Click here to switch to the map view.

The map label for this gene is fabG2 [H]

Identifier: 222526268

GI number: 222526268

Start: 3743282

End: 3744040

Strand: Direct

Name: fabG2 [H]

Synonym: Chy400_3034

Alternate gene names: 222526268

Gene position: 3743282-3744040 (Clockwise)

Preceding gene: 222526267

Following gene: 222526269

Centisome position: 71.04

GC content: 61.0

Gene sequence:

>759_bases
ATGCAACTGCAAGGGTTGAGTGTCCTCGTTACCGGTGGTGCATCCGGTCTGGGCGCAGCGACGGCTGAGCGATTGGCCGG
GGCCGGCGCACGAGTAACGATTGCTGATTTGAACGAAGCTGCCGGTACGGAACTGGCGGAGCGGATCGGGGGGCAATTTG
TGCGCACCGATGTCACCGATCCGGCGCAGTGTGCTGCGGCTGTCAGCGCCGCGGCTGCGCAGCAGGGGCTGCACGTTCTG
GTATGTTGCGCCGGGATCGTGCTGGCCGAGCGGATGCTTGGTCGGGAAGGCGTGCATGATCCGGCGCGTTTCAAGCGGGT
GATCGAGGTCAATTTGATTGGTACCTTTCAAATGATGCTGTACGCTGCCCAGGCGATGAGTCAGAATCAGCCGAACGATG
AGGGCGAGCGTGGTGTTATCATCAATACGGCGTCGATTGCGGCCTTCGATGGGCAGATCGGGCAGGTAGCCTACGCTGCT
TCAAAGGCGGGGGTGGTTGGGATGGCACTACCGGCAGCGCGGGAGCTGGCCCGCTTTGGGATTCGGGTGATGACAATCGC
GCCGGGTATTTTTGATACGGCCATGATGGCGAGTCTGCCGGCGGCTGCCCGTGAGTCGCTTGGTGCCCAGGTGCCGTTTC
CACCGCGACTGGGGCGACCTGCCGAGTACGCAGCATTGGCCCAACATATCATTGAAAATCCGATGTTGAACGGAGAAGTT
ATTCGGCTCGATGGCGCGATTCGGATGGCGCCAAAATAA

Upstream 100 bases:

>100_bases
CGGTTTCTTCTGGGGTGGTCACTGGAACTACGATGGCAGGGGAGCCAGTGATGGTATGCATTTTGAGTGGGCAGTTGCCC
GTTGAGCAAAGGAGCGCATC

Downstream 100 bases:

>100_bases
CGGAGGAGACTAATGCAAATCTATCTCGATACGGCAAATCTGGCCGAGATTCGTGAAGCAGCCAGTTGGGGCATTCTTAG
CGGGGTGACGACGAACCCGA

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MQLQGLSVLVTGGASGLGAATAERLAGAGARVTIADLNEAAGTELAERIGGQFVRTDVTDPAQCAAAVSAAAAQQGLHVL
VCCAGIVLAERMLGREGVHDPARFKRVIEVNLIGTFQMMLYAAQAMSQNQPNDEGERGVIINTASIAAFDGQIGQVAYAA
SKAGVVGMALPAARELARFGIRVMTIAPGIFDTAMMASLPAAARESLGAQVPFPPRLGRPAEYAALAQHIIENPMLNGEV
IRLDGAIRMAPK

Sequences:

>Translated_252_residues
MQLQGLSVLVTGGASGLGAATAERLAGAGARVTIADLNEAAGTELAERIGGQFVRTDVTDPAQCAAAVSAAAAQQGLHVL
VCCAGIVLAERMLGREGVHDPARFKRVIEVNLIGTFQMMLYAAQAMSQNQPNDEGERGVIINTASIAAFDGQIGQVAYAA
SKAGVVGMALPAARELARFGIRVMTIAPGIFDTAMMASLPAAARESLGAQVPFPPRLGRPAEYAALAQHIIENPMLNGEV
IRLDGAIRMAPK
>Mature_252_residues
MQLQGLSVLVTGGASGLGAATAERLAGAGARVTIADLNEAAGTELAERIGGQFVRTDVTDPAQCAAAVSAAAAQQGLHVL
VCCAGIVLAERMLGREGVHDPARFKRVIEVNLIGTFQMMLYAAQAMSQNQPNDEGERGVIINTASIAAFDGQIGQVAYAA
SKAGVVGMALPAARELARFGIRVMTIAPGIFDTAMMASLPAAARESLGAQVPFPPRLGRPAEYAALAQHIIENPMLNGEV
IRLDGAIRMAPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=254, Percent_Identity=53.9370078740158, Blast_Score=253, Evalue=9e-68,
Organism=Homo sapiens, GI83715985, Length=254, Percent_Identity=50.3937007874016, Blast_Score=228, Evalue=3e-60,
Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=35.0194552529183, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI31542939, Length=262, Percent_Identity=28.2442748091603, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=29.2682926829268, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI59889578, Length=220, Percent_Identity=29.5454545454545, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI224922801, Length=181, Percent_Identity=30.939226519337, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=32.6848249027237, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI87082160, Length=200, Percent_Identity=32, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=32.4324324324324, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI87082100, Length=261, Percent_Identity=28.3524904214559, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI2367175, Length=198, Percent_Identity=33.8383838383838, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=29.9212598425197, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787905, Length=232, Percent_Identity=29.7413793103448, Blast_Score=60, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17538182, Length=249, Percent_Identity=49.3975903614458, Blast_Score=230, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI17555706, Length=221, Percent_Identity=33.4841628959276, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25147288, Length=239, Percent_Identity=33.0543933054393, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6322861, Length=241, Percent_Identity=28.6307053941909, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI17737361, Length=248, Percent_Identity=54.0322580645161, Blast_Score=255, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24639444, Length=256, Percent_Identity=33.984375, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21357041, Length=229, Percent_Identity=30.1310043668122, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28571526, Length=229, Percent_Identity=27.9475982532751, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26029; Mature: 26029

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLQGLSVLVTGGASGLGAATAERLAGAGARVTIADLNEAAGTELAERIGGQFVRTDVTD
CCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCEEEECCCCC
PAQCAAAVSAAAAQQGLHVLVCCAGIVLAERMLGREGVHDPARFKRVIEVNLIGTFQMML
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEHHHHHHHHH
YAAQAMSQNQPNDEGERGVIINTASIAAFDGQIGQVAYAASKAGVVGMALPAARELARFG
HHHHHHHCCCCCCCCCCEEEEEECEEEEECCCHHHHHHHHHHCCEEEHHHHHHHHHHHHC
IRVMTIAPGIFDTAMMASLPAAARESLGAQVPFPPRLGRPAEYAALAQHIIENPMLNGEV
EEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
IRLDGAIRMAPK
EEECCEEEECCC
>Mature Secondary Structure
MQLQGLSVLVTGGASGLGAATAERLAGAGARVTIADLNEAAGTELAERIGGQFVRTDVTD
CCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCEEEECCCCC
PAQCAAAVSAAAAQQGLHVLVCCAGIVLAERMLGREGVHDPARFKRVIEVNLIGTFQMML
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEHHHHHHHHH
YAAQAMSQNQPNDEGERGVIINTASIAAFDGQIGQVAYAASKAGVVGMALPAARELARFG
HHHHHHHCCCCCCCCCCEEEEEECEEEEECCCHHHHHHHHHHCCEEEHHHHHHHHHHHHC
IRVMTIAPGIFDTAMMASLPAAARESLGAQVPFPPRLGRPAEYAALAQHIIENPMLNGEV
EEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
IRLDGAIRMAPK
EEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]