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The map label for this gene is cysG [H]

Identifier: 222526015

GI number: 222526015

Start: 3415389

End: 3416168

Strand: Reverse

Name: cysG [H]

Synonym: Chy400_2771

Alternate gene names: 222526015

Gene position: 3416168-3415389 (Counterclockwise)

Preceding gene: 222526016

Following gene: 222526014

Centisome position: 64.84

GC content: 65.38

Gene sequence:

>780_bases
ATGAGCGGTAAAGCATACCTTGTCGGCGCCGGCCCCGGTCGCGCCGATCTGATCACAGTGCGTGGGTTGACGGTGTTGCG
CCAGGCTGATGTCGTGCTCTACGACCGGCTGATCGCCGCTGCCCTGCTCGACGAAGCACCGGCTCACGCCGAACGCATCT
TTGTCGGGAAAAGGCCAGGCCACCACGCCTTTCGTCAGGATGGGATCAACGAGACGCTGGTGCGCTTGGTGCGCGAAGGC
TTACAGGTGGTGCGCTTGAAGGGTGGCGATCCCGGCGTCTTCGCCCACGTCGCCGAAGAAGCGGCTGCCCTGGCCGCCGC
CGGTCTACCCTTCGAGATCGTTCCCGGCGTGTCATCGGCCCTGGCCGTTCCTCTGTACGCTGGCATTCCGCTGACGTGGC
GCGGCGTAGCGACTGCCTTCACCGTTGTCTCCGGCCATGAAGCGACCCCACACGGTTGCAGCGGCATCAGTTGGTCACTC
CTGGCCGCCTCGCCAACCGTGGTCGTACTGATGGCCCTCGGTCGGCTTGAACAGGTCTGTTCGGCCCTGATCGCTGCCGG
ACGCAATCCCGACACTCCGGCAGCACTGATCAGCCGGGGTGCCACATCCCAACAGGCAACCTTGCGGGCAACGCTGGCAA
CCCTTTGCGACCAGCAACGGCTGATCCAGCTCCCACCGCCCGCGGTGCTGGTGGTGGGAGAGGTTGCGGCGCTGGCAGAT
CGACTTGCCTGGTACAACCCTGCCCGATCTCCTGGCGACGCCATGCTGTGGGAAGAGTAG

Upstream 100 bases:

>100_bases
ATCACGATTACGGTGAGCAGCGCCGGCACAGCCCCAGGTCGGGCCGTTGCCTTGCGCGATGCAATCGCCGATTGGCTAGA
CAGCATTGGAGTTCACAACC

Downstream 100 bases:

>100_bases
CGATACCGCACCCATTAGCCATGGATAACGAGCGGAATAGACGGAGTACATGCGATGCAGCTTCCCCGACTGTTGCTCGC
CGCACCGATGAGCGGGAGCG

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MSGKAYLVGAGPGRADLITVRGLTVLRQADVVLYDRLIAAALLDEAPAHAERIFVGKRPGHHAFRQDGINETLVRLVREG
LQVVRLKGGDPGVFAHVAEEAAALAAAGLPFEIVPGVSSALAVPLYAGIPLTWRGVATAFTVVSGHEATPHGCSGISWSL
LAASPTVVVLMALGRLEQVCSALIAAGRNPDTPAALISRGATSQQATLRATLATLCDQQRLIQLPPPAVLVVGEVAALAD
RLAWYNPARSPGDAMLWEE

Sequences:

>Translated_259_residues
MSGKAYLVGAGPGRADLITVRGLTVLRQADVVLYDRLIAAALLDEAPAHAERIFVGKRPGHHAFRQDGINETLVRLVREG
LQVVRLKGGDPGVFAHVAEEAAALAAAGLPFEIVPGVSSALAVPLYAGIPLTWRGVATAFTVVSGHEATPHGCSGISWSL
LAASPTVVVLMALGRLEQVCSALIAAGRNPDTPAALISRGATSQQATLRATLATLCDQQRLIQLPPPAVLVVGEVAALAD
RLAWYNPARSPGDAMLWEE
>Mature_258_residues
SGKAYLVGAGPGRADLITVRGLTVLRQADVVLYDRLIAAALLDEAPAHAERIFVGKRPGHHAFRQDGINETLVRLVREGL
QVVRLKGGDPGVFAHVAEEAAALAAAGLPFEIVPGVSSALAVPLYAGIPLTWRGVATAFTVVSGHEATPHGCSGISWSLL
AASPTVVVLMALGRLEQVCSALIAAGRNPDTPAALISRGATSQQATLRATLATLCDQQRLIQLPPPAVLVVGEVAALADR
LAWYNPARSPGDAMLWEE

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=245, Percent_Identity=38.7755102040816, Blast_Score=179, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322922, Length=255, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 27020; Mature: 26888

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGKAYLVGAGPGRADLITVRGLTVLRQADVVLYDRLIAAALLDEAPAHAERIFVGKRPG
CCCCEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCC
HHAFRQDGINETLVRLVREGLQVVRLKGGDPGVFAHVAEEAAALAAAGLPFEIVPGVSSA
CHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHCCCCEEECCCCHHH
LAVPLYAGIPLTWRGVATAFTVVSGHEATPHGCSGISWSLLAASPTVVVLMALGRLEQVC
HHHHHHCCCCEEEHHHHHHHHEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHH
SALIAAGRNPDTPAALISRGATSQQATLRATLATLCDQQRLIQLPPPAVLVVGEVAALAD
HHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCEEEHHHHHHHHH
RLAWYNPARSPGDAMLWEE
HHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SGKAYLVGAGPGRADLITVRGLTVLRQADVVLYDRLIAAALLDEAPAHAERIFVGKRPG
CCCEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCC
HHAFRQDGINETLVRLVREGLQVVRLKGGDPGVFAHVAEEAAALAAAGLPFEIVPGVSSA
CHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHCCCCEEECCCCHHH
LAVPLYAGIPLTWRGVATAFTVVSGHEATPHGCSGISWSLLAASPTVVVLMALGRLEQVC
HHHHHHCCCCEEEHHHHHHHHEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHH
SALIAAGRNPDTPAALISRGATSQQATLRATLATLCDQQRLIQLPPPAVLVVGEVAALAD
HHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCEEEHHHHHHHHH
RLAWYNPARSPGDAMLWEE
HHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA