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The map label for this gene is guaB [H]

Identifier: 225630007

GI number: 225630007

Start: 162021

End: 163514

Strand: Direct

Name: guaB [H]

Synonym: WRi_001620

Alternate gene names: 225630007

Gene position: 162021-163514 (Clockwise)

Preceding gene: 225630006

Following gene: 225630008

Centisome position: 11.21

GC content: 38.42

Gene sequence:

>1494_bases
ATGAAAAAAATGGAAGCTTGTTATTCGTTTGACGATATACTTCTTTTGCCAGCCTATTCTAATATATTGCCTTGCGGTGC
AGATACAAAAACTTATTTAACAAATAATATAGAACTAAATATCCCTCTCATATCCTCTGCAATGGATACTGTTACTGAAT
CGGGCTTTGCAATAGCTATTGCCCAACATGGAGGGATAGGTTGCATACATAAGAATTTATCAATAGATGAACAAGTTTTA
GAAGTAAGAAGGGTGAAAAAATATGAAAGTTGGATCGTGTATAACCCAATTACGATTTCACCGGATAAAACAGTTGCGGA
AGCAATTTCATTAATGAGAGAGCACAATTATTCTGGCATTCCTGTAGTCGATCAACGCAAGTTAGTTGGAATTTTAACTA
ACCGAGATGTGAGATTTATTGAAGACCAGAACATGAATGTAAAAGTTTCCGAAGTGATGACAAAAGATAAGTTAGTGACA
GTGCGGGAGCAGGGAGTGAATAGTGCCTCAGCAATGAAATTGTTGCATGAAAATAGAATAGAAAAGCTTTTGGTCGTAGA
TGAAAATTCTTGTTGTATAGGTTTAATTACGGTTAAAGACATTGAAAAATACAATAGATATCCAAATTCATGTAAAGACA
GTAAAGGGCGGCTCAGAGTTGCCGCTGCAATTGGCACTGGTAAAAAAGATGGTATAGACAGATGTGAAGCTTTGATCGGA
GAAGAAGTTGATGTAGTTGTTGTGGATACTGCTCACGGTCATTCCGAAAACGTTATCAATACCATTAGGGAAATAAAAAA
GATGTATCCTAATACGCAATTAATTGGCGGAAACATTGCAACAAAGGAGGCTGCTGAAGCGTTGATTGATGCGGGTGTTG
ATGCAGTGAAGGTTGGAATAGGACCAGGATCAATCTGTACAACCAGAATAGTTACAGGTGTTGGTGTGCCACAATTCTCT
GCAATCAAGAATGTTGCAGAGGCGTGTAGAGCAAGAAACGTCAGACTAATTGCTGATGGTGGGGTAAAATACTCAGGAGA
TGTTGCAAAAGCTATTGCAGCTGGTGCTGACTCTGTGATGATTGGTTCGATTTTTGCTGGCACTGACGAAAGCCCAGGTG
AGATTATTATGTATAAGGGCAGAGCATATAAAGGCTATCGAGGAATGGGATCTATTAGTGCAATGAAACGAGGTTCAGCT
AGCCGTTATTTTCAAGATAAAGATTCAAAACTCAAATTAGTTCCACAAGGAGTGGAAGGAAGAGTTCCATTCAAAGGTCC
AGCTTCAGGAGTAATCCATCAATTGATTGGCGGATTGCAAGCTGCAATGGGGTATACTGGTAATAGGAATATAGAAGAGA
TGAAAAAAAATTGTAAATTTGTTACTATTACTGCATCAGGATTAAGAGAGAGTCACGCTCATGATATAGTCATTACACAA
GAAGCTCCAAATTATGCTTATCAAACGTCCAATTTGTCAACCGATTCGGAGTAG

Upstream 100 bases:

>100_bases
ATTGAGCAGTTTTGTTTGCTGGCAAATAATGTAGAATGCTTATTTTGCAAAAGCCCTATTGCAATTTAATTAATTGGCGT
ATAAGCTTTAAATAAAGCCT

Downstream 100 bases:

>100_bases
TCCAGAAAAAGTAGAGAGAAAGTTAAAACGTTTTTGGAGTAAAATAAAACGTTTTTTCAAAATATGACAAATAGAAGAGA
ATATACAGCAGAATTCAAAT

Product: inosine monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MKKMEACYSFDDILLLPAYSNILPCGADTKTYLTNNIELNIPLISSAMDTVTESGFAIAIAQHGGIGCIHKNLSIDEQVL
EVRRVKKYESWIVYNPITISPDKTVAEAISLMREHNYSGIPVVDQRKLVGILTNRDVRFIEDQNMNVKVSEVMTKDKLVT
VREQGVNSASAMKLLHENRIEKLLVVDENSCCIGLITVKDIEKYNRYPNSCKDSKGRLRVAAAIGTGKKDGIDRCEALIG
EEVDVVVVDTAHGHSENVINTIREIKKMYPNTQLIGGNIATKEAAEALIDAGVDAVKVGIGPGSICTTRIVTGVGVPQFS
AIKNVAEACRARNVRLIADGGVKYSGDVAKAIAAGADSVMIGSIFAGTDESPGEIIMYKGRAYKGYRGMGSISAMKRGSA
SRYFQDKDSKLKLVPQGVEGRVPFKGPASGVIHQLIGGLQAAMGYTGNRNIEEMKKNCKFVTITASGLRESHAHDIVITQ
EAPNYAYQTSNLSTDSE

Sequences:

>Translated_497_residues
MKKMEACYSFDDILLLPAYSNILPCGADTKTYLTNNIELNIPLISSAMDTVTESGFAIAIAQHGGIGCIHKNLSIDEQVL
EVRRVKKYESWIVYNPITISPDKTVAEAISLMREHNYSGIPVVDQRKLVGILTNRDVRFIEDQNMNVKVSEVMTKDKLVT
VREQGVNSASAMKLLHENRIEKLLVVDENSCCIGLITVKDIEKYNRYPNSCKDSKGRLRVAAAIGTGKKDGIDRCEALIG
EEVDVVVVDTAHGHSENVINTIREIKKMYPNTQLIGGNIATKEAAEALIDAGVDAVKVGIGPGSICTTRIVTGVGVPQFS
AIKNVAEACRARNVRLIADGGVKYSGDVAKAIAAGADSVMIGSIFAGTDESPGEIIMYKGRAYKGYRGMGSISAMKRGSA
SRYFQDKDSKLKLVPQGVEGRVPFKGPASGVIHQLIGGLQAAMGYTGNRNIEEMKKNCKFVTITASGLRESHAHDIVITQ
EAPNYAYQTSNLSTDSE
>Mature_497_residues
MKKMEACYSFDDILLLPAYSNILPCGADTKTYLTNNIELNIPLISSAMDTVTESGFAIAIAQHGGIGCIHKNLSIDEQVL
EVRRVKKYESWIVYNPITISPDKTVAEAISLMREHNYSGIPVVDQRKLVGILTNRDVRFIEDQNMNVKVSEVMTKDKLVT
VREQGVNSASAMKLLHENRIEKLLVVDENSCCIGLITVKDIEKYNRYPNSCKDSKGRLRVAAAIGTGKKDGIDRCEALIG
EEVDVVVVDTAHGHSENVINTIREIKKMYPNTQLIGGNIATKEAAEALIDAGVDAVKVGIGPGSICTTRIVTGVGVPQFS
AIKNVAEACRARNVRLIADGGVKYSGDVAKAIAAGADSVMIGSIFAGTDESPGEIIMYKGRAYKGYRGMGSISAMKRGSA
SRYFQDKDSKLKLVPQGVEGRVPFKGPASGVIHQLIGGLQAAMGYTGNRNIEEMKKNCKFVTITASGLRESHAHDIVITQ
EAPNYAYQTSNLSTDSE

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=479, Percent_Identity=40.0835073068894, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=39.4572025052192, Blast_Score=322, Evalue=6e-88,
Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=39.4572025052192, Blast_Score=322, Evalue=7e-88,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=39.4572025052192, Blast_Score=322, Evalue=7e-88,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=39.4572025052192, Blast_Score=321, Evalue=8e-88,
Organism=Homo sapiens, GI217035152, Length=485, Percent_Identity=39.1752577319588, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=38.6221294363257, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=36.7432150313152, Blast_Score=285, Evalue=5e-77,
Organism=Homo sapiens, GI50541956, Length=250, Percent_Identity=38.8, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI50541954, Length=250, Percent_Identity=38.8, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI50541952, Length=250, Percent_Identity=38.8, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI50541948, Length=250, Percent_Identity=38.8, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI156104880, Length=249, Percent_Identity=35.7429718875502, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1788855, Length=480, Percent_Identity=54.375, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI1786293, Length=223, Percent_Identity=38.1165919282511, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71994385, Length=482, Percent_Identity=34.2323651452282, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI71994389, Length=430, Percent_Identity=35.1162790697674, Blast_Score=244, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI17560440, Length=244, Percent_Identity=38.9344262295082, Blast_Score=181, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6322012, Length=490, Percent_Identity=38.9795918367347, Blast_Score=319, Evalue=6e-88,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=38.8429752066116, Blast_Score=317, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6323464, Length=490, Percent_Identity=39.3877551020408, Blast_Score=311, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6319352, Length=346, Percent_Identity=39.0173410404624, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6319353, Length=118, Percent_Identity=43.2203389830509, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=39.2116182572614, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=39.2116182572614, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=39.7291196388262, Blast_Score=292, Evalue=4e-79,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53839; Mature: 53839

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKMEACYSFDDILLLPAYSNILPCGADTKTYLTNNIELNIPLISSAMDTVTESGFAIAI
CCCHHHHCCCCCEEEEECCCCEECCCCCCCEEEECCEEEEECCHHHHHHHHHCCCEEEEE
AQHGGIGCIHKNLSIDEQVLEVRRVKKYESWIVYNPITISPDKTVAEAISLMREHNYSGI
ECCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEECCEEECCCHHHHHHHHHHHHCCCCCC
PVVDQRKLVGILTNRDVRFIEDQNMNVKVSEVMTKDKLVTVREQGVNSASAMKLLHENRI
CEECCCCEEEEEECCCEEEEECCCCCEEHHHHHCCCCEEEEHHCCCCHHHHHHHHHHCCC
EKLLVVDENSCCIGLITVKDIEKYNRYPNSCKDSKGRLRVAAAIGTGKKDGIDRCEALIG
CEEEEEECCCCEEEEEEHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
EEVDVVVVDTAHGHSENVINTIREIKKMYPNTQLIGGNIATKEAAEALIDAGVDAVKVGI
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCEEEEEC
GPGSICTTRIVTGVGVPQFSAIKNVAEACRARNVRLIADGGVKYSGDVAKAIAAGADSVM
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEECCCEEECCHHHHHHHCCCCCEE
IGSIFAGTDESPGEIIMYKGRAYKGYRGMGSISAMKRGSASRYFQDKDSKLKLVPQGVEG
EEEEEECCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCCCHHCCCCCCCEEEEEECCCCC
RVPFKGPASGVIHQLIGGLQAAMGYTGNRNIEEMKKNCKFVTITASGLRESHAHDIVITQ
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEEEECCCCCCCCCCEEEEEE
EAPNYAYQTSNLSTDSE
CCCCCEEECCCCCCCCC
>Mature Secondary Structure
MKKMEACYSFDDILLLPAYSNILPCGADTKTYLTNNIELNIPLISSAMDTVTESGFAIAI
CCCHHHHCCCCCEEEEECCCCEECCCCCCCEEEECCEEEEECCHHHHHHHHHCCCEEEEE
AQHGGIGCIHKNLSIDEQVLEVRRVKKYESWIVYNPITISPDKTVAEAISLMREHNYSGI
ECCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEECCEEECCCHHHHHHHHHHHHCCCCCC
PVVDQRKLVGILTNRDVRFIEDQNMNVKVSEVMTKDKLVTVREQGVNSASAMKLLHENRI
CEECCCCEEEEEECCCEEEEECCCCCEEHHHHHCCCCEEEEHHCCCCHHHHHHHHHHCCC
EKLLVVDENSCCIGLITVKDIEKYNRYPNSCKDSKGRLRVAAAIGTGKKDGIDRCEALIG
CEEEEEECCCCEEEEEEHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
EEVDVVVVDTAHGHSENVINTIREIKKMYPNTQLIGGNIATKEAAEALIDAGVDAVKVGI
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCEEEEEC
GPGSICTTRIVTGVGVPQFSAIKNVAEACRARNVRLIADGGVKYSGDVAKAIAAGADSVM
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEECCCEEECCHHHHHHHCCCCCEE
IGSIFAGTDESPGEIIMYKGRAYKGYRGMGSISAMKRGSASRYFQDKDSKLKLVPQGVEG
EEEEEECCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCCCHHCCCCCCCEEEEEECCCCC
RVPFKGPASGVIHQLIGGLQAAMGYTGNRNIEEMKKNCKFVTITASGLRESHAHDIVITQ
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEEEECCCCCCCCCCEEEEEE
EAPNYAYQTSNLSTDSE
CCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]