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The map label for this gene is uvrC [H]

Identifier: 225629953

GI number: 225629953

Start: 98471

End: 100288

Strand: Direct

Name: uvrC [H]

Synonym: WRi_000980

Alternate gene names: 225629953

Gene position: 98471-100288 (Clockwise)

Preceding gene: 225629952

Following gene: 225629954

Centisome position: 6.81

GC content: 34.6

Gene sequence:

>1818_bases
ATGCTCAGGCAATATAAAGAACAAATTAAATCATCTCCACAGTCCTGTGGCGTGTATAAGATGGTTGGAGATAAGAATAA
AGTTTTATATGTTGGAAAAGCAAAAAACTTAAAGTCAAGGTTATCTGACTACCTTCAATTCGAAAATCTTTCTGAACGAA
TTAGAGTTATGCTCTCACAAGTTATTAAGGTTGAAATATTCATCACTGAGAATGAAATCGAAGCACTGCTTCTTGAAGCA
CAGCTAATAAAATCATTGAAACCACTTTATAATATTGTGCTCAAGGATGGAAAATTTTATCCTTATATAACAATTTCCAA
GCACGATTATCCAAGAATAGCAAAATATAGAGGCAAATTTAAGAAGAATGAGTTTCATTATTATGGTCCCTTTACATCTG
CCGCTGCTGTTAAGCAAACTATATTATCATTGCAAAAAGCTTTTCTCCTAAGAGTATGTTCAGATCAATACTTTTCCTCA
ACAAAAAGACCATGTATTGAATATCAAATTAAGCGCTGCTCAGCACCATGCGTAGATAAAATCACAAAAGACGACTACTG
CCAATCAGTAAAACAGGCACGAAATACATTGCTTGGAAGAAATAAGGAAGTGAAAGAACAGTTACTTTTCACAATGAGAA
AGTGCAGCAGTGAAGAAAACTATGAGCTTGCTGCTATATATAGAGATCGGGTAAAGTTTCTTGAGCAAATTCAAATACAG
CACACGGATTTTTCTTTTGAAAAAGATGCAGATTTCTTCAGTATTGTACGTGAAGAGGATCTAGCATGTATTAGTGTGTT
ATCGTTTAGAAATAAAGACAACTACGGCAGCACTCCTTACTTTGCCGAGAACTGTGGTGATCACTCAAATGATGAAATTT
TATCCACCTTTTTGGTCAATTTTTATAATTCAGCTAACATACCTCCAATACAAATTTACGTTCCAGATTCTATTGTGGAT
AAGGAAATTATAGAACAAGCACTATATAAGGTTGCTCAAAAGCCAGTAAAAGTTCTGCATGCAAAGAATAAAAAAGAGCG
TGATTTATTGAAATTTGTTTATGATAACTCTCAGCATAGCTTAGAGCAGAAGCTTATCGATTATAGAAATAACCTAGAAA
AGCTTGAAGAGCTTAGCAAAATCTTCTTGTTACCAAACATTCCAAAGCGTATTGAGGTTTATGACAATAGCCATATATTT
GGAAACCAACAAATTGGTGTAATGGTTGTTGCAGGGCAGGAGGGTTTTTTAAAAAGTGAGTACAGAAAATTTACTATAAA
GGAAAAATTTTCAGGCGATGACTATAAAATGATGAGGGAAGTGCTAACCAGACGTTTCTCCGGCAATATAAAAGGCATAA
TACCTGATTTTTTACTGATTGATGGTGGACCAGGACATGTTTCCATAGTACAGAATGTACTGGAAGTATTGAATATAAAC
GTTCCTTTTGCTTGTATGGCAAAAGGTCCTGATCGTAACGCAGGAAATGAAAGATTTTATATGCTGGGCAGGGAAGAATT
CAGTCTGGCAAATGATAGCAAAGTCATGCTTTACTTACAATCGCTGCGTAATGAAGCCCACCGTTTTGCGATAACTTCAC
ATAGAAAAAAACGCGATAAACAGTTTATAGTTTCACAATTAAGCAAAATACCCGGCATTGGCAACAAAAGAAAAAAAGCG
TTGATGTCTTATTTTGGTTCAGTGAAAAATATAAGTAAAGCTTCTCTGGCTGAAATTCAAAACATACCTGGAATTAGTAA
AGGTTTAGCAGAAGTTATTCTTAAACACGTAAATTATAAGAGAGGAGTACTGGAATGA

Upstream 100 bases:

>100_bases
GATAAGCTGAGAAGAAACAGATTATCTTTGCTTGAAAATGTAGTTTCCATCTTTCATTTAGTAGCAGATTTTAACCTCAT
ACAGGTTAAGCAATGGATAA

Downstream 100 bases:

>100_bases
CACAAAACCCGTTTTATTATTAGGGAATTTATATCTTAAAACCGCAAAAAAAGGTGTGCGTATTTGTGAAAAAAAATCTC
CATAAAATTTGTGAAGCAAT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MLRQYKEQIKSSPQSCGVYKMVGDKNKVLYVGKAKNLKSRLSDYLQFENLSERIRVMLSQVIKVEIFITENEIEALLLEA
QLIKSLKPLYNIVLKDGKFYPYITISKHDYPRIAKYRGKFKKNEFHYYGPFTSAAAVKQTILSLQKAFLLRVCSDQYFSS
TKRPCIEYQIKRCSAPCVDKITKDDYCQSVKQARNTLLGRNKEVKEQLLFTMRKCSSEENYELAAIYRDRVKFLEQIQIQ
HTDFSFEKDADFFSIVREEDLACISVLSFRNKDNYGSTPYFAENCGDHSNDEILSTFLVNFYNSANIPPIQIYVPDSIVD
KEIIEQALYKVAQKPVKVLHAKNKKERDLLKFVYDNSQHSLEQKLIDYRNNLEKLEELSKIFLLPNIPKRIEVYDNSHIF
GNQQIGVMVVAGQEGFLKSEYRKFTIKEKFSGDDYKMMREVLTRRFSGNIKGIIPDFLLIDGGPGHVSIVQNVLEVLNIN
VPFACMAKGPDRNAGNERFYMLGREEFSLANDSKVMLYLQSLRNEAHRFAITSHRKKRDKQFIVSQLSKIPGIGNKRKKA
LMSYFGSVKNISKASLAEIQNIPGISKGLAEVILKHVNYKRGVLE

Sequences:

>Translated_605_residues
MLRQYKEQIKSSPQSCGVYKMVGDKNKVLYVGKAKNLKSRLSDYLQFENLSERIRVMLSQVIKVEIFITENEIEALLLEA
QLIKSLKPLYNIVLKDGKFYPYITISKHDYPRIAKYRGKFKKNEFHYYGPFTSAAAVKQTILSLQKAFLLRVCSDQYFSS
TKRPCIEYQIKRCSAPCVDKITKDDYCQSVKQARNTLLGRNKEVKEQLLFTMRKCSSEENYELAAIYRDRVKFLEQIQIQ
HTDFSFEKDADFFSIVREEDLACISVLSFRNKDNYGSTPYFAENCGDHSNDEILSTFLVNFYNSANIPPIQIYVPDSIVD
KEIIEQALYKVAQKPVKVLHAKNKKERDLLKFVYDNSQHSLEQKLIDYRNNLEKLEELSKIFLLPNIPKRIEVYDNSHIF
GNQQIGVMVVAGQEGFLKSEYRKFTIKEKFSGDDYKMMREVLTRRFSGNIKGIIPDFLLIDGGPGHVSIVQNVLEVLNIN
VPFACMAKGPDRNAGNERFYMLGREEFSLANDSKVMLYLQSLRNEAHRFAITSHRKKRDKQFIVSQLSKIPGIGNKRKKA
LMSYFGSVKNISKASLAEIQNIPGISKGLAEVILKHVNYKRGVLE
>Mature_605_residues
MLRQYKEQIKSSPQSCGVYKMVGDKNKVLYVGKAKNLKSRLSDYLQFENLSERIRVMLSQVIKVEIFITENEIEALLLEA
QLIKSLKPLYNIVLKDGKFYPYITISKHDYPRIAKYRGKFKKNEFHYYGPFTSAAAVKQTILSLQKAFLLRVCSDQYFSS
TKRPCIEYQIKRCSAPCVDKITKDDYCQSVKQARNTLLGRNKEVKEQLLFTMRKCSSEENYELAAIYRDRVKFLEQIQIQ
HTDFSFEKDADFFSIVREEDLACISVLSFRNKDNYGSTPYFAENCGDHSNDEILSTFLVNFYNSANIPPIQIYVPDSIVD
KEIIEQALYKVAQKPVKVLHAKNKKERDLLKFVYDNSQHSLEQKLIDYRNNLEKLEELSKIFLLPNIPKRIEVYDNSHIF
GNQQIGVMVVAGQEGFLKSEYRKFTIKEKFSGDDYKMMREVLTRRFSGNIKGIIPDFLLIDGGPGHVSIVQNVLEVLNIN
VPFACMAKGPDRNAGNERFYMLGREEFSLANDSKVMLYLQSLRNEAHRFAITSHRKKRDKQFIVSQLSKIPGIGNKRKKA
LMSYFGSVKNISKASLAEIQNIPGISKGLAEVILKHVNYKRGVLE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=603, Percent_Identity=35.6550580431177, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1788037, Length=197, Percent_Identity=26.9035532994924, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 69862; Mature: 69862

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRQYKEQIKSSPQSCGVYKMVGDKNKVLYVGKAKNLKSRLSDYLQFENLSERIRVMLSQ
CCHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
VIKVEIFITENEIEALLLEAQLIKSLKPLYNIVLKDGKFYPYITISKHDYPRIAKYRGKF
HHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCC
KKNEFHYYGPFTSAAAVKQTILSLQKAFLLRVCSDQYFSSTKRPCIEYQIKRCSAPCVDK
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHH
ITKDDYCQSVKQARNTLLGRNKEVKEQLLFTMRKCSSEENYELAAIYRDRVKFLEQIQIQ
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
HTDFSFEKDADFFSIVREEDLACISVLSFRNKDNYGSTPYFAENCGDHSNDEILSTFLVN
CCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHH
FYNSANIPPIQIYVPDSIVDKEIIEQALYKVAQKPVKVLHAKNKKERDLLKFVYDNSQHS
HHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHH
LEQKLIDYRNNLEKLEELSKIFLLPNIPKRIEVYDNSHIFGNQQIGVMVVAGQEGFLKSE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEECCCCEEEEEEECCCCCHHHH
YRKFTIKEKFSGDDYKMMREVLTRRFSGNIKGIIPDFLLIDGGPGHVSIVQNVLEVLNIN
HHHEEEHHCCCCCHHHHHHHHHHHHHCCCCCEECCCEEEECCCCCHHHHHHHHHHHHCCC
VPFACMAKGPDRNAGNERFYMLGREEFSLANDSKVMLYLQSLRNEAHRFAITSHRKKRDK
CCEEEEECCCCCCCCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFIVSQLSKIPGIGNKRKKALMSYFGSVKNISKASLAEIQNIPGISKGLAEVILKHVNYK
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
RGVLE
CCCCC
>Mature Secondary Structure
MLRQYKEQIKSSPQSCGVYKMVGDKNKVLYVGKAKNLKSRLSDYLQFENLSERIRVMLSQ
CCHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
VIKVEIFITENEIEALLLEAQLIKSLKPLYNIVLKDGKFYPYITISKHDYPRIAKYRGKF
HHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCC
KKNEFHYYGPFTSAAAVKQTILSLQKAFLLRVCSDQYFSSTKRPCIEYQIKRCSAPCVDK
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHH
ITKDDYCQSVKQARNTLLGRNKEVKEQLLFTMRKCSSEENYELAAIYRDRVKFLEQIQIQ
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
HTDFSFEKDADFFSIVREEDLACISVLSFRNKDNYGSTPYFAENCGDHSNDEILSTFLVN
CCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHH
FYNSANIPPIQIYVPDSIVDKEIIEQALYKVAQKPVKVLHAKNKKERDLLKFVYDNSQHS
HHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHH
LEQKLIDYRNNLEKLEELSKIFLLPNIPKRIEVYDNSHIFGNQQIGVMVVAGQEGFLKSE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEECCCCEEEEEEECCCCCHHHH
YRKFTIKEKFSGDDYKMMREVLTRRFSGNIKGIIPDFLLIDGGPGHVSIVQNVLEVLNIN
HHHEEEHHCCCCCHHHHHHHHHHHHHCCCCCEECCCEEEECCCCCHHHHHHHHHHHHCCC
VPFACMAKGPDRNAGNERFYMLGREEFSLANDSKVMLYLQSLRNEAHRFAITSHRKKRDK
CCEEEEECCCCCCCCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFIVSQLSKIPGIGNKRKKALMSYFGSVKNISKASLAEIQNIPGISKGLAEVILKHVNYK
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
RGVLE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA