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The map label for this gene is trxA

Identifier: 222525986

GI number: 222525986

Start: 3380469

End: 3380801

Strand: Reverse

Name: trxA

Synonym: Chy400_2742

Alternate gene names: 222525986

Gene position: 3380801-3380469 (Counterclockwise)

Preceding gene: 222525989

Following gene: 222525985

Centisome position: 64.16

GC content: 53.15

Gene sequence:

>333_bases
ATGGCTAAGCCGATTGAGGTACACGACTCGGATTTTGCCGAGAAAGTTTTGAAGTCGAAAACGCCGGTTGTGGTTGACTT
TTGGGCACCGTGGTGTGGGCCGTGTCGCGTGATTGCACCGATTCTCGATAAACTGGCCGGCGAATACGCAGGCCGTTTGA
CTATTGCCAAGGTCAATACAGACGATAATGTTCAGTATGCCTCGCAGCTCGGTATTCAGGGTATCCCAACGCTGGTTATC
TTCAAGGATGGCCGCGAGGTAGGCCGCCTGGTCGGCGCTCGACCAGAAGCGATGTACCGCGAAATCTTTGATAAAGTTCT
GGCAATGGCGTGA

Upstream 100 bases:

>100_bases
TCCCTCTTGACAGATGCTCTTCTGCGCGCTATAGTATACCCCCAGGGGGTATCTAATACAGATACTGCCTGTATGATTAC
TGTGGAGGAGGAATAATTCA

Downstream 100 bases:

>100_bases
ACACACCATCGCCGGAACCAGAATCTGCGGGTGAAGCAGCAATGAGCACGGGGGTTCGTCCGCTTGCGCCAGAACGACGC
GACGAAGTGTTACGGCGTTT

Product: thioredoxin

Products: NA

Alternate protein names: Trx

Number of amino acids: Translated: 110; Mature: 109

Protein sequence:

>110_residues
MAKPIEVHDSDFAEKVLKSKTPVVVDFWAPWCGPCRVIAPILDKLAGEYAGRLTIAKVNTDDNVQYASQLGIQGIPTLVI
FKDGREVGRLVGARPEAMYREIFDKVLAMA

Sequences:

>Translated_110_residues
MAKPIEVHDSDFAEKVLKSKTPVVVDFWAPWCGPCRVIAPILDKLAGEYAGRLTIAKVNTDDNVQYASQLGIQGIPTLVI
FKDGREVGRLVGARPEAMYREIFDKVLAMA
>Mature_109_residues
AKPIEVHDSDFAEKVLKSKTPVVVDFWAPWCGPCRVIAPILDKLAGEYAGRLTIAKVNTDDNVQYASQLGIQGIPTLVIF
KDGREVGRLVGARPEAMYREIFDKVLAMA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=98, Percent_Identity=36.734693877551, Blast_Score=85, Evalue=1e-17,
Organism=Homo sapiens, GI21361657, Length=92, Percent_Identity=34.7826086956522, Blast_Score=69, Evalue=6e-13,
Organism=Homo sapiens, GI50592994, Length=76, Percent_Identity=39.4736842105263, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87082331, Length=106, Percent_Identity=49.0566037735849, Blast_Score=111, Evalue=1e-26,
Organism=Escherichia coli, GI1788936, Length=94, Percent_Identity=46.8085106382979, Blast_Score=98, Evalue=1e-22,
Organism=Escherichia coli, GI87081747, Length=104, Percent_Identity=33.6538461538462, Blast_Score=76, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI212646193, Length=98, Percent_Identity=36.734693877551, Blast_Score=81, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17507705, Length=80, Percent_Identity=36.25, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=91, Percent_Identity=35.1648351648352, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=76, Percent_Identity=39.4736842105263, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=91, Percent_Identity=37.3626373626374, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=83, Percent_Identity=36.144578313253, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532378, Length=72, Percent_Identity=38.8888888888889, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115532380, Length=72, Percent_Identity=38.8888888888889, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=105, Percent_Identity=27.6190476190476, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17544108, Length=72, Percent_Identity=38.8888888888889, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=41.6666666666667, Blast_Score=77, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=93, Percent_Identity=38.7096774193548, Blast_Score=77, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319925, Length=89, Percent_Identity=34.8314606741573, Blast_Score=70, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=36.0824742268041, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24639826, Length=100, Percent_Identity=35, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358065, Length=90, Percent_Identity=40, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24664269, Length=74, Percent_Identity=39.1891891891892, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17648013, Length=76, Percent_Identity=36.8421052631579, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583090, Length=76, Percent_Identity=36.8421052631579, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921434, Length=77, Percent_Identity=38.961038961039, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO_CHLAA (Q7M1B9)

Other databases:

- EMBL:   CP000909
- PIR:   A55124
- RefSeq:   YP_001636136.1
- ProteinModelPortal:   Q7M1B9
- SMR:   Q7M1B9
- GeneID:   5827009
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_2541
- HOGENOM:   HBG493509
- OMA:   NPGIAST
- ProtClustDB:   CLSK974666
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 12131; Mature: 12000

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPIEVHDSDFAEKVLKSKTPVVVDFWAPWCGPCRVIAPILDKLAGEYAGRLTIAKVNT
CCCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECC
DDNVQYASQLGIQGIPTLVIFKDGREVGRLVGARPEAMYREIFDKVLAMA
CCCHHHHHHCCCCCCCEEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKPIEVHDSDFAEKVLKSKTPVVVDFWAPWCGPCRVIAPILDKLAGEYAGRLTIAKVNT
CCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECC
DDNVQYASQLGIQGIPTLVIFKDGREVGRLVGARPEAMYREIFDKVLAMA
CCCHHHHHHCCCCCCCEEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA