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The map label for this gene is rsbRA [H]

Identifier: 222526948

GI number: 222526948

Start: 4644219

End: 4645268

Strand: Reverse

Name: rsbRA [H]

Synonym: Chy400_3726

Alternate gene names: 222526948

Gene position: 4645268-4644219 (Counterclockwise)

Preceding gene: 222526949

Following gene: 222526947

Centisome position: 88.16

GC content: 54.38

Gene sequence:

>1050_bases
GTGAACAGAGATAGTGAATGTGAGCATTGTTTCCGTAAGGAACTGCTCAGCAATGTCGAGTCGCTGATCCGATCTTTACG
TAATGCGCATGAACGCTACAGTCTGCTTCAAGTATCCGATCAAGATATGATTGTCCGCCAGACCGAAACCCTTCTGAGTC
TGACGCAAGCATTGCAAGAACAGATACCCCCTGACGTCCAATCACTGACTGAAGCGCAAGCCGACGTCTTATACGAAACA
ATTGAGACGATTGAAGAGCAACGTGAACAATTCTCAGCCCAGGCAATGGAGTATATTGCGGACATGAAGGCGGCTACACA
GCGCCAGATAGCCATCGAAGTGATGGCAACGTTTACCGGTATTGGGGTAGCGCTGGCAGGCATGGGGGTACTTACGCTGT
TCCTGCTCTGGCTGATCGAGCGCTCGATTGTCCGCCCCTTGCGGCATCTCTCTGCTGCCGCAGCAGCGCTGGCCGAAGGG
CGCTCTGATCAACCAATCACCATTACCAGTGAAGACGAAGTCGGTGCACTACAACGAGCGTTCAACCAAATGACCGACAC
AATCCGGCGGCAAACTCGCGATCTGGAACGGCTCTACCAGCAGGCAATTCAGTCCCGCGATGCAATCGAAGCCGCACACC
GACAGGTGTCGGAACAACTGGCAATTATTCAGCAGCAACGCGATGCTATTCGCGAACTAAGCGTACCGGTGCTACCGATC
AATCGCGACACCCTGGTGATGCCGCTGGTTGGAGCGCTTGATACGGCACGCTTGAGCCAGGTACAGGAGCAGGCGCTTGG
ACGGCTTGCCGCGACCGGCGCCCGTCGATTGTTACTCGACGTTACCGGTGTACCGGTGATCGATACCCAGATAGCGCAGG
GGTTAATCCGGGTAGTACAGGCTGCACGCTTGCTTGGGGCACAGGTCGTCCTGGTCGGTATCCGCCCTGAAGTTGTGCAA
TCAATTGTTGGCCTTGGTGTGCATTTGAATGGTATTCGTTCGTTTAGTGACCTGCAGAGCGCTCTGAAATTGTCAGGAGA
TCAGGGATGA

Upstream 100 bases:

>100_bases
GCACCACAGAGCCACAGAGAACACAGAGATGTTCTGTATCCTTACGCTGGCGGTTATTCCCGGTGCAGTGTAGTGAGGAA
TTGCACCACAGAGACACTAA

Downstream 100 bases:

>100_bases
TCCGCCTCACACAGCAACAGATCAACCACGGCGTTTTTGGCTTCCTTACCGGATTGGCCGTCATTGCACTTTTTCTTGCA
TTCTTTCCCGAACCACTATT

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MNRDSECEHCFRKELLSNVESLIRSLRNAHERYSLLQVSDQDMIVRQTETLLSLTQALQEQIPPDVQSLTEAQADVLYET
IETIEEQREQFSAQAMEYIADMKAATQRQIAIEVMATFTGIGVALAGMGVLTLFLLWLIERSIVRPLRHLSAAAAALAEG
RSDQPITITSEDEVGALQRAFNQMTDTIRRQTRDLERLYQQAIQSRDAIEAAHRQVSEQLAIIQQQRDAIRELSVPVLPI
NRDTLVMPLVGALDTARLSQVQEQALGRLAATGARRLLLDVTGVPVIDTQIAQGLIRVVQAARLLGAQVVLVGIRPEVVQ
SIVGLGVHLNGIRSFSDLQSALKLSGDQG

Sequences:

>Translated_349_residues
MNRDSECEHCFRKELLSNVESLIRSLRNAHERYSLLQVSDQDMIVRQTETLLSLTQALQEQIPPDVQSLTEAQADVLYET
IETIEEQREQFSAQAMEYIADMKAATQRQIAIEVMATFTGIGVALAGMGVLTLFLLWLIERSIVRPLRHLSAAAAALAEG
RSDQPITITSEDEVGALQRAFNQMTDTIRRQTRDLERLYQQAIQSRDAIEAAHRQVSEQLAIIQQQRDAIRELSVPVLPI
NRDTLVMPLVGALDTARLSQVQEQALGRLAATGARRLLLDVTGVPVIDTQIAQGLIRVVQAARLLGAQVVLVGIRPEVVQ
SIVGLGVHLNGIRSFSDLQSALKLSGDQG
>Mature_349_residues
MNRDSECEHCFRKELLSNVESLIRSLRNAHERYSLLQVSDQDMIVRQTETLLSLTQALQEQIPPDVQSLTEAQADVLYET
IETIEEQREQFSAQAMEYIADMKAATQRQIAIEVMATFTGIGVALAGMGVLTLFLLWLIERSIVRPLRHLSAAAAALAEG
RSDQPITITSEDEVGALQRAFNQMTDTIRRQTRDLERLYQQAIQSRDAIEAAHRQVSEQLAIIQQQRDAIRELSVPVLPI
NRDTLVMPLVGALDTARLSQVQEQALGRLAATGARRLLLDVTGVPVIDTQIAQGLIRVVQAARLLGAQVVLVGIRPEVVQ
SIVGLGVHLNGIRSFSDLQSALKLSGDQG

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: 2.7.3.- [C]

Molecular weight: Translated: 38571; Mature: 38571

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50885 HAMP ; PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRDSECEHCFRKELLSNVESLIRSLRNAHERYSLLQVSDQDMIVRQTETLLSLTQALQE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QIPPDVQSLTEAQADVLYETIETIEEQREQFSAQAMEYIADMKAATQRQIAIEVMATFTG
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGVALAGMGVLTLFLLWLIERSIVRPLRHLSAAAAALAEGRSDQPITITSEDEVGALQRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHH
FNQMTDTIRRQTRDLERLYQQAIQSRDAIEAAHRQVSEQLAIIQQQRDAIRELSVPVLPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
NRDTLVMPLVGALDTARLSQVQEQALGRLAATGARRLLLDVTGVPVIDTQIAQGLIRVVQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AARLLGAQVVLVGIRPEVVQSIVGLGVHLNGIRSFSDLQSALKLSGDQG
HHHHHCCHHEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNRDSECEHCFRKELLSNVESLIRSLRNAHERYSLLQVSDQDMIVRQTETLLSLTQALQE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QIPPDVQSLTEAQADVLYETIETIEEQREQFSAQAMEYIADMKAATQRQIAIEVMATFTG
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGVALAGMGVLTLFLLWLIERSIVRPLRHLSAAAAALAEGRSDQPITITSEDEVGALQRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHH
FNQMTDTIRRQTRDLERLYQQAIQSRDAIEAAHRQVSEQLAIIQQQRDAIRELSVPVLPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
NRDTLVMPLVGALDTARLSQVQEQALGRLAATGARRLLLDVTGVPVIDTQIAQGLIRVVQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AARLLGAQVVLVGIRPEVVQSIVGLGVHLNGIRSFSDLQSALKLSGDQG
HHHHHCCHHEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with a nitrogenous group as acceptor [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]