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The map label for this gene is icd [H]

Identifier: 222526367

GI number: 222526367

Start: 3876264

End: 3878066

Strand: Reverse

Name: icd [H]

Synonym: Chy400_3133

Alternate gene names: 222526367

Gene position: 3878066-3876264 (Counterclockwise)

Preceding gene: 222526382

Following gene: 222526363

Centisome position: 73.6

GC content: 57.52

Gene sequence:

>1803_bases
ATGAAACCGACGCCAGCAGGCGAAGCCATTCAAATCAGCAACGGGCGCTTGCAAGTACCCGATCATCCAATTATTCCATT
CGTAGAAGGTGACGGTACCGGACGTGACATCTGGCGGGCAAGTGTACGTGTCTTCGACGCGGCGGTTGCACTGGCTTACG
GCGGAAAGCGTAAGATCGAGTGGCTTGAGGTGTTGGCAGGCGAAAAAGCCTTCCACGAGACGGGTAACTGGCTCCCCGAC
GAGACAATTGAGACGTTTCAGAAGTACCTGGTCGGGATCAAAGGCCCATTGACAACCCCGGTCGGCGGTGGCATTCGCTC
GTTGAACGTTGCCTTGCGCAAGCATCTCGATCTCTACGTCTGTCAGCGGCCGGTTCGCCATTTTGCCGGTGTTCCTTCGC
CGGTCAAGCACCCGGAGAAGGTTGATATGGTTATCTTCCGTGAGAACACGGAGGATGTTTACACCGGCATCGAGTATCGC
GGCGGTAGCGAAGAAGCGGCGAAGATCATCGCATTTTTGCAGCGTGAATTCCCGAAGGATTTCGACAAGATTCGCTTCGG
CACGCCTGAAAAGACTGATGAATTCCGCCAACTGATCGGCGAAGAACCGGAAGGAAAGATTGAGGTTGGCATCGGTATCA
AGCCAATCAGCCGCATTGGTACCGAGCGCATCATGGCAGCGGCTATTCAGTACGCCATTACCTACAAGCGCAAGAGCATC
ACCCTGATGCACAAGGGTAACATCCAGAAATTCACCGAGGGCGCTTTCCGCGATTGGGCCTATGAATATGCTGAGCGGGC
CTTTGGTGATTATGTCTATACGTGGGCACAATGGGAGCGCACGAAGGCTGCGCGGGGTGAAGCAGCGGCGAATGCCGAGC
AGAAAGAGGCGCTGGCCGCCGGTAAGATTCTGGTCAAGGACGCAATTGCCGACATTATCTTCCAGCAGGTTCTGACCCGC
CCCGATGAGTTTGATGTGATTGTTGCGCCGAACCTCAACGGCGACTACCTCTCTGACGCCCTCGCGGCCCAGGTCGGTGG
CATCGGGATCGCCCCTGGCGGTAACATCAATTACGTCACCGGTCACGCTATCTTCGAGGCTACCCACGGTACGGCACCAA
AATATGCCGATCTTGACAAGGTCAACCCCGGCTCAGTCATTCTGTCGGGTGAGATGATGCTGCGCTATATGGGCTGGACG
GAAGCCGCCGATCTGATTATTGCCGGCCTCGAGCGCACCATTGCCGACAAGACGGTGACATACGACTTTGCCCGTCTGAT
GGAGGGCGCGCGCGAGGTGAAGACCTCGGAGTTTGCCAGCCTGATCATTGCCAACATGGAGAAGATCGTTGCCGGCGATG
TGCCGCATCCCACCCCGACCTTCGGCCCGGAGATTCTGCGCCGTGCCGATGGCCGTGTTTACCCGCACGGCAGTGTTGGT
GCGGTGATGACACGGGCGGTGGTGGCGGTACCGGCGGAAGCCTCGCTCCGCGAGACATCGATCTATATGCGTGGACGTGG
CATCCATTCGGTGATTGTCAAACCCGACGCCAGCGGCGAATGGGGCATTATGACTATGCGTGACGTGTTGAAGAAGGTCG
TGCGCGAGGGCCGGGCCATCGATGGTTTGACCGTCGGTGATCTGACGAGCCGGCCATTGCTGAGTGTTAGCCCGGATACG
CCGATTACCGAATGCGCAGCGTTGATGGTCGAGCGCAATATTCGCCGGCTGGCGGTATTTGAGAATGGCGAGCCGGTTGG
GATTATCTCTGAGACTGACATCTTCAGCCACGTGGCGGAGTAG

Upstream 100 bases:

>100_bases
AGAACGGGATTATATCGCATGGTAATAGTGGTCAAGACAGCGATTGTCGGCTATAATACAGGCCGCAATCTATTGTAAGG
CATGTTTAAGGAGAGTAACC

Downstream 100 bases:

>100_bases
GCCGGATATAACAGGGGTAATGTTCGGGCAGCCTGGATGTCATTAGAGCGCATCCGCAGTATTCTGACAGGCGGGGTAGG
TGAAGGCAATAGCTTCACCT

Product: isocitrate dehydrogenase, NADP-dependent

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MKPTPAGEAIQISNGRLQVPDHPIIPFVEGDGTGRDIWRASVRVFDAAVALAYGGKRKIEWLEVLAGEKAFHETGNWLPD
ETIETFQKYLVGIKGPLTTPVGGGIRSLNVALRKHLDLYVCQRPVRHFAGVPSPVKHPEKVDMVIFRENTEDVYTGIEYR
GGSEEAAKIIAFLQREFPKDFDKIRFGTPEKTDEFRQLIGEEPEGKIEVGIGIKPISRIGTERIMAAAIQYAITYKRKSI
TLMHKGNIQKFTEGAFRDWAYEYAERAFGDYVYTWAQWERTKAARGEAAANAEQKEALAAGKILVKDAIADIIFQQVLTR
PDEFDVIVAPNLNGDYLSDALAAQVGGIGIAPGGNINYVTGHAIFEATHGTAPKYADLDKVNPGSVILSGEMMLRYMGWT
EAADLIIAGLERTIADKTVTYDFARLMEGAREVKTSEFASLIIANMEKIVAGDVPHPTPTFGPEILRRADGRVYPHGSVG
AVMTRAVVAVPAEASLRETSIYMRGRGIHSVIVKPDASGEWGIMTMRDVLKKVVREGRAIDGLTVGDLTSRPLLSVSPDT
PITECAALMVERNIRRLAVFENGEPVGIISETDIFSHVAE

Sequences:

>Translated_600_residues
MKPTPAGEAIQISNGRLQVPDHPIIPFVEGDGTGRDIWRASVRVFDAAVALAYGGKRKIEWLEVLAGEKAFHETGNWLPD
ETIETFQKYLVGIKGPLTTPVGGGIRSLNVALRKHLDLYVCQRPVRHFAGVPSPVKHPEKVDMVIFRENTEDVYTGIEYR
GGSEEAAKIIAFLQREFPKDFDKIRFGTPEKTDEFRQLIGEEPEGKIEVGIGIKPISRIGTERIMAAAIQYAITYKRKSI
TLMHKGNIQKFTEGAFRDWAYEYAERAFGDYVYTWAQWERTKAARGEAAANAEQKEALAAGKILVKDAIADIIFQQVLTR
PDEFDVIVAPNLNGDYLSDALAAQVGGIGIAPGGNINYVTGHAIFEATHGTAPKYADLDKVNPGSVILSGEMMLRYMGWT
EAADLIIAGLERTIADKTVTYDFARLMEGAREVKTSEFASLIIANMEKIVAGDVPHPTPTFGPEILRRADGRVYPHGSVG
AVMTRAVVAVPAEASLRETSIYMRGRGIHSVIVKPDASGEWGIMTMRDVLKKVVREGRAIDGLTVGDLTSRPLLSVSPDT
PITECAALMVERNIRRLAVFENGEPVGIISETDIFSHVAE
>Mature_600_residues
MKPTPAGEAIQISNGRLQVPDHPIIPFVEGDGTGRDIWRASVRVFDAAVALAYGGKRKIEWLEVLAGEKAFHETGNWLPD
ETIETFQKYLVGIKGPLTTPVGGGIRSLNVALRKHLDLYVCQRPVRHFAGVPSPVKHPEKVDMVIFRENTEDVYTGIEYR
GGSEEAAKIIAFLQREFPKDFDKIRFGTPEKTDEFRQLIGEEPEGKIEVGIGIKPISRIGTERIMAAAIQYAITYKRKSI
TLMHKGNIQKFTEGAFRDWAYEYAERAFGDYVYTWAQWERTKAARGEAAANAEQKEALAAGKILVKDAIADIIFQQVLTR
PDEFDVIVAPNLNGDYLSDALAAQVGGIGIAPGGNINYVTGHAIFEATHGTAPKYADLDKVNPGSVILSGEMMLRYMGWT
EAADLIIAGLERTIADKTVTYDFARLMEGAREVKTSEFASLIIANMEKIVAGDVPHPTPTFGPEILRRADGRVYPHGSVG
AVMTRAVVAVPAEASLRETSIYMRGRGIHSVIVKPDASGEWGIMTMRDVLKKVVREGRAIDGLTVGDLTSRPLLSVSPDT
PITECAALMVERNIRRLAVFENGEPVGIISETDIFSHVAE

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=403, Percent_Identity=31.7617866004963, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1787381, Length=442, Percent_Identity=56.1085972850679, Blast_Score=480, Evalue=1e-136,
Organism=Escherichia coli, GI1788101, Length=408, Percent_Identity=27.6960784313726, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI87081683, Length=433, Percent_Identity=24.4803695150115, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71986051, Length=410, Percent_Identity=30.4878048780488, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI25144293, Length=398, Percent_Identity=26.3819095477387, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324709, Length=397, Percent_Identity=30.4785894206549, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322097, Length=402, Percent_Identity=28.3582089552239, Blast_Score=133, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24661184, Length=425, Percent_Identity=29.1764705882353, Blast_Score=172, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24643270, Length=427, Percent_Identity=30.6791569086651, Blast_Score=165, Evalue=8e-41,
Organism=Drosophila melanogaster, GI24643268, Length=427, Percent_Identity=30.6791569086651, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20130355, Length=419, Percent_Identity=22.1957040572792, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 65890; Mature: 65890

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTPAGEAIQISNGRLQVPDHPIIPFVEGDGTGRDIWRASVRVFDAAVALAYGGKRKIE
CCCCCCCCEEEECCCEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHH
WLEVLAGEKAFHETGNWLPDETIETFQKYLVGIKGPLTTPVGGGIRSLNVALRKHLDLYV
HHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
CQRPVRHFAGVPSPVKHPEKVDMVIFRENTEDVYTGIEYRGGSEEAAKIIAFLQREFPKD
HHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHCCCEECCCCHHHHHHHHHHHHHCCCC
FDKIRFGTPEKTDEFRQLIGEEPEGKIEVGIGIKPISRIGTERIMAAAIQYAITYKRKSI
HHHCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCEE
TLMHKGNIQKFTEGAFRDWAYEYAERAFGDYVYTWAQWERTKAARGEAAANAEQKEALAA
EEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCHHCCCHHHHHHHH
GKILVKDAIADIIFQQVLTRPDEFDVIVAPNLNGDYLSDALAAQVGGIGIAPGGNINYVT
HHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHCCEEECCCCCEEEEE
GHAIFEATHGTAPKYADLDKVNPGSVILSGEMMLRYMGWTEAADLIIAGLERTIADKTVT
CCEEEEECCCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
YDFARLMEGAREVKTSEFASLIIANMEKIVAGDVPHPTPTFGPEILRRADGRVYPHGSVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCHH
AVMTRAVVAVPAEASLRETSIYMRGRGIHSVIVKPDASGEWGIMTMRDVLKKVVREGRAI
HHHHHHHHCCCCCCCHHHHEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCC
DGLTVGDLTSRPLLSVSPDTPITECAALMVERNIRRLAVFENGEPVGIISETDIFSHVAE
CCEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCEEEEEEECCCCEEEEECHHHHHHHCC
>Mature Secondary Structure
MKPTPAGEAIQISNGRLQVPDHPIIPFVEGDGTGRDIWRASVRVFDAAVALAYGGKRKIE
CCCCCCCCEEEECCCEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHH
WLEVLAGEKAFHETGNWLPDETIETFQKYLVGIKGPLTTPVGGGIRSLNVALRKHLDLYV
HHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
CQRPVRHFAGVPSPVKHPEKVDMVIFRENTEDVYTGIEYRGGSEEAAKIIAFLQREFPKD
HHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHCCCEECCCCHHHHHHHHHHHHHCCCC
FDKIRFGTPEKTDEFRQLIGEEPEGKIEVGIGIKPISRIGTERIMAAAIQYAITYKRKSI
HHHCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCEE
TLMHKGNIQKFTEGAFRDWAYEYAERAFGDYVYTWAQWERTKAARGEAAANAEQKEALAA
EEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCHHCCCHHHHHHHH
GKILVKDAIADIIFQQVLTRPDEFDVIVAPNLNGDYLSDALAAQVGGIGIAPGGNINYVT
HHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHCCEEECCCCCEEEEE
GHAIFEATHGTAPKYADLDKVNPGSVILSGEMMLRYMGWTEAADLIIAGLERTIADKTVT
CCEEEEECCCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
YDFARLMEGAREVKTSEFASLIIANMEKIVAGDVPHPTPTFGPEILRRADGRVYPHGSVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCHH
AVMTRAVVAVPAEASLRETSIYMRGRGIHSVIVKPDASGEWGIMTMRDVLKKVVREGRAI
HHHHHHHHCCCCCCCHHHHEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCC
DGLTVGDLTSRPLLSVSPDTPITECAALMVERNIRRLAVFENGEPVGIISETDIFSHVAE
CCEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCEEEEEEECCCCEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377; 11751849; 11290745 [H]