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The map label for this gene is ribA [H]

Identifier: 225629875

GI number: 225629875

Start: 3145

End: 4227

Strand: Direct

Name: ribA [H]

Synonym: WRi_000040

Alternate gene names: 225629875

Gene position: 3145-4227 (Clockwise)

Preceding gene: 225629873

Following gene: 225629876

Centisome position: 0.22

GC content: 33.33

Gene sequence:

>1083_bases
ATGTTTATAGGAAATCAGAGTAGCAATAAGGTAGAAAGAGCTATCAGCGAAATCAGGCGCGGTCGGCCAATTGTAATATA
TGATGAAAGTAATTACCTATTGTTCGCTGCTGCTGAGGCTTTAGAAAGAGATTTATTTAATCAATACAAGCTTATATCAA
GTAATGTATATGTTACTTTAACTTCAAGTAAGGTAAAATACATATCTCAGAATAAAGAACATAACAGCAAACGTCTGTTG
GTGAATAATTTTGATGAACTGCTCCATTTAATAAACTGTTCAAAGGAAGATTGCATAAAAGAGTTGCAATGCTCAAAGAC
AATAGATGAATGTGCTATTGCCTTGCTTAAGTTCTCAGAATTATTGCCATACGCGTTAGTAGCTGATATGACTTTTGAGA
ATAAGTATGAAATGCGAAATTGGTGTGAAGAAAATGACATTATTGCACTAGATACGTTACTCGTAAATGATTTTCAACAA
AATCAGAGTGTGTATGAAGTGTGCAAAACATCATTATTTTTAAAACAGACTCAAGAAGTAGATATCATATCTTATAGAAC
CGAAAGTGGCGGAAGAGAACATCATGCAATTATCATTGGCAATCCAGATAAAGATGACGAACCATTAGTAAGAATTCATT
CTTCGTGCTATACGGGTGACTTGTTAGATAGCTTATCATGCGATTGCAGAAGTCAGTTACATCAAGCAATTCAAATGATA
GCTGACTTTGGAAGTGGTATTATATTGTATTTGATGCAGGATGGAAGAGGTATTGGTTTAACTAATAAGTTAAGAGCATA
CAGTGTGCAAAGAGAACATAACCTTGATACTGTTGATGCAAATAGAATATTGGGTTTTGAAGATGATGAAAGGAGTTTTG
TTGTTGCAGCTAAAATGCTTAAGAAATTGAACATTAACAAAATCCAATTACTTACAAACAATGATAGGAAATTGTCAGAA
TTGGAAAGTAGTGGTATAGAGGTTACAAAGTGTCTACCACTTATTGTGGAACGTAATAAATATAACGATTCATATATGGA
GACAAAGTTTGGTAAGCTAGGCCATAAGTTAAGAGTTTTTTAG

Upstream 100 bases:

>100_bases
GGTAGACACGCAGCGTTGAGGTCGCTGTGGCTCATAAGGCCTTGGAAGTTCAAGTCTTCTCGGCCGCACCAGTTTTTATC
GCTGTTTAATATGGGTAAAA

Downstream 100 bases:

>100_bases
CTTTTTTGTTGTAACTACTTTGTTAATTTGCTATGTTTATTAACACAAGTTAAGATTTTTAAGAATATTAAAATGCTAAG
ATTTTTTAAGCGAGAGAAAA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MFIGNQSSNKVERAISEIRRGRPIVIYDESNYLLFAAAEALERDLFNQYKLISSNVYVTLTSSKVKYISQNKEHNSKRLL
VNNFDELLHLINCSKEDCIKELQCSKTIDECAIALLKFSELLPYALVADMTFENKYEMRNWCEENDIIALDTLLVNDFQQ
NQSVYEVCKTSLFLKQTQEVDIISYRTESGGREHHAIIIGNPDKDDEPLVRIHSSCYTGDLLDSLSCDCRSQLHQAIQMI
ADFGSGIILYLMQDGRGIGLTNKLRAYSVQREHNLDTVDANRILGFEDDERSFVVAAKMLKKLNINKIQLLTNNDRKLSE
LESSGIEVTKCLPLIVERNKYNDSYMETKFGKLGHKLRVF

Sequences:

>Translated_360_residues
MFIGNQSSNKVERAISEIRRGRPIVIYDESNYLLFAAAEALERDLFNQYKLISSNVYVTLTSSKVKYISQNKEHNSKRLL
VNNFDELLHLINCSKEDCIKELQCSKTIDECAIALLKFSELLPYALVADMTFENKYEMRNWCEENDIIALDTLLVNDFQQ
NQSVYEVCKTSLFLKQTQEVDIISYRTESGGREHHAIIIGNPDKDDEPLVRIHSSCYTGDLLDSLSCDCRSQLHQAIQMI
ADFGSGIILYLMQDGRGIGLTNKLRAYSVQREHNLDTVDANRILGFEDDERSFVVAAKMLKKLNINKIQLLTNNDRKLSE
LESSGIEVTKCLPLIVERNKYNDSYMETKFGKLGHKLRVF
>Mature_360_residues
MFIGNQSSNKVERAISEIRRGRPIVIYDESNYLLFAAAEALERDLFNQYKLISSNVYVTLTSSKVKYISQNKEHNSKRLL
VNNFDELLHLINCSKEDCIKELQCSKTIDECAIALLKFSELLPYALVADMTFENKYEMRNWCEENDIIALDTLLVNDFQQ
NQSVYEVCKTSLFLKQTQEVDIISYRTESGGREHHAIIIGNPDKDDEPLVRIHSSCYTGDLLDSLSCDCRSQLHQAIQMI
ADFGSGIILYLMQDGRGIGLTNKLRAYSVQREHNLDTVDANRILGFEDDERSFVVAAKMLKKLNINKIQLLTNNDRKLSE
LESSGIEVTKCLPLIVERNKYNDSYMETKFGKLGHKLRVF

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=176, Percent_Identity=45.4545454545455, Blast_Score=159, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6319438, Length=176, Percent_Identity=35.7954545454545, Blast_Score=99, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 41295; Mature: 41295

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIGNQSSNKVERAISEIRRGRPIVIYDESNYLLFAAAEALERDLFNQYKLISSNVYVTL
CCCCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEEEHHHHHHHHHHHHEEECCCEEEEE
TSSKVKYISQNKEHNSKRLLVNNFDELLHLINCSKEDCIKELQCSKTIDECAIALLKFSE
ECCHHHHHHCCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
LLPYALVADMTFENKYEMRNWCEENDIIALDTLLVNDFQQNQSVYEVCKTSLFLKQTQEV
HCCHHHHHHCCCCCCHHHHHCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHCCCE
DIISYRTESGGREHHAIIIGNPDKDDEPLVRIHSSCYTGDLLDSLSCDCRSQLHQAIQMI
EEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHH
ADFGSGIILYLMQDGRGIGLTNKLRAYSVQREHNLDTVDANRILGFEDDERSFVVAAKML
HHCCCCEEEEEEECCCCCCCCCHHHHEEEHHHCCCCCCCCCCEECCCCCCCHHHHHHHHH
KKLNINKIQLLTNNDRKLSELESSGIEVTKCLPLIVERNKYNDSYMETKFGKLGHKLRVF
HHCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEECC
>Mature Secondary Structure
MFIGNQSSNKVERAISEIRRGRPIVIYDESNYLLFAAAEALERDLFNQYKLISSNVYVTL
CCCCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEEEHHHHHHHHHHHHEEECCCEEEEE
TSSKVKYISQNKEHNSKRLLVNNFDELLHLINCSKEDCIKELQCSKTIDECAIALLKFSE
ECCHHHHHHCCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
LLPYALVADMTFENKYEMRNWCEENDIIALDTLLVNDFQQNQSVYEVCKTSLFLKQTQEV
HCCHHHHHHCCCCCCHHHHHCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHCCCE
DIISYRTESGGREHHAIIIGNPDKDDEPLVRIHSSCYTGDLLDSLSCDCRSQLHQAIQMI
EEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHH
ADFGSGIILYLMQDGRGIGLTNKLRAYSVQREHNLDTVDANRILGFEDDERSFVVAAKML
HHCCCCEEEEEEECCCCCCCCCHHHHEEEHHHCCCCCCCCCCEECCCCCCCHHHHHHHHH
KKLNINKIQLLTNNDRKLSELESSGIEVTKCLPLIVERNKYNDSYMETKFGKLGHKLRVF
HHCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7883178 [H]