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The map label for this gene is 222526172

Identifier: 222526172

GI number: 222526172

Start: 3626451

End: 3627185

Strand: Reverse

Name: 222526172

Synonym: Chy400_2931

Alternate gene names: NA

Gene position: 3627185-3626451 (Counterclockwise)

Preceding gene: 222526173

Following gene: 222526171

Centisome position: 68.84

GC content: 53.74

Gene sequence:

>735_bases
ATGAACCGTCTCTTACACACAACCTATTGGGATATTGTTCGCCAGTATCGCAACGGATTTTACTTCGTTACGGTGTTGAT
CGTCGCGCTCCTGGTTGTTTTGTTACGTCAACTCGATGGCGTGGACTGGCAACTGTGGTGGCCGGCCATTCTGCTGGAAA
CGCTGGTGGTTAACAGCTTTTTCTTTATGGCCGGGCTGGTCTTGCTGGAGAAGGGGGAAGGCGTGCTGGAAGCACAGGTT
GTCACCCCGCTCCGCGACTGGGAGTATCTGCTGGCGAAGATTATCAGTCTATTCGTCCTTTCAGCCAGCGAGTCGCTGGC
CCTGATCCTGCTGGTGAGCGGCCCAGCCTTTAACTGGTTGTGGATGCTAATCGGCATCGGTTGTTTTGTCGCCATGTACA
CGTTATACGGATTTTTTGTTGTGGCGCGTTACGATTCGATCTCTGAATTCATCCTGCCTTCGGCGCTATGGACGATGGGT
TTTTCGATTCCGCTGTTACCCTATTTTGATCTCTGGCAACACTGGCTGATCTACCTGCATCCACTTCAGGCACCCCTGAT
ACTGGTGGAGGCAGCCTACAAGCCGCTACCGGCCTGGCAGTTGTGGTACGGTATTCTTTACAGTCTGGTCTGGATCAGTA
TCGGATGGGTCGTCGGGCGGCACACCTTCTACCGCTTCGTGGTGACCAAAGAGGGCAGTCGGCGGCGAAGCGTATCGTTA
GCGAGGTCGTTATGA

Upstream 100 bases:

>100_bases
CCGGTTCTACGCTGCCACGCTCAGGGGTGGCAGGTTGATCGCTGGATCACGGGTCATAAACGTTATAACACCGGATTAGA
TATTACACTGCGAGAACGCT

Downstream 100 bases:

>100_bases
ATATGTTGCAAACACTCCGTGCTCTTGGCCCAATCGATCTGCGCAGTGTCTGGCGCGATAAGATGCTCTCGTGGATGATC
TTCCTGCCGATCCTGGGAGC

Product: ABC-2 type transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MNRLLHTTYWDIVRQYRNGFYFVTVLIVALLVVLLRQLDGVDWQLWWPAILLETLVVNSFFFMAGLVLLEKGEGVLEAQV
VTPLRDWEYLLAKIISLFVLSASESLALILLVSGPAFNWLWMLIGIGCFVAMYTLYGFFVVARYDSISEFILPSALWTMG
FSIPLLPYFDLWQHWLIYLHPLQAPLILVEAAYKPLPAWQLWYGILYSLVWISIGWVVGRHTFYRFVVTKEGSRRRSVSL
ARSL

Sequences:

>Translated_244_residues
MNRLLHTTYWDIVRQYRNGFYFVTVLIVALLVVLLRQLDGVDWQLWWPAILLETLVVNSFFFMAGLVLLEKGEGVLEAQV
VTPLRDWEYLLAKIISLFVLSASESLALILLVSGPAFNWLWMLIGIGCFVAMYTLYGFFVVARYDSISEFILPSALWTMG
FSIPLLPYFDLWQHWLIYLHPLQAPLILVEAAYKPLPAWQLWYGILYSLVWISIGWVVGRHTFYRFVVTKEGSRRRSVSL
ARSL
>Mature_244_residues
MNRLLHTTYWDIVRQYRNGFYFVTVLIVALLVVLLRQLDGVDWQLWWPAILLETLVVNSFFFMAGLVLLEKGEGVLEAQV
VTPLRDWEYLLAKIISLFVLSASESLALILLVSGPAFNWLWMLIGIGCFVAMYTLYGFFVVARYDSISEFILPSALWTMG
FSIPLLPYFDLWQHWLIYLHPLQAPLILVEAAYKPLPAWQLWYGILYSLVWISIGWVVGRHTFYRFVVTKEGSRRRSVSL
ARSL

Specific function: Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin. Probably responsible for the translocation of the sub

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 28333; Mature: 28333

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLLHTTYWDIVRQYRNGFYFVTVLIVALLVVLLRQLDGVDWQLWWPAILLETLVVNSF
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHH
FFMAGLVLLEKGEGVLEAQVVTPLRDWEYLLAKIISLFVLSASESLALILLVSGPAFNWL
HHHHHHHHHHCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHH
WMLIGIGCFVAMYTLYGFFVVARYDSISEFILPSALWTMGFSIPLLPYFDLWQHWLIYLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
PLQAPLILVEAAYKPLPAWQLWYGILYSLVWISIGWVVGRHTFYRFVVTKEGSRRRSVSL
HHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHH
ARSL
HHCC
>Mature Secondary Structure
MNRLLHTTYWDIVRQYRNGFYFVTVLIVALLVVLLRQLDGVDWQLWWPAILLETLVVNSF
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHH
FFMAGLVLLEKGEGVLEAQVVTPLRDWEYLLAKIISLFVLSASESLALILLVSGPAFNWL
HHHHHHHHHHCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHH
WMLIGIGCFVAMYTLYGFFVVARYDSISEFILPSALWTMGFSIPLLPYFDLWQHWLIYLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
PLQAPLILVEAAYKPLPAWQLWYGILYSLVWISIGWVVGRHTFYRFVVTKEGSRRRSVSL
HHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHH
ARSL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]