Click here to switch to the map view.

The map label for this gene is tdk

Identifier: 222525736

GI number: 222525736

Start: 3131248

End: 3131829

Strand: Reverse

Name: tdk

Synonym: Chy400_2487

Alternate gene names: 222525736

Gene position: 3131829-3131248 (Counterclockwise)

Preceding gene: 222525739

Following gene: 222525734

Centisome position: 59.44

GC content: 58.42

Gene sequence:

>582_bases
ATGACTCGCCCAAGCGATGGTGGCCGCATCGAGGTGATTTGCGGCTGTATGTACAGCGGGAAGACCGAGGAACTCATTCG
GCGAATGCGTCAGGTACGGATTGCCCGCCAGTCGTACCGCATCTTCACACCGCGTATGGATACGCGCTATGCCGAAGGGC
AGGTGGCGAGCCATAGCGGGAGCCGGCTCGAGGCAATCACAGTGGCGACCATGAAGGACATTCTGGCCCATGCCGAGGAT
GCCCAGGTTGTGGCCATTGATGAATTGCACCTCTTTGATGATGATCCGGCCGAAATGGTACGTGGGTGTCAATGGCTGGC
CAATCGCGGTGTGCGAGTGATTGTAGCCGGCCTTGATCTAAATTATCGCGCCGAGCCATTTCCGGCCATGATGCATCTGC
TGGCGCTCGCCGAGCAGGTAGACAAGCTATACGCCATTTGTGTGAAGTGTGGCGCCTACGCAACCCGGTCACAACGATTA
ATTGACGGCAAACCGGCACCCGCCGATGCGCCCACCATTGTGGTGGGAGGGCTTGACATGTACGAAGCGCGCTGCCGGAC
CTGTTACGAGCCAGCGGTATAA

Upstream 100 bases:

>100_bases
CAACAATCGTTCGTCTTCTGTCTGTCGTGACATGGTATGGTATACTCCGCAAATTGATGGGCAACACTGCCCATAGGATA
CTACAAATTCAGGAGGAGTG

Downstream 100 bases:

>100_bases
GCTGTAGCAATGGGGCGAGCATCAGCCCGCCCCATCACCAGGTGCATTGGAGACGAATGTCAATCAGCTCAAGCCGAGTT
TACGCTTCAGCTCAGCCAGC

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MTRPSDGGRIEVICGCMYSGKTEELIRRMRQVRIARQSYRIFTPRMDTRYAEGQVASHSGSRLEAITVATMKDILAHAED
AQVVAIDELHLFDDDPAEMVRGCQWLANRGVRVIVAGLDLNYRAEPFPAMMHLLALAEQVDKLYAICVKCGAYATRSQRL
IDGKPAPADAPTIVVGGLDMYEARCRTCYEPAV

Sequences:

>Translated_193_residues
MTRPSDGGRIEVICGCMYSGKTEELIRRMRQVRIARQSYRIFTPRMDTRYAEGQVASHSGSRLEAITVATMKDILAHAED
AQVVAIDELHLFDDDPAEMVRGCQWLANRGVRVIVAGLDLNYRAEPFPAMMHLLALAEQVDKLYAICVKCGAYATRSQRL
IDGKPAPADAPTIVVGGLDMYEARCRTCYEPAV
>Mature_192_residues
TRPSDGGRIEVICGCMYSGKTEELIRRMRQVRIARQSYRIFTPRMDTRYAEGQVASHSGSRLEAITVATMKDILAHAEDA
QVVAIDELHLFDDDPAEMVRGCQWLANRGVRVIVAGLDLNYRAEPFPAMMHLLALAEQVDKLYAICVKCGAYATRSQRLI
DGKPAPADAPTIVVGGLDMYEARCRTCYEPAV

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Homo sapiens, GI164698438, Length=182, Percent_Identity=37.3626373626374, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17543396, Length=191, Percent_Identity=36.1256544502618, Blast_Score=105, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_CHLAA (A9WGI6)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001635907.1
- ProteinModelPortal:   A9WGI6
- SMR:   A9WGI6
- GeneID:   5826773
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_2309
- HOGENOM:   HBG522108
- OMA:   VITGPMY
- ProtClustDB:   PRK04296
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020633
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 21452; Mature: 21321

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: ACT_SITE 88-88

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
8.3 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPSDGGRIEVICGCMYSGKTEELIRRMRQVRIARQSYRIFTPRMDTRYAEGQVASHSG
CCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEECCCCC
SRLEAITVATMKDILAHAEDAQVVAIDELHLFDDDPAEMVRGCQWLANRGVRVIVAGLDL
CCEEEHHHHHHHHHHHCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCC
NYRAEPFPAMMHLLALAEQVDKLYAICVKCGAYATRSQRLIDGKPAPADAPTIVVGGLDM
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEECCCCCCCCCCEEEECCCHH
YEARCRTCYEPAV
HHHHHHHHCCCCC
>Mature Secondary Structure 
TRPSDGGRIEVICGCMYSGKTEELIRRMRQVRIARQSYRIFTPRMDTRYAEGQVASHSG
CCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEECCCCC
SRLEAITVATMKDILAHAEDAQVVAIDELHLFDDDPAEMVRGCQWLANRGVRVIVAGLDL
CCEEEHHHHHHHHHHHCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCC
NYRAEPFPAMMHLLALAEQVDKLYAICVKCGAYATRSQRLIDGKPAPADAPTIVVGGLDM
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEECCCCCCCCCCEEEECCCHH
YEARCRTCYEPAV
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA