAGTAGTGAGTTAGGTAAAAAAATAAAGGGTACCGTGG
AATCTGGTAATTTAATTCAAGATGAAATTATATGTGGATTATTACGTGACCAGCTTGCATTAGTGGATGATAATTGCTTA
TTAGATGGTTTTCCGAGAAATTTAAACCAGGCTCATTTTTTGACTCAAGTTTTGCAAGAAAAATATAATAGGGATGTTGA
CATTGTAGTTGAGCTACAGCTTGACGATAATATTGCAATCGATAGGTTAAAAAATCGTCTCGCGTGTTTGGACTGTAAAA
GCATATATAGTGTATCTTCTTTTAAGAGTACTACTTGTGCTAAATGTAAAAGTACGAGGTTAGAGAAAAGAATTGATGAT
GCTGATATGTCTGCAATTAATAAGAGAATAAGTGAATATCACCTTCAAATGAAAGGTTTACGCGAGTATTATAAAGGCAA
ATTATTAACAATTGACGCTAATTTGAGTGTTGATGAGGTAACGCAAGAGATTGAAAGTAAAATTTCTTGTAATTTGGTTT
GA

Upstream 100 bases:

>100_bases
ACGTTATTACTGATACTATTATGCAAATACAATCTTATATTTTTTCAAATAGGTACGACAACTGGATAAAGAAATATGAG
TCTAAAACGAGGAAAGTAAG

Downstream 100 bases:

>100_bases
CTCTGAGTTGTTTTATGGTATAAATTAAGAGTTGTTATTAATAAAGTATCGAGGTACCAGTGGCACGTATTGCAGGCATA
AATATTCCAGTGAGGAAATG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MIITIFGPPGSGKGTQSSLLIAKYNLKLISVGDLLRNIISSSSELGKKIKGTVESGNLIQDEIICGLLRDQLALVDDNCL
LDGFPRNLNQAHFLTQVLQEKYNRDVDIVVELQLDDNIAIDRLKNRLACLDCKSIYSVSSFKSTTCAKCKSTRLEKRIDD
ADMSAINKRISEYHLQMKGLREYYKGKLLTIDANLSVDEVTQEIESKISCNLV

Sequences:

>Translated_213_residues
MIITIFGPPGSGKGTQSSLLIAKYNLKLISVGDLLRNIISSSSELGKKIKGTVESGNLIQDEIICGLLRDQLALVDDNCL
LDGFPRNLNQAHFLTQVLQEKYNRDVDIVVELQLDDNIAIDRLKNRLACLDCKSIYSVSSFKSTTCAKCKSTRLEKRIDD
ADMSAINKRISEYHLQMKGLREYYKGKLLTIDANLSVDEVTQEIESKISCNLV
>Mature_213_residues
MIITIFGPPGSGKGTQSSLLIAKYNLKLISVGDLLRNIISSSSELGKKIKGTVESGNLIQDEIICGLLRDQLALVDDNCL
LDGFPRNLNQAHFLTQVLQEKYNRDVDIVVELQLDDNIAIDRLKNRLACLDCKSIYSVSSFKSTTCAKCKSTRLEKRIDD
ADMSAINKRISEYHLQMKGLREYYKGKLLTIDANLSVDEVTQEIESKISCNLV

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=211, Percent_Identity=34.5971563981043, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI7524346, Length=211, Percent_Identity=34.5971563981043, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI19923437, Length=186, Percent_Identity=33.8709677419355, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI310110345, Length=186, Percent_Identity=30.1075268817204, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI53832003, Length=186, Percent_Identity=30.1075268817204, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI8051579, Length=186, Percent_Identity=30.1075268817204, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI53832001, Length=186, Percent_Identity=30.1075268817204, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4502011, Length=208, Percent_Identity=27.8846153846154, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI7706497, Length=213, Percent_Identity=29.5774647887324, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI28144899, Length=204, Percent_Identity=30.3921568627451, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI28144897, Length=204, Percent_Identity=30.3921568627451, Blast_Score=71, Evalue=5e-13,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=32.8703703703704, Blast_Score=114, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17552384, Length=212, Percent_Identity=34.4339622641509, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17567503, Length=205, Percent_Identity=28.780487804878, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17550688, Length=208, Percent_Identity=25.9615384615385, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17537943, Length=184, Percent_Identity=24.4565217391304, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17533833, Length=209, Percent_Identity=27.7511961722488, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=214, Percent_Identity=29.4392523364486, Blast_Score=104, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321018, Length=187, Percent_Identity=33.1550802139037, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322828, Length=219, Percent_Identity=26.027397260274, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI22026816, Length=208, Percent_Identity=34.1346153846154, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17737899, Length=189, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24645822, Length=189, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24663208, Length=215, Percent_Identity=27.4418604651163, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647141, Length=215, Percent_Identity=27.4418604651163, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221459597, Length=208, Percent_Identity=27.4038461538462, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21356893, Length=208, Percent_Identity=27.4038461538462, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23760; Mature: 23760

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIITIFGPPGSGKGTQSSLLIAKYNLKLISVGDLLRNIISSSSELGKKIKGTVESGNLIQ
CEEEEECCCCCCCCCCCEEEEEEECEEEEEHHHHHHHHHHCCHHHHHHHCCCCCCCCCHH
DEIICGLLRDQLALVDDNCLLDGFPRNLNQAHFLTQVLQEKYNRDVDIVVELQLDDNIAI
HHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCHH
DRLKNRLACLDCKSIYSVSSFKSTTCAKCKSTRLEKRIDDADMSAINKRISEYHLQMKGL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
REYYKGKLLTIDANLSVDEVTQEIESKISCNLV
HHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIITIFGPPGSGKGTQSSLLIAKYNLKLISVGDLLRNIISSSSELGKKIKGTVESGNLIQ
CEEEEECCCCCCCCCCCEEEEEEECEEEEEHHHHHHHHHHCCHHHHHHHCCCCCCCCCHH
DEIICGLLRDQLALVDDNCLLDGFPRNLNQAHFLTQVLQEKYNRDVDIVVELQLDDNIAI
HHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCHH
DRLKNRLACLDCKSIYSVSSFKSTTCAKCKSTRLEKRIDDADMSAINKRISEYHLQMKGL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
REYYKGKLLTIDANLSVDEVTQEIESKISCNLV
HHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA