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The map label for this gene is virB11 [H]

Identifier: 225629879

GI number: 225629879

Start: 7282

End: 8274

Strand: Direct

Name: virB11 [H]

Synonym: WRi_000080

Alternate gene names: 225629879

Gene position: 7282-8274 (Clockwise)

Preceding gene: 225629878

Following gene: 225629880

Centisome position: 0.5

GC content: 37.66

Gene sequence:

>993_bases
ATGAACTATGCTGCACTTGATACATATTTGGAGCCATTACAAGGCATATTTCAAGAAGAAGGCGTAAATGAAATATCAAT
AAATAAGCCAAAGGAAGTATGGATTGAAAATCGTGGTGAAATAAGGTGTGAAAAATTAGAAATATTCGATCTTAACCATT
TGAAATCTCTTGGCAGACTGATTGCTCAAGCTACAGAACAAAAACTTAGCGAAGAAGCACCTTTACTTTCGGCAACATTA
CCAAATGGTTATCGTATACAGATAGTATTTCCGCCAGCATGTGAGCCTGATAAAGTAGTCATGTCGATTCGTAAGCCTTC
TAGCATGCAGTTAGCACTCGATGATTACGAAAAAATGGGGGCTTTTTCTGAAACTGTTACAGAAGCAACTGATAATCCAG
TTGACCGTCATTTGGATTTATTGTTAAGGCAAAAAAAAATAAAAGAGTTTTTAGAATACGCTGTAATAAGTAAGAAAAAT
ATTATAATTAGTGGTGGAACTTCCACTGGTAAGACTACTTTTACTAATGCTACTTTGCGTGCTATTCCAGCTGAGGAAAG
AATTATTACTGTTGAGGATGCAAGGGAAATCGTTTTGAACGATCATCCCAATAAAGTCCATCTAATTGCCTCTAAAGGAG
GGCAGGGCAGAGCAAAAGTAACCACTCAAGATTTGATAGAAGCGTGCTTACGTTTAAGGCCAGACAGAATAATAGTTGGT
GAGCTCCGTGGAGCGGAAGCTTTTAGTTTTCTCAGGGCGATAAATACTGGTCACCCTGGATCAATATCAACCCTTCATGC
AGATAGTCCAACAATGGCCCTTGAGCAAATAAAATTGATGGTTATGCAGGCAAATCTTGGCATTCCTCCAGACCAAATTA
TACCATACATTAAAAATGTGATTGATATTGTTATTCAGCTAAAAAGAACCGGTGGGGGCAAAAGAAGCATTTCTGAGATA
TTATTTACTAGATCTGCGAGCGAAAATGCTTAA

Upstream 100 bases:

>100_bases
GATAAAAAACCAACTATTTATGTCGATCAAGGCACTGCATTGAAAGTATTTGTTAACCAAGATATAGTATTTCCTCCACA
GGCAATATTAAATCAATGAA

Downstream 100 bases:

>100_bases
ATTTATACATAAGTTAAGGAAGAGTAGTTTATGAGTAATGGAAATCACCTACGTAATATTCTCATAGGAGGTGTAGTAGC
TTTTAGCGTACTTGAGTTTT

Product: type IV secretion system ATPase VirB11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNYAALDTYLEPLQGIFQEEGVNEISINKPKEVWIENRGEIRCEKLEIFDLNHLKSLGRLIAQATEQKLSEEAPLLSATL
PNGYRIQIVFPPACEPDKVVMSIRKPSSMQLALDDYEKMGAFSETVTEATDNPVDRHLDLLLRQKKIKEFLEYAVISKKN
IIISGGTSTGKTTFTNATLRAIPAEERIITVEDAREIVLNDHPNKVHLIASKGGQGRAKVTTQDLIEACLRLRPDRIIVG
ELRGAEAFSFLRAINTGHPGSISTLHADSPTMALEQIKLMVMQANLGIPPDQIIPYIKNVIDIVIQLKRTGGGKRSISEI
LFTRSASENA

Sequences:

>Translated_330_residues
MNYAALDTYLEPLQGIFQEEGVNEISINKPKEVWIENRGEIRCEKLEIFDLNHLKSLGRLIAQATEQKLSEEAPLLSATL
PNGYRIQIVFPPACEPDKVVMSIRKPSSMQLALDDYEKMGAFSETVTEATDNPVDRHLDLLLRQKKIKEFLEYAVISKKN
IIISGGTSTGKTTFTNATLRAIPAEERIITVEDAREIVLNDHPNKVHLIASKGGQGRAKVTTQDLIEACLRLRPDRIIVG
ELRGAEAFSFLRAINTGHPGSISTLHADSPTMALEQIKLMVMQANLGIPPDQIIPYIKNVIDIVIQLKRTGGGKRSISEI
LFTRSASENA
>Mature_330_residues
MNYAALDTYLEPLQGIFQEEGVNEISINKPKEVWIENRGEIRCEKLEIFDLNHLKSLGRLIAQATEQKLSEEAPLLSATL
PNGYRIQIVFPPACEPDKVVMSIRKPSSMQLALDDYEKMGAFSETVTEATDNPVDRHLDLLLRQKKIKEFLEYAVISKKN
IIISGGTSTGKTTFTNATLRAIPAEERIITVEDAREIVLNDHPNKVHLIASKGGQGRAKVTTQDLIEACLRLRPDRIIVG
ELRGAEAFSFLRAINTGHPGSISTLHADSPTMALEQIKLMVMQANLGIPPDQIIPYIKNVIDIVIQLKRTGGGKRSISEI
LFTRSASENA

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 36622; Mature: 36622

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYAALDTYLEPLQGIFQEEGVNEISINKPKEVWIENRGEIRCEKLEIFDLNHLKSLGRL
CCCHHHHHHHHHHHHHHHHCCCCEEECCCCHHHEECCCCCEEEEEEEEECHHHHHHHHHH
IAQATEQKLSEEAPLLSATLPNGYRIQIVFPPACEPDKVVMSIRKPSSMQLALDDYEKMG
HHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCCCCEEEEECCCCCEEEEHHHHHHHC
AFSETVTEATDNPVDRHLDLLLRQKKIKEFLEYAVISKKNIIISGGTSTGKTTFTNATLR
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCEEE
AIPAEERIITVEDAREIVLNDHPNKVHLIASKGGQGRAKVTTQDLIEACLRLRPDRIIVG
ECCCCCCEEECCCCCEEEECCCCCEEEEEEECCCCCCEEECHHHHHHHHHHCCCCEEEEE
ELRGAEAFSFLRAINTGHPGSISTLHADSPTMALEQIKLMVMQANLGIPPDQIIPYIKNV
ECCCHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHEECCCCCCHHHHHHHHHHH
IDIVIQLKRTGGGKRSISEILFTRSASENA
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNYAALDTYLEPLQGIFQEEGVNEISINKPKEVWIENRGEIRCEKLEIFDLNHLKSLGRL
CCCHHHHHHHHHHHHHHHHCCCCEEECCCCHHHEECCCCCEEEEEEEEECHHHHHHHHHH
IAQATEQKLSEEAPLLSATLPNGYRIQIVFPPACEPDKVVMSIRKPSSMQLALDDYEKMG
HHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCCCCEEEEECCCCCEEEEHHHHHHHC
AFSETVTEATDNPVDRHLDLLLRQKKIKEFLEYAVISKKNIIISGGTSTGKTTFTNATLR
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCEEE
AIPAEERIITVEDAREIVLNDHPNKVHLIASKGGQGRAKVTTQDLIEACLRLRPDRIIVG
ECCCCCCEEECCCCCEEEECCCCCEEEEEEECCCCCCEEECHHHHHHHHHHCCCCEEEEE
ELRGAEAFSFLRAINTGHPGSISTLHADSPTMALEQIKLMVMQANLGIPPDQIIPYIKNV
ECCCHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHEECCCCCCHHHHHHHHHHH
IDIVIQLKRTGGGKRSISEILFTRSASENA
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]