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The map label for this gene is coxB [H]

Identifier: 225630267

GI number: 225630267

Start: 528441

End: 529205

Strand: Reverse

Name: coxB [H]

Synonym: WRi_004830

Alternate gene names: 225630267

Gene position: 529205-528441 (Counterclockwise)

Preceding gene: 225630268

Following gene: 225630266

Centisome position: 36.6

GC content: 36.34

Gene sequence:

>765_bases
ATGGTGAAGTTATTTGCACTATTGATAATATTTTACTCAAATATATCTGTTGCCTCTGCTCCTACTTCCTGGCAATTTGG
ATTTCCTGCTCCTGCAACTGAAGTAATGGAGGCTGTAGTTAGGTCACATTCGTTTGTGATGCTTGTGATGGTTACAATAA
TGCTTTTTGTGTGGGCGCTGCTTGCTTATATAGCGTTTCGCTTTCGTAAAAGCAAAGTAACAAACATAAGTAAAACTACC
CATAGTGTTCCTTTAGAAATTATTTGGTTTGTTATACCAACTATCATTGTTGGAATATTAGCCTTTGAAAACGCTAAATT
ACTGAAGCTACAGGAAGAAATACCGAAAGCTGATATAACACTGAAAGTTATTGGCCATCAATGGTATTGGAGTTACCAAT
ATCCAGAATATCAAGGTGTGTCATTTGATAGTTATATTAAGGGAAAAGAAGACTTTATCGAAGGAGATTTAAAGCTATTC
TCTGTTGATAACAACATCGTTTTACCCATTAATACTAATGTTCGTTTACAAGTTACAGCAGGAGATGTGATACACAGCTG
GGGAGTGCCGGCTTTTGGTGTAAAAATTGATGCGATACCAGGTAGGCTGAATGAGGCGTGGTTTAATATCAAAAAGTCTG
GTGTTTATTACGGGCAGTGCTATGAATTGTGTGGTCAAGGCCATGGATTTATGCCAATTGTTGTTGAAGCAGTAAGCAAA
GAAGATTTTAATAAGTGGATTGAAAATAGAAAATTAGTGAGTTAA

Upstream 100 bases:

>100_bases
TAAAAAATTATTAACCATCACTAATCTCTATTTGCATAGTAAGTTTATATATACTATTATACAGTATATCATTTAGTTTT
ACAGCAAACAAACAAAAGAT

Downstream 100 bases:

>100_bases
ATTTGGAGTATAGATATGAGTGACGTACCAAAGGGCGTAAAGCGTTGGTTGTTTTCCACCAATCATAAAGATATAGGGAC
ACTGTACATTATTTTTTCCA

Product: cytochrome c oxidase, subunit II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MVKLFALLIIFYSNISVASAPTSWQFGFPAPATEVMEAVVRSHSFVMLVMVTIMLFVWALLAYIAFRFRKSKVTNISKTT
HSVPLEIIWFVIPTIIVGILAFENAKLLKLQEEIPKADITLKVIGHQWYWSYQYPEYQGVSFDSYIKGKEDFIEGDLKLF
SVDNNIVLPINTNVRLQVTAGDVIHSWGVPAFGVKIDAIPGRLNEAWFNIKKSGVYYGQCYELCGQGHGFMPIVVEAVSK
EDFNKWIENRKLVS

Sequences:

>Translated_254_residues
MVKLFALLIIFYSNISVASAPTSWQFGFPAPATEVMEAVVRSHSFVMLVMVTIMLFVWALLAYIAFRFRKSKVTNISKTT
HSVPLEIIWFVIPTIIVGILAFENAKLLKLQEEIPKADITLKVIGHQWYWSYQYPEYQGVSFDSYIKGKEDFIEGDLKLF
SVDNNIVLPINTNVRLQVTAGDVIHSWGVPAFGVKIDAIPGRLNEAWFNIKKSGVYYGQCYELCGQGHGFMPIVVEAVSK
EDFNKWIENRKLVS
>Mature_254_residues
MVKLFALLIIFYSNISVASAPTSWQFGFPAPATEVMEAVVRSHSFVMLVMVTIMLFVWALLAYIAFRFRKSKVTNISKTT
HSVPLEIIWFVIPTIIVGILAFENAKLLKLQEEIPKADITLKVIGHQWYWSYQYPEYQGVSFDSYIKGKEDFIEGDLKLF
SVDNNIVLPINTNVRLQVTAGDVIHSWGVPAFGVKIDAIPGRLNEAWFNIKKSGVYYGQCYELCGQGHGFMPIVVEAVSK
EDFNKWIENRKLVS

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=220, Percent_Identity=36.8181818181818, Blast_Score=181, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6226540, Length=252, Percent_Identity=35.7142857142857, Blast_Score=179, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 28838; Mature: 28838

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLFALLIIFYSNISVASAPTSWQFGFPAPATEVMEAVVRSHSFVMLVMVTIMLFVWAL
CHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LAYIAFRFRKSKVTNISKTTHSVPLEIIWFVIPTIIVGILAFENAKLLKLQEEIPKADIT
HHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCEE
LKVIGHQWYWSYQYPEYQGVSFDSYIKGKEDFIEGDLKLFSVDNNIVLPINTNVRLQVTA
EEEEECEEEEEECCCCCCCCCHHHHHCCCHHHHCCCEEEEEECCCEEEEECCCEEEEEEE
GDVIHSWGVPAFGVKIDAIPGRLNEAWFNIKKSGVYYGQCYELCGQGHGFMPIVVEAVSK
CCHHHHCCCCEECEEEECCCCCCCHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHCH
EDFNKWIENRKLVS
HHHHHHHHCCCCCC
>Mature Secondary Structure
MVKLFALLIIFYSNISVASAPTSWQFGFPAPATEVMEAVVRSHSFVMLVMVTIMLFVWAL
CHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LAYIAFRFRKSKVTNISKTTHSVPLEIIWFVIPTIIVGILAFENAKLLKLQEEIPKADIT
HHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCEE
LKVIGHQWYWSYQYPEYQGVSFDSYIKGKEDFIEGDLKLFSVDNNIVLPINTNVRLQVTA
EEEEECEEEEEECCCCCCCCCHHHHHCCCHHHHCCCEEEEEECCCEEEEECCCEEEEEEE
GDVIHSWGVPAFGVKIDAIPGRLNEAWFNIKKSGVYYGQCYELCGQGHGFMPIVVEAVSK
CCHHHHCCCCEECEEEECCCCCCCHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHCH
EDFNKWIENRKLVS
HHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA