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The map label for this gene is acdA [H]

Identifier: 222526122

GI number: 222526122

Start: 3563798

End: 3565051

Strand: Reverse

Name: acdA [H]

Synonym: Chy400_2879

Alternate gene names: 222526122

Gene position: 3565051-3563798 (Counterclockwise)

Preceding gene: 222526124

Following gene: 222526121

Centisome position: 67.66

GC content: 57.89

Gene sequence:

>1254_bases
ATGGATTTGACGGCAAATTATGACATGTTTCTCGGCCCCGAACACGAGATGTTGCGCCAGACGGTGCGCAACTTTGCCGA
GCGCGAAGTCGCACCGCATATTCGCGAATGGGATCGGAGTGGCGCAGCGGCTGAGGGGCCAGAAGATCGGCCTCATCTAC
GTCCGGTGCTGAAGCGGATGGGTGAATTGGGGCTGTTGGGTATCTGTATTCCACAACGCTACGGTGGCGCCGGGATGGAT
TACCTGGCGCTGGCGGTAGTCTGTGAAGAGCTTGAGCGAGTCGACAGTTTCTTGCGGGTGGTCATGAGTGTCCACACCGG
TCTGAATTCGCTCTCGATCTTCCAATGGGGAACGGAAGAGCAGAAACAGCGCTTCCTGGTGCCACAGGCGCGGGGTGAAA
AGCTGGCCGCCTTCTGTCTCACCGAACCCAACAGCGGTACCGACGCTGCCGCTATGCAGGCGACCGCCCGCCGCGACGGC
GAGGACTATATTCTCAACGGCGAGAAGATATGGATTAGTCTGGCCGATCTGGCCGATAACTTCCTGGTATTCGCAAAAAC
CGACCCCGGTGCCGGCCCGCGCGGGATCACAGCCTTTATCGTCGAGCGTTCGATGCCCGGTGTCAGCAGCTATCCCATTC
ACGGCAAACTGGGAGTACGCGCCGGTAATACCGGTGGTGTCGTCTTTAACGATGTTCGCGTGCCGCGCTCGCACCGGCTG
GGCGAAGAGGGTGAAGGGTTCAAGATTGCAATGGCAGCGCTTGATAATGGCCGTTACACTGTAGCTGCCGGCGCTACCGG
TCTGATCCAGGCCAGTCTCGAAGCCAGCATTCGTTACGCTCGCGAGCGGCAAACCTTTGGCGTACCCATTGCCGAGCACC
AGCTCGTCAAGCGGATGATCAGCCATATGGTGCGCAAACTTGACACCTCACGTCTGCTGGTCTATCGAGCGGGATGGATG
AAGAATAAGGGCATTCGCAACACCCGTGAAACGACACTGGCCAAGTGGCACGCGACGGTTAGCAGCTTTGAGGCTGCCGA
TGATGCCATTCAAATCCATGGCGCCTACGGCTACGCCGATGAATACCCGGTTGAGCGTTATCTGCGTAATGCACGCGGTG
CTATCATCTACGAAGGTACCCGCGAACTACAAGAGTTGTTGCAGGCAGATTTCGTGATGGGGTATCGCAAGTATCCGAAT
TTGCGCTGTGAATTGCCGGCGTATGACCCCGATTTCTGGGAGAGCGACGGCTGA

Upstream 100 bases:

>100_bases
ACCGGTGCCATCCACAGTGAGAGCACTCGCGGTATAATCAAAGCGTTCGTACATTGGCGAGCGAGAGGCGCTGCTCTGCC
TGATACAAAGGAGTATCACA

Downstream 100 bases:

>100_bases
TCCAGCGATTACCGGCTCTTGCGCTGATGGTAGCGGGTGGGCGACAGCAATACCGTCGCCCACCCAATCTCATACCGGTT
TTGCAACAGGTTCTCTATGA

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MDLTANYDMFLGPEHEMLRQTVRNFAEREVAPHIREWDRSGAAAEGPEDRPHLRPVLKRMGELGLLGICIPQRYGGAGMD
YLALAVVCEELERVDSFLRVVMSVHTGLNSLSIFQWGTEEQKQRFLVPQARGEKLAAFCLTEPNSGTDAAAMQATARRDG
EDYILNGEKIWISLADLADNFLVFAKTDPGAGPRGITAFIVERSMPGVSSYPIHGKLGVRAGNTGGVVFNDVRVPRSHRL
GEEGEGFKIAMAALDNGRYTVAAGATGLIQASLEASIRYARERQTFGVPIAEHQLVKRMISHMVRKLDTSRLLVYRAGWM
KNKGIRNTRETTLAKWHATVSSFEAADDAIQIHGAYGYADEYPVERYLRNARGAIIYEGTRELQELLQADFVMGYRKYPN
LRCELPAYDPDFWESDG

Sequences:

>Translated_417_residues
MDLTANYDMFLGPEHEMLRQTVRNFAEREVAPHIREWDRSGAAAEGPEDRPHLRPVLKRMGELGLLGICIPQRYGGAGMD
YLALAVVCEELERVDSFLRVVMSVHTGLNSLSIFQWGTEEQKQRFLVPQARGEKLAAFCLTEPNSGTDAAAMQATARRDG
EDYILNGEKIWISLADLADNFLVFAKTDPGAGPRGITAFIVERSMPGVSSYPIHGKLGVRAGNTGGVVFNDVRVPRSHRL
GEEGEGFKIAMAALDNGRYTVAAGATGLIQASLEASIRYARERQTFGVPIAEHQLVKRMISHMVRKLDTSRLLVYRAGWM
KNKGIRNTRETTLAKWHATVSSFEAADDAIQIHGAYGYADEYPVERYLRNARGAIIYEGTRELQELLQADFVMGYRKYPN
LRCELPAYDPDFWESDG
>Mature_417_residues
MDLTANYDMFLGPEHEMLRQTVRNFAEREVAPHIREWDRSGAAAEGPEDRPHLRPVLKRMGELGLLGICIPQRYGGAGMD
YLALAVVCEELERVDSFLRVVMSVHTGLNSLSIFQWGTEEQKQRFLVPQARGEKLAAFCLTEPNSGTDAAAMQATARRDG
EDYILNGEKIWISLADLADNFLVFAKTDPGAGPRGITAFIVERSMPGVSSYPIHGKLGVRAGNTGGVVFNDVRVPRSHRL
GEEGEGFKIAMAALDNGRYTVAAGATGLIQASLEASIRYARERQTFGVPIAEHQLVKRMISHMVRKLDTSRLLVYRAGWM
KNKGIRNTRETTLAKWHATVSSFEAADDAIQIHGAYGYADEYPVERYLRNARGAIIYEGTRELQELLQADFVMGYRKYPN
LRCELPAYDPDFWESDG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=388, Percent_Identity=39.9484536082474, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI4501859, Length=371, Percent_Identity=35.5795148247978, Blast_Score=254, Evalue=7e-68,
Organism=Homo sapiens, GI4557231, Length=379, Percent_Identity=34.8284960422164, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI187960098, Length=379, Percent_Identity=34.8284960422164, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI226958412, Length=388, Percent_Identity=35.8247422680412, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI7656849, Length=391, Percent_Identity=33.7595907928389, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=36.3636363636364, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI21361497, Length=384, Percent_Identity=35.4166666666667, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI76496475, Length=338, Percent_Identity=36.6863905325444, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI4557235, Length=338, Percent_Identity=36.6863905325444, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI4501857, Length=388, Percent_Identity=31.9587628865979, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4503943, Length=384, Percent_Identity=32.03125, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI7669494, Length=364, Percent_Identity=32.6923076923077, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI211971008, Length=401, Percent_Identity=26.4339152119701, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI48976061, Length=401, Percent_Identity=26.6832917705736, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI38505218, Length=373, Percent_Identity=26.5415549597855, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI218563752, Length=232, Percent_Identity=26.2931034482759, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=27.1052631578947, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87081958, Length=386, Percent_Identity=29.5336787564767, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI87081702, Length=315, Percent_Identity=26.6666666666667, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87082384, Length=286, Percent_Identity=26.5734265734266, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17508101, Length=375, Percent_Identity=37.6, Blast_Score=258, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI17506239, Length=392, Percent_Identity=34.6938775510204, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=34.7368421052632, Blast_Score=244, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI17534899, Length=367, Percent_Identity=37.0572207084469, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17569725, Length=389, Percent_Identity=33.6760925449871, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI17570075, Length=391, Percent_Identity=33.2480818414322, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI71985184, Length=343, Percent_Identity=36.4431486880466, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17533517, Length=374, Percent_Identity=33.4224598930481, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI71990804, Length=284, Percent_Identity=39.0845070422535, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI71982178, Length=277, Percent_Identity=37.9061371841155, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17534353, Length=390, Percent_Identity=31.025641025641, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71985192, Length=279, Percent_Identity=36.9175627240143, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=38.0952380952381, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17551932, Length=377, Percent_Identity=27.8514588859416, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17505929, Length=377, Percent_Identity=27.0557029177719, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=33.6099585062241, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562446, Length=321, Percent_Identity=27.1028037383178, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=28.4090909090909, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646207, Length=388, Percent_Identity=42.0103092783505, Blast_Score=305, Evalue=6e-83,
Organism=Drosophila melanogaster, GI21356377, Length=385, Percent_Identity=38.7012987012987, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24660351, Length=380, Percent_Identity=36.8421052631579, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24666513, Length=375, Percent_Identity=34.1333333333333, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI21355753, Length=385, Percent_Identity=33.7662337662338, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI19920834, Length=399, Percent_Identity=31.5789473684211, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI281363737, Length=336, Percent_Identity=35.1190476190476, Blast_Score=204, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 46518; Mature: 46518

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTANYDMFLGPEHEMLRQTVRNFAEREVAPHIREWDRSGAAAEGPEDRPHLRPVLKRM
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
GELGLLGICIPQRYGGAGMDYLALAVVCEELERVDSFLRVVMSVHTGLNSLSIFQWGTEE
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHH
QKQRFLVPQARGEKLAAFCLTEPNSGTDAAAMQATARRDGEDYILNGEKIWISLADLADN
HHHEECCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCEEECCCEEEEEEEHHHCC
FLVFAKTDPGAGPRGITAFIVERSMPGVSSYPIHGKLGVRAGNTGGVVFNDVRVPRSHRL
EEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCHHHCC
GEEGEGFKIAMAALDNGRYTVAAGATGLIQASLEASIRYARERQTFGVPIAEHQLVKRMI
CCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SHMVRKLDTSRLLVYRAGWMKNKGIRNTRETTLAKWHATVSSFEAADDAIQIHGAYGYAD
HHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCC
EYPVERYLRNARGAIIYEGTRELQELLQADFVMGYRKYPNLRCELPAYDPDFWESDG
CCCHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure
MDLTANYDMFLGPEHEMLRQTVRNFAEREVAPHIREWDRSGAAAEGPEDRPHLRPVLKRM
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
GELGLLGICIPQRYGGAGMDYLALAVVCEELERVDSFLRVVMSVHTGLNSLSIFQWGTEE
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHH
QKQRFLVPQARGEKLAAFCLTEPNSGTDAAAMQATARRDGEDYILNGEKIWISLADLADN
HHHEECCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCEEECCCEEEEEEEHHHCC
FLVFAKTDPGAGPRGITAFIVERSMPGVSSYPIHGKLGVRAGNTGGVVFNDVRVPRSHRL
EEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCHHHCC
GEEGEGFKIAMAALDNGRYTVAAGATGLIQASLEASIRYARERQTFGVPIAEHQLVKRMI
CCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SHMVRKLDTSRLLVYRAGWMKNKGIRNTRETTLAKWHATVSSFEAADDAIQIHGAYGYAD
HHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCC
EYPVERYLRNARGAIIYEGTRELQELLQADFVMGYRKYPNLRCELPAYDPDFWESDG
CCCHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]