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The map label for this gene is purE [H]

Identifier: 222525740

GI number: 222525740

Start: 3134037

End: 3134531

Strand: Reverse

Name: purE [H]

Synonym: Chy400_2491

Alternate gene names: 222525740

Gene position: 3134531-3134037 (Counterclockwise)

Preceding gene: 222525741

Following gene: 222525739

Centisome position: 59.49

GC content: 59.39

Gene sequence:

>495_bases
ATGACAGATCATCCATTAGTAGGCATTATTATGGGCAGCGACAGCGACCTGCCAACCATGCAGGGCGCAATTGATGTCTG
TCGCGAATTCGCCATTCCCTACGAAGCACGGGTTGTCTCGGCCCATCGCACCCCGCTCGATATGGCCGAATATGGCATGA
CAGCCCATCAACGCGGTATTCGGGTGATCATTGCCGGTGCCGGCGGAGCGGCCCATTTACCCGGCATGATTGCGGCGCAC
TCACCTTTGCCCGTGATCGGGGTACCTGTCCCCAGCAAGGCCCTCAACGGTCTCGACTCGTTACTCTCGATTGTGCAGAT
GCCGGCGGGAGTGCCGGTAGCCACAGTCGCGATTGGGAACGGTCGCAACGCCGGTTTGCTGGCCGTCCAGATTCTGGCGA
GTGCCGATCCAGAACTCCTGGCGCGCGTACAGGCGTACAAAGAGCGCATGGCCGCTGAGTCGCGGGCCAAGAACCGCATC
TTTACTGAAATGTAA

Upstream 100 bases:

>100_bases
TTGCCCGTCAGGCGGCGGCGCTAGTGGCGATGCCGGACGGGCAGCAATGATTAATCGTTCTGGGCCAGATACAGCATTTC
TCGCGGATAAGGAACGAGCG

Downstream 100 bases:

>100_bases
TATGATGGCCTGTTGTTGTCATCGTGCTGCGCATCCGGTATGCTATAACCCAATTGCGGGTATACCGAACGCTCGCAGGA
TGTTGCAGGTCATCATTCTG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MTDHPLVGIIMGSDSDLPTMQGAIDVCREFAIPYEARVVSAHRTPLDMAEYGMTAHQRGIRVIIAGAGGAAHLPGMIAAH
SPLPVIGVPVPSKALNGLDSLLSIVQMPAGVPVATVAIGNGRNAGLLAVQILASADPELLARVQAYKERMAAESRAKNRI
FTEM

Sequences:

>Translated_164_residues
MTDHPLVGIIMGSDSDLPTMQGAIDVCREFAIPYEARVVSAHRTPLDMAEYGMTAHQRGIRVIIAGAGGAAHLPGMIAAH
SPLPVIGVPVPSKALNGLDSLLSIVQMPAGVPVATVAIGNGRNAGLLAVQILASADPELLARVQAYKERMAAESRAKNRI
FTEM
>Mature_163_residues
TDHPLVGIIMGSDSDLPTMQGAIDVCREFAIPYEARVVSAHRTPLDMAEYGMTAHQRGIRVIIAGAGGAAHLPGMIAAHS
PLPVIGVPVPSKALNGLDSLLSIVQMPAGVPVATVAIGNGRNAGLLAVQILASADPELLARVQAYKERMAAESRAKNRIF
TEM

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=110, Percent_Identity=57.2727272727273, Blast_Score=125, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324702, Length=153, Percent_Identity=58.1699346405229, Blast_Score=180, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17156; Mature: 17025

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDHPLVGIIMGSDSDLPTMQGAIDVCREFAIPYEARVVSAHRTPLDMAEYGMTAHQRGI
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHEEEECCCCCCCHHHHCCHHHCCCC
RVIIAGAGGAAHLPGMIAAHSPLPVIGVPVPSKALNGLDSLLSIVQMPAGVPVATVAIGN
EEEEECCCCCHHCCCEEECCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GRNAGLLAVQILASADPELLARVQAYKERMAAESRAKNRIFTEM
CCCCCHHEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TDHPLVGIIMGSDSDLPTMQGAIDVCREFAIPYEARVVSAHRTPLDMAEYGMTAHQRGI
CCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHEEEECCCCCCCHHHHCCHHHCCCC
RVIIAGAGGAAHLPGMIAAHSPLPVIGVPVPSKALNGLDSLLSIVQMPAGVPVATVAIGN
EEEEECCCCCHHCCCEEECCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GRNAGLLAVQILASADPELLARVQAYKERMAAESRAKNRIFTEM
CCCCCHHEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]