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The map label for this gene is coxA [H]

Identifier: 225630266

GI number: 225630266

Start: 526875

End: 528425

Strand: Reverse

Name: coxA [H]

Synonym: WRi_004820

Alternate gene names: 225630266

Gene position: 528425-526875 (Counterclockwise)

Preceding gene: 225630267

Following gene: 225630265

Centisome position: 36.55

GC content: 38.49

Gene sequence:

>1551_bases
ATGAGTGACGTACCAAAGGGCGTAAAGCGTTGGTTGTTTTCCACCAATCATAAAGATATAGGGACACTGTACATTATTTT
TTCCATATTAGCTGGAATTATTGGTGGATTATTATCGGTGATTATTCGCACTCAGCTAATGCACATTAATATACTTAACA
ATAATTATCAATTATATAACGTAATGGTTACAGGGCATGCGTTGATAATGGTGTTTTTTATGATAATGCCAGCCCTCATG
GGAGGATTTGGTAATTGGTTTGTGCCTCTTATGATCGGTGCACCAGATATGGCGTTTCCTCGTATGAATAATTTGAGTTT
CTGGTTATTAGTGTCATCTTTTATTTTGCTCATTCTCTCAGTGTTTATTGGTGAAGGTCCAGGTACAGGTTGGACTTTAT
ATCCACCTTTATCACAGGTAATGTCCCATCCAAGTGCAGGAGTTGACATTGCTATACTTGCACTTCATGTTGCTGGTATG
TCGTCAATTGTTGGGGCGATCAACTTTATAGTTACTATATTTAACATGCGCGCAAAAGGCATGTCATTAACTAAGATGCC
ACTGTTTGTTTGGTCTGTCTTGCTAACAGCATTTATGTTGATTGTTGCCTTACCAGTGCTTGCCGGTGCTATAACTATGC
TTCTTACTGATCGCAATATTGGTACTTCCTTTTTTGATCCTGCCGGTGGTGGCGATCCTGTGTTATTTCAACATCTATTT
TGGTTTTTTGGTCATCCAGAAGTTTACGTAATTATTTTTCCTGCATTTGGCATCATAAGTCAGGTTGTATCAACTTTTTC
TCACAGACCTGTATTTGGTTACATAGGGATGGTTTATGCAATGATAGGTATAGCAGTATTTGGCTTTATGGTTTGGGCTC
ACCATATGTTCACTGTTGGGCTTAGTGCTGACGCTGCTGCATTTTTTAGCACTACCACAATTTTTATCGGTGTTATAACT
GGTGTAAAAGTCTTTAGCTGGATTGCAACTATGTGGGGCGGAGCAATTGAGTTTAAAACCCCTATGCTATTTGCACTAGG
TTTTATTTTTATGTTTGTTGGCGGTGGCATAACGGGAATAATTCTTTCTCATGGTGGAATAGATAAGCTCCTGCACGACA
CCTATTATGTTGTTGCTCACTTCCATTATGTCATGTCACTTGCTGCATTATTTGGAGCTTTTGCTGGCTTTTATTATTGG
ATTGGTAAAATGTCGGGTAAACAATATAATGAGCGCTTAGGTCAAATCCACTTTTGGCTTACTTTTATTAGCACCAATAT
CACTTTTTTACCTCAACATTTCTTAGGATTAGCTGGTATGCCAAGGCGTATACCTGATTATCCTGATGCGTTTATCCCTT
GGAATTATATATCCTCAATTGGTTCGTATATGTCCTTTGTTTCAGTTATGTTTTTTGTGTTTATAGTTATACATCTTTTT
AAATGGGGCAAGAAAGCTGGAGATAATCCTTGGGGAGGTGACACCTTGGAATGGACGGTATCTTCACCACCGCCTTTTCA
TACTTTCGAAAAACCACCAGTGGTAAAATAG

Upstream 100 bases:

>100_bases
CCATGGATTTATGCCAATTGTTGTTGAAGCAGTAAGCAAAGAAGATTTTAATAAGTGGATTGAAAATAGAAAATTAGTGA
GTTAAATTTGGAGTATAGAT

Downstream 100 bases:

>100_bases
AATGTACACAAGTGTTTTGCTAAATGTTGAATCAACAATACTGGATTTTTGGCGTTTGCTGAAGCCAAGGATAATGTATC
TTGTGGTATTTACTGCAGTT

Product: cytochrome c oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MSDVPKGVKRWLFSTNHKDIGTLYIIFSILAGIIGGLLSVIIRTQLMHINILNNNYQLYNVMVTGHALIMVFFMIMPALM
GGFGNWFVPLMIGAPDMAFPRMNNLSFWLLVSSFILLILSVFIGEGPGTGWTLYPPLSQVMSHPSAGVDIAILALHVAGM
SSIVGAINFIVTIFNMRAKGMSLTKMPLFVWSVLLTAFMLIVALPVLAGAITMLLTDRNIGTSFFDPAGGGDPVLFQHLF
WFFGHPEVYVIIFPAFGIISQVVSTFSHRPVFGYIGMVYAMIGIAVFGFMVWAHHMFTVGLSADAAAFFSTTTIFIGVIT
GVKVFSWIATMWGGAIEFKTPMLFALGFIFMFVGGGITGIILSHGGIDKLLHDTYYVVAHFHYVMSLAALFGAFAGFYYW
IGKMSGKQYNERLGQIHFWLTFISTNITFLPQHFLGLAGMPRRIPDYPDAFIPWNYISSIGSYMSFVSVMFFVFIVIHLF
KWGKKAGDNPWGGDTLEWTVSSPPPFHTFEKPPVVK

Sequences:

>Translated_516_residues
MSDVPKGVKRWLFSTNHKDIGTLYIIFSILAGIIGGLLSVIIRTQLMHINILNNNYQLYNVMVTGHALIMVFFMIMPALM
GGFGNWFVPLMIGAPDMAFPRMNNLSFWLLVSSFILLILSVFIGEGPGTGWTLYPPLSQVMSHPSAGVDIAILALHVAGM
SSIVGAINFIVTIFNMRAKGMSLTKMPLFVWSVLLTAFMLIVALPVLAGAITMLLTDRNIGTSFFDPAGGGDPVLFQHLF
WFFGHPEVYVIIFPAFGIISQVVSTFSHRPVFGYIGMVYAMIGIAVFGFMVWAHHMFTVGLSADAAAFFSTTTIFIGVIT
GVKVFSWIATMWGGAIEFKTPMLFALGFIFMFVGGGITGIILSHGGIDKLLHDTYYVVAHFHYVMSLAALFGAFAGFYYW
IGKMSGKQYNERLGQIHFWLTFISTNITFLPQHFLGLAGMPRRIPDYPDAFIPWNYISSIGSYMSFVSVMFFVFIVIHLF
KWGKKAGDNPWGGDTLEWTVSSPPPFHTFEKPPVVK
>Mature_515_residues
SDVPKGVKRWLFSTNHKDIGTLYIIFSILAGIIGGLLSVIIRTQLMHINILNNNYQLYNVMVTGHALIMVFFMIMPALMG
GFGNWFVPLMIGAPDMAFPRMNNLSFWLLVSSFILLILSVFIGEGPGTGWTLYPPLSQVMSHPSAGVDIAILALHVAGMS
SIVGAINFIVTIFNMRAKGMSLTKMPLFVWSVLLTAFMLIVALPVLAGAITMLLTDRNIGTSFFDPAGGGDPVLFQHLFW
FFGHPEVYVIIFPAFGIISQVVSTFSHRPVFGYIGMVYAMIGIAVFGFMVWAHHMFTVGLSADAAAFFSTTTIFIGVITG
VKVFSWIATMWGGAIEFKTPMLFALGFIFMFVGGGITGIILSHGGIDKLLHDTYYVVAHFHYVMSLAALFGAFAGFYYWI
GKMSGKQYNERLGQIHFWLTFISTNITFLPQHFLGLAGMPRRIPDYPDAFIPWNYISSIGSYMSFVSVMFFVFIVIHLFK
WGKKAGDNPWGGDTLEWTVSSPPPFHTFEKPPVVK

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=509, Percent_Identity=56.385068762279, Blast_Score=565, Evalue=1e-161,
Organism=Escherichia coli, GI1786634, Length=514, Percent_Identity=40.0778210116732, Blast_Score=374, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6226519, Length=531, Percent_Identity=52.5423728813559, Blast_Score=575, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6226524, Length=323, Percent_Identity=56.9659442724458, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=52.0161290322581, Blast_Score=254, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 57216; Mature: 57085

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVPKGVKRWLFSTNHKDIGTLYIIFSILAGIIGGLLSVIIRTQLMHINILNNNYQLYN
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEE
VMVTGHALIMVFFMIMPALMGGFGNWFVPLMIGAPDMAFPRMNNLSFWLLVSSFILLILS
EEEHHHHHHHHHHHHHHHHHCCCCCHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
VFIGEGPGTGWTLYPPLSQVMSHPSAGVDIAILALHVAGMSSIVGAINFIVTIFNMRAKG
HHHCCCCCCCCEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MSLTKMPLFVWSVLLTAFMLIVALPVLAGAITMLLTDRNIGTSFFDPAGGGDPVLFQHLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
WFFGHPEVYVIIFPAFGIISQVVSTFSHRPVFGYIGMVYAMIGIAVFGFMVWAHHMFTVG
HHHCCCCEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LSADAAAFFSTTTIFIGVITGVKVFSWIATMWGGAIEFKTPMLFALGFIFMFVGGGITGI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHCCCCEEE
ILSHGGIDKLLHDTYYVVAHFHYVMSLAALFGAFAGFYYWIGKMSGKQYNERLGQIHFWL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TFISTNITFLPQHFLGLAGMPRRIPDYPDAFIPWNYISSIGSYMSFVSVMFFVFIVIHLF
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KWGKKAGDNPWGGDTLEWTVSSPPPFHTFEKPPVVK
HHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDVPKGVKRWLFSTNHKDIGTLYIIFSILAGIIGGLLSVIIRTQLMHINILNNNYQLYN
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEE
VMVTGHALIMVFFMIMPALMGGFGNWFVPLMIGAPDMAFPRMNNLSFWLLVSSFILLILS
EEEHHHHHHHHHHHHHHHHHCCCCCHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
VFIGEGPGTGWTLYPPLSQVMSHPSAGVDIAILALHVAGMSSIVGAINFIVTIFNMRAKG
HHHCCCCCCCCEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MSLTKMPLFVWSVLLTAFMLIVALPVLAGAITMLLTDRNIGTSFFDPAGGGDPVLFQHLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
WFFGHPEVYVIIFPAFGIISQVVSTFSHRPVFGYIGMVYAMIGIAVFGFMVWAHHMFTVG
HHHCCCCEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LSADAAAFFSTTTIFIGVITGVKVFSWIATMWGGAIEFKTPMLFALGFIFMFVGGGITGI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHCCCCEEE
ILSHGGIDKLLHDTYYVVAHFHYVMSLAALFGAFAGFYYWIGKMSGKQYNERLGQIHFWL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TFISTNITFLPQHFLGLAGMPRRIPDYPDAFIPWNYISSIGSYMSFVSVMFFVFIVIHLF
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KWGKKAGDNPWGGDTLEWTVSSPPPFHTFEKPPVVK
HHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]