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The map label for this gene is cyaA [H]

Identifier: 222527017

GI number: 222527017

Start: 4728013

End: 4729245

Strand: Reverse

Name: cyaA [H]

Synonym: Chy400_3796

Alternate gene names: 222527017

Gene position: 4729245-4728013 (Counterclockwise)

Preceding gene: 222527018

Following gene: 222527016

Centisome position: 89.76

GC content: 45.17

Gene sequence:

>1233_bases
ATGAAAGCGTTCCATCACGTGTCAACCCCCACGCTCATTGAAGAGAGCATTTATGGTACGTTTCGTGCCCGATTTGCACT
TGAGCTGTTCAACAACACATTGTATTTTCCTATCACCAATATCCTGTACGAATTGCTCATGGGGCACCCCCTTGACTATC
TTCGATCATCAGACCCTTACATCATCATCGTTGCTGCGCTTATACAGGCCTATTGGCTAACCTGTCAGGCCGAAAAACGG
CTTCATCGACTGTTTGGACATTTAATAGGGCCAGCTATTTATACGTTCATCGAAGCATCTCTGGAAGGTGCCCAATTCTT
TACCGAGCCTAACCACCTGGCGTATTGGTTCTTTTCGATAGCGATTGGGATTGTGCAGGAATTAAAGCTTTACCTGCCGC
GCTTTTCTTCGCTATTTACCATCATCGAAAATGCTACTCGTGTCTCTATCCTCTTTTTTATGTATGGAATATTTGAAACC
CATGTAAATCATGATCAGACACTGTCGTTAATGTCGTTCTTTGCCGATCCCAGCCATGTGTTTGTTGGCATGTCGGTAAT
GATCATTGGTTTAAGTATTGGTTTGGCTAATGTTACTGCTGATACCTATCTGAAAAAGCTACGGCATACGTCGCAGATGC
TAAAAACGTATTCTGAATGGCTTCTTGGAAGAGACCTTTTGGTGCGATCCCTGAGTGATCCAACAGCTTTACAAACTACA
CGTCGTGAACGAACAATTTTGTTTATGGACATCCGGGGATTTACTGCCTGGAGCGAAGTTCATACACCTGAAGAAGTAGT
TGATCTTCTCAATGAGTATTATCGTCGATCCGAGTCGATTCTTCTCCAACACTCGGCAATCAAATGGAAATTCACGGCTG
ATGAAGTCATGGCTATTTTTCCCCACATCCAGGCAGCAATTGCCGCTGCGAACAGGATGATCGACGAAATCCATCGATTT
TTGACCGATAAACAACTTGGCGTAGGGATTGGCATCGACGTTGGTCCGGTTGTTGAAGGGTTGCTGGGTGGTGCGAACGT
GCGTTTCTACGATGCCATGGGTGATACTGTAAATACGGCCAAACGAATCGAGAATCACGCTCAGGCAGGTGAAATTCTGA
TTTCCGAACGAGCGCAACAATACCTTACTGCGACAATACCAGTGGCAAATCGTCGTGAACTGCGTGCTAAAGGTAAGTCA
CAAGCTATTATCACCTACTTGCTGAATGCCTGA

Upstream 100 bases:

>100_bases
CAGTGTGCTCTTGCTGACGATCTATCGGGTGCTGGTGACGATGGTGCTGAGGAAAAAAGAGCGATTGTAATCATTTCCTT
TAGATGTGGAGGTGCCATCC

Downstream 100 bases:

>100_bases
ACGTAGCCGTAGACAAGAGATCGACCTTTTTCGGCTACACCCTGGTTGCCATCGTTGTCAGACTACGGTACAATCAAGAG
GTTAGATACCGAACTTTAAG

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKAFHHVSTPTLIEESIYGTFRARFALELFNNTLYFPITNILYELLMGHPLDYLRSSDPYIIIVAALIQAYWLTCQAEKR
LHRLFGHLIGPAIYTFIEASLEGAQFFTEPNHLAYWFFSIAIGIVQELKLYLPRFSSLFTIIENATRVSILFFMYGIFET
HVNHDQTLSLMSFFADPSHVFVGMSVMIIGLSIGLANVTADTYLKKLRHTSQMLKTYSEWLLGRDLLVRSLSDPTALQTT
RRERTILFMDIRGFTAWSEVHTPEEVVDLLNEYYRRSESILLQHSAIKWKFTADEVMAIFPHIQAAIAAANRMIDEIHRF
LTDKQLGVGIGIDVGPVVEGLLGGANVRFYDAMGDTVNTAKRIENHAQAGEILISERAQQYLTATIPVANRRELRAKGKS
QAIITYLLNA

Sequences:

>Translated_410_residues
MKAFHHVSTPTLIEESIYGTFRARFALELFNNTLYFPITNILYELLMGHPLDYLRSSDPYIIIVAALIQAYWLTCQAEKR
LHRLFGHLIGPAIYTFIEASLEGAQFFTEPNHLAYWFFSIAIGIVQELKLYLPRFSSLFTIIENATRVSILFFMYGIFET
HVNHDQTLSLMSFFADPSHVFVGMSVMIIGLSIGLANVTADTYLKKLRHTSQMLKTYSEWLLGRDLLVRSLSDPTALQTT
RRERTILFMDIRGFTAWSEVHTPEEVVDLLNEYYRRSESILLQHSAIKWKFTADEVMAIFPHIQAAIAAANRMIDEIHRF
LTDKQLGVGIGIDVGPVVEGLLGGANVRFYDAMGDTVNTAKRIENHAQAGEILISERAQQYLTATIPVANRRELRAKGKS
QAIITYLLNA
>Mature_410_residues
MKAFHHVSTPTLIEESIYGTFRARFALELFNNTLYFPITNILYELLMGHPLDYLRSSDPYIIIVAALIQAYWLTCQAEKR
LHRLFGHLIGPAIYTFIEASLEGAQFFTEPNHLAYWFFSIAIGIVQELKLYLPRFSSLFTIIENATRVSILFFMYGIFET
HVNHDQTLSLMSFFADPSHVFVGMSVMIIGLSIGLANVTADTYLKKLRHTSQMLKTYSEWLLGRDLLVRSLSDPTALQTT
RRERTILFMDIRGFTAWSEVHTPEEVVDLLNEYYRRSESILLQHSAIKWKFTADEVMAIFPHIQAAIAAANRMIDEIHRF
LTDKQLGVGIGIDVGPVVEGLLGGANVRFYDAMGDTVNTAKRIENHAQAGEILISERAQQYLTATIPVANRRELRAKGKS
QAIITYLLNA

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI4580422, Length=179, Percent_Identity=32.4022346368715, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI167830411, Length=179, Percent_Identity=31.8435754189944, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561804, Length=179, Percent_Identity=30.7262569832402, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17534657, Length=171, Percent_Identity=30.9941520467836, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86564713, Length=208, Percent_Identity=28.3653846153846, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17534659, Length=184, Percent_Identity=34.2391304347826, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193206054, Length=235, Percent_Identity=28.936170212766, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17534653, Length=205, Percent_Identity=28.780487804878, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17534655, Length=250, Percent_Identity=26.8, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17534649, Length=205, Percent_Identity=27.8048780487805, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561800, Length=210, Percent_Identity=30.952380952381, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17568383, Length=191, Percent_Identity=31.9371727748691, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995305, Length=204, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17534651, Length=205, Percent_Identity=27.3170731707317, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561802, Length=210, Percent_Identity=30.952380952381, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193207841, Length=191, Percent_Identity=29.8429319371728, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI212645052, Length=179, Percent_Identity=31.2849162011173, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193210669, Length=224, Percent_Identity=26.7857142857143, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71994363, Length=189, Percent_Identity=27.5132275132275, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI161076872, Length=150, Percent_Identity=32.6666666666667, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28574512, Length=150, Percent_Identity=32.6666666666667, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24647268, Length=204, Percent_Identity=30.8823529411765, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281366459, Length=184, Percent_Identity=31.5217391304348, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI281366457, Length=184, Percent_Identity=31.5217391304348, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI281366455, Length=184, Percent_Identity=31.5217391304348, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI56292422, Length=184, Percent_Identity=31.5217391304348, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI56292424, Length=184, Percent_Identity=31.5217391304348, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24666940, Length=184, Percent_Identity=31.5217391304348, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 46622; Mature: 46622

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFHHVSTPTLIEESIYGTFRARFALELFNNTLYFPITNILYELLMGHPLDYLRSSDPY
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHCCCHHHHCCCCCE
IIIVAALIQAYWLTCQAEKRLHRLFGHLIGPAIYTFIEASLEGAQFFTEPNHLAYWFFSI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHH
AIGIVQELKLYLPRFSSLFTIIENATRVSILFFMYGIFETHVNHDQTLSLMSFFADPSHV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHH
FVGMSVMIIGLSIGLANVTADTYLKKLRHTSQMLKTYSEWLLGRDLLVRSLSDPTALQTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RRERTILFMDIRGFTAWSEVHTPEEVVDLLNEYYRRSESILLQHSAIKWKFTADEVMAIF
CCCCEEEEEEECCCCCHHHCCCHHHHHHHHHHHHHCCHHEEEEECCEEEEECHHHHHHHH
PHIQAAIAAANRMIDEIHRFLTDKQLGVGIGIDVGPVVEGLLGGANVRFYDAMGDTVNTA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHH
KRIENHAQAGEILISERAQQYLTATIPVANRRELRAKGKSQAIITYLLNA
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHCCCCCEEHHEEECC
>Mature Secondary Structure
MKAFHHVSTPTLIEESIYGTFRARFALELFNNTLYFPITNILYELLMGHPLDYLRSSDPY
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHCCCHHHHCCCCCE
IIIVAALIQAYWLTCQAEKRLHRLFGHLIGPAIYTFIEASLEGAQFFTEPNHLAYWFFSI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHH
AIGIVQELKLYLPRFSSLFTIIENATRVSILFFMYGIFETHVNHDQTLSLMSFFADPSHV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHH
FVGMSVMIIGLSIGLANVTADTYLKKLRHTSQMLKTYSEWLLGRDLLVRSLSDPTALQTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RRERTILFMDIRGFTAWSEVHTPEEVVDLLNEYYRRSESILLQHSAIKWKFTADEVMAIF
CCCCEEEEEEECCCCCHHHCCCHHHHHHHHHHHHHCCHHEEEEECCEEEEECHHHHHHHH
PHIQAAIAAANRMIDEIHRFLTDKQLGVGIGIDVGPVVEGLLGGANVRFYDAMGDTVNTA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHH
KRIENHAQAGEILISERAQQYLTATIPVANRRELRAKGKSQAIITYLLNA
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHCCCCCEEHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]