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The map label for this gene is trpF [H]

Identifier: 222526168

GI number: 222526168

Start: 3621762

End: 3622415

Strand: Reverse

Name: trpF [H]

Synonym: Chy400_2927

Alternate gene names: 222526168

Gene position: 3622415-3621762 (Counterclockwise)

Preceding gene: 222526169

Following gene: 222526167

Centisome position: 68.75

GC content: 62.84

Gene sequence:

>654_bases
GTGAGTAGCCTGATCAAAATCTGTGGCCTACGCACAGTCGATCTGGCGCTGGCAGCCGCCACTGCCGGCGCCGATCTGAT
CGGCCTGGTCTTTGCGCCCAGCCGACGGCAAGTCACCGTCGCCGCAGCTCAACAGATTGCCGCCGCCGTGCGCGCCCTGC
CACCACCACGCCCGTTGATCGTCGGCTTATTCGTGAATGAACCGGCGGCCCACGTAGCCGACATTGCCGCCACAGTGGGA
TTAGAGGCGATTCAGTTGAGTGGCGATGAGCCGCCAGATTACCCGACCCCACACGGGCTACCGGTGATCAAAGCGATTCG
GATGATCGATACCCCACTTGAGCAGGCATGGCTGGCGCGTATTGCAGCTATACCAACAGTTGGTCAGGGGCTACCCCCAC
TGACTGCACTGATCGACGCGCACGTCAGTGGTGCCTACGGCGGTACCGGCATCCAGGCCGACTGGGGACGGGCCGCACAC
ATTGCGCGGCAGGTGCCGACCATCCTGGCCGGTGGCCTGACACCGGTGAATGTCGCACAGGCCATCGCCATCGTGCAGCC
AATGGGTGTCGATGTCAGTAGCGGTGTCGAGCGTGATGGCCAGAAAGACCCGGCCCTGATCAGGGCATTTATCGCTGCTG
CACGCAGTGCATAA

Upstream 100 bases:

>100_bases
ACTACCGAAGAGAATCGCACAATGCTCAAGCAAGCCATTCACCATGGCATGTTTGAGCGCACGACTCGGAGCCGTCGCGT
TTATTACACCCTGAAGACGA

Downstream 100 bases:

>100_bases
GAACTTGAGACTGCAACACGCCGCTATCGCTCAACGTCAGATAGCAGCATACACGCCTTTAACACTCTGCCTGATGCACA
GCCGGGCACACGACACCTGA

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MSSLIKICGLRTVDLALAAATAGADLIGLVFAPSRRQVTVAAAQQIAAAVRALPPPRPLIVGLFVNEPAAHVADIAATVG
LEAIQLSGDEPPDYPTPHGLPVIKAIRMIDTPLEQAWLARIAAIPTVGQGLPPLTALIDAHVSGAYGGTGIQADWGRAAH
IARQVPTILAGGLTPVNVAQAIAIVQPMGVDVSSGVERDGQKDPALIRAFIAAARSA

Sequences:

>Translated_217_residues
MSSLIKICGLRTVDLALAAATAGADLIGLVFAPSRRQVTVAAAQQIAAAVRALPPPRPLIVGLFVNEPAAHVADIAATVG
LEAIQLSGDEPPDYPTPHGLPVIKAIRMIDTPLEQAWLARIAAIPTVGQGLPPLTALIDAHVSGAYGGTGIQADWGRAAH
IARQVPTILAGGLTPVNVAQAIAIVQPMGVDVSSGVERDGQKDPALIRAFIAAARSA
>Mature_216_residues
SSLIKICGLRTVDLALAAATAGADLIGLVFAPSRRQVTVAAAQQIAAAVRALPPPRPLIVGLFVNEPAAHVADIAATVGL
EAIQLSGDEPPDYPTPHGLPVIKAIRMIDTPLEQAWLARIAAIPTVGQGLPPLTALIDAHVSGAYGGTGIQADWGRAAHI
ARQVPTILAGGLTPVNVAQAIAIVQPMGVDVSSGVERDGQKDPALIRAFIAAARSA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=220, Percent_Identity=34.0909090909091, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320210, Length=223, Percent_Identity=34.0807174887892, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 22145; Mature: 22014

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLIKICGLRTVDLALAAATAGADLIGLVFAPSRRQVTVAAAQQIAAAVRALPPPRPLI
CCCHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCCEE
VGLFVNEPAAHVADIAATVGLEAIQLSGDEPPDYPTPHGLPVIKAIRMIDTPLEQAWLAR
EEEEECCCHHHHHHHHHHHCHHEEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHH
IAAIPTVGQGLPPLTALIDAHVSGAYGGTGIQADWGRAAHIARQVPTILAGGLTPVNVAQ
HHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
AIAIVQPMGVDVSSGVERDGQKDPALIRAFIAAARSA
HHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSLIKICGLRTVDLALAAATAGADLIGLVFAPSRRQVTVAAAQQIAAAVRALPPPRPLI
CCHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCCEE
VGLFVNEPAAHVADIAATVGLEAIQLSGDEPPDYPTPHGLPVIKAIRMIDTPLEQAWLAR
EEEEECCCHHHHHHHHHHHCHHEEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHH
IAAIPTVGQGLPPLTALIDAHVSGAYGGTGIQADWGRAAHIARQVPTILAGGLTPVNVAQ
HHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
AIAIVQPMGVDVSSGVERDGQKDPALIRAFIAAARSA
HHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA