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The map label for this gene is dhaT [H]

Identifier: 222526123

GI number: 222526123

Start: 3565382

End: 3566569

Strand: Direct

Name: dhaT [H]

Synonym: Chy400_2880

Alternate gene names: 222526123

Gene position: 3565382-3566569 (Clockwise)

Preceding gene: 222526120

Following gene: 222526128

Centisome position: 67.67

GC content: 55.47

Gene sequence:

>1188_bases
ATGATGCCACCACGTGAGTTTATCATGCCGGCACAGATGATCATTGGTTCAGGTGCTGTCGATCAGGTTGGTGCACAGTG
CGCGAAGCGGGGCTGGAAGAAGGCACTCATCGTCACCGATCAGATCATGCAGAAACTCGGCATCGTCGGCCAGGTCGAAC
AGAATCTGGCTCATCACGGCATAAACAGTGTGGTGTATGCCGGTGTCAACACCGAACCGGTGGTGGAATATGTGCAAGAG
GGGTTGACAACATTCCGGGAGGGTGGCTGCGATTTTGTGCTGGCAGTTGGTGGTGGCAGTCCAATTGATACCGCAAAAGC
GGTTGCTGTGCTCGTAACCAATCCCGGTTCCATCGAGCAATACAAGGGGATTGGCAAGATTGGCGCTCCCGGTGTGCCGC
TGGTCGCTATCCCCACTACAGCCGGCACCGGTAGTGAAGCGACAATCTACACCGTCATTACCGATCAAAAGACCGATGTG
AAAATGTTGATCGGTAGCCCCTATTTAATGCCGACCATCGCCATCGTCGATCCGATGTTGACCATCTCATCGCCACCCAG
TGTGACCGCAGCTACCGGTGTTGATGCGCTGGTACACGCGATTGAAGCCTATGTGTCGGTCAAACGCCAGCCGATGACTG
ATGTATTATGTTTGTCGGCCATCGAGCTAATCGCCGGTAATATTCGTCAGGCCTGGGCCAATGGCAACAATATCGAAGCC
CGCGAGAAGATGATGTTGGGGGCAACACAGGCCGGGATTGCGTTCAGTAATTCGTCAGTAGCGCTTGTCCACGGCATGTC
CAGACCGATTGGCGCTTACTTCCACATTGCCCATGGCGTCTCAAACGCAGCCCTCCTTGCCGTAGTGACTGAATTCAGCC
TGGTTGGTGATCCACAGCGCTATGCCGATATTGCCAGAGCAATGGGCGAGCCGACCGAGGGTCTATCGCTGATGGAAGCG
GCTGATCGAGCGGTCGTTGCCATCCGTCGTCTGGTGCGAGACATCAAGATACCCTCGCTTCGCCAGTTAGGCGTGGAGCG
CGAGCGGTTGATGGAACTGGCGCCGGCAATGGCCGATGCCGCCATTGATAGCGGTAGTCCGGCGAATAATCCGCGCAAGC
CCACCAAACAAGAAATTATTGAACTGTATGCCAGGGCCTACGATGAAGGCGACCGGATGAGTGCATGA

Upstream 100 bases:

>100_bases
ACGAAAGCACGGCTTTTGTCTCTTCATCGCTGTAGACCCTGCGTGGACTGTTCGGATAGGCGCCGGGCTGTCGTTCACCT
GTTGGAAAGGAGGGGCGTGT

Downstream 100 bases:

>100_bases
GTGGTCCGGTTGAGGGTATATCAAATCTGACGTGATCGAGGTCATAGCACGCTATCCGACAAACACCCTGACACTGTACC
TGAGCCGGGGCTGCGAAATC

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MMPPREFIMPAQMIIGSGAVDQVGAQCAKRGWKKALIVTDQIMQKLGIVGQVEQNLAHHGINSVVYAGVNTEPVVEYVQE
GLTTFREGGCDFVLAVGGGSPIDTAKAVAVLVTNPGSIEQYKGIGKIGAPGVPLVAIPTTAGTGSEATIYTVITDQKTDV
KMLIGSPYLMPTIAIVDPMLTISSPPSVTAATGVDALVHAIEAYVSVKRQPMTDVLCLSAIELIAGNIRQAWANGNNIEA
REKMMLGATQAGIAFSNSSVALVHGMSRPIGAYFHIAHGVSNAALLAVVTEFSLVGDPQRYADIARAMGEPTEGLSLMEA
ADRAVVAIRRLVRDIKIPSLRQLGVERERLMELAPAMADAAIDSGSPANNPRKPTKQEIIELYARAYDEGDRMSA

Sequences:

>Translated_395_residues
MMPPREFIMPAQMIIGSGAVDQVGAQCAKRGWKKALIVTDQIMQKLGIVGQVEQNLAHHGINSVVYAGVNTEPVVEYVQE
GLTTFREGGCDFVLAVGGGSPIDTAKAVAVLVTNPGSIEQYKGIGKIGAPGVPLVAIPTTAGTGSEATIYTVITDQKTDV
KMLIGSPYLMPTIAIVDPMLTISSPPSVTAATGVDALVHAIEAYVSVKRQPMTDVLCLSAIELIAGNIRQAWANGNNIEA
REKMMLGATQAGIAFSNSSVALVHGMSRPIGAYFHIAHGVSNAALLAVVTEFSLVGDPQRYADIARAMGEPTEGLSLMEA
ADRAVVAIRRLVRDIKIPSLRQLGVERERLMELAPAMADAAIDSGSPANNPRKPTKQEIIELYARAYDEGDRMSA
>Mature_395_residues
MMPPREFIMPAQMIIGSGAVDQVGAQCAKRGWKKALIVTDQIMQKLGIVGQVEQNLAHHGINSVVYAGVNTEPVVEYVQE
GLTTFREGGCDFVLAVGGGSPIDTAKAVAVLVTNPGSIEQYKGIGKIGAPGVPLVAIPTTAGTGSEATIYTVITDQKTDV
KMLIGSPYLMPTIAIVDPMLTISSPPSVTAATGVDALVHAIEAYVSVKRQPMTDVLCLSAIELIAGNIRQAWANGNNIEA
REKMMLGATQAGIAFSNSSVALVHGMSRPIGAYFHIAHGVSNAALLAVVTEFSLVGDPQRYADIARAMGEPTEGLSLMEA
ADRAVVAIRRLVRDIKIPSLRQLGVERERLMELAPAMADAAIDSGSPANNPRKPTKQEIIELYARAYDEGDRMSA

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=393, Percent_Identity=28.7531806615776, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI1789163, Length=390, Percent_Identity=41.2820512820513, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI48994951, Length=383, Percent_Identity=38.9033942558747, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI87082107, Length=384, Percent_Identity=37.2395833333333, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1787493, Length=394, Percent_Identity=32.741116751269, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789386, Length=343, Percent_Identity=26.8221574344023, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17537053, Length=412, Percent_Identity=28.1553398058252, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321181, Length=385, Percent_Identity=34.5454545454545, Blast_Score=238, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24657991, Length=423, Percent_Identity=29.7872340425532, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 41757; Mature: 41757

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPPREFIMPAQMIIGSGAVDQVGAQCAKRGWKKALIVTDQIMQKLGIVGQVEQNLAHHG
CCCCHHHHCHHHHHHCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHCCHHHHHHHHHHCC
INSVVYAGVNTEPVVEYVQEGLTTFREGGCDFVLAVGGGSPIDTAKAVAVLVTNPGSIEQ
CCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEECCCCHHH
YKGIGKIGAPGVPLVAIPTTAGTGSEATIYTVITDQKTDVKMLIGSPYLMPTIAIVDPML
HCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHCCHH
TISSPPSVTAATGVDALVHAIEAYVSVKRQPMTDVLCLSAIELIAGNIRQAWANGNNIEA
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
REKMMLGATQAGIAFSNSSVALVHGMSRPIGAYFHIAHGVSNAALLAVVTEFSLVGDPQR
HHHHHHCCHHHCEEECCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHH
YADIARAMGEPTEGLSLMEAADRAVVAIRRLVRDIKIPSLRQLGVERERLMELAPAMADA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHH
AIDSGSPANNPRKPTKQEIIELYARAYDEGDRMSA
HCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MMPPREFIMPAQMIIGSGAVDQVGAQCAKRGWKKALIVTDQIMQKLGIVGQVEQNLAHHG
CCCCHHHHCHHHHHHCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHCCHHHHHHHHHHCC
INSVVYAGVNTEPVVEYVQEGLTTFREGGCDFVLAVGGGSPIDTAKAVAVLVTNPGSIEQ
CCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEECCCCHHH
YKGIGKIGAPGVPLVAIPTTAGTGSEATIYTVITDQKTDVKMLIGSPYLMPTIAIVDPML
HCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHCCHH
TISSPPSVTAATGVDALVHAIEAYVSVKRQPMTDVLCLSAIELIAGNIRQAWANGNNIEA
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
REKMMLGATQAGIAFSNSSVALVHGMSRPIGAYFHIAHGVSNAALLAVVTEFSLVGDPQR
HHHHHHCCHHHCEEECCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHH
YADIARAMGEPTEGLSLMEAADRAVVAIRRLVRDIKIPSLRQLGVERERLMELAPAMADA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHH
AIDSGSPANNPRKPTKQEIIELYARAYDEGDRMSA
HCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]