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The map label for this gene is 222525956

Identifier: 222525956

GI number: 222525956

Start: 3347232

End: 3348398

Strand: Reverse

Name: 222525956

Synonym: Chy400_2712

Alternate gene names: NA

Gene position: 3348398-3347232 (Counterclockwise)

Preceding gene: 222525957

Following gene: 222525955

Centisome position: 63.55

GC content: 56.56

Gene sequence:

>1167_bases
ATGCCGTTTTATCAGCGTCTCGGTCAGGTCCCTCACAAGCGCCATACCCAGTTCCGTAAGCCCGATGGCAAACTTTACCG
CGAAGAGGTAATGGGACTGGAAGGGTTCCACGGAATTCAATCAATCCTCTACCACCACTTTCTACCACCACGGGTGCTCC
GCACCGAGTTGATCGGTTCAGCTAAACCAACGTATGTCGATTTCGGCCCGATTCGTCACCGTGCCTTCGCCACCGCGAAT
GTGCCTGCCGGCGGTGATGCAGTGAGCGCCCGCGTTACCCTGCTCGGTAATAATGATGTGACGATTGGGATTAGCCGGCC
AACGGAAAGCATGACCTTTTTCTACCGCAACGCTCAGGCGTATGAGGTCTGGTTTACCCACGAAGGCAGCGGTGAATTGC
TCTCGCAATTTGGCCGCTTGCCCTTCAGCGCCGGTGACTACCTGGTCATTCCCTTCGGCACTACCTGGCAAATGCGGCTG
AATGAGCCGGCACGGTTCCTGGTGATTGAGTCGGCCAGCCAGATTGCGCCACCCAAACGCTACCGCAATCAGTTTGGGCA
ACTGCTCGAGCACGCCCCCTACTGCGAGCGCGACATCCGTGGCCCAAGTGAATTGCTCACGTTTACCGACACCGGTGAGT
TTGAGGTGCGGATCAAGGTGCGTGATCAGCTTACCCGGCATATTCTTGATCATCACCCCTTCGATGTGGTCGGCTGGGAT
GGCTATCTCTATCCCTGGGCTTTCTCGATTCACGATTTTGAGCCGATCACCGGACGGATTCACCAGCCACCACCGGTCCA
TCAGACGTTTGAGGGGCACAATTTTGTCGTCTGCTCGTTTGTGCCGCGATTGTTCGATTATCACCCGGAAGCAATTCCAG
CGCCGTACAATCACTCAAACGTGAATTCTGATGAGGTAATCTATTACTGCGACGGCAACTTTATGTCACGTCGTGGTATC
GAGCGCTGCGATATTACGTTGCACCCCGCCGGTCTGCCCCATGGCCCTCAACCGGGCAGCACCGAAGCCAGTATCGGCGC
GAAAGAGACTCACGAGCTGGCGGTGATGATTGATACATTCCATCCACTGCACCTGACCGCAGCCGCGCTGGAGCTGGAGA
AGGCCGGGTATATGGATTCGTGGAGTGTTGGCGGGCCGGAGGGCTAG

Upstream 100 bases:

>100_bases
GTTCGAGTCCCTCCCGGGTCGCCAGATCGCCCGACGCCACGAGCGTCGGGCGTGTATCTCTAGCGTCCAGAACGACACTC
GCGGCACAAGGAGGTGTGCG

Downstream 100 bases:

>100_bases
GCTGTACCACGCGCAGACCATCGGTACACAGCGCACCGTTACGTCTATCTGGTGATCGGGCAGTCTATCGGGTACTGGTG
TGCAATCGTATGGCTGCCCG

Product: homogentisate 12-dioxygenase

Products: 4-maleylacetoacetate

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MPFYQRLGQVPHKRHTQFRKPDGKLYREEVMGLEGFHGIQSILYHHFLPPRVLRTELIGSAKPTYVDFGPIRHRAFATAN
VPAGGDAVSARVTLLGNNDVTIGISRPTESMTFFYRNAQAYEVWFTHEGSGELLSQFGRLPFSAGDYLVIPFGTTWQMRL
NEPARFLVIESASQIAPPKRYRNQFGQLLEHAPYCERDIRGPSELLTFTDTGEFEVRIKVRDQLTRHILDHHPFDVVGWD
GYLYPWAFSIHDFEPITGRIHQPPPVHQTFEGHNFVVCSFVPRLFDYHPEAIPAPYNHSNVNSDEVIYYCDGNFMSRRGI
ERCDITLHPAGLPHGPQPGSTEASIGAKETHELAVMIDTFHPLHLTAAALELEKAGYMDSWSVGGPEG

Sequences:

>Translated_388_residues
MPFYQRLGQVPHKRHTQFRKPDGKLYREEVMGLEGFHGIQSILYHHFLPPRVLRTELIGSAKPTYVDFGPIRHRAFATAN
VPAGGDAVSARVTLLGNNDVTIGISRPTESMTFFYRNAQAYEVWFTHEGSGELLSQFGRLPFSAGDYLVIPFGTTWQMRL
NEPARFLVIESASQIAPPKRYRNQFGQLLEHAPYCERDIRGPSELLTFTDTGEFEVRIKVRDQLTRHILDHHPFDVVGWD
GYLYPWAFSIHDFEPITGRIHQPPPVHQTFEGHNFVVCSFVPRLFDYHPEAIPAPYNHSNVNSDEVIYYCDGNFMSRRGI
ERCDITLHPAGLPHGPQPGSTEASIGAKETHELAVMIDTFHPLHLTAAALELEKAGYMDSWSVGGPEG
>Mature_387_residues
PFYQRLGQVPHKRHTQFRKPDGKLYREEVMGLEGFHGIQSILYHHFLPPRVLRTELIGSAKPTYVDFGPIRHRAFATANV
PAGGDAVSARVTLLGNNDVTIGISRPTESMTFFYRNAQAYEVWFTHEGSGELLSQFGRLPFSAGDYLVIPFGTTWQMRLN
EPARFLVIESASQIAPPKRYRNQFGQLLEHAPYCERDIRGPSELLTFTDTGEFEVRIKVRDQLTRHILDHHPFDVVGWDG
YLYPWAFSIHDFEPITGRIHQPPPVHQTFEGHNFVVCSFVPRLFDYHPEAIPAPYNHSNVNSDEVIYYCDGNFMSRRGIE
RCDITLHPAGLPHGPQPGSTEASIGAKETHELAVMIDTFHPLHLTAAALELEKAGYMDSWSVGGPEG

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR014710 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: 1.13.11.5

Molecular weight: Translated: 43936; Mature: 43805

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFYQRLGQVPHKRHTQFRKPDGKLYREEVMGLEGFHGIQSILYHHFLPPRVLRTELIGS
CCHHHHHCCCCCHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCC
AKPTYVDFGPIRHRAFATANVPAGGDAVSARVTLLGNNDVTIGISRPTESMTFFYRNAQA
CCCCEEECCCCCCCEEEECCCCCCCCEEEEEEEEEECCCEEEEECCCCCCEEEEEECCEE
YEVWFTHEGSGELLSQFGRLPFSAGDYLVIPFGTTWQMRLNEPARFLVIESASQIAPPKR
EEEEEEECCCHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCEEEEEEECCHHCCCCHH
YRNQFGQLLEHAPYCERDIRGPSELLTFTDTGEFEVRIKVRDQLTRHILDHHPFDVVGWD
HHHHHHHHHHHCCCCHHHCCCHHHEEEEECCCCEEEEEEHHHHHHHHHHHCCCCEEEECC
GYLYPWAFSIHDFEPITGRIHQPPPVHQTFEGHNFVVCSFVPRLFDYHPEAIPAPYNHSN
CEECEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCC
VNSDEVIYYCDGNFMSRRGIERCDITLHPAGLPHGPQPGSTEASIGAKETHELAVMIDTF
CCCCCEEEEECCCCHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECC
HPLHLTAAALELEKAGYMDSWSVGGPEG
CCHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PFYQRLGQVPHKRHTQFRKPDGKLYREEVMGLEGFHGIQSILYHHFLPPRVLRTELIGS
CHHHHHCCCCCHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCC
AKPTYVDFGPIRHRAFATANVPAGGDAVSARVTLLGNNDVTIGISRPTESMTFFYRNAQA
CCCCEEECCCCCCCEEEECCCCCCCCEEEEEEEEEECCCEEEEECCCCCCEEEEEECCEE
YEVWFTHEGSGELLSQFGRLPFSAGDYLVIPFGTTWQMRLNEPARFLVIESASQIAPPKR
EEEEEEECCCHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCEEEEEEECCHHCCCCHH
YRNQFGQLLEHAPYCERDIRGPSELLTFTDTGEFEVRIKVRDQLTRHILDHHPFDVVGWD
HHHHHHHHHHHCCCCHHHCCCHHHEEEEECCCCEEEEEEHHHHHHHHHHHCCCCEEEECC
GYLYPWAFSIHDFEPITGRIHQPPPVHQTFEGHNFVVCSFVPRLFDYHPEAIPAPYNHSN
CEECEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCC
VNSDEVIYYCDGNFMSRRGIERCDITLHPAGLPHGPQPGSTEASIGAKETHELAVMIDTF
CCCCCEEEEECCCCHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECC
HPLHLTAAALELEKAGYMDSWSVGGPEG
CCHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: homogentisate; O2

Specific reaction: homogentisate + O2 = 4-maleylacetoacetate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]