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The map label for this gene is purK [H]

Identifier: 222525741

GI number: 222525741

Start: 3134582

End: 3135724

Strand: Reverse

Name: purK [H]

Synonym: Chy400_2492

Alternate gene names: 222525741

Gene position: 3135724-3134582 (Counterclockwise)

Preceding gene: 222525744

Following gene: 222525740

Centisome position: 59.51

GC content: 59.84

Gene sequence:

>1143_bases
ATGCGTATTGGAATCTTTGGTGGTGGACAACTGGCCCAGATGTTGACCCAGGCGGCAATTTCACTGGGGATTGAGATCGT
GATCTGCGAACGGGTTGCGGATAGTCCCGCTGCGCGCTATACCCAACACGCCATCGTTGGCCCCTGGGAGGATGAGACGG
TACTGACTACGTTTGCCCATCAGTGCGATATTGTGACGCTGGAAAATGAGTTTATCGATGCCGGCCTGCTCGAACGGGTC
GTCGCTCAGGGGGTACCGGTCTGGCCGGCACCGGCAACTGTAGCAGTGGTGCAGGACAAATTGTGGCAGAAAGAACGGCT
GGCCGCTGCCGGCCTGGCCGTACCACCGTTTCGTTCTGTTGCGACCCCGGATGACGTCCTCACTGCGGCCCAGGCGTTCG
GCTGGCCACTCGTGCTCAAGACACGTCGTAACGGGTATGATGGCTATGGCAATGCGACGCTCCGCACGGCAGAAGATGTG
CTGCCGGCCTGGGAACGGCTTACCCGCGGTGGTAGTCCGTTGCTGGTGGAGGCGTGGGTACCTTTTACGTGTGAACTGGC
AGTGATGGTGGTGCGTGGACGTGATGGCACCATCGCGTCCTATCCTGTGGTAGAGACGGTGCAGCAAAACCACATTTGTC
ACATTGTCCGGGCACCGGCCCCGATTGAGGCAAAGCTGGCCGCACAGGCGACCGATCTGGCTGTAGCGGCTATTCAGGCT
GTTGATGGAGTGGGTATTTTTGGGGTTGAGTTGTTTGCCCTGGCCGATGGTCAGGTGCTGATCAATGAATTAGCGCCCCG
TCCCCACAACTCTGGTCACTACACGATTGAAGCGTGCGTAACCTCGCAATTTGAGAACCACCTGCGTGCTGTTGCCGGAT
GGCCGTTGGGAGCAACCGCACTCCGCTCACCGGCAGCGGTGATGGTCAACCTGCTTGGCCGTCGTAATGGGCCGATCACC
CCAACGGCGATCACCGCAGCGTTGGCCGTACCCGGTGCCCATATGCACTTTTATGGAAAGCGCGAGGAGCGCATCGGACG
TAAGATGGGGCACGTCACTGCGCTTGGGTCAACACTGGCTGAAGCAGAAGCCATTGCCCGTCAGGCGGCGGCGCTAGTGG
CGATGCCGGACGGGCAGCAATGA

Upstream 100 bases:

>100_bases
GTTACCGGCAGCTTGCACATCCGCTCTTCTGAGGGTACTATACCCGACGTAGATTCATGACGGTTCAGACTCAAACGAGG
CTTTATTGCTCAATAACTAT

Downstream 100 bases:

>100_bases
TTAATCGTTCTGGGCCAGATACAGCATTTCTCGCGGATAAGGAACGAGCGATGACAGATCATCCATTAGTAGGCATTATT
ATGGGCAGCGACAGCGACCT

Product: phosphoribosylaminoimidazole carboxylase, ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MRIGIFGGGQLAQMLTQAAISLGIEIVICERVADSPAARYTQHAIVGPWEDETVLTTFAHQCDIVTLENEFIDAGLLERV
VAQGVPVWPAPATVAVVQDKLWQKERLAAAGLAVPPFRSVATPDDVLTAAQAFGWPLVLKTRRNGYDGYGNATLRTAEDV
LPAWERLTRGGSPLLVEAWVPFTCELAVMVVRGRDGTIASYPVVETVQQNHICHIVRAPAPIEAKLAAQATDLAVAAIQA
VDGVGIFGVELFALADGQVLINELAPRPHNSGHYTIEACVTSQFENHLRAVAGWPLGATALRSPAAVMVNLLGRRNGPIT
PTAITAALAVPGAHMHFYGKREERIGRKMGHVTALGSTLAEAEAIARQAAALVAMPDGQQ

Sequences:

>Translated_380_residues
MRIGIFGGGQLAQMLTQAAISLGIEIVICERVADSPAARYTQHAIVGPWEDETVLTTFAHQCDIVTLENEFIDAGLLERV
VAQGVPVWPAPATVAVVQDKLWQKERLAAAGLAVPPFRSVATPDDVLTAAQAFGWPLVLKTRRNGYDGYGNATLRTAEDV
LPAWERLTRGGSPLLVEAWVPFTCELAVMVVRGRDGTIASYPVVETVQQNHICHIVRAPAPIEAKLAAQATDLAVAAIQA
VDGVGIFGVELFALADGQVLINELAPRPHNSGHYTIEACVTSQFENHLRAVAGWPLGATALRSPAAVMVNLLGRRNGPIT
PTAITAALAVPGAHMHFYGKREERIGRKMGHVTALGSTLAEAEAIARQAAALVAMPDGQQ
>Mature_380_residues
MRIGIFGGGQLAQMLTQAAISLGIEIVICERVADSPAARYTQHAIVGPWEDETVLTTFAHQCDIVTLENEFIDAGLLERV
VAQGVPVWPAPATVAVVQDKLWQKERLAAAGLAVPPFRSVATPDDVLTAAQAFGWPLVLKTRRNGYDGYGNATLRTAEDV
LPAWERLTRGGSPLLVEAWVPFTCELAVMVVRGRDGTIASYPVVETVQQNHICHIVRAPAPIEAKLAAQATDLAVAAIQA
VDGVGIFGVELFALADGQVLINELAPRPHNSGHYTIEACVTSQFENHLRAVAGWPLGATALRSPAAVMVNLLGRRNGPIT
PTAITAALAVPGAHMHFYGKREERIGRKMGHVTALGSTLAEAEAIARQAAALVAMPDGQQ

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=364, Percent_Identity=30.4945054945055, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1788155, Length=403, Percent_Identity=25.8064516129032, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324702, Length=372, Percent_Identity=40.0537634408602, Blast_Score=275, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 40422; Mature: 40422

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGIFGGGQLAQMLTQAAISLGIEIVICERVADSPAARYTQHAIVGPWEDETVLTTFAH
CEEEEECCHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHCCCCCCCCCCCHHHEEHHH
QCDIVTLENEFIDAGLLERVVAQGVPVWPAPATVAVVQDKLWQKERLAAAGLAVPPFRSV
HCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
ATPDDVLTAAQAFGWPLVLKTRRNGYDGYGNATLRTAEDVLPAWERLTRGGSPLLVEAWV
CCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCEEEEECC
PFTCELAVMVVRGRDGTIASYPVVETVQQNHICHIVRAPAPIEAKLAAQATDLAVAAIQA
CCEEEEEEEEEECCCCCEECCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
VDGVGIFGVELFALADGQVLINELAPRPHNSGHYTIEACVTSQFENHLRAVAGWPLGATA
HCCCCEEEEEEEEECCCHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCHHH
LRSPAAVMVNLLGRRNGPITPTAITAALAVPGAHMHFYGKREERIGRKMGHVTALGSTLA
HCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
EAEAIARQAAALVAMPDGQQ
HHHHHHHHHHEEEECCCCCC
>Mature Secondary Structure
MRIGIFGGGQLAQMLTQAAISLGIEIVICERVADSPAARYTQHAIVGPWEDETVLTTFAH
CEEEEECCHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHCCCCCCCCCCCHHHEEHHH
QCDIVTLENEFIDAGLLERVVAQGVPVWPAPATVAVVQDKLWQKERLAAAGLAVPPFRSV
HCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
ATPDDVLTAAQAFGWPLVLKTRRNGYDGYGNATLRTAEDVLPAWERLTRGGSPLLVEAWV
CCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCEEEEECC
PFTCELAVMVVRGRDGTIASYPVVETVQQNHICHIVRAPAPIEAKLAAQATDLAVAAIQA
CCEEEEEEEEEECCCCCEECCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
VDGVGIFGVELFALADGQVLINELAPRPHNSGHYTIEACVTSQFENHLRAVAGWPLGATA
HCCCCEEEEEEEEECCCHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCHHH
LRSPAAVMVNLLGRRNGPITPTAITAALAVPGAHMHFYGKREERIGRKMGHVTALGSTLA
HCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
EAEAIARQAAALVAMPDGQQ
HHHHHHHHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA