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The map label for this gene is ribBA [H]

Identifier: 222525621

GI number: 222525621

Start: 2994832

End: 2996040

Strand: Direct

Name: ribBA [H]

Synonym: Chy400_2372

Alternate gene names: 222525621

Gene position: 2994832-2996040 (Clockwise)

Preceding gene: 222525620

Following gene: 222525622

Centisome position: 56.84

GC content: 58.97

Gene sequence:

>1209_bases
ATGTTCGCATCAGTGGAAGAAGCGCTGCGCGATTACGCGGCTGGCCGGATGATCATCATCGTTGATGATGCTGATCGCGA
GAATGAGGGCGATCTGGCCTGTGCTGCACAACACGTCACTGCTGAAACAATTGCATTTATGGCGCGCGAAGGGCGGGGGC
TGATCTGTCTGGCGCTCGCCGGCGAGATAGCCGACCGTCTGGGGCTAGAGCCGATGGTACGGCAGAATCGGGCTCGTTTC
GGTACCAATTTTACGGTATCAATTGAAGCTGCTCACGGCGTTACCACCGGTATCTCGGCTGCCGACCGGGCGCATACGAT
TCGCGTTGCGGTTGACCCACACAGTGGCCCGCACGATCTGGTACAACCGGGTCACGTCTTTCCCCTGCGGGCTGCGCCCA
ACGGTGTCCTGGAGCGGCGCGGTCAGACGGAAGCGGCAGTTGATCTGGCCCGGCTGGCGGGCCTGCGACCGGCTGGTGTC
ATCTGCGAAATAATGAACGACGATGGTACGATGGCCCGTGGCCCTGATCTTGTCCGCTTCGCCGTCAGGCACAACCTCAA
GATCATCAGCGTCGAGCAACTGGTTGCCTACCGCAAACGTCACGAACGTCTGATTGAGCGCATGGCCGAAGCGCAGCTTC
CAACCCGCTATGGCACGTTTCGCGCCGTCTCGTACAGCGCCCGTTGTGCCCCCCACGAAGCAGTTGCGCTGATCATCGGT
CATCCCAAACCTGATCAGCCGATCCTGGTGCGCCTCCACTCTGAATGCCTGACCGGTGATGTATTTGGGAGTCTCCGCTG
CGATTGCGGCGAGCAGATCGATACCGCGCTGCATCAGATGGCTGCTGCCGGCTGTGGGGTATTGGTCTACCTGCGCCAGG
AAGGTCGTGGCATCGGCCTGCACAACAAACTGCGCGCCTATGCCCTACAAGAACAGGGATTTGACACCGTGGCCGCAAAC
GAACAACTCGGCTTCCCTGCCGATCTGCGCGACTATACGGTTGGCGCACAGATTCTTACCGATCTCGGCGTGCGCACCGT
TCATCTGCTGACCAACAACCCGCAGAAAGTAGCTGCCTTACGCGAATTTGGCTTTGCCGTGACGCAGGTTCCCATCTGTG
GTACACCAAATCCGCACAACATTGCCTATCTGCTCACCAAACGGAATCGTCTAGGACATCAACTGGAGTGCATCTATGAC
CATCTATGA

Upstream 100 bases:

>100_bases
TGGGCCGTCAGACGGTGGGAGCATTGGTGAATATAGAGGTTGATATTATCGCCAAGTATGTTGAACGCCTGCTTGAGGCG
TATCGCCAGGAGGCTCGCTA

Downstream 100 bases:

>100_bases
AGGCACGTATATCGGCAGTGGCTTACGGATAGCGATTGTCGTCAGCCGCTGGAACGACCTGATTACCAACCGTCTGCTCG
AAGGTGCGCGAGATGGACTG

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MFASVEEALRDYAAGRMIIIVDDADRENEGDLACAAQHVTAETIAFMAREGRGLICLALAGEIADRLGLEPMVRQNRARF
GTNFTVSIEAAHGVTTGISAADRAHTIRVAVDPHSGPHDLVQPGHVFPLRAAPNGVLERRGQTEAAVDLARLAGLRPAGV
ICEIMNDDGTMARGPDLVRFAVRHNLKIISVEQLVAYRKRHERLIERMAEAQLPTRYGTFRAVSYSARCAPHEAVALIIG
HPKPDQPILVRLHSECLTGDVFGSLRCDCGEQIDTALHQMAAAGCGVLVYLRQEGRGIGLHNKLRAYALQEQGFDTVAAN
EQLGFPADLRDYTVGAQILTDLGVRTVHLLTNNPQKVAALREFGFAVTQVPICGTPNPHNIAYLLTKRNRLGHQLECIYD
HL

Sequences:

>Translated_402_residues
MFASVEEALRDYAAGRMIIIVDDADRENEGDLACAAQHVTAETIAFMAREGRGLICLALAGEIADRLGLEPMVRQNRARF
GTNFTVSIEAAHGVTTGISAADRAHTIRVAVDPHSGPHDLVQPGHVFPLRAAPNGVLERRGQTEAAVDLARLAGLRPAGV
ICEIMNDDGTMARGPDLVRFAVRHNLKIISVEQLVAYRKRHERLIERMAEAQLPTRYGTFRAVSYSARCAPHEAVALIIG
HPKPDQPILVRLHSECLTGDVFGSLRCDCGEQIDTALHQMAAAGCGVLVYLRQEGRGIGLHNKLRAYALQEQGFDTVAAN
EQLGFPADLRDYTVGAQILTDLGVRTVHLLTNNPQKVAALREFGFAVTQVPICGTPNPHNIAYLLTKRNRLGHQLECIYD
HL
>Mature_402_residues
MFASVEEALRDYAAGRMIIIVDDADRENEGDLACAAQHVTAETIAFMAREGRGLICLALAGEIADRLGLEPMVRQNRARF
GTNFTVSIEAAHGVTTGISAADRAHTIRVAVDPHSGPHDLVQPGHVFPLRAAPNGVLERRGQTEAAVDLARLAGLRPAGV
ICEIMNDDGTMARGPDLVRFAVRHNLKIISVEQLVAYRKRHERLIERMAEAQLPTRYGTFRAVSYSARCAPHEAVALIIG
HPKPDQPILVRLHSECLTGDVFGSLRCDCGEQIDTALHQMAAAGCGVLVYLRQEGRGIGLHNKLRAYALQEQGFDTVAAN
EQLGFPADLRDYTVGAQILTDLGVRTVHLLTNNPQKVAALREFGFAVTQVPICGTPNPHNIAYLLTKRNRLGHQLECIYD
HL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=202, Percent_Identity=51.980198019802, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1787533, Length=192, Percent_Identity=53.125, Blast_Score=199, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6320695, Length=209, Percent_Identity=44.4976076555024, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6319438, Length=169, Percent_Identity=47.3372781065089, Blast_Score=133, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 43857; Mature: 43857

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFASVEEALRDYAAGRMIIIVDDADRENEGDLACAAQHVTAETIAFMAREGRGLICLALA
CCCCHHHHHHHHHCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEEH
GEIADRLGLEPMVRQNRARFGTNFTVSIEAAHGVTTGISAADRAHTIRVAVDPHSGPHDL
HHHHHHHCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCHHH
VQPGHVFPLRAAPNGVLERRGQTEAAVDLARLAGLRPAGVICEIMNDDGTMARGPDLVRF
CCCCCEEEECCCCCHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHH
AVRHNLKIISVEQLVAYRKRHERLIERMAEAQLPTRYGTFRAVSYSARCAPHEAVALIIG
HHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEEE
HPKPDQPILVRLHSECLTGDVFGSLRCDCGEQIDTALHQMAAAGCGVLVYLRQEGRGIGL
CCCCCCCEEEEEEHHHHCCHHCCCEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
HNKLRAYALQEQGFDTVAANEQLGFPADLRDYTVGAQILTDLGVRTVHLLTNNPQKVAAL
HHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHH
REFGFAVTQVPICGTPNPHNIAYLLTKRNRLGHQLECIYDHL
HHHCCEEEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHHCC
>Mature Secondary Structure
MFASVEEALRDYAAGRMIIIVDDADRENEGDLACAAQHVTAETIAFMAREGRGLICLALA
CCCCHHHHHHHHHCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEEH
GEIADRLGLEPMVRQNRARFGTNFTVSIEAAHGVTTGISAADRAHTIRVAVDPHSGPHDL
HHHHHHHCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCHHH
VQPGHVFPLRAAPNGVLERRGQTEAAVDLARLAGLRPAGVICEIMNDDGTMARGPDLVRF
CCCCCEEEECCCCCHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHH
AVRHNLKIISVEQLVAYRKRHERLIERMAEAQLPTRYGTFRAVSYSARCAPHEAVALIIG
HHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEEE
HPKPDQPILVRLHSECLTGDVFGSLRCDCGEQIDTALHQMAAAGCGVLVYLRQEGRGIGL
CCCCCCCEEEEEEHHHHCCHHCCCEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
HNKLRAYALQEQGFDTVAANEQLGFPADLRDYTVGAQILTDLGVRTVHLLTNNPQKVAAL
HHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHH
REFGFAVTQVPICGTPNPHNIAYLLTKRNRLGHQLECIYDHL
HHHCCEEEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]