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The map label for this gene is hpt [H]

Identifier: 222525451

GI number: 222525451

Start: 2786433

End: 2786978

Strand: Direct

Name: hpt [H]

Synonym: Chy400_2199

Alternate gene names: 222525451

Gene position: 2786433-2786978 (Clockwise)

Preceding gene: 222525450

Following gene: 222525452

Centisome position: 52.88

GC content: 54.76

Gene sequence:

>546_bases
ATGCGTCAGGACATTGATTACATCTTGATTGGGGAAGATCAGATCAAACAGCGGGTTGCGGAGCTGGCTGCTGAGATCAG
TGCCGATTATCGCGACCTCGGTGATCTGCTGCTGGTCGGCGTTCTGAAGGGCTGCGCCATGTTTATGGTTGATCTGGCGC
GGGCAATTGATCTGCCACTTGCGATTGATTTCATCGCGGTTGCCAGTTATGGCGCCAGTACCGAGTCGTCGGGTGTGGTG
CGTTTGATCAAAGACCTCGACACCGACATTTCGCAGCGCCACGTATTGATTGTCGAAGACATTATTGATAGCGGCCTGAC
CCTGGCGTACCTGCGGTCGCAATTGCTGCGGCGCAATCCGGCCAGTCTGCGCATCTGCACGTTGCTCAACAAACCTGAAC
GACGTACAGCAGATGTGCCGGTTGACTACATTGGTTTTGACATCCCGAATGCCTTTGTGGTTGGGTACGGCCTGGATTAT
GCAGAGCGCTATCGCAATCTCCCCTTCATTGGCGTGTTGCGCCCTGAGGTCTACCAGTCAGCGTAG

Upstream 100 bases:

>100_bases
TTGGCTTGCGAGTTGCTGCCGGCGTCGCTGCATCTGAGCCGAATCAGGCTACAATGTGGATTGGGATCGTTCACTCTGCC
ACAACAAGACAGGAGTAAGC

Downstream 100 bases:

>100_bases
TTGTGATCCAGATCACATTCTGAGTGTAATCTGTTCCCTTGCCGTCGGTGATCGGCTGATGCTATAATTCCAACAAGCGG
CGTACAGGATGGCTGATTGC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MRQDIDYILIGEDQIKQRVAELAAEISADYRDLGDLLLVGVLKGCAMFMVDLARAIDLPLAIDFIAVASYGASTESSGVV
RLIKDLDTDISQRHVLIVEDIIDSGLTLAYLRSQLLRRNPASLRICTLLNKPERRTADVPVDYIGFDIPNAFVVGYGLDY
AERYRNLPFIGVLRPEVYQSA

Sequences:

>Translated_181_residues
MRQDIDYILIGEDQIKQRVAELAAEISADYRDLGDLLLVGVLKGCAMFMVDLARAIDLPLAIDFIAVASYGASTESSGVV
RLIKDLDTDISQRHVLIVEDIIDSGLTLAYLRSQLLRRNPASLRICTLLNKPERRTADVPVDYIGFDIPNAFVVGYGLDY
AERYRNLPFIGVLRPEVYQSA
>Mature_181_residues
MRQDIDYILIGEDQIKQRVAELAAEISADYRDLGDLLLVGVLKGCAMFMVDLARAIDLPLAIDFIAVASYGASTESSGVV
RLIKDLDTDISQRHVLIVEDIIDSGLTLAYLRSQLLRRNPASLRICTLLNKPERRTADVPVDYIGFDIPNAFVVGYGLDY
AERYRNLPFIGVLRPEVYQSA

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI9910262, Length=186, Percent_Identity=34.9462365591398, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI4504483, Length=184, Percent_Identity=34.7826086956522, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI87081689, Length=172, Percent_Identity=51.7441860465116, Blast_Score=183, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17510817, Length=189, Percent_Identity=35.4497354497354, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20164; Mature: 20164

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQDIDYILIGEDQIKQRVAELAAEISADYRDLGDLLLVGVLKGCAMFMVDLARAIDLPL
CCCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AIDFIAVASYGASTESSGVVRLIKDLDTDISQRHVLIVEDIIDSGLTLAYLRSQLLRRNP
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHCEEEEHHHHHCCCCHHHHHHHHHHHCCC
ASLRICTLLNKPERRTADVPVDYIGFDIPNAFVVGYGLDYAERYRNLPFIGVLRPEVYQS
CCEEEEEECCCCCCCCCCCCHHHHCCCCCCCEEEECCCCHHHHHCCCCEEEEECHHHHCC
A
C
>Mature Secondary Structure
MRQDIDYILIGEDQIKQRVAELAAEISADYRDLGDLLLVGVLKGCAMFMVDLARAIDLPL
CCCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AIDFIAVASYGASTESSGVVRLIKDLDTDISQRHVLIVEDIIDSGLTLAYLRSQLLRRNP
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHCEEEEHHHHHCCCCHHHHHHHHHHHCCC
ASLRICTLLNKPERRTADVPVDYIGFDIPNAFVVGYGLDYAERYRNLPFIGVLRPEVYQS
CCEEEEEECCCCCCCCCCCCHHHHCCCCCCCEEEECCCCHHHHHCCCCEEEEECHHHHCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]